journal
https://read.qxmd.com/read/38637850/targeting-brain-peripheral-immune-responses-for-secondary-brain-injury-after-ischemic-and-hemorrhagic-stroke
#1
REVIEW
Mingxu Duan, Ya Xu, Yuanshu Li, Hua Feng, Yujie Chen
The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades, with increasing evidence of strong links and interactions between the central nervous system and the peripheral immune system, both in the healthy state and after ischemic and hemorrhagic stroke. Although primary injury after stroke is certainly important, the limited therapeutic efficacy, poor neurological prognosis and high mortality have led researchers to realize that secondary injury and damage may also play important roles in influencing long-term neurological prognosis and mortality and that the neuroinflammatory process in secondary injury is one of the most important influences on disease progression...
April 18, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38632579/microbiota-derived-acetate-attenuates-neuroinflammation-in-rostral-ventrolateral-medulla-of-spontaneously-hypertensive-rats
#2
JOURNAL ARTICLE
Xiaopeng Yin, Changhao Duan, Lin Zhang, Yufang Zhu, Yueyao Qiu, Kaiyi Shi, Sen Wang, Xiaoguang Zhang, Huaxing Zhang, Yinchao Hao, Fang Yuan, Yanming Tian
BACKGROUND: Increased neuroinflammation in brain regions regulating sympathetic nerves is associated with hypertension. Emerging evidence from both human and animal studies suggests a link between hypertension and gut microbiota, as well as microbiota-derived metabolites short-chain fatty acids (SCFAs). However, the precise mechanisms underlying this gut-brain axis remain unclear. METHODS: The levels of microbiota-derived SCFAs in spontaneously hypertensive rats (SHRs) were determined by gas chromatography-mass spectrometry...
April 18, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38632655/schwann-cell-derived-extracellular-vesicles-promote-memory-impairment-associated-with-chronic-neuropathic-pain
#3
JOURNAL ARTICLE
Yidan Tang, Jiahui Wu, Changliang Liu, Lu Gan, Hai Chen, Ya-Lan Sun, Jin Liu, Yuan-Xiang Tao, Tao Zhu, Chan Chen
BACKGROUND: The pathogenesis of memory impairment, a common complication of chronic neuropathic pain (CNP), has not been fully elucidated. Schwann cell (SC)-derived extracellular vesicles (EVs) contribute to remote organ injury. Here, we showed that SC-EVs may mediate pathological communication between SCs and hippocampal neurons in the context of CNP. METHODS: We used an adeno-associated virus harboring the SC-specific promoter Mpz and expressing the CD63-GFP gene to track SC-EVs transport...
April 17, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38632654/igm-anti-gm2-antibodies-in-patients-with-multifocal-motor-neuropathy-target-schwann-cells-and-are-associated-with-early-onset
#4
JOURNAL ARTICLE
Kevin Budding, Jeroen W Bos, Kim Dijkxhoorn, Elisabeth de Zeeuw, Lauri M Bloemenkamp, Eva M Zekveld, Ewout J N Groen, Bart C Jacobs, Ruth Huizinga, H Stephan Goedee, Elisabeth A Cats, Jeanette H W Leusen, Leonard H van den Berg, C Erik Hack, W Ludo van der Pol
BACKGROUND: Multifocal motor neuropathy (MMN) is a rare, chronic immune-mediated polyneuropathy characterized by asymmetric distal limb weakness. An important feature of MMN is the presence of IgM antibodies against gangliosides, in particular GM1 and less often GM2. Antibodies against GM1 bind to motor neurons (MNs) and cause damage through complement activation. The involvement of Schwann cells (SCs), expressing GM1 and GM2, in the pathogenesis of MMN is unknown. METHODS: Combining the data of our 2007 and 2015 combined cross-sectional and follow-up studies in Dutch patients with MMN, we evaluated the presence of IgM antibodies against GM1 and GM2 in serum from 124 patients with MMN and investigated their binding to SCs and complement-activating properties...
April 17, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38632569/complement-propagates-visual-system-pathology-following-traumatic-brain-injury
#5
JOURNAL ARTICLE
Davis M Borucki, Baerbel Rohrer, Stephen Tomlinson
BACKGROUND: Traumatic brain injury (TBI) is associated with the development of visual system disorders. Visual deficits can present with delay and worsen over time, and may be associated with an ongoing neuroinflammatory response that is known to occur after TBI. Complement system activation is strongly associated with the neuroinflammatory response after TBI, but whether it contributes to vision loss after TBI is unexplored. METHODS: Acute and chronic neuroinflammatory changes within the dorsal lateral geniculate nucleus (dLGN) and retina were investigated subsequent to a moderate to severe murine unilateral controlled cortical impact...
April 17, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38627787/lxr-agonism-for-cns-diseases-promises-and-challenges
#6
REVIEW
Ruiyi Zhang, Emily Wuerch, V Wee Yong, Mengzhou Xue
The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while liver X receptor (LXR) may regulate both processes due to its pivotal role in cholesterol metabolism and inflammatory response, and thus receives increasing attentions from neuroscientists and clinicians. Here, we summarize the signal transduction of LXR pathway, discuss the therapeutic potentials of LXR agonists based on preclinical data using different disease models, and analyze the dilemma and possible resolutions for clinical translation to encourage further investigations of LXR related therapies in CNS disorders...
April 16, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38627764/gsdmd-drp1-signaling-pathway-mediates-hippocampal-synaptic-damage-and-neural-oscillation-abnormalities-in-a-mouse-model-of-sepsis-associated-encephalopathy
#7
JOURNAL ARTICLE
Qun Fu, Yi-Bao Zhang, Chang-Xi Shi, Ming Jiang, Kai Lu, Zi-Hui Fu, Jia-Ping Ruan, Jing Wu, Xiao-Ping Gu
BACKGROUND: Gasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits in sepsis-associated encephalopathy (SAE), yet the underlying mechanisms remain largely unclear. Dynamin-related protein 1 (Drp1) facilitates mitochondrial fission and ensures quality control to maintain cellular homeostasis during infection. This study aimed to investigate the potential role of the GSDMD/Drp1 signaling pathway in cognitive impairments in a mouse model of SAE...
April 16, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38622726/a-p2ry12-deficiency-results-in-sex-specific-cellular-perturbations-and-sexually-dimorphic-behavioral-anomalies
#8
JOURNAL ARTICLE
Ogochukwu J Uweru, Akhabue K Okojie, Aparna Trivedi, Jordan Benderoth, Lauren S Thomas, Georgia Davidson, Kendall Cox, Ukpong B Eyo
Microglia are sexually dimorphic, yet, this critical aspect is often overlooked in neuroscientific studies. Decades of research have revealed the dynamic nature of microglial-neuronal interactions, but seldom consider how this dynamism varies with microglial sex differences, leaving a significant gap in our knowledge. This study focuses on P2RY12, a highly expressed microglial signature gene that mediates microglial-neuronal interactions, we show that adult females have a significantly higher expression of the receptor than adult male microglia...
April 15, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38622654/immunotherapy-with-an-antibody-against-cd1d-modulates-neuroinflammation-in-an-%C3%AE-synuclein-transgenic-model-of-lewy-body-like-disease
#9
JOURNAL ARTICLE
Michiyo Iba, Somin Kwon, Changyoun Kim, Marcell Szabo, Liam Horan-Portelance, Maria Lopez-Ocasio, Pradeep Dagur, Cassia Overk, Robert A Rissman, Eliezer Masliah
The neuroinflammatory process in synucleinopathies of the aging population such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB) involves microglial activation as well as infiltration of the CNS by T cells and natural killer T cells (NKTs). To evaluate the potential of targeting NKT cells to modulate neuroinflammation, we treated α-syn transgenic (tg) mice (e.g.: Thy1 promoter line 61) with an antibody against CD1d, which is a glycoprotein expressed in antigen presenting cells (APCs). CD1d-presented lipid antigens activate NKT cells through the interaction with T cell receptor in NKTs, resulting in the production of cytokines...
April 15, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38622640/fibrin-promotes-oxidative-stress-and-neuronal-loss-in-traumatic-brain-injury-via-innate-immune-activation
#10
JOURNAL ARTICLE
Terry Dean, Andrew S Mendiola, Zhaoqi Yan, Rosa Meza-Acevedo, Belinda Cabriga, Katerina Akassoglou, Jae Kyu Ryu
BACKGROUND: Traumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blood proteins into the brain. The impact of blood proteins, especially fibrinogen, on inflammation and neurodegeneration post-TBI is not fully understood, highlighting a critical gap in our comprehension of TBI pathology and its connection to innate immune activation. METHODS: We combined vascular casting with 3D imaging of solvent-cleared organs (uDISCO) to study the spatial distribution of the blood coagulation protein fibrinogen in large, intact brain volumes and assessed the temporal regulation of the fibrin(ogen) deposition by immunohistochemistry in a murine model of TBI...
April 15, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38610019/nigrostriatal-degeneration-determines-dynamics-of-glial-inflammatory-and-phagocytic-activity
#11
JOURNAL ARTICLE
Leyre Ayerra, Miguel Angel Abellanas, Leyre Basurco, Ibon Tamayo, Enrique Conde, Adriana Tavira, Amaya Trigo, Clara Vidaurre, Amaia Vilas, Patxi San Martin-Uriz, Esther Luquin, Pedro Clavero, Elisa Mengual, Sandra Hervás-Stubbs, Maria S Aymerich
Glial cells are key players in the initiation of innate immunity in neurodegeneration. Upon damage, they switch their basal activation state and acquire new functions in a context and time-dependent manner. Since modulation of neuroinflammation is becoming an interesting approach for the treatment of neurodegenerative diseases, it is crucial to understand the specific contribution of these cells to the inflammatory reaction and to select experimental models that recapitulate what occurs in the human disease...
April 12, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38609999/soluble-cd27-is-an-intrathecal-biomarker-of-t-cell-mediated-lesion-activity-in-multiple-sclerosis
#12
JOURNAL ARTICLE
Maria T Cencioni, Roberta Magliozzi, Ilaria Palmisano, Keittisak Suwan, Antonella Mensi, Laura Fuentes-Font, Luisa M Villar, José I Fernández-Velasco, Noelia Villarrubia Migallón, Lucienne Costa-Frossard, Enric Monreal, Rehiana Ali, Marina Romozzi, Nicholas Mazarakis, Richard Reynolds, Richard Nicholas, Paolo A Muraro
OBJECTIVE: Soluble CD27 is a promising cerebrospinal fluid inflammatory biomarker in multiple sclerosis. In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis. METHODS: Protein levels of soluble CD27 were correlated to inflammatory cell subpopulations and inflammatory cytokines and chemokines detected in cerebrospinal fluid of 137 patients with multiple sclerosis and 47 patients with inflammatory and non-inflammatory neurological disease from three independent cohorts...
April 12, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38600570/correction-advanced-patient-specific-microglia-cell-models-for-pre-clinical-studies-in-alzheimer-s-disease
#13
Carla Cuní-López, Romal Stewart, Lotta E Oikari, Tam Hong Nguyen, Tara L Roberts, Yifan Sun, Christine C Guo, Michelle K Lupton, Anthony R White, Hazel Quek
No abstract text is available yet for this article.
April 10, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38600569/fascin-1-limits-myosin-activity-in-microglia-to-control-mechanical-characterization-of-the-injured-spinal-cord
#14
JOURNAL ARTICLE
Jinxin Huang, Xuyang Hu, Zeqiang Chen, Fangru Ouyang, Jianjian Li, Yixue Hu, Yuanzhe Zhao, Jingwen Wang, Fei Yao, Juehua Jing, Li Cheng
BACKGROUND: Mechanical softening of the glial scar region regulates axonal regeneration to impede neurological recovery in central nervous system (CNS) injury. Microglia, a crucial cellular component of the glial scar, facilitate neuronal survival and neurological recovery after spinal cord injury (SCI). However, the critical mechanical characterization of injured spinal cord that harmonizes neuroprotective function of microglia remains poorly understood. METHODS: Spinal cord tissue stiffness was assessed using atomic force microscopy (AFM) in a mouse model of crush injury...
April 10, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38600510/constitutive-knockout-of-interleukin-6-ameliorates-memory-deficits-and-entorhinal-astrocytosis-in-the-mrl-lpr-mouse-model-of-neuropsychiatric-lupus
#15
JOURNAL ARTICLE
Joshua Reynolds, Michelle Huang, Yaxi Li, Myriam Meineck, Tamara Moeckel, Julia Weinmann-Menke, Chandra Mohan, Andreas Schwarting, Chaim Putterman
BACKGROUND: Neuropsychiatric lupus (NPSLE) describes the cognitive, memory, and affective emotional burdens faced by many lupus patients. While NPSLE's pathogenesis has not been fully elucidated, clinical imaging studies and cerebrospinal fluid (CSF) findings, namely elevated interleukin-6 (IL-6) levels, point to ongoing neuroinflammation in affected patients. Not only linked to systemic autoimmunity, IL-6 can also activate neurotoxic glial cells the brain. A prior pre-clinical study demonstrated that IL-6 can acutely induce a loss of sucrose preference; the present study sought to assess the necessity of chronic IL-6 exposure in the NPSLE-like disease of MRL/lpr lupus mice...
April 10, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38589917/impact-of-microglia-isolation-and-culture-methodology-on-transcriptional-profile-and-function
#16
JOURNAL ARTICLE
Mark Mizrachi, Betty Diamond
BACKGROUND: Microglial isolation and culturing methods continue to be explored to maximize cellular yield, purity, responsiveness to stimulation and similarity to in vivo microglia. This study aims to evaluate five different microglia isolation methods-three variants of microglia isolation from neonatal mice and two variants of microglia isolation from adult mice-on transcriptional profile and response to HMGB1. METHODS: Microglia from neonatal mice, age 0-3 days (P0-P3) were isolated from mixed glial cultures (MGC)...
April 8, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38584255/sting-inhibition-suppresses-microglia-mediated-synapses-engulfment-and-alleviates-motor-functional-deficits-after-stroke
#17
JOURNAL ARTICLE
Chaoran Wu, Shiwen Zhang, Hao Sun, Ao Li, Fengsheng Hou, Long Qi, Hong Liao
Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. The engulfment of stressed synapses by microglia further contributes to the disruption of the surviving neuronal network and related brain function. Unfortunately, there is currently no effective target for suppressing the microglia-mediated synapse engulfment. Stimulator of interferon genes (STING) is an important participant in innate immune response. In the brain, microglia are the primary cell type that mediate immune response after brain insult...
April 8, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38582897/extracellular-vesicle-encapsulated-homer1a-as-novel-nanotherapeutics-against-intracerebral-hemorrhage-in-a-mouse-model
#18
JOURNAL ARTICLE
Xiaowei Fei, Li Wang, Ya-Nan Dou, Fei Fei, Yanyu Zhang, Weihao Lv, Xin He, Xiuquan Wu, Wangshu Chao, Hongqing Chen, Jialiang Wei, Dakuan Gao, Zhou Fei
Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare Homer1a+ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. Homer1a+ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice...
April 6, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38582873/profiling-of-long-non-coding-rnas-in-hippocampal-entorhinal-system-subfields-impact-of-rn7sl1-on-neuroimmune-response-modulation-in-alzheimer-s-disease
#19
JOURNAL ARTICLE
Hanyou Liu, Jingying Li, Xue Wang, Shiqi Luo, Dan Luo, Wei Ge, Chao Ma
Alzheimer's disease (AD) is recognized as the predominant cause of dementia, and neuroimmune processes play a pivotal role in its pathological progression. The involvement of long non-coding RNAs (lncRNAs) in AD has attracted widespread attention. Herein, transcriptomic analysis of 262 unique samples extracted from five hippocampal-entorhinal system subfields of individuals with AD pathology and without AD pathology revealed distinctive lncRNA expression profiles. Through differential expression and coexpression analyses, we identified 16 pivotal lncRNAs...
April 6, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38581043/bi-directional-neuro-immune-dysfunction-after-chronic-experimental-brain-injury
#20
JOURNAL ARTICLE
Rodney M Ritzel, Yun Li, Yun Jiao, Sarah J Doran, Niaz Khan, Rebecca J Henry, Kavitha Brunner, David J Loane, Alan I Faden, Gregory L Szeto, Junfang Wu
BACKGROUND: It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic immune changes contribute to posttraumatic neuroinflammation and neurodegeneration. However, how TBI affects bone marrow (BM) hematopoietic stem/progenitor cells chronically and to what extent such changes may negatively impact innate immunity and neurological function has not been examined. METHODS: To further understand the role of BM cell derivatives on TBI outcome, we generated BM chimeric mice by transplanting BM from chronically injured or sham (i...
April 5, 2024: Journal of Neuroinflammation
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