Chiara Cipriani, Martina Giudice, Vita Petrone, Marialaura Fanelli, Antonella Minutolo, Martino T Miele, Nicola Toschi, Christian Maracchioni, Martina Siracusano, Arianna Benvenuto, Antonella Coniglio, Paolo Curatolo, Luigi Mazzone, Grelli Sandro, Enrico Garaci, Paola Sinibaldi-Vallebona, Claudia Matteucci, Emanuela Balestrieri
BACKGROUND: Putative pathogenic effects mediated by human endogenous retroviruses (HERVs) in neurological and psychiatric disorders in humans have been extensively described. HERVs may alter the development of the brain by means of several mechanisms, including modulation of gene expression, alteration of DNA stability, and activation of immune system. We recently demonstrated that autistic children and their mothers share high expression levels of some HERVs and cytokines in peripheral blood mononuclear cells (PBMCs) ex vivo, suggesting a close mother-child association in Autism Spectrum Disorder (ASD)...
November 30, 2022: Retrovirology