Liang Liu, Lantian Lu, Min Qiu, Ning Han, Shijie Dai, Shuiping Shi, Shanshan He, Jing Zhang, Qingfeng Yan, Shuqing Chen
Pathological scarring resulting from traumas and wounds, such as hypertrophic scars and keloids, pose significant aesthetic, functional and psychological challenges. This study provides a comprehensive transcriptomic analysis of these conditions, aiming to illuminate underlying molecular mechanisms and potential therapeutic targets. We employed a co-expression and module analysis tool to identify significant gene clusters associated with distinct pathophysiological processes and mechanisms, notably lipid metabolism, sebum production, cellular energy metabolism and skin barrier function...
September 11, 2023: International Wound Journal