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International Journal of Medical Sciences

https://read.qxmd.com/read/38818479/targeting-cancer-mitochondria-by-inducing-an-abnormal-mitochondrial-unfolded-protein-response-leads-to-tumor-suppression
#1
JOURNAL ARTICLE
Baoxiao Wang, Wenjun Chen, Qiqi Huang, Ye Chen, Yajing Wang
The mitochondrial unfolded protein response (UPRmt) is a pivotal cellular mechanism that ensures mitochondrial homeostasis and cellular survival under stress conditions. This study investigates the role of UPRmt in modulating the response of nasopharyngeal carcinoma cells to cisplatin-induced stress. We report that the inhibition of UPRmt via AEB5F exacerbates cisplatin cytotoxicity, as evidenced by increased lactate dehydrogenase (LDH) release and apoptosis, characterized by a surge in TUNEL-positive cells...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818478/the-effect-of-pregabalin-on-microglia-differentiation-in-rat-with-neuropathic-pain-a-preliminary-study
#2
JOURNAL ARTICLE
Seung-Wan Hong, Liyun Piao, Eun-Hwa Cho, Eun-Hye Seo, Seong-Hyop Kim
This study investigated the effects of pregabalin on microglial differentiation in rats with neuropathic pain (NP) induced by sciatic nerve ligation and transection. After confirming NP, the rats were randomly allocated to either a pregabalin or control group. The pregabalin group received intraperitoneal injections of 10 mg/kg pregabalin, while the control group received an equivalent volume of normal saline following surgery. On postoperative day 28, neuronal damage, microglial activity, and microglial differentiation were assessed...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818477/comparison-of-myopic-control-between-orthokeratology-contact-lenses-and-defocus-incorporated-multiple-segments-spectacle-lenses
#3
COMPARATIVE STUDY
Chia-Yi Lee, Shun-Fa Yang, Yu-Ling Chang, Jing-Yang Huang, Ie-Bin Lian, Chao-Kai Chang
Purpose: The purpose of this study was to compare the differences in myopic control effects between orthokeratology (OK) contact lenses and defocus incorporated multiple segments (DIMS) spectacle lenses. Methods: A retrospective cohort study was conducted that included patients who had received OK lens, DIMS spectacle lens or single-vision spectacle treatments. A total of 54 eyes from 27 individuals, 38 eyes from 19 individuals and 42 eyes from 21 individuals were enrolled into the OK lens, DIMS and control groups, respectively...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818476/interleukin-25-as-a-potential-biomarker-in-lung-metastasis-of-hepatocellular-carcinoma-with-hbv-history-in-chinese-patients-a-single-center-case-control-study
#4
JOURNAL ARTICLE
Yuan Liao, Yixin Xu, Ziying Mo, Tianyi Zhu, Huimin Dong, Wenying Zhou, Qing Xia
Background: Interleukin-25 (IL-25) has been proved to play a role in the pathogenesis and metastasis of Hepatocellular carcinoma (HCC), but the relationship between the level of IL-25 and the metastasis and prognosis of HCC is still not clear. This study aimed to investigate the expression of IL-25 and other potential biochemical indicators among healthy people, HBV-associated HCC patients without lung metastasis and HBV-associated HCC patients with lung metastasis. Methods: From September 2019 to November 2021, 33 HCC patients without lung metastasis, 37 HCC patients with lung metastasis and 29 healthy controls were included in the study...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818475/comparison-of-the-recovery-time-of-remimazolam-besylate-and-propofol-for-gastrointestinal-endoscopy-sedation-in-elderly-patients
#5
RANDOMIZED CONTROLLED TRIAL
Hai-Yan Chen, Xiao-Xi Wang, Yu-Gang Lu, Shu-Heng Tang, Tong Ding, Jin-Chao Song, Gang Chen
Background: Recovery time is a crucial factor in ensuring the safety and effectiveness of both patients and endoscopy centers. Propofol is often preferred due to its fast onset and minimal side effects. Remimazolam is a new intravenous sedative agent, characterized by its rapid onset of action, quick recovery and organ-independent metabolism. Importantly, its effect can be specifically antagonized by flumazenil. The primary goal of this study is to compare the recovery time of remimazolam besylate and propofol anesthesia during endoscopic procedures in elderly patients...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818474/effect-of-spectacle-correction-on-hyperopic-children
#6
JOURNAL ARTICLE
Chia-Wei Lin, Cai-Mei Zheng, Yo-Chang Chen, Fu-Gong Lin, Ching-Long Chen, Yun-Hsiang Chang, Jiann-Torng Chen, Jing-Quan Zheng, Ming-Cheng Tai, Yu-Han Huang, Yuh-Feng Lin, Hsin-Ting Lin
Background: Hyperopia is a significant refractive error in children, often leading to vision impairment. This study aimed to investigate whether partial or full spectacle correction is benefit for hyperopia in preschool-aged children. Methods: A retrospective study was conducted on hyperopic children visited to teaching medical center outpatient clinic between October 2011 and October 2018, and were categorized into three groups: full correction, overcorrection, and undercorrection. The study was approved by the institutional ethical committee of Tri-Service General Hospital...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818473/gastroesophageal-reflux-disease-and-atrial-fibrillation-a-bidirectional-mendelian-randomization-study
#7
JOURNAL ARTICLE
Xiaoli Chen, Aihua Li, Yuanyuan Kuang, Qilin Ma
Background: In observational studies, gastroesophageal reflux disease (GERD) is linked to atrial fibrillation (AF). It is uncertain whether the relationship is due to GERD-induced AF or GERD caused by AF, or confusion with factors related to GERD and AF such as obesity and sleep-disordered breathing. We applied bidirectional Mendelian randomization (MR), in which genetic variations are used as instrumental variables to resolve confounding and reverse causation issues, to determine the causal effect between GERD and AF...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818472/a-dynamic-prediction-model-for-renal-progression-in-primary-membranous-nephropathy
#8
JOURNAL ARTICLE
Yufeng Liang, Qiu Li, Zhenhuan Zou, Binsan Huang, Nan Zhong, Chenlun Li, Azhen Wang, Yongping Chen, Shuzhen Tu, Jianxin Wan
Objective: This study aimed to build and validate a practical web-based dynamic prediction model for predicting renal progression in patients with primary membranous nephropathy (PMN). Method: A total of 359 PMN patients from The First Affiliated Hospital of Fujian Medical University and 102 patients with PMN from The Second Hospital of Longyan between January 2018 to December 2023 were included in the derivation and validation cohorts, respectively. Renal progression was delineated as a decrease in eGFR of 30% or more from the baseline measurement at biopsy or the onset of End-Stage Renal Disease (ESRD)...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818471/cross-talk-between-the-tgf-%C3%AE-and-cell-adhesion-signaling-pathways-in-cancer
#9
REVIEW
Jiahao Liao, Rentang Chen, Bihua Lin, Runhua Deng, Yanfang Liang, Jincheng Zeng, Sha Ma, Xianxiu Qiu
Transforming growth factor-β (TGF-β) is strongly associated with the cell adhesion signaling pathway in cell differentiation, migration, etc. Mechanistically, TGF-β is secreted in an inactive form and localizes to the extracellular matrix (ECM) via the latent TGF-β binding protein (LTBP). However, it is the release of mature TGF-β that is essential for the activation of the TGF-β signaling pathway. This progress requires specific integrins (one of the main groups of cell adhesion molecules (CAMs)) to recognize and activate the dormant TGF-β...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818470/potential-markers-to-differentiate-uterine-leiomyosarcomas-from-leiomyomas
#10
REVIEW
Jialu Guo, Jianfeng Zheng, Jinyi Tong
Uterine leiomyomas (ULM) are the most common benign tumors of the female genitalia, while uterine leiomyosarcomas (ULMS) are rare. The sarcoma is diffuse growth, prone to hematogenous metastasis, and has a poor prognosis. Due to their similar clinical symptoms and morphological features, it is sometimes difficult to distinguish them, and the final diagnosis depends on histological diagnosis. Misdiagnosis of ULM as ULMS will lead to more invasive and extensive surgery when it is not needed, while misdiagnosis of ULMS as ULM may lead to delayed treatment and poor prognosis...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818469/the-potential-mechanisms-of-arrhythmia-in-coronavirus-disease-2019
#11
REVIEW
Jianhong Li, Qiuyuan Huang, Yifan Liang, Jun Jiang, Yan Yang, Jian Feng, Xiaoqiu Tan, Tao Li
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) leads to coronavirus disease-2019 (COVID-19) which can cause severe cardiovascular complications including myocardial injury, arrhythmias, acute coronary syndrome and others. Among these complications, arrhythmias are considered serious and life-threatening. Although arrhythmias have been associated with factors such as direct virus invasion leading to myocardial injury, myocarditis, immune response disorder, cytokine storms, myocardial ischemia/hypoxia, electrolyte abnormalities, intravascular volume imbalances, drug interactions, side effects of COVID-19 vaccines and autonomic nervous system dysfunction, the exact mechanisms of arrhythmic complications in patients with COVID-19 are complex and not well understood...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818468/pgam5-aggravates-hyperglycemia-induced-myocardial-dysfunction-through-disrupting-phb2-dependent-mitochondrial-dynamics
#12
JOURNAL ARTICLE
Yingzhen Chen, Jungang Huang, Hao Zhou, Jianguo Lin, Jun Tao
This study aims to elucidate the roles of Phosphoglycerate Mutase Family Member 5 (Pgam5) and Prohibitin 2 (Phb2) in the context of hyperglycemia-induced myocardial dysfunction, a critical aspect of diabetic cardiomyopathy. The research employed primary cardiomyocytes, which were then subjected to hyperglycemia treatment to mimic diabetic conditions. We used siRNA transfection to knock down Pgam5 and overexpressed Phb2 using adenovirus transfection to assess their individual and combined effects on cardiomyocyte health...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818467/efficacy-of-citicoline-delivered-via-brain-extracellular-space-against-experimental-acute-ischemic-stroke-in-rats
#13
JOURNAL ARTICLE
Guomei Zhao, He Chen, Junhao Yan, Zhiqian Tong, Yu Fu, Zhaoheng Xie, Hongbin Han
Objective: Citicoline can be used to reduce acute ischemic stroke injury via venous infusion, however, its protective effects in the brain extracellular space remain largely unknown. Herein, we investigated the brain protective effects of citicoline administered via the brain extracellular space and sought precise effective dosage range that can protect against ischemic injury after experimental ischemic stroke in rats. Methods : Fifty-six Sprague-Dawley rats were randomly divided into control, intraperitoneal (IP), caudate-putamen (CPu)-25, CPu-40, CPu-50, CPu-60 and CPu-75 groups based on the infusion site and concentration of citicoline...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818466/association-of-oxidative-balance-score-with-helicobacter-pylori-infection-and-mortality-in-the-us-population
#14
JOURNAL ARTICLE
Yujun Xiong, Huazhao Xu, Xingyun Zhu, Zitian Zheng, Qingfeng Luo
Background: Limited research has examined the association between Oxidative Balance Score (OBS) and mortality, particularly in individuals with Helicobacter pylori (H. pylori) infection. This study investigates the correlation between OBS and H. pylori infection and their impacts on all-cause mortality within a cohort of individuals, considering both infected and uninfected individuals. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, comprising 4,532 participants, were analyzed...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818465/bioinformatics-analysis-reveals-a-novel-prognostic-model-for-esophageal-squamous-cell-carcinoma
#15
JOURNAL ARTICLE
Huan Yang, Yang Chen, Xiancong Huang, Yixuan Gu, Zhongjian Chen, Weimin Mao
Background : Esophageal squamous cell carcinoma (ESCC), a gastrointestinal cancer, is associated with poor prognosis. Prognostic models predict the likelihood of disease progression and are important for the management of patients with ESCC. The objective of this study was to develop a prognostic model for ESCC using bioinformatics analysis. Methods : Two transcriptome microarray Gene Expression Omnibus ESCC datasets (GSE53624 and GSE53622) were analyzed using bioinformatics methods. Differentially expressed genes (DEGs) were identified using the R package limma, and genes associated with survival outcomes in both datasets were identified by Kaplan-Meier analysis...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818464/evaluation-of-qrs-duration-and-presence-of-fragmented-qrs-in-patients-with-inflammatory-bowel-disease
#16
JOURNAL ARTICLE
İbrahim Ethem Güven, Mustafa Candemir, Ertugrul Kayacetin
Background: Inflammatory Bowel Disease (IBD) is mostly characterized by gastrointestinal tract involvement, however can also be accompanied with cardiac manifestations. QRS prolongation and the presence of QRS fragmentation (fQRS) have been previously evaluated in many chronic inflammatory diseases, as an independent predictor of cardiac events. In this study, we aimed to evaluate the QRS duration and fQRS in patients with IBD. Methods: The presented study was designed as a single-center retrospective cohort study...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818463/a-circular-network-of-adenosine-mediated-mitochondrial-dysfunction-as-coregulators-of-acute-myocardial-infarction
#17
JOURNAL ARTICLE
Yang Liu, Tianci Xiao, Zili Wang, Yangbin Ou, Ying Tan, Liting Chen, Na Zhou, Rongjun Zou
This study aims to explore the molecular mechanisms and associated pathways of myocardial infarction (MI). We employed a variety of analytical methods, including Mendelian Randomization (MR) analysis, transcriptome microarray data analysis, gene function and pathway enrichment analysis, untargeted metabolomic mass spectrometry analysis, and gene-metabolite interaction network analysis. The MR analysis results revealed a significant impact of mitochondrial DNA copy number on MI and coronary artery bypass grafting...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818462/clinical-effects-of-traditional-chinese-herbal-medicine-management-in-patients-with-covid-19-sequelae-a-hospital-based-retrospective-cohort-study-in-taiwan
#18
JOURNAL ARTICLE
Po-Chun Hsieh, Chih-Chin Yu, I-Shiang Tzeng, Tsung-Han Hsieh, Chiu-Feng Wu, Li-Fan Ko, Chou-Chin Lan, You-Chen Chao
Introduction: An estimated 43% of COVID-19 patients showed sequelae, including fatigue, neurocognitive impairment, respiratory symptoms, and smell or taste disorders. These sequelae significantly affect an individual's health, work capacity, healthcare systems, and socioeconomic aspects. Traditional Chinese herbal medicine (TCHM) management showed clinical benefits in treating patients with COVID-19 sequelae. This study aimed to analyze the effects of personalized TCHM management in patients with COVID-19 sequelae...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818461/effect-of-bilateral-low-serratus-anterior-plane-block-on-quality-of-recovery-after-trans-subxiphoid-robotic-thymectomy-results-of-a-randomized-placebo-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Yu Fu, Huimin Fu, Wei Wei, Huqing Liu, Zongmei Wen, Xin Lv, Yugang Lu
Purpose: This study aimed to investigate the impact of ultrasound-guided, bilateral, low level (T8-T9) deep serratus anterior plane (DSAP) blocks on postoperative recovery quality and postoperative analgesia in patients undergoing trans-subxiphoid robotic thymectomy (TRT). Methods: 39 patients undergoing TRT were randomized to receive either low DSAP block under general anesthesia (Group S) or the sham block (Group C) on each side. The primary outcome was the QoR-40 score at postoperative day (POD) 1. Secondary outcomes included numeric rating scale (NRS) scores over time, postoperative 48 hours opioid consumption, QoR-40 scores at POD 2, 30, and 90...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38818460/translational-potential-of-baicalein-in-mitigating-rsl3-induced-ferroptosis-in-fibroblasts-implications-for-therapeutic-interventions
#20
JOURNAL ARTICLE
Pao-Jen Kuo, Cheng-Shyuan Rau, Yi-Chan Wu, Chia-Wen Tsai, Chia-Jung Wu, Chia-Wei Lin, Ching-Hua Hsieh
Background: Ferroptosis is an iron-driven cell-death mechanism that plays a central role in various diseases. Recent studies have suggested that baicalein inhibits ferroptosis, making it a promising therapeutic candidate. Materials and Methods: Fibroblast cultures were treated with different agents to determine the effects of baicalein on ferroptosis. Ferroptosis-related gene expression, lipid peroxidation, and post-treatment cellular structural changes were measured using real-time quantitative polymerase chain reaction, C11-BODIPY dye, and transmission electron microscopy, respectively...
2024: International Journal of Medical Sciences
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