Maolin Liu, Jiandong Lu, Chengjun Yu, Jie Zhao, Ling Wang, Yang Hu, Long Chen, Rong Han, Yan Liu, Miao Sun, Guanghui Wei, Shengde Wu
Background Wilms tumor (WT) is highly curable, although anaplastic histology or relapse imparts a worse prognosis. Nephrogenic rests (NR) associated with a high risk of developing WT are abnormally retained embryonic kidney precursor cells. Methods After pseudo-time analysis using single-cell RNA sequencing (scRNA-seq) data, we generated and validated a WT differentiation-related gene (WTDRG) signature to predict overall survival (OS) in children with a poor OS. Results A differentiation trajectory from NR to WT was identified and showed that hypodifferentiated subsets of NR could differentiate into WT...
January 12, 2024: Fetal and Pediatric Pathology