Melanie Jawerka, Dilek Colak, Leda Dimou, Carmen Spiller, Sabine Lagger, Rusty L Montgomery, Eric N Olson, Wolfgang Wurst, Martin Göttlicher, Magdalena Götz
Gene expression changes during cell differentiation are thought to be coordinated by histone modifications, but still little is known about the role of specific histone deacetylases (HDACs) in cell fate decisions in vivo. Here we demonstrate that the catalytic function of HDAC2 is required in adult, but not embryonic neurogenesis. While brain development and adult stem cell fate were normal upon conditional deletion of HDAC2 or in mice lacking the catalytic activity of HDAC2, neurons derived from both zones of adult neurogenesis die at a specific maturation stage...
May 2010: Neuron Glia Biology