Katiana Simões Lopes, Aline Aparecida Macedo Marques, Karyne Garcia Tafarelo Moreno, Ariany Carvalho Dos Santos, Roosevelt Isaías Carvalho Souza, Emerson Luiz Botelho Lourenço, Rodrigo Juliano Oliveira, Roberto da Silva Gomes, Francislaine Aparecida Dos Reis Lívero, Arquimedes Gasparotto Junior
Solidago microglossa DC. (Asteraceae), "arnica brasileira," is a Brazilian species popularly used to treat hypertension or renal ailments. This study investigated the cardioprotective effects of standardized S. microglossa extract (EESM) in nicotine-treated spontaneously hypertensive rats (SHRs). Moreover, the molecular mechanisms involved in the cardiovascular effects were also investigated. The acute toxicity was evaluated in female Wistar rats. Afterwards, six-month-old male spontaneously hypertensive rats received the EESM (14, 28, and 56 mg/kg), hydrochlorothiazide (25 mg/kg), and vehicle (filtered water; 0...
2023: Evidence-based Complementary and Alternative Medicine: ECAM