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International Journal of Medical Sciences

https://read.qxmd.com/read/38903932/impact-of-cd44-genetic-variants-on-clinicopathological-characteristics-of-uterine-cervical-cancer-patients
#21
JOURNAL ARTICLE
Yi-Hung Sun, Ching-Ming Wang, Huang-Pin Shen, Chung-Yuan Lee, Chiao-Wen Lin, Shun-Fa Yang, Po-Hui Wang
CD44 genetic variants have been found to be related to various cancers. However, to date, no study has demonstrated the involvement of CD44 polymorphisms in uterine cervical cancer in Taiwanese women. Therefore, we conducted a retrospective study, consecutively recruiting 113 patients with invasive cancer, 92 patients with high-grade cervical intraepithelial neoplasias, and 302 control women to assess the relationships among CD44 polymorphisms, cervical carcinogenesis, and patient survival. Real-time polymerase chain reaction was used to determine the genotypic distributions of six polymorphisms: rs1425802, rs187115, rs713330, rs11821102, rs10836347, and rs13347...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903931/fgl2-as-a-predictive-biomarker-for-prognosis-and-immunotherapy-in-bladder-cancer
#22
JOURNAL ARTICLE
Zhengnan Huang, Zeyi Wang, Chengdang Xu, Yilin Yan, Xiangqian Cao, Fang Zhang, Bing Shen
Background: Metastasis and immunosuppression result in unfavorable prognosis in bladder cancer (BLCA). FGL1 and FGL2 are two members of the fibrinogen-related proteins family, but their potential effects on BLCA remain elusive. Methods: The expression profile of FGL1 and FGL2 in BLCA was analyzed in multiple databases. Furthermore, the expression of FGL2 was validated in BLCA tissues. The predictive capability of FGL2 was evaluated by Kaplan-Meier analysis, univariate analysis, and multivariate Cox regression...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903930/mesenchymal-stem-cells-preconditioned-with-hypoxia-and-dexamethasone-promote-osteoblast-differentiation-under-stress-conditions
#23
JOURNAL ARTICLE
Miyako Shimasaki, Toru Ichiseki, Shusuke Ueda, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda
Bone marrow-derived mesenchymal stem cells (MSCs), which are capable of differentiating into osteoblasts, are used in effective regenerative therapies. MSCs must be prompted to differentiate into osteoblasts for MSC transplantation to be effective. In this study, osteoblast differentiation markers involved in bone formation were evaluated to investigate the stress resistance of bone marrow-derived rat MSCs to dexamethasone and hypoxia and their ability to differentiate into osteoblasts. MSCs were allowed to differentiate into osteoblasts for 21 days in three different environments (dexamethasone treatment, hypoxic conditions [1% oxygen], or both)...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903929/application-of-sutureless-corneal-incision-for-patients-with-congenital-ectopia-lentis-is-it-feasible-effective-and-safe
#24
JOURNAL ARTICLE
Yang Sun, Tianhui Chen, Zexu Chen, Wannan Jia, Yan Liu, Zhennan Zhao, Yongxiang Jiang
Purpose: To compare the clinical outcomes, feasibility, and safety between groups with sutured and sutureless wound closure in congenital ectopia lentis (CEL) patients. Methods: Patients with CEL who received phacoemulsification combined with intrascleral fixation of capsular hook (CH) and implantation of capsular tension ring (CTR) and in-the-bag intraocular lens (IOL) were included in this study. Results: A total of 68 eyes of 34 patients aged 18 years or younger were enrolled in this study. Incisions of 21 patients (34 eyes) did not require sutures while sutures were applied in 21 patients (34 eyes)...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903928/renal-protective-effects-of-alpinate-oxyphyllae-fructus-and-mesenchymal-stem-cells-co-treatment-against-d-galactose-induced-renal-deterioration
#25
JOURNAL ARTICLE
Tsung-Jung Ho, Tamilselvi Shanmugam, Po-Hsiang Liao, Marthandam Asokan Shibu, William Shao-Tsu Chen, Kuan-Ho Lin, Shang-Yeh Lu, Chia-Hua Kuo, Wei-Wen Kuo, Chih-Yang Huang
Age-related structural and functional changes in the kidney can eventually lead to development of chronic kidney disease, which is one of the leading causes of mortality among elderly people. For effective management of age-related kidney complications, it is important to identify new therapeutic interventions with minimal side-effects. The present study was designed to evaluate the synergistic effect of a traditional Chinese herb, Alpinate Oxyphyllae Fructus (AOF), and adipose-derived mesenchymal stem cells (ADMSCs) in ameliorating D-galactose (D-gal)-induced renal aging phenotypes in WKY rats...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903927/analysis-of-prognostic-biomarker-models-of-txnip-nlrp3-il1b-inflammasome-pathway-in-patients-with-acute-myeloid-leukemia
#26
JOURNAL ARTICLE
Junjie Chen, Qi Hou, Tao Chang, Jiamian Zheng, Chao Yao, Junyi He, Shengting Chen, Xiuli Wu, Zhenyi Jin
Background: Exploring potential biomarkers for predicting clinical outcomes and developing targeted therapies for acute myeloid leukemia (AML) is of utmost importance. This study aimed to investigate the expression pattern of the thioredoxin-interacting protein (TXNIP)/nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) pathway and its role in the prognosis of AML patients. Methods: In this study, we examined the prognostic value of TXNIP/NLRP3 pathway in AML patients using microarray data from Gene Expression Omnibus (GEO) and transcriptome data from the Cancer Genome Atlas (TCGA) to develop a prognostic model and validated the results by quantitative real-time PCR (qRT-PCR) in a validation cohort of 26 AML patients and 18 healthy individuals from Jinan University (JNU) database...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903926/the-effect-of-age-on-the-regenerative-potential-of-adipose-stem-cell-derived-apoptotic-extracellular-vesicles-in-rat-skin-wound-healing
#27
JOURNAL ARTICLE
Kaixin Yan, Lu Han, Siwei Xu, Linli Jiang, Xinnan Chang, Hui Li, Lei Liu
Introduction: Skin, being the body's largest organ, is susceptible to injuries. Despite the adoption of common treatments such as debridement, wound dressing, and infection control measures for skin injuries, the outcomes remain unsatisfactory, especially in diabetic patients or elderly patients. The use of adipose stem cell-derived apoptotic extracellular vesicles (apoEVs-ASCs) has been shown great therapeutic potential in wound repair. The effect of the donor age on the biological properties and functions of apoEVs-ASCs has not been reported...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903925/comparison-emergence-of-sedation-using-dexmedetomidine-and-remimazolam-in-spinal-anaesthesia-double-blinded-randomized-controlled-trial
#28
RANDOMIZED CONTROLLED TRIAL
Seung-Wan Hong, Jun-Young Park, Ka-Young Rhee, Seong-Hyop Kim
Background: Continuous intravenous infusion of remimazolam may be suitable for sedation in patients undergoing regional anaesthesia. However, there have been no studies comparing remimazolam and dexmedetomidine for this purpose. This study compared emergence from sedation between dexmedetomidine and remimazolam following continuous intravenous infusion in patients undergoing spinal anaesthesia. Methods: This double-blinded, randomised controlled trial assessed the sedative effects of dexmedetomidine and remimazolam...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903924/clinical-characteristics-and-prognosis-of-acute-pulmonary-embolism-with-hemoptysis-in-autoimmune-disease-patients
#29
JOURNAL ARTICLE
Yiyao Li, Jianian Yang, Peijun Xue, Ting Zhang, Xuefeng Sun, Min Peng, Juhong Shi
Background: Hemoptysis is prevalent in acute pulmonary embolism (PE) and significantly influences clinical decision-making. Despite the increasing reports of PE in patients with autoimmune diseases, limited studies have investigated the association between acute PE with hemoptysis and autoimmune disease. Methods: The retrospective study aimed to investigate patients with autoimmune disease who presented with acute PE and hemoptysis at Peking Union Medical College Hospital (PUMCH) between January 2012 and October 2020...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903923/the-lower-incidence-of-endometrial-cancer-after-sodium-glucose-cotransporter-2-inhibitors-administration-in-type-2-diabetes-mellitus-population-a-nationwide-cohort-study
#30
JOURNAL ARTICLE
Po-Jen Yang, Po-Hui Wang, Jing-Yang Huang, Chia-Yi Lee, Chiao-Wen Lin, Chung-Yuan Lee, Shun-Fa Yang
The Sodium-glucose co-transporter 2 (SGLT2) inhibitor is an anti-glycemic agent that frequently used in type 2 diabetes mellitus (T2DM) with antioxidant effects. Endometrial cancer (EC) is a common gynecological malignancy that correlates with oxidative stress. The aim in the present study is to survey the potential association between the SGLT2 inhibitor administration and the incidence of EC by the application of the National Health Insurance Research Database (NHIRD) of Taiwan. A retrospective cohort study was directed and the T2DM participants were divided into the SGLT2 inhibitors users and non-SGLT2 inhibitors users...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903922/dasatinib-promotes-muscle-differentiation-and-disrupts-normal-muscle-regeneration
#31
JOURNAL ARTICLE
Nanami Ishida, Tamaki Kurosawa, Momo Goto, Noriyuki Kaji, Yayoi Tokunaga, Taiki Mihara, Masatoshi Hori
Dasatinib is one of the second-generation tyrosine kinase inhibitors used to treat chronic myeloid leukemia and has a broad target spectrum, including KIT, PDGFR, and SRC family kinases. Due to its broad drug spectrum, dasatinib has been reported at the basic research level to improve athletic performance by eliminating senescent cell removal and to have an effect on muscle diseases such as Duchenne muscular dystrophy, but its effect on myoblasts has not been investigated. In this study, we evaluated the effects of dasatinib on skeletal muscle both under normal conditions and in the regenerating state...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903921/integrated-single-cell-and-transcriptome-sequencing-analyses-identified-prex1-as-an-immune-related-prognostic-biomarker-for-liver-hepatocellular-carcinoma
#32
JOURNAL ARTICLE
Jing Yang, Lin-Yin Fan, Kai-Yuan Shi
Background: PtdIns (3,4,5) P3-dependent Rac exchanger 1 (PREX1), also known as PREX1, a member of the Rac guanine nucleotide exchange factors (Rac-GEF) family. Studies have suggested that PREX1 plays a role in mediating oncogenic pathway activation and controlling various biological mechanisms in different types of cancer, including liver hepatocellular carcinoma (LIHC). However, the function of PREX1 in the pathogenesis of LIHC and its potential role on immunological regulation is not clearly elucidated. Methods: The expression level and the clinical role of PREX1 in LIHC was analyzed based on database from the Cancer Genome Atlas (TCGA), TNM plotter and University of Alabama Cancer Database (UALCAN)...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903920/sex-difference-in-the-associations-among-secondhand-smoke-with-metabolic-syndrome-in-non-smokers-in-a-large-taiwanese-population-follow-up-study
#33
JOURNAL ARTICLE
Tzu-Yu Chiang, Che-Sheng Pai, Jiun-Hung Geng, Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen, Jer-Ming Chang
Close associations among secondhand smoke (SHS) and metabolic syndrome (MetS) and its components have been demonstrated, however sex differences in these associations remain unclear. We collected 121,364 participants from the Taiwan Biobank, and excluded those with smoking history, the remaining 88,297 participants (male: 18,595; female: 69,702; mean age 50.1 ± 11.0 years) were included. SHS exposure was evaluated based on self-reported questionnaires. SHS was associated with MetS (odds ratio [OR], 1.268, p < 0...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903919/risk-factors-and-clinical-characteristics-of-first-ever-ischemic-stroke-caused-by-icas-with-leukoaraiosis
#34
JOURNAL ARTICLE
Xiaopan Liu, Ning Wu, Jian Li, Meng Pang, Yaozhen Wang, Yuge Wang, Shuai Jia, Yanqiang Wang
Background: Previous studies have mostly investigated the risk factors affecting the occurrence of leukoaraiosis and the risk factors affecting the severity of leukoaraiosis in patients with ischemic stroke, but there are relatively few studies on the risk factors and clinical characteristics affecting the severity of leukoaraiosis in the population with the most common type of first-episode ischemic stroke caused by intracranial atherosclerotic stenosis in China. Methods: We retrospectively studied patients with first-ever ischemic stroke due to intracranial atherosclerotic stenosis...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903918/f-box-proteins-and-gastric-cancer-an-update-from-functional-and-regulatory-mechanism-to-therapeutic-clinical-prospects
#35
REVIEW
Yanzhen Yang, Qu Xie, Can Hu, Jingli Xu, Lei Chen, Yuan Li, Cong Luo
Gastric cancer (GC) is a prevalent malignancy characterized by significant morbidity and mortality, yet its underlying pathogenesis remains elusive. The etiology of GC is multifaceted, involving the activation of oncogenes and the inactivation of antioncogenes. The ubiquitin-proteasome system (UPS), responsible for protein degradation and the regulation of physiological and pathological processes, emerges as a pivotal player in GC development. Specifically, the F-box protein (FBP), an integral component of the SKP1-Cullin1-F-box protein (SCF) E3 ligase complex within the UPS, has garnered attention for its prominent role in carcinogenesis, tumor progression, and drug resistance...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903917/validation-of-the-saga-fall-injury-risk-model
#36
MULTICENTER STUDY
Risa Hirata, Naoko E Katsuki, Shizuka Yaita, Eiji Nakatani, Hitomi Shimada, Yoshimasa Oda, Midori Tokushima, Hidetoshi Aihara, Motoshi Fujiwara, Masaki Tago
Background: Predicting fall injuries can mitigate the sequelae of falls and potentially utilize medical resources effectively. This study aimed to externally validate the accuracy of the Saga Fall Injury Risk Model (SFIRM), consisting of six factors including age, sex, emergency transport, medical referral letter, Bedriddenness Rank, and history of falls, assessed upon admission. Methods: This was a two-center, prospective, observational study. We included inpatients aged 20 years or older in two hospitals, an acute and a chronic care hospital, from October 2018 to September 2019...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903916/glutamine-protects-against-mouse-abdominal-aortic-aneurysm-through-modulating-vsmc-apoptosis-and-m1-macrophage-activation
#37
JOURNAL ARTICLE
Jinxi Wang, Xingwen Da, Yifei Chen, Ancai Yuan, Jun Pu
Glutamine (Gln), known as the most abundant free amino acid, is widely spread in human body. In this study, we demonstrated the protective effects of glutamine against mouse abdominal aortic aneurysm (AAA) induced by both angiotensin II (AngII) and calcium phosphate (Ca3 (PO4 )2 ) in vivo , which was characterized with lower incidence of mouse AAA. Moreover, histomorphological staining visually presented more intact elastic fiber and less collagen deposition in abdominal aortas of mice treated by glutamine...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903915/macrophagic-hdac3-inhibition-ameliorates-dextran-sulfate-sodium-induced-inflammatory-bowel-disease-through-gbp5-nlrp3-pathway
#38
JOURNAL ARTICLE
Na Che, Yang Zhang, Shu Zhang, Xiangxi Kong, Ying Zhang, Shukun Wang, Zengqiang Yuan, Yajin Liao
Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disease, characterized by dysregulated immune response. HDAC3 is reported to be an epigenetic brake in inflammation, playing critical roles in macrophages. However, its role in IBD is unclear. In our study, we found HDAC3 was upregulated in CX3CR1-positive cells in the mucosa from IBD mice. Conditional knockout (cKO) of Hdac3 in CX3CR1 positive cells attenuated the disease severity of Dextran Sulfate Sodium (DSS)-induced colitis. In addition, inhibition of HDAC3 with RGFP966 could also alleviate the DSS-induced tissue injury and inflammation in IBD...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38903914/retinal-ganglion-cell-type-specific-expression-of-synuclein-family-members-revealed-by-scrna-sequencing
#39
JOURNAL ARTICLE
Qingwen Yang, Lin Liu, Fang He, Wenna Zhao, Zhongqun Chen, Xiaotian Wu, Bilin Rao, Xin Lin, Fangyuan Mao, Jia Qu, Jun Zhang
Synuclein family members (Snca, Sncb, and Scng) are expressed in the retina, but their precise locations and roles are poorly understood. We performed an extensive analysis of the single-cell transcriptome in healthy and injured retinas to investigate their expression patterns and roles. We observed the expression of all synuclein family members in retinal ganglion cells (RGCs), which remained consistent across species (human, mouse, and chicken). We unveiled differential expression of Snca across distinct clusters (highly expressed in most), while Sncb and Sncg displayed uniform expression across all clusters...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818479/targeting-cancer-mitochondria-by-inducing-an-abnormal-mitochondrial-unfolded-protein-response-leads-to-tumor-suppression
#40
JOURNAL ARTICLE
Baoxiao Wang, Wenjun Chen, Qiqi Huang, Ye Chen, Yajing Wang
The mitochondrial unfolded protein response (UPRmt) is a pivotal cellular mechanism that ensures mitochondrial homeostasis and cellular survival under stress conditions. This study investigates the role of UPRmt in modulating the response of nasopharyngeal carcinoma cells to cisplatin-induced stress. We report that the inhibition of UPRmt via AEB5F exacerbates cisplatin cytotoxicity, as evidenced by increased lactate dehydrogenase (LDH) release and apoptosis, characterized by a surge in TUNEL-positive cells...
2024: International Journal of Medical Sciences
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