Xu Ximei, Luo Yiqun, Zhang Zhikun, Nie Yueli, Liu Xiuli, Shi Wei, Wu Tao, Wu Pan, Liu Xiyu, Huang Yong, Zhao Yongxiang, Gan Lu, Zhong Liping, Chen Qiaoying, He Jian
To conduct an anti-tumor research by using targeted drug-loaded cell-derived microparticles to target the tumor microenvironment and enhance NK cell killing function. In this experiment, we obtained HepG2 tumor cell-derived microparticles by physical extrusion, high speed centrifugation and filtration, modified the hepatocellular carcinoma targeting peptide SP94 on the surface of microparticles and encapsulated the TGF- β inhibitor SB505124. Finally we validated and analyzed whether the new drug delivery system can target to tumor site and enhance the anti-tumor function of NK cells...
April 1, 2022: Journal of Biomedical Nanotechnology