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Georgian Medical News

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https://read.qxmd.com/read/30702086/public-attitudes-towards-the-use-of-animals-in-biomedical-research-in-georgia
#1
M Melikishvili, N Mitskevich, N Pitskhelauri, G Lobzhanidze, N Chikhladze
In different societies there are different opinions about moral and ethical aspects of animal testing in biomedical research. Many studies have been conducted worldwide since 1980s to evaluate public perception and attitude towards the animal research. In EU Eastern Neighboring Countries, including Georgia, ethical aspects of animal usage for biomedical experiments have not been well emphasized. There are no ethical-legal regulations on animal use for biomedical research in Georgia neither on national nor on institutional level...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702085/awareness-of-primary-immunodeficiency-diseases-among-medical-students
#2
O Boyarchuk, L Volyanska, T Kosovska, A Lewandowicz-Uszynska, M Kinash
Primary immunodeficiency diseases (PID) are a group of more than 300 rare, chronic disorders in which a part of the body's immune system is missing or functions improperly. The issue of early diagnosis, timely and effective treatment, prevention of complications and improved prognosis remains extremely relevant. The aim of this study was to assess the awareness of graduating medical university students about the signs of primary immunodeficiency in children and adults. A survey on awareness of primary immunodeficiencies was conducted among sixth year (graduating) students of the Faculty of Medicine of I...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702084/-radioprotective-activity-of-polymetoxy-lated-flavonoids-of-citrus-extract
#3
I Gvilava, G Ormotsadze, I Chkhikvishvili, M Giorgobiani, Nina V Kipiani, T Sanikidze
The aim of the study was to establish the radioprotective activity of citrus polymetoxylated flavonoids extract (CPMFE) on the X-irradiated rats. The experiments were carried out on white Wistar rats. Animals were irradiated with X rays in doses of 5 Gy and 7 Gy. The control group consisted the sham-irradiated rats. Part of animals of each group were treated with intramusculary injections of CPMFE (dose 30 mg/kg) during 7 days; blood was taken from the tail vein (0.5 ml) for detection of lipoperoxides (LOO...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702083/interaction-between-the-thalamic-nucleus-and-preoptic-area-neurons
#4
I Bilanishvili, M Barbakadze, N Khizanishvili, T Gaikharashvili, Z Nanobashvili
The thalamic reticular nucleus which is known to delineate the dorsal thalamus stipulates development of inhibitory processes in the thalamo-cortical neurons that is necessary for generating slow (8-12 Hz), high-amplitude electric activity in this system. It was demonstrated that majority of preoptic area neurons get activated during slow-wave sleep. Activation of neurons in the anterior hypothalamus and preoptic area during slow-wave sleep and synchronization of the brain electric activity was demonstrated...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702082/selection-of-the-active-phages-against-b-fragilis-for-further-study-of-thrapeutic-perpectives
#5
N Bakuradze, Kh Makalatia, M Merabishvili, L Togoshvili, N Chanishvili
B.fragilis is an obligate anaerobic commensal colonizing human intestines and carries number of physiological functions. At the same time B.fragilis is commonly isolated from the septic clinical samples and due to its capsule represents one of the provoking agents for abscess development. Enterotoxigenic B.fragilis (ETBF) strains also increase the likelihood of developing colon cancer. Increasing incidence of antibiotic-resistant pathogens led to the high demand to alternative antimicrobials. Bacteriophage (phage) therapy already practiced for a century in some of the Post-Soviet countries including Georgia has been suggested as a substitute of antibiotics...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702081/the-effect-of-vibro-acoustic-stimulation-on-cell-dynamics-of-inflammation-in-rats-and-the-possibilities-for-vibroacoustic-sound-therapy-in-complex-treatment-of-bronchitis-in-children
#6
O Nechypurenko, A Kaliuzhka, O Lutsenko
One of the methods of physiotherapy used in the complex treatment of various diseases is vibroacoustic exposure (VAE), however, the anti-inflammatory effect of this factor has not been studied insufficiently. The purpose of this research was to study the effect of VAE on the cellular dynamics of the inflammation focus. The experimental study was performed on 72 male Wistar rats weighing 180-200 g. The age of the rats was 1-1.5 months. All painful and stressful procedures were performed under ether drug (according to the European Convention for the Protection of Vertebrate Animals (Strasbourg, 08...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702080/comparative-analysis-of-whole-cartilage-tissue-thermostability-in-diseased-patients-versus-injured-patients
#7
J Monaselidze, L Kikalishvili, Sh Sharia, M Ramishvili, T Lezhava
We conducted comparative thermodynamic analysis of femoral cartilages tissue of injured (healthy) patients and patients with congenital hip dislocation. It is shown, that temperature which corresponds to maximum of heat absorption peak of femoral cartilages tissue of diseased patient is on 6.4oC lower than heat absorption peak of femoral cartilages tissue of healthy patient. Heat absorbed during denaturation process in all these cases are close to each other with experimental error accuracy and corresponds to 52±2...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702079/-the-structure-of-the-ileum-after-the-resection-of-liver-parenchyma
#8
L Tatarchuk, T Gargula, M Hnatiuk, O Slabyi, O Yasinovskyi
The ileum was morphologically examined in 45 sexually mature white male rats, which were divided into 3 groups: I group included 15 intact animals, II - 15 rats, in which 31.5% of the liver parenchyma was removed, III - 15 animals after resection 58,1% of liver parenchyma. Euthanasia of rats was performed by bloodletting under the conditions of thiopental anesthesia 1 month after the beginning of the experiment. Histological micropreparations were made from the ileum, which were studied morphometrically. Quantitative indicators were processed statistically...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702078/overexpressed-progenitor-gene-csf1r-in-pancreatic-cancer-tissues-and-nerve-invasive-pancreatic-cancer-cells
#9
I Abiatari, T Midelashvili, M Motsikulashvili, A Tchavtchavadze, S Tawfeeq, I Amiranashvili
Aim- pancreatic ductal adenocarcinoma is one of the most aggressive oncological disease with early metastasis and high mortality rate. CSF1R is a gene with progenitor activity, which is also associated with different malignant diseases. In this study our objective was to analyze expression of CSF1R in pancreatic cancer tissues and nerve invasive cancer cells. Quantitative real time polymerase chain reaction (QRT-PCR) was used to analyze the expression of CSF1R mRNA in nine cultured pancreatic cancer cell lines and pancreatic bulk tissues of the normal pancreas, chronic pancreatitis (n=20/20) and pancreatic ductal adenocarcinoma (n=58)...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702077/-influence-of-chronic-immobilization-stress-during-pregnancy-on-morphofunctional-state-of-the-liver-in-female-rats-during-postpartum-period
#10
O Nikolayeva, M Kyznetsova
Morphofunctional state of the liver (in particular, indexes of carbohydrate, protein, and fat metabolism, structural elements and condition of vascular endothelium of the liver) in female rats subjected to immobilization stress during pregnancy, has been studied. Morphological changes in the liver include discomplexation of beam-radial structure, pyknosis of hepatocyte nucleus, increased regeneration activity of parenchyma, and increased stromal parenchymal index. Functional disorders are manifested by development of dysproteinemia, hyperlipidemia, hyperglycemia, and increased activity of organo-specific liver enzymes...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702076/the-role-of-pro12ala-polymorphism-of-the-ppar-%C3%AE-gene-in-the-genesis-of-the-gestational-weight-gain
#11
S Ostafiichuk, N Henyk, Z Rossokha
The aim of this study was to determine the role of Pro12Ala polymorphism of the PPAR-γ gene, associated with lipid and carbohydrate metabolism, in the genesis of gestational weight gain (GWG). We performed anthropometry, the determination of GWG, the study of PPAR-γ Pro12Ala polymorphism, the concentration of markers of lipid and carbohydrate metabolism in 97 pregnant women with normal body weight before pregnancy (55.2±4.8 kg, body mass index 20.3±1.5 kg/m2). The recommended GWG was diagnosed in 33 (34...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702075/clinical-pathogenetical-role-of-toll-like-receptor-2-rs-5743708-and-interleukin-10-rs-1800896-genes-polymorphism-in-the-course-of-herpes-zoster-in-adults
#12
N Onishchenko, Yu Riabokon, E Riabokon
The study included 50 adult patients with shingles by which analyzed the clinical course of the disease depending on the gene polymorphism of interleukin-10 (rs 1800896) and toll-like receptor 2 (rs 5743708). According to the results of our study, it was established that genotype AA of gene Toll-like receptor 2 was associated with a high risk of Varicella-Zoster virus reactivation and manifestation of herpes zoster, moderate course. Analysis of the IL-10 gene polymorphism showed that genotype TT was associated with a risk of the development severe complicated course of shingles...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702074/the-restless-legs-syndrome-review
#13
G Japaridze, S Kasradze, L Maisuradze, R Popp, Th Wetter
The restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a common sleep related neurological disorder with prevalence between 1 and 10%, increasing with age. Women are more frequently affected than men. RLS is characterized by an urge to move the legs accompanied by uncomfortable and unpleasant sensations in the legs, worsening of complaints during periods of rest, improvement by movement and an increase of symptoms in the evening or at night. In addition, affected patients may also suffer from severe sleep disorders and negative effects on daily activities...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702073/influence-of-physical-activity-on-cardiovascular-system-and-prevention-of-cardiovascular-diseases-review
#14
O Makar, G Siabrenko
Regular physical activity causes many positive effects on the cardiovascular system and improves cardiorespiratory fitness. Long term exercise leads to physiologic remodeling of the heart, including adaptive molecular and cellular reprogramming, that have cardioprotective effect. Aerobic physical activity, the most studied modality with beneficial dose-response effect on prognosis, is recommended for all healthy adults, subjects with coronary risk factors and patients with chronic cardiac diseases. To check cardiorespiratory fitness is recommended to carry out cardiopulmonary exercise testing with measuring VO2max for risk assessment, exercise prescription, physical activity counseling and improving patient management...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702072/-the-level-of-protection-from-oxidative-stress-and-three-year-dynamics-of-structural-and-functional-changes-of-the-myocardium-in-chronic-ischemic-heart-disease-in-men
#15
O Gorbunova, T Panova, E Chernysheva, E Popov
Aim - to assess the nature and three-year dynamics of structural and functional changes in the cardiovascular system in relation to the levels of enzymatic and non-enzymatic antioxidants in chronic coronary heart disease in men. The study included 246 men aged 48 to 65 years (mean age 58 years (53,0; 63,0)) with stable form of ischemic heart disease - angina FC II-III CHF I-III FC (NYHA), observed during 2012-2015. To assess the level of oxidative stress in all patients by ELISA was determined by lipid peroxide, total antioxidant status (CCA) and levels of non-enzymatic antioxidant bilirubin (BR)...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702071/-non-cardial-effects-of-sglt2-inhibitors-review
#16
I Doroshkevych, L Vozniuk, N Voloshchuk, O Klekot, O Kyrychenko
The article reveals the efficacy and safety aspects of a new class of antidiabetic drugs - SGLT2 inhibitors. The results of clinical and experimental studies of the principle of renal glucose reabsorption inhibition usage in the treatment of type 2 diabetes are presented in the article. Drugs of this class offer a new, non-insulin-dependent mechanism of action, lack of negative effect on body weight, favorable pharmacokinetic properties and good tolerance. However, data, requiring further more detailed analysis, were found, namely: a glucosuria as a risk factor for genitourinary system infections, increased levels of blood creatinine, increased urinary calcium excretion, ketogenesis...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702070/the-impact-of-the-degree-of-obesity-on-metabolic-parameters-in-children-and-adolescents
#17
N Tskhvedadze, E Giorgadze, Sh Janjgava
The aim of our investigation was to determine the impact of the degree of obesity on metabolic characteristics in children and adolescents with metabolic syndrome. We studied 117 children and adolescents 8-15 years of age with BMI exceeded the 85th percentile for their age and sex and the complaints associated with obesity. Investigated patients were divided according BMI percentiles for age and sex established by the U.S. Centers for Disease Control and Prevention (CDC) as follows: Group 1. Overweight (OW; 85-94...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702069/oral-facial-digital-syndrome-type-i-clinical-case
#18
O Horlenko, A Lenchenko, G Kossey, A Tomey, O Debretseni
The oral-facial-digital syndrome belongs to a group of hereditary diseases, manifested by multiple birth defects (usually, the face and fingers). At the current stage, there are 14 genetic variations of the oral-facial-digital syndrome. The presence of various abnormalities of the oral cavity, face and fingers is common for all of them, but each syndrome has a specific phenotype or type of inheritance. The etiology of this syndrome is unknown. It is inherited in an X-linked dominant pattern. Aim of the study: to describe and analyze the clinical case of oral-facial-digital syndrome...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702068/brain-derived-neurotrophic-factor-diagnostic-perspective-in-neonates-with-gestational-age-less-than-34-weeks
#19
Iu Kyslova, O Yablon, O Mazulov, T Savrun, O Bykovska
The aim of the research was to determine the diagnostic significance of Brain-derived neurotrophic factor (BDNF) in preterm infants with gestational age less than 34 weeks. The study group included 30 preterm infants with average birth weight 1373.5±66.0 g and gestational age 29.3±0.5 weeks. The catamnestic observation was conducted over this category of infants until reaching the corrected age of 18 months. The relationship between BDNF levels and antenatal factors, postnatal results and remote effects were determined...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30702067/monitoring-of-changes-in-physicochemical-and-clinical-characteristics-of-the-dental-polymer-materials-used-in-additive-manufacturing-of-dental-prostheses
#20
S Arutyunov, S Krasheninnikov, I Levchenko, R Orjonikidze, N Sadovskaya, L Kirakosyan, Y Kharakh
The use of additive technologies in dentistry is a promising trend; however, the physical and mechanical properties of the materials intended for the fabrication of long-term fixed restorations remain understudied. The aim of this research is to determine the feasibility of the use of long-term fixed provisional restorations made of polymer materials, fabricated using 3D printing. The conformance of the physical and mechanical properties of NextDent C&B Micro Filled Hybrid (ND) and Detax Freeprint temp UV (DX) materials to ISO 1567:1999 standard, stability of their physical and mechanical properties under the conditions of accelerated aging, as well as their resistance to the oral cavity environment were studied...
December 2018: Georgian Medical News
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