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Evidence-based Complementary and Alternative Medicine: ECAM

Xiang Wang, Peihuan Li, Chen Pan, Lisha Dai, Yan Wu, Yunlong Deng
Background/Purpose: Sleep plays an important role in individuals' health. The functions of the brain, the cardiovascular system, the immune system, and the metabolic system are closely associated with sleep. As a prevalent sleep disorder, insomnia has been closely concerned, and it is necessary to find effective therapies. In recent years, a growing body of studies has shown that mind-body therapies (MBTs) can improve sleep quality and ameliorate insomnia severity. However, a comprehensive and overall systematic review has not been conducted...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Shu-Chao Pang, Shuo Wang, Mei-Ling Chen, Jun-Ping Zhang, Yuan-Yuan Wang, Hui-Yun Jia, Li-Yuan Bi, Hui Wang
BuShenKangShuai tablet (BSKS) is a Chinese herbal compound, which has been used to treat nonalcoholic fatty liver disease and cardiovascular diseases in clinic for over four decades. This study intends to explore whether BSKS administration can alleviates hepatic steatosis via improving liver adiponectin resistance in ApoE-/- mice. ApoE-/- mice were fed with western-type diet for 6 weeks and then were administrated with BSKS or atorvastatin for 6 weeks by gavage, and then blood and liver were collected for analysis...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Xiuze Jin, Liuyan Shi, Feng Chang, Yun Lu
Background: Diabetic nephropathy (DN) is a major cause of end-stage renal disease. In order to palliate renal function impairment and reduce kidney related mortality, it is crucial to treating DN patients at the early stage. This study aims to assess the efficacy and safety of conventional therapy combined with safflower yellow versus conventional therapy alone in early DN patients. Methods: A meta-analysis of randomized controlled trials that compared safflower yellow plus conventional therapy with conventional therapy alone in early DN patients was conducted...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Yuheng Chen, Xiaoxi Li, Xiufeng Tang, Yingying Gao, Ping Yu, Liping Xu, Renhui Liu
This study aimed to investigate the osteoprotective effect and the possible molecular mechanisms of the combined extracts of Herba Epimedii and Fructus Ligustri Lucidi on postmenopausal osteoporosis (PMOP). Forty-eight female SD rats were sham-operated (Sham, n = 8) or ovariectomized (OVX, n = 40). Then after a week, OVX rats were divided randomly into five groups ( n = 8 in each group): OVX, extracts of Herba Epimedii (HE, 0.35 g/kg), extracts of Fructus Ligustri Lucidi (FLL, 0.35 g/kg), combined extracts of HE and FLL (HE & FLL, 0...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Xu Lixin, Gu Erli, Huang Songping, Zhu Yonggen, Jianping Wang, Yan Lijun
Objective: To study the protective effect of Yi Guan Jian (YGJ) on liver injury induced by carbon tetrachloride (CCl4 ) in mice. Methods: 50 ICR mice were randomly divided into 5 groups: control group, carbon tetrachloride (CCl4 ) group, CCl4 + silymarin Group (200 mg/kg), carbon CCl4 + YGJ Group (11.5, 23 g/kg). Except the mice in the control group and the CCl4 group that were given the same volume of distilled water, the mice in other groups were given the drugs for seven days...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Jun-Feng Liu, An-Na Hu, Jun-Feng Zan, Ping Wang, Qiu-Yun You, Ai-Hua Tan
Objective: To explore the mechanisms of the volatiles of Wendan granule (WDG) for the treatment of Alzheimer's disease, network pharmacology method integrating absorption, distribution, metabolism, and excretion (ADME) screening, target fishing, network constructing, pathway analysing, and correlated diseases prediction was applied. Methods: Twelve small molecular compounds of WDG were selected as the objects from 74 volatiles with the relative abundances above 2 %, and their ADME parameters were collected from Traditional Chinese Medicine Systems Pharmacology platform (TCMSP), and the corresponding targets, genes, pathways, and diseases were predicted according to the data provided by TCMSP, DrugBank, Uniport, and the Database for Annotation, Visualization, and Integrated Discovery (DAVID)...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Chongyang Ma, Tian Xu, Xiaoguang Sun, Shuang Zhang, Shuling Liu, Shuning Fan, Chaofang Lei, Feifei Tang, Changming Zhai, Changxiang Li, Juan Luo, Qingguo Wang, Wei Wei, Xueqian Wang, Fafeng Cheng
Liver cancer is the fourth leading cause of cancer death worldwide, and hepatocellular carcinoma (HCC) accounts for the greatest proportion of these deaths. Baicalein, a flavonoid isolated from the root of Scutellariae radix , is considered a potential candidate to treat HCC. However, the underlying molecular mechanisms remain poorly understood. In the present study, a network pharmacological approach was combined with microarray data (GSE95504) acquired from the Gene Expression Omnibus database to reveal the therapeutic mechanisms of action of baicalein at a systemic level...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Xiaoxi Liu, Fenghua Liu, Yunfei Ma, Huanrong Li, Xianghong Ju, Jianqin Xu
Puerarin, baicalin and berberine hydrochloride are the main components of Gegen Qinlian Decoction, which has been used to treat diarrhoea in China for hundreds of years, yet the biological function and molecular mechanism of these components are not clear. To investigate the effects of puerarin, baicalin, and berberine hydrochloride on the regulation of porcine intestinal epithelial cells (IPEC-J2 cells) infected with enterotoxigenic Escherichia coli (ETEC). IPEC-J2 cells were pretreated with puerarin (200 μ g/mL), baicalin (1 μ g/mL), and berberine hydrochloride (100 μ g/mL) at 37°C for 3 h and then coincubated with the F4ac ETEC bacterial strain 200 at 37°C for 3 h...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Bo Li, Shan-Shan Lei, Jie Su, Xia-Miao Cai, Hao Xu, Xinglishang He, Ye-Hui Chen, Hai-Xia Lu, He Li, Liu-Qing Qian, Xiang Zheng, Gui-Yuan Lv, Su-Hong Chen
Objectives . Fatty liver disease (FLD) is a major cause of morbidity and mortality worldwide. Dietary cholesterol and alcohol consumption are important risk factors for the progression of FLD, but whether and how alcohol induces more severe FLD with cholesterol ingestion remain unclear. Herein, we mainly used the Lieber-DeCarli diet to establish the FLD mouse model to investigate the synergistic effects of alcohol and cholesterol metabolism on liver damage. The indices of aspartate transaminase (AST), alanine transaminase (ALT), low-density lipoprotein cholesterol (LDL-c), and total cholesterol (TC) levels, inflammation foci, and pathogenesis by hematoxylin and eosin (H&E) and Oil Red O staining revealed that alcohol induces more severe liver damage by influencing cholesterol metabolism, which might be primarily related to the influence of cholesterol absorption, synthesis, and excretion on the liver or small intestine...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Yanni Zhang, Zhongxin Li, Zhaolong Zhao, Wentao Kuai, Cong Wei, Jian Lv, Jie Zhi, Yitao Jia
Background: Fatigue is a common, distressing, and persistent symptom for patients with malignant tumor including colorectal cancer (CRC). Although studies of cancer-related fatigue (CRF) have sprung out in recent years, the pathophysiological mechanisms that induce CRF remain unclear, and effective therapeutic interventions have yet to be established. Methods: To investigate the effect of the traditional Chinese medicine YangZheng XiaoJi (YZXJ) on CRF, we constructed orthotopic colon cancer mice, randomly divided into YZXJ group and control (NS) group...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Sun Hwa Lee, Eun Jin Yang
Neuroinflammation is considered a critical factor in the pathologic mechanisms of amyotrophic lateral sclerosis (ALS). This study examined the levels of neuroinflammatory proteins in the spinal cord of JGT-treated hSOD1 G93A transgenic mice to determine the effect of Jaeumganghwa-Tang (JGT) on neuroinflammation. Twelve 8-week-old male experimental mice were randomly allocated to three groups: a non-transgenic group, a hSOD1G93A transgenic group, and a hSOD1G93A transgenic group that received JGT 1 mg/g orally once daily for 6 weeks...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Weiyue Zhang, Xiaoyan Liu, Yiping Jiang, Nani Wang, Feng Li, Hailiang Xin
Myocardial ischemia/reperfusion (I/R) injury is a key factor in deterioration of myocardial function. The c-Jun NH2-terminal kinase (JNK) activation and the transcription factor nuclear factor-kappaB (NF- κ B) nuclear translocation have been found in I/R injury. 6-Gingerol, an important bioactive ingredient of ginger, has been reported to have cardiovascular pharmacological effects. However, the molecular mechanism through which it is beneficial is unclear. In this work, I/R induced the increase in the apoptosis and reactive oxygen species level in AC16 cardiomyocytes...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Zhihui Zhang, Ying Cao, Qiang Yuan, Aiguo Zhang, Kaiqi Zhang, Zhiwen Wang
Shexiang-Wulong Pill (SWP) is derived from " Moschus Yuan," first formulated during the Song Dynasty for the treatment of joint pain. The aim of this study was to evaluate the therapeutic effect of SWP in a mouse model of collagen-induced arthritis (CIA). Forty-five DBA/1 mice were randomly divided into control group, model group, and SWP-treated group. SWP was administered by oral gavage for 22 days after the booster immunization. The clinical arthritic scores and joint histopathology, including synovial hyperplasia and hypoxic regions, cartilage erosion, and bone destruction, were evaluated...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Min Sung Kim, Chul Won Lee, Jung-Hoon Kim, Jang-Cheon Lee, Won Gun An
Rhus verniciflua Stokes has long been used as a food supplement and traditional herbal medicine for various ailments in East Asia. We evaluated the anticancer effects of Rhus verniciflua Stokes extract (RVSE) on MCF-7 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry, annexin V/7-AAD staining, and western blotting. In addition, the gallic acid content of RVSE was assayed using high-performance liquid chromatography. RVSE inhibited the growth of MCF-7 cells in a dose-dependent manner by inducing apoptosis in the sub-G1 phase...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Evidence-Based Complementary And Alternative Medicine
[This corrects the article DOI: 10.1155/2015/649265.].
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Fuhai Bai, Yongyuan Ma, Haiyun Guo, Yuheng Li, Feifei Xu, Ming Zhang, Hailong Dong, Jiao Deng, Lize Xiong
The concept of "acupoint sensitization" refers to the functional status of acupoint switches from silent to active under pathological conditions. In clinic, acupoint sensitization provides important guidance for acupoints selection in different diseases. However, the mechanism behind this phenomenon remains unclear. We generated a model of knee osteoarthritis (KOA) by intra-articular injection of monosodium iodoacetate (MIA) into the left knee of rats. The paw withdrawal mechanical threshold (PWMT) and the total number of mast cells as well as mast cell degranulation rate (MCDR) of acupoint tissue were used to test whether the acupoints were sensitized...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Evidence-Based Complementary And Alternative Medicine
[This corrects the article DOI: 10.1155/2015/365205.].
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Dong-Woo Lim, Hyuck Kim, Seung-Jun Lee, Ga-Ram Yu, Jai-Eun Kim, Won-Hwan Park
Over the last decade, the link between nonalcoholic fatty liver disease (NAFLD) and insulin resistance has attracted considerable attention. Caused by chronic hyperglycemic stress, insulin resistance (IR) impairs insulin signal transduction and leads to the development of NAFLD. Jwa Kum Whan (JKW), a herbal formula in Traditional Korean Medicine, consists of two medicinal herbs that possess notable effects against hyperglycemia and IR. In this study, we sought to determine the pharmacological effects of JKW, and the mechanisms responsible, on hepatic steatosis in free fatty acids (FFAs)-stimulated HepG2 cells and in high-fat diet (HFD)-fed obese mice...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Yuanyuan Ge, Shujing Chen, Qian Luo, Chun-Peng Wang, Jia Hao, Jun He, Xiaopeng Chen, Xuejing Yang, Jin Li, Yan-Xu Chang
Angelicae pubescentis radix (APR) is widely applied in treating rheumatoid arthritis in China. Coumarins are the major active compounds of APR extract including columbianetin, columbianetin acetate, osthole, and columbianadin. The in vivo behavior of the four major coumarins of APR has not been systematically reported. A feasible and reliable ultra-performance liquid chromatography (UPLC) method was established and validated for the quantification of the above four coumarins in rat various tissues (including heart, liver, spleen, lung, kidney, uterus, ovary, and muscle) after oral administration of APR extract...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Beatriz Mendes Santos, Adriana Bezerra-Souza, Sonia Aragaki, Eliana Rodrigues, Eric Umehara, João Henrique Ghilardi Lago, Márcia Dalastra Laurenti, Susan Pereira Ribeiro, Luiz Felipe Domingues Passero
Leishmaniasis is an infectious disease caused by a protozoan belonging to Leishmania genus. Different clinical outcomes can be observed depending on the parasite species and patient's health condition. The outcomes can range from single cutaneous lesions to lethal visceral form. The treatment of all forms of leishmaniasis is based on pentavalent antimonials, and, in some cases, the second-line drug, amphotericin B, is used. Beside the toxicity of both classes of drugs, in some areas of the world, parasites are resistant to antimonial...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
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