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Photodiagnosis and Photodynamic Therapy

Xiaowen Huang, Kai Han, Li Wang, Xiaoming Peng, Kang Zeng, Li Li
No abstract text is available yet for this article.
February 12, 2019: Photodiagnosis and Photodynamic Therapy
Łukasz Lamch, Julita Kulbacka, Magda Dubińska-Magiera, Jolanta Saczko, Kazimiera A Wilk
Targeted and effective drug transport is becoming an attractive option in cancer therapy since it can improve drug efficacy and reduce drugs' side effects in normal tissues. In addition to using specific surface ligand molecules, the selective drug delivery can be accomplished via enhanced permeability and retention effect. Therefore, in our studies, we entrapped zinc (II) phthalocyanine (ZnPc) - a second generation photosensitizer - in folate-functionalized micelles of the biocompatible, FDA-approved for biomedical application diblock copolymer methoxypoly(ethylene oxide)-b-poly(L-lactide) (mPEG-b-PLLA) and its derivative with folate (FA) attached to the end of PEG chain (FA-PEG-b-PLLA)...
February 12, 2019: Photodiagnosis and Photodynamic Therapy
S Alves, D R N Sonego, K A Fudimura, M L Hallack, L A Azzalis, V B C Junqueira, K C Rocha, R L A Fonseca, F W S Figueiredo, F L A Fonseca
Cancer is a disease that affects cell metabolism causing an imbalance in the health of the patient. On the other hand, malnutrition, presented by oncological patients, is caused by both the disease and its treatment. Some serum biochemical parameters cannot be determined by the traditional method of laboratory blood analysis (spectrophotometry). Among the various techniques that could be used for blood biochemical analysis, we opted for the Z-Scan technique, due to its sensitivity to the reading of blood components...
February 12, 2019: Photodiagnosis and Photodynamic Therapy
Deema Al-Shammery, Dimitrios Michelogiannakis, Zain Uddin Ahmed, Hameeda Bashir Ahmed, P Emile Rossouw, Georgios E Romanos, Fawad Javed
BACKGROUND: The aim of the present study was to comprehensively review indexed literature regarding the potential role of antimicrobial photodynamic therapy (aPDT) in Orthodontics. METHODS: Indexed databases were searched up to and including January 2019 using the following key words: (a) antimicrobial photodynamic therapy; (b) antimicrobial photodynamic chemotherapy; (c) orthodontic; and (d) orthodontics. Original (clinical and experimental) studies, case-reports, and case-series were included...
February 9, 2019: Photodiagnosis and Photodynamic Therapy
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: To investigate the efficacy of antimicrobial photodynamic therapy (aPDT) adjunctive to conventional chemo-mechanical debridement of root canal system in patients with endodontic infections. METHODS: A meta-analysis was done according to the Cochrane Collaboration recommendations and PRISMA statement. Two independent reviewers performed an extensive literature search on electronic databases of MEDLINE, EMBASE, and SCOPUS up to January 2019. The search strategy was done from the following terms: antimicrobial photodynamic therapy OR photo-activated disinfection AND root canal therapy OR endodontic therapy OR root canal infection OR endodontic infection...
February 9, 2019: Photodiagnosis and Photodynamic Therapy
Saghar Hendiani, Majid Pornour, Nasim Kashef
BACKGROUND: Photodynamic inactivation (PDI) is being recognized as a new antimicrobial approach. It is likely that in human hosts receiving this therapy, pathogens may encounter sub-lethal doses of PDI (sPDI), which may affect microbial virulence. This study was aimed to evaluate the effect of sPDI using methylene blue (MB) on the expression of genes belonging to two quorum sensing (QS) operons (rhl and las systems) and two genes necessary for pyocyanin and rhamnolipid production (phzM and rhlA) under QS control in Pseudomonas aeruginosa...
February 9, 2019: Photodiagnosis and Photodynamic Therapy
K Moghissi
No abstract text is available yet for this article.
February 7, 2019: Photodiagnosis and Photodynamic Therapy
Łukasz Ożóg, Wojciech Domka, Adrian Truszkiewicz, Jacek Tarbarkiewicz, David Aebisher
Photodynamic oxygen consumption was measured by changes in spin-lattice relaxation time (T1 ) in aqueous solution in a clinical GE scanner at 1.5 Tesla. Similar measurements were attempted in excised laryngeal and thyroid tissues that were infused with Rose Bengal. First, T1 was measured as a function of dissolved oxygen in argon and in oxygen pre-saturated water samples that were opened to the atmosphere in a series of steps allowing air to diffuse into or out of solution; for both argon and oxygen saturated water solutions, stepwise air re-equilibration resulted in a return to air-saturated water T1 ...
February 7, 2019: Photodiagnosis and Photodynamic Therapy
Furkan Ayaz, Naz Ugur, Kasım Ocakoglu, Mine Ince
In this study, a series of subphthalocyanines (SubPcs) derivatives were synthesized to generate unique immunomodulatory molecules that can be activated through photo-induction. Immunomodulatory agents have a great potential in the medicine to manipulate the immune system according to our needs and prevent the disease symptoms. Inflammation is one of these symptoms and macrophages play a crucial role in the generation of inflammatory responses. Being able to control the activity of these agents through photo-induction enables the fine tuning on their activities in a location specific and non-invasive manner with possibly minor side effects...
February 7, 2019: Photodiagnosis and Photodynamic Therapy
Dongxia Fan, Jeany Qiuchen Li, Rui Hua
PURPOSE: To investigate the different imaging characteristics between unilateral and bilateral polypoidal choroidal vasculopathy (PCV) cases, based on confocal scanning laser ophthalmoscopes. MATERIALS: For this retrospective case series study, diagnostic indocyanine green angiography (ICGA) and spectral domain optical coherence tomography (SD-OCT) were performed to assess the eligible PCV eyes. RESULTS: Among the 53 patients at baseline, 14 showed bilateral PCV lesions, including two cases of branching vessel network (BVN) without leakage...
February 6, 2019: Photodiagnosis and Photodynamic Therapy
Jingying Wang, Songshan Li, Zhijia Li, Junpeng Li, Xiaoming Peng, Shujiao Li, Lifen Jiang, Hui Liu, Kang Zeng
5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) is a highly effective, safe, and promising treatment for human papillomavirus (HPV)-induced anogenital condyloma acuminata (CA). Specific HPV subtypes are responsible for the pathogenesis of CA and dynamic changes in viral loads may reflect the efficiency of PDT. Here we present two cases of anogenital CA successfully treated by ALA-PDT under the guidance of HPV DNA detection including genotype identification and viral load measurement, which provided clues for unexpected intra-anal infection...
February 6, 2019: Photodiagnosis and Photodynamic Therapy
Takeshi Yoneyama, Tetsuyo Watanabe, Sho Tamai, Katsuyoshi Miyashita, Mitsutoshi Nakada
BACKGROUND: In a previous study of photodynamic tumor diagnosis using 5-aminolevulinic acid (5-ALA), the authors proposed using fluorescence intensity and bright spot analyses under confocal microscopy for the precise discrimination of tumorous brain tissue (such as glioblastoma, GBM) from normal tissue. However, it remains unclear if bright spot analysis can discriminate infiltrating tumor in the boundary zone and whether this method is suitable for GBM with no 5-ALA fluorescence or for other tumor types...
February 6, 2019: Photodiagnosis and Photodynamic Therapy
Maryam Bakhshizadeh, Seyed Ahmad Mohajeri, Habibollah Esmaily, Seyed Amir Aledavood, Fatemeh Varshoei Tabrizi, Mahmoud Seifi, Farzin Hadizadeh, Ameneh Sazgarnia
BACKGROUND: Some materials such as TiO2 display a luminescence property when exposed to X-ray radiation. Therefore, a proper photosensitizer can induce photodynamic effects by absorbing the emitted photons from these materials during radiotherapy. In this way, the problem of limited photo- penetration depth in photodynamic therapy is resolved. In this paper, following the production of a nanopolymer containing TiO2 cores and imprinted for mitoxantron (MIP), the possibility of utilizing its optical and radio properties on two lines of cancer cells were studied...
February 6, 2019: Photodiagnosis and Photodynamic Therapy
Ana Cristina da Silva Sousa, Manuel António Costa Campos, Armando Manuel Baptista, Nuno Miguel Bouças Vasconcelos Noronha Menezes
BACKGROUND: Daylight photodynamic therapy has been reported as having similar efficacy to conventional photodynamic therapy in actinic keratosis treatment. METHODS: 25 patients with actinic keratosis of the scalp and/or face were submitted to a daylight photodynamic therapy session. Adverse reactions were evaluated after one week and efficacy after 3 months. Confocal Microscopy was performed in 6 patients, before and one week after the treatment. Our aim was to compare our results with others studies and analyse the changes occurring in the epidermis and upper dermis with confocal microscopy...
February 2, 2019: Photodiagnosis and Photodynamic Therapy
Leila Moradi Eslami
BACKGROUND AND AIM: Long term success in endodontic therapy is attributed to removal and debridement of intracanal microorganisms. The aim of this study was to compare the antimicrobial effects calcium hydroxide (Ca(OH)2 ), triple antibiotic paste (TAP), photodynamic therapy(PDT), toluidine blue(TOL), light emitting diode (LED) and 940 nm diode laser (DL) on the biofilm of Enterococcus faecalis and Candida albicans in the root canal system of ex-vivo human teeth. MATERIALS & METHODS: 84 intact, uniradicular, extracted human premolar teeth were prepared and the apical foramina were sealed with glass ionomer...
January 29, 2019: Photodiagnosis and Photodynamic Therapy
William R Potter
No abstract text is available yet for this article.
January 29, 2019: Photodiagnosis and Photodynamic Therapy
G Bœuf-Muraille, G Rigaux, M Callewaert, N Zambrano, L Van Gulick, V G Roullin, C Terryn, M-C Andry, F Chuburu, S Dukic, M Molinari
Photodynamic therapy (PDT) is a very attractive strategy to complement or replace common cancer treatments such as radiotherapy, surgery, and chemotherapy. If some molecules have shown their efficiency as photosensitizers (PS), many issues have to be solved such as the inherent cytotoxicity of the PS or its hydrophobic properties causing limitation in their solubility and leading to side effects. In this study, the encapsulation of an approved PS, the meso-tetra hydroxyphenylchlorine (mTHPC, Foscan®) within biocompatible and biodegradable poly(D, L-lactide-co-glycolide) acid (PLGA) NPs prepared by the nanoprecipitation method was studied...
January 29, 2019: Photodiagnosis and Photodynamic Therapy
Pan He, Tao Huang, Cheng Fang, Song Su, Jie Tian, XianMing Xia, Bo Li
BACKGROUND/PURPOSE: Intraoperative fluorescence imaging with indocyanine green (ICG) plays a significant role in the identification of hepatocellular carcinoma (HCC) during Hepatectomy. Despite that, few researchers have reported using ICG fluorescence imaging to detect extrahepatic metastases. Herein, we report the successful application of ICG fluorescence imaging in the detection of extrahepatic metastatic lesions from primary liver cancer. METHODS: In two HCC patients, a near-infrared fluorescence imaging system was used to intraoperatively examine the abdominal cavity implantation metastasis after multiple hepatectomy and the primary tumor after the pre-operation with ICG...
January 29, 2019: Photodiagnosis and Photodynamic Therapy
Lixue Zhang, Xiufang Li, Xinqiao Liu, Ying Gao, Qingning Tang
BACKGROUND: Condyloma acuminatum(CA)is a venereal disease associated with a high rate of recurrence due to the rapid replication and subtle immune escape mechanism of Human Papillomavirus(HPV). Topical CO2 laser can remove verruca accurately. Photodynamic therapy with 5-aminolevulinic acid(PDT-ALA) is an effective therapy which targets on HPV infected sites. Some studies demonstrate that when combined with use of CO2 lasers, photodynamic therapy can become more effective. METHODS: We attempted to clinically cure a series of CA grown on cervix, urethra, urinary meatus, vulva, crissum and anal canal with treatment of topical CO2 laser combined photodynamic therapy and report herein 6 cases...
January 28, 2019: Photodiagnosis and Photodynamic Therapy
Rana Sulaiman Al-Hamdan
BACKGROUND: The aim of the current systematic review was to evaluate the efficacy of phototherapy (PT) on bond strength of bleached enamel. METHODS: Electronic databases including MEDLINE (PubMed), ISI Web of Science, Scopus, ScIELO, LILACS and EMBASE until January 2019. The addressed focused question was: "Does PT increase the bond integrity of bleached enamel?" Only in-vitro studies evaluating the effect of PT compared with bleaching agent or no phototherapy were included...
January 28, 2019: Photodiagnosis and Photodynamic Therapy
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