Georgian Medical News

Our experiments showed that papaverine inhibits sugar absorption in vivo as well as in vitro. Papaverine blocks the absorption of sugar both in healthy and diabetic animals. Oral administration of papaverine significantly reduced blood sugar level but after an hour blood sugar level showed tendency to come back to the initial levels that were characteristic for these diabetic dogs. Dietary supplement made of herbal remedies and papaverine has proven to be quite effective in reducing body weight in dogs. For a month, dogs with initial overweight lost on average more than 1 kg (10+%), that is a very good result for their size...

Idiopathic sudden hearing loss (ISHL) is associated with vestibular complaints in 30% of cases. In this study, we aimed to determine the change in caloric test responses in ISHL, determine the degree of influence on the vestibular nerve, investigate the correlation between vestibular nerve damage and vestibular complaints during admission, and evaluate the effect of vestibular nerve influence on the recovery process. Patients with ISHL were divided into groups with and without vestibular complaints and classified according to their hearing level...

The rapid development of modern scientific medicine and practice (development of genetic engineering, coronary angiography, use of microprocessors (microminiature implant in eye retina, 3D-print of implants, prostheses) is connected with the scientific-technical progress in recent years, which gave impetus to introduction of extremely complex treatment and diagnostic methods. The use of high-tech medical equipment requires the implementation of modern sanitary and anti-epidemic measures of disinfection and sterilization after each manipulation to prevent in-hospital infection/infectious diseases which are related to the grant of medicare (IHI/IPNMD)...

The present work is dedicated to the study of vitamin D content among residents of Tyumen city and Tyumen region. The study analyzed the correlation between the level of vitamin D in the blood and the gender, age, place of residence and season of seeking medical care. This study was carried out on the basis of multidisciplinary clinic of Tyumen State Medical University (MDC of Tyumen SMU). During the research, 231 medical records were analyzed. It was estimated that 51% of patients (118 people) had insufficient blood content of vitamin D...

The ACL is the primary stabilizer of the knee joint. The injury leads to instability of the knee joint, which is a trigger for the subsequent destructive changes of the intra-articular structures such as menisci and cartilage of the joint surfaces. The most affected group is people of an active age, engaged in amateur sports. Also, this pathology is an occupational hazard in the military. In this community, ACL injuries have reached 3.24% in men and 3.51% in women, with increasing trends, especially among women...

The article presents a difficult-to-diagnose clinical case of progressive growth of two intrapericardial dermoid cysts in a 42-year-old man, diagnosed only 6 months after acute transdermal poisoning with lithium salts (Litol 24), which the patient, on his own initiative, used locally for the treatment of existing psoriasis. The peculiarity of this clinical case lies in the fact that, due to the extremely rare occurrence of intrapericardial dermoid cysts, their presence was perceived by doctors as hydropericardium...

The aim of the study was to evaluate the effectiveness of radiofrequency denervation (neuroablation) of the suprascapular nerve in the treatment process of omalgia in patients with degenerative and dystrophic disorders of the shoulder joint. 31 patients (31 joints were researched) took the treatment and analyzed their data in the rehabilitation department of the State Institution "Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine" from 2019 to 2021. X-ray assessment was performed to find out the stage of the disease according to the classification of M...

Osteochondral lesions of the dome of the talus are becoming an increasingly frequent problem in sports traumatology, and questioning is a major element in the diagnostic orientation, as these are usually young, athletic patients. The main part of the diagnosis is based on complementary imaging examinations. We report the clinical observation of an adult patient, an athlete, referred to a rheumatology consultation for chronic pain of the right ankle with a mechanical appearance and difficulty in walking. Clinical and paraclinical examinations (standard X-ray, CT scan and magnetic resonance imaging) finally led to the conclusion of an osteochondritis of the talus...

If Paget's disease can undermine Alzheimer's disease, there is the possibility of an association between Alzheimer's disease and Paget's disease. We report the observation of an 81-year-old hypertensive patient with Alzheimer's disease, who presented with an isolated increase in alkaline phosphatase, which led to the discovery of Paget's disease. The physician must therefore be careful to distinguish between genuine Alzheimer's disease and a neurological complication of Paget's disease.

Direct critical attack of the coronavirus on the alveoli and the excessive release of a large number of cytokines (IL-6, IL-1, TNF-α, etc.) provides suitable conditions for the further development of acute respiratory distress syndrome (ARDS) and severe acute respiratory failure. Serious decrease in blood oxygenation often lead to the deterioration of macro- and microcirculation, irreversible brain damage and hence, persistent neurological and mental disorders despite background intensive therapy and adequate respiratory support...

Among the general population, there is a category of individuals with an innate predisposition to obesity. In recent decades, the increase in the prevalence of obesity and related diseases worldwide indicates the need to study the etiological factors associated with its development. At present, it is still unknown how many genes are involved in the pathophysiology of obesity, and many studies are underway to identify "candidate genes" in clinical medicine. The detection of obesity by molecular genetic diagnostics and the implementation of appropriate preventive measures can significantly reduce the incidence...

Primary lymphomas of peripheral nerves (PLPNs) are extremely rare and most commonly reported in lumbar nerves and have been found in only five cases in the upper extremities. We describe two patterns of presentation focusing on clinical, radiological, and pathological findings of two patients affected by primary multifocal lymphoma of the ulnar nerve without systemic involvement or other medical conditions. We report a case of extraneural lymphoma in a 72-years-old (patient #1) and a case of intraneural lymphoma in a 45-years old woman (Patient #2)...

From 1991 to 2019, the mortality rate from lower respiratory tract infections has been on a downward trend. Overall, in 1991, 4.42% [4.08% - 4.79%] of the population died from lower respiratory tract infections. Further, over a period of approximately 20 years, mortality has been declining: 1995 - 3.39% [3.16% - 3.64%]; 2000 - 2.99% [2.78% - 3.2%]; 2005 - 2.66% [2.49% - 2.85%]; 2010 - 2.52% [2.37% - 2.7%]. Despite the fact that until 2010 the number of deaths for the group of diseases studied by us decreased, since 2011 the mortality rate began slightly, but increased, and by 2015 the mortality rate from lower respiratory tract infections was 3...

Nitrosamines as contaminants in a wide variety of drugs are also found to be one of the most likely causes of skin cancer. A detailed analysis of this contamination could in the near future solve to a large extent the puzzle of carcinogenesis concerning the keratinocytic forms of cancer and melanoma. But also, probably cancer in general. Over 80% of skin cancer is due to acquired mutations, and nitrosamines, which are contained as contamination in certain batches of the most commonly distributed drugs worldwide (such as sartans, ACE inhibitors, ranitidine, metformin, hydrochlorothiazide, rifampicin, and a number of others...

The conceptual model of rehabilitation and suicidal behaviour prevention in dementia, considering the multiple components, is presented in the article. The developed program of the complex differentiated medical and psychological rehabilitation and suicidal behaviour prevention (MPRS BP) in patients with dementia is aimed at the preventive measures of the suicidal behaviour (SB) through the depressive symptoms reduction, patient's mind and cognitive status stabilization, self-aggression decreases, social functioning and independence increase in patients with dementia...

In the present study, on the one hand, the epigenetic modification of condensed "old" chromatin was determined, and on the other hand, the influence of peptide bioregulators (Ala-Glu-Asp-Gly-Epitalon; Lys-Glu-Asp-Ala-Livagen; Ala-Glu-Asp-Pro - Cortagen and Lys-Glu - Vilon) on condensed chromatin in lymphocytes from old individuals. Were used molecular-cytogenetic methods: differential scanning calorimetry; activity of ribosomal genes of acrocentric chromosome satellite stalks-NORs; polymorphism of structural pericentromeric C-heterochromatin; variability of the facultative heterochromatin (sister chromatid exchanges - SCE) in the culture of lymphocytes from 75-88-year-old individuals...

The method of dental implantation in patients with generalized periodontitis is one of the priority areas requiring in-depth study. The aim of the study was to increase the efficiency of dental implantation by developing methods for eliminating bone resorption in patients with generalized periodontitis. There were examined 240 patients with generalized periodontitis of I, II, III degree of development with partial adentia of the upper and lower jaws, who later underwent comprehensive periodontal treatment using dental implantation methods...

Haematospermia is the medical term used to describe the presence of blood in semen. It can occur due to a variety of reasons and can be a benign or serious condition. The present study aimed to identify the prevalence and characterization of haematospermia in patients visiting hospital clinics. To do so, a total of 44 patients were recruited and characterized regarding their demographic variation, symptoms, severity, associated diseases, and measured prostate-specific-antigen (PSA). Results confirmed that patients were middle-aged (around 40 years) and the duration (days) of haematospermia is around 16±12...

Tibial plateau fractures (TPF) comprise 1% of all fractures, despite their limited frequency, due to their intraarticular nature they commonly result in significant functional morbidity. Generally, younger, and middle-aged men (64%) tend to have fractures as a result of high-energy trauma, such as high-speed motor vehicle accidents or falls from a considerable height, while older women have low-energy fractures (35%). While there is growing evidence on the clinical and radiological outcomes of surgical techniques, there remains limited evidence on return to sport following TPF...

Insulin, glimepiride, and metformin prescribe as monotherapy or in combination to control glycemic state. The present study aimed to identify the anti-inflammatory activity of commonly used antidiabetic medications insulin, glimepiride, and metformin if any. A follow-up study of added metformin alone or with glimepiride to newly diagnosed diabetic patients and add metformin to patients treated with insulin or glimepiride monotherapy to establish the effect on the glycemic and inflammatory state. There are highly significant differences in glycemic and inflammatory markers when adding metformin to newly diagnosed diabetic patients and when combined with insulin or glimepiride monotherapy...