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Korean Journal of Pediatrics

Ga Won Jeon
After the first successful trial of surfactant replacement therapy for preterm infants with respiratory distress syndrome (RDS) by Fujiwara in 1980, several animal-derived natural surfactants and synthetic surfactants have been developed. Synthetic surfactants were made to overcome limitations of natural surfactants such as expensiveness, immune reactions, and infections due to animal proteins contained in natural surfactants. However, first-generation synthetic surfactants that are protein-free have failed to prove superiority over natural surfactants because they do not have surfactant protein (SP)...
February 8, 2019: Korean Journal of Pediatrics
Sohyun Kim, Lucy Youngmin Eun
Purpose: Coronary artery abnormalities (CAA) are the most important complication of Kawasaki disease (KD). Iron deficiency anemia (IDA) is prevalent micronutrient deficiencies and its association with KD remains unknown. We hypothesized the presence of IDA could be a predictor of CAA. Methods: This retrospective study included 173 KD patients, divided into two groups by absence (Group 1) and presence (Group 2) of CAA. The odds ratio (OR) with 95% confidence interval (CI) was calculated using a logistic regression model to estimate the association between CAA and other indicators...
February 8, 2019: Korean Journal of Pediatrics
Teechaya Nonboonyawat, Wuttipat Pusanasuwannasri, Nattanon Chanrat, Natta Wongthanavimok, Danutanut Tubngern, Piengkwan Panutrakul, Mathirut Mungthin, Thirapa Nivesvivat, Panadda Hatthachote, Ram Rangsin, Phunlerd Piyaraj
Purpose: There is limited information of overweight and obesity among students in rural area of Thailand. Therefore, the present study aimed to determine the prevalence of overweight and obesity and associated factors among school aged children in a rural community of Thailand. Methods: Nine public schools were selected by cluster sampling in two provinces located in central of Thailand in 2016. Anthropometric measurements were measured using standard techniques, classified as overweight (>1SD) and obese (>2SD) with respect to their age and sex using 2007 WHO reference charts...
February 8, 2019: Korean Journal of Pediatrics
Yvan Vandenplas, Zakiudin Munasir, Badriul Hegar, Dewi Kumarawati, Ahmad Suryawan, Muzal Kadim, Julistio Tb Djais, Ray Wagiu Basrowi, Deni Krisnamurti
The World Health Organization (WHO) recommends that infants should be exclusively breastfed for the first six month of life to provide optimal nutrition in this critical period of life. After this, infants should receive nutritionally adequate and safe complementary foods while breastfeeding continues for up to 2 years of age or beyond. For non-breastfed infants, infant formula is an available option to provide the nutrition needed. Infant formula is usually made from industrially-modified cow's milk and processed to adjust for the nutritional need of infants...
January 14, 2019: Korean Journal of Pediatrics
Hye Ran Yang
No abstract text is available yet for this article.
January 11, 2019: Korean Journal of Pediatrics
Hae Il Cheong
No abstract text is available yet for this article.
January 3, 2019: Korean Journal of Pediatrics
Dae Yong Yi, Soon Chul Kim, Ji Hyuk Lee, Eun Hye Lee, Jae Young Kim, Yong Joo Kim, Ki Soo Kang, Jeana Hong, Jung Ok Shim, Yoon Lee, Ben Kang, Yeoun Joo Lee, Mi Jin Kim, Jin Soo Moon, Hong Koh, JeongAe You, Young-Sook Kwak, Hyunjung Lim, Hye Ran Yang
The Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition newly developed the first Korean Guideline on the Diagnosis and Treatment of Obesity in Children and Adolescents to deliver an evidence-based systematic approach to childhood obesity in South Korea. The following areas were systematically reviewed, especially on the basis of all available references published in South Korea and worldwide, and new guidelines were established in each area with the strength of recommendations based on the levels of evidence: 1) definition and diagnosis of overweight and obesity in children and adolescents; 2) principles of treatment of pediatric obesity; 3) behavioral interventions for children and adolescents with obesity, including diet, exercise, lifestyle, and mental health; 4) pharmacotherapy; and 5) bariatric surgery...
December 27, 2018: Korean Journal of Pediatrics
Yuni Yun, Dongsub Kim, Yun-Jeong Lee, Soonhak Kwon, Su-Kyeong Hwang
Purpose: There is limited data on the use of perampanel in children under 12 years of age. We evaluated the efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy. Methods: This retrospective observational study was performed in Kyungpook National University Hospital from July 2016 to March 2018. Responder was defined as a patient with ≥50% reduction in monthly seizure frequency compared with the baseline...
December 26, 2018: Korean Journal of Pediatrics
Ensiyeh Jenabi, Manoochehr Karami, Salman Khazaei, Saeid Bashirian
Purpose: This meta-analysis pooled all of case-control and cohort studies to obtain the association between preeclampsia and the risk of ASD children. Methods: The search for relevant studies in major databases was performed including; Web of Science, PubMed and Scopus up to May 2018. The ORs or RRs with 95% confidence intervals (CI) extracted from eligible studies for measuring of association among studies. Results: The pooled estimates of OR and RR indicated a significant association between preeclampsia and ASD (OR = 1...
December 24, 2018: Korean Journal of Pediatrics
Hye Jung Cho, Hye-Kyung Cho
Newborn infants, including premature infants, are high-risk patients susceptible to various microorganisms. Catheter-related bloodstream infections are the most common type of nosocomial infections in this population. Regularly educating and training the medical staffs are most important as a preventive strategy for central line-associated bloodstream infections (CLABSIs). Bundle approaches and the use of checklists during the insertion and maintenance of central catheters are effective measures to reduce the incidence of CLABSIs...
December 19, 2018: Korean Journal of Pediatrics
Kyo Jin Jo, Yoo Mi Kim, Ju Young Yoon, Yeoun Joo Lee, Young Mi Han, Han-Wook Yoo, Hyang-Sook Kim, Chong Kun Cheon
Purpose: In the present study, the growth response following growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations was analyzed. Methods: Twenty three patients with prepubertal NS were enrolled in the study at Pusan National University Children's Hospital, between March 2009 and July 2017. According to disease-causing genes identified, patients with NS were divided into four groups. Three groups were mutation-positive groups in three genes, PTPN11, RAF1, and SOS1, respectively...
December 3, 2018: Korean Journal of Pediatrics
Min Sub Kim, Se Young Kim, Jae Hyun Kim
Purpose: The aims of this study were to evaluate time trend of waist circumference (WC) and waist-height ratio (WHR) and to present WC and WHR distribution with optimal WHR cutoff for abdominal obesity in Korean children and adolescents. Methods: We performed a retrospective, cross-sectional analysis of data from 13,257 children and adolescents (6,987 boys and 6,270 girls) aged 6-18 years who were included in the 3rd to 6th Korea National Health and Nutrition Examination Survey (KNHANES, 2005-2015)...
December 3, 2018: Korean Journal of Pediatrics
Kyoung Hee Han, Jong Eun Park, Chang-Seok Ki
Alport syndrome (ATS) is an inherited glomerular disease caused by mutations in one of the type IV collagen novel chains (α3, α4, and α5). ATS is characterized by persistent microscopic hematuria starting from infancy, eventually leading to either progressive nephritis or end-stage renal disease. There are three known genetic forms of ATS, i.e., X-linked ATS, autosomal recessive ATS, and autosomal dominant ATS. About 80% of patients with ATS have X-linked ATS, caused by mutations in the type IV collagen α5 chain gene, COL4A5...
November 26, 2018: Korean Journal of Pediatrics
Ki Eun Kim, Kyung Suk Baek, Sol Han, Jung Hyun Kim, Youn Ho Sheen
Purpose: Liver metabolism plays a pivotal role in the development of metabolic disorders. We aimed to investigate the clinical and laboratory risk factors associated with alanine aminotransferase (ALT) levels in young adolescents from an urban population in Korea. Methods: A population of 120 apparently healthy adolescents aged 12-13 years was included in the cross-sectional design study; 58 were overweight or obese and 62 were of normal weight. We estimated anthropometric and laboratory measurements, including waist-to-height ratio, blood pressure, insulin sensitivity, aspartate and alanine aminotransferases (AST and ALT), and lipid profiles...
November 23, 2018: Korean Journal of Pediatrics
Min Jae Kang
With the increase in the prevalence of overweight and obesity worldwide, early adiposity rebound, which is known to have a strong association with obesity, has recently been a focus of research. Early adiposity rebound is conventionally known to have a close relationship with non-communicable diseases. However, novel insights into early adiposity rebound have implied an acceleration of growth and puberty, which is directly reflected in the trends in the timing of adiposity rebound, in the 21st century compared with in the past...
December 2018: Korean Journal of Pediatrics
Sun Jin Lee, Jin Kyu Kim, Sun Jun Kim
PURPOSE: Subgaleal hemorrhage (SGH) is a rare but potentially fatal condition in newborns; however, few studies have reported on this condition. We aimed to identify the clinical characteristics and prognostic factors of SGH. METHODS: We retrospectively reviewed the medical records of 20 neonates diagnosed with SGH between January 2000 and June 2017. Enrolled neonates were clinically diagnosed when they had tender fluctuant scalp swelling that crossed the suture lines...
December 2018: Korean Journal of Pediatrics
Soo-Kyeong Jeon, Geena Kim, Hoon Ko, Joung-Hee Byun, Hyoung Doo Lee
Purpose: Prognostic factors of coronary aneurysm in Kawasaki disease have been investigated in many studies. The aim of this study is to identify risk factors associated with early and late coronary artery outcomes in the treated patients with Kawasaki disease. Methods: A total of 392 patients diagnosed with Kawasaki disease from January 2012 to December 2015 in Pusan National University Children's Hospital were retrospectively selected as subjects of the present study to determine risk factors for coronary aneurysm and persistence of coronary aneurysm after one-year follow up...
November 22, 2018: Korean Journal of Pediatrics
Yoon Jin Lee, Kyoung Soo Park, Hong Ryang Kil
Purpose: Coronary arterial lesion assessment in children can be difficult depending on the coronary dominance pattern. Although it is easier to determine coronary dominance with echocardiography in children than in adults, difficulty still exists. This study aimed to examine coronary dominance pattern according to objective Coronary artery (CA) indices. Methods: CA diameter, aortic valve annulus, and abdominal aorta were measured with cross-sectional echocardiography in 69 children without any cardiovascular disease at Chungnam National University Hospital...
November 22, 2018: Korean Journal of Pediatrics
Song-I Yang
Particulate matter (PM) is a ubiquitous air pollutant that is a growing public health concern. Previous studies have suggested that PM is associated with asthma development and exacerbation of asthma symptoms. Although several studies have suggested increased risks of atopic dermatitis, allergic rhinitis, and allergic sensitization in relation to PM exposure, the evidence remains inconsistent. The plausible mechanisms underlying these effects are related to oxidative stress, enhancement of sensitization to allergens, inflammatory and immunological responses, and epigenetics...
November 7, 2018: Korean Journal of Pediatrics
Dong Eun Min, Do Hee Kim, Mi Young Han, Sung Ho Cha, Kyung Lim Yoon
Purpose: In Kawasaki disease(KD) patients, coronary artery complications, incomplete and refractory types occur more frequently in patients with streptococcal or other bacterial/viral infections. Recently, we observed a higher incidence of coronary lesions in KD patients with high anti-streptolysin O(ASO) titer. Therefore, we hypothesized that KD patients diagnosed with concurrent streptococcal infection have poor prognosis, with respect to treatment response and development of coronary artery lesions...
November 7, 2018: Korean Journal of Pediatrics
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