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Quarterly Journal of Nuclear Medicine and Molecular Imaging

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https://read.qxmd.com/read/30781938/baseline-pet-as-prognostic-index-in-diffuse-large-b-cell-lymphoma-and-grade-iiib-follicular-lymphoma-a-retrospective-study-of-a-single-centre-experience
#1
Leonardo Campiotti, Diego De Palma, Luigina Guasti, Ilaria Proserpio, Sabrina Casagrande, Ilaria Schiorlin, Elena Bolzacchini, Matteo Suter, Francesca Ogliari, Alessandro Squizzato
BACKGROUND: International guidelines support performing baseline positron emission tomography (PET) in lymphoma. Metabolic tumor volume (MTV) measurement has been proposed as a good measurement of disease burden. We investigated if MTV at baseline PET can be predictive of complete response (CR) to first line standard chemotherapy in diffuse large B-cell lymphoma (DLBCL) and in follicular lymphoma (FL) grade 3b. METHODS: We retrospectively analyzed data on54 consecutive patients with DLBCL and FL grade 3b treated in our institution...
February 14, 2019: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30654605/is-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-useful-to-discriminate-metachronous-lung-cancer-from-metastasis-in-patients-with-oncological-history
#2
Silvia Taralli, Valentina Scolozzi, Elizabeth K Triumbari, Francesco Carleo, Marco Di Martino, Alessia R De Massimi, Sara Ricciardi, Giuseppe Cardillo, Maria L Calcagni
BACKGROUND: Solitary pulmonary nodules detected during follow-up in patients with previous cancer history have a high probability of malignancy being either a metachronous lung cancer or a metastasis. This distinction represents a crucial issue in the perspective of "personalized medicine", implying different treatments and prognosis. Aim - to evaluate the role of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in distinguishing whether solitary pulmonary nodules are metachronous cancers or metastases and the relationship between the nodule's characteristics and their nature...
January 17, 2019: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30644307/impact-of-functional-imaging-in-prostate-cancer-a-clinical-point-of-view
#3
Daniele G Nicolotti, Monica Finessi, Alessia Guarneri, Emanuela Pilati, Francesca Giunta, Désirée Deandreis
No abstract text is available yet for this article.
January 15, 2019: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30644306/psma-radioligand-therapy-of-prostate-cancer
#4
Mohsen Beheshti, Alexander Heinzel, Dirk von Mallek, Christian Filss, Felix M Mottaghy
Defining an optimal therapeutic approach in metastatic castration-resistance prostate cancer (mCRPC) patients in advanced stages is still challenging in routine clinical practice. Prostate- specific membrane antigen (PSMA) targeted radionuclide therapy with β- or α-emitters such as 177-Lutethium (177Lu) or 225-Actinium (225A) has been a main focus at multiple academic researche centers in the last few years. This review article provides an overview of PSMA characteristics, clinical performance, safety and toxicity of PSMA targeted β- or α-radiation therapy...
January 15, 2019: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30497233/role-of-pet-imaging-in-adaptive-radiotherapy-for-lymphoma
#5
Robert Urwin, Sally F Barrington, N George Mikhaeel
Positron emission tomography/Computed tomography (PET/CT) is an essential part of modern radiotherapy for patients with lymphoma. PET/CT can be used to adapt treatment algorithms in Hodgkin lymphoma, reserving consolidation radiotherapy for patients with residual fluoro-D-glucose (FDG) avidity after treatment with intensive chemotherapy such as escalated BEACOPP and limiting the need for radiotherapy for some patients with complete metabolic response on PET if radiotherapy may be associated with increased toxicity...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30497232/molecular-pet-imaging-in-adaptive-radiotherapy-brain
#6
Guillaume Peyraga, Nesrine Robaine, Jonathan Khalifa, Elizabeth Cohen-Jonathan-Moyal, Pierre Payoux, Anne Laprie
INTRODUCTION: Owing to their heterogeneity and radioresistance, the prognosis of primitive brain tumors, which are mainly glial tumors, remains poor. Dose escalation in radioresistant areas is a potential issue for improving local control and overall survival. This review focuses on advances in biological and metabolic imaging of brain tumors that are proving to be essential for defining tumor target volumes in radiation therapy (RT) and for increasing the use of DPRT (dose painting RT) and ART (adaptative RT), to optimize dose in radio-resistant areas...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/29869487/biological-pet-guided-adaptive-radiotherapy-for-dose-escalation-in-head-and-neck-cancer-a-systematic-review
#7
Olga Hamming-Vrieze, Arash Navran, Abrahim Al-Mamgani, Wouter V Vogel
INTRODUCTION: In recent years, the possibility of adapting radiotherapy to changes in biological tissue parameters has emerged. It is hypothesized that early identification of radio-resistant parts of the tumor during treatment provides the possibility to adjust the radiotherapy plan to improve outcome. The aim of this systematic literature review was to evaluate the current state of the art of biological PET-guided adaptive radiotherapy, focusing on dose escalation to radio-resistant tumor...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/29869486/image-guided-adaptive-radiotherapy-in-patients-with-locally-advanced-non-small-cell-lung-cancer-the-art-of-pet
#8
Willem Grootjans, Lioe-Fee de Geus-Oei, Johan Bussink
With a worldwide annual incidence of 1.8 million cases, lung cancer is the most diagnosed form of cancer in men and the third most diagnosed form of cancer in women. Histologically, 80-85% of all lung cancers can be categorized as non-small cell lung cancer (NSCLC). For patients with locally advanced NSCLC, standard of care is fractionated radiotherapy combined with chemotherapy. With the aim of improving clinical outcome of patients with locally advanced NSCLC, combined and intensified treatment approaches are increasingly being used...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/29869485/18f-fdg-pet-ct-guided-external-beam-radiotherapy-volumes-in-inoperable-uterine-cervical-cancer
#9
Judit A Adam, Hester Arkies, Karel Hinnen, Lukas J Stalpers, Jan H van Waesberghe, Jaap Stoker, Rob van Os, Janna J Laan, Constantijne H Mom, Berthe L van Eck-Smit
BACKGROUND: In patients with advanced stage cancer of the uterine cervix who undergo irradiation with curative intent, there is the necessity to treat all suspicious nodes on imaging. Our hypothesis was that adding fluorodeoxyglucose positron emission computer tomography/computer tomography (FDG-PET/CT) to the imaging workup would alter the external beam radiotherapy (EBRT) treatment plan, either resulting in an extended external beam radiotherapy (EBRT) field to the para-aortal region or an additional boost to suspicious nodes...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/29869484/pet-imaging-in-adaptive-radiotherapy-of-gastrointestinal-tumors
#10
Philippe Bulens, Melissa Thomas, Christophe M Deroose, Karin Haustermans
INTRODUCTION: Radiotherapy is a cornerstone in the multimodality treatment of several gastrointestinal (GI) tumors. Positron-emission tomography (PET) has an established role in the diagnosis, response assessment and (re-)staging of these tumors. Nevertheless, the value of PET in adaptive radiotherapy remains unclear. This review focuses on the role of PET in adaptive radiotherapy, i.e. during the treatment course and in the delineation process. EVIDENCE ACQUISITION: The MEDLINE database was searched for the terms ("Radiotherapy"[Mesh] AND "Positron-Emission Tomography"[Mesh] AND one of the site-specific keywords, yielding a total of 1710 articles...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/29869483/pet-imaging-in-adaptive-radiotherapy-of-prostate-tumors
#11
REVIEW
Bettina Beuthien-Baumann, Stefan A Koerber
The integration of data from positron-emission-tomography, combined with computed tomography as positron emission tomography computed tomography (PET/CT) or combined with magnet resonance imaging as PET/MRI, into radiation treatment planning of prostate cancer is gaining higher impact with the development of more sensitive and specific radioligands. The classic PET-tracer for prostate cancer imaging are [11C]choline and [11C]acetate, which are currently outperformed by ligands binding to the prostate-specific-membrane-antigen (PSMA)...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/27045577/sympathetic-denervation-in-patients-with-ischemic-cardiomyopathy-and-risk-on-ventricular-tachy-arrhythmias-a-pilot-study
#12
Walter Noordzij, Arif Elvan, Fatma Demirel, Piet L Jager, René A Tio, Riemer H Slart
BACKGROUND: Patients with ischemic cardiomyopathy (ICM) are at risk for ventricular arrhythmias and are protected by an implantable cardioverter defibrillator (ICD). Visualization of cardiac sympathetic innervation may play an additional role to left ventricular ejection fraction (LVEF) in identifying those patients who will benefit from ICD therapy. The purpose of this study was to detect the role of sympathetic denervation in the genesis of ventricular arrhythmias in ICM patients. METHODS: Twenty patients with ICM and LVEF <30% were included in this pilot study...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/27045576/clinical-value-of-intratumoral-metabolic-heterogeneity-in-18f-fdg-pet-ct-for-prediction-of-recurrence-in-patients-with-locally-advanced-colorectal-cancer
#13
Yeon-Hee Han, Hwan-Jeong Jeong, Myung-Hee Sohn, Seok T Lim
BACKGROUND: The aim of this study was to find a reliable predictor of recurrence in patients with locally advanced colorectal cancer. METHODS: We enrolled 96 patients for this retrospective study. We investigated metabolic (SUVmax, metabolic tumor volume, total lesion glycolysis, and heterogeneity), clinical (age, sex, stage, and CEA level) and pathologic (Ki-67, p53, CD31, COX-2, E-cadherin and EGFR) parameters. The coefficient of variation (COV) was chosen to assess heterogeneity of [18F]FDG uptake by dividing the standard deviation of the SUV by SUVmean...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/27007664/the-proposed-physiology-based-fdg-pet-ct-criteria-in-reducing-false-positive-results-in-advanced-head-and-neck-cancer-after-chemoradiotherapy
#14
Shu-Hua Huang, Hui-Ching Chuang, Chih-Yen Chien, Yen-Hsiang Chang, Bor-Tau Hung, Fu-Ming Fang, Chiung-Chih Chang
BACKGROUND: Distinguishing benign complications after concurrent chemoradiotherapy (CCRT) from a local residual tumor in advanced head and neck squamous cell carcinoma (HNSCC) remains a clinical challenge. In this study, we propose criteria when considering physiological uptake patterns on F-18-fluorodeoxyglucose (FDG) PET/CT in patients with advanced HNSCC after CCRT. METHODS: We retrospectively reviewed FDG PET/CT images of 62 patients with advanced HNSCC, which were taken within 16 weeks following CCRT...
December 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30221907/comparison-of-post-therapeutic-sequential-131i-whole-body-scans-in-the-detection-of-metastatic-thyroid-cancer
#15
Lin Qiu, Hui Tan, Hongyan Yin, Jun Zhou, Dengfeng Cheng, Hongcheng Shi
BACKGROUND: The aim was to compare the detect ability of 3 sequential 131I whole-body scans (tri-WBS) on the second, third, and fourth day after 131I therapy for metastatic thyroid cancer. METHODS: Differentiated thyroid cancer patients who received oral high-dose 131I therapy underwent routinely tri-WBS on the second, third, and fourth day after total or near-total thyroidectomy in our hospital. We enrolled 137 patients with 261 tri-WBSs in this study between January 2015 and November 2017...
September 13, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30221906/evaluation-of-physiologic-and-abnormal-glucose-uptake-in-palatine-tonsils-differential-diagnostics-with-sequential-dual-time-point-2-deoxy-2-18f-fluoro-d-glucose-positron-emission-tomography-computed-tomography-examinations
#16
Agata K Pietrzak, Joanna Kazmierska, Andrzej Marszalek, Witold Cholewinski
BACKGROUND: The aim of this article was to evaluate the usefulness of sequential dual- time-point 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (DTP [18F]FDG PET/CT) in distinguishing physiologic, inflammatory and malignant palatine tonsils as difficult to differentiate in the oncological practice. METHODS: A total of 90 patients before the treatment underwent sequential DTP [18F]FDG PET/CT examinations. We analyzed 104 structures in 90 patients: 31 physiologic tonsils, 28 histopathologically confirmed inflammatory tonsils of non-specified origin, 31 histopathologically confirmed palatine tonsils cancer and 14 non-malignant contralateral tonsils in patients with histopathologically confirmed unilateral palatine tonsil malignancy...
September 13, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30221905/predictive-factors-determining-incomplete-response-to-radioiodine-therapy-in-patients-with-differentiated-thyroid-cancer
#17
Ewelina Szczepanek-Parulska, Magdalena Wojewoda-Korbelak, Martyna Borowczyk, Malgorzata Kaluzna, Barbara Brominska, Katarzyna Ziemnicka, Rafal Czepczynski, Maciej Baczyk, Marek Ruchala
BACKGROUND: Although differentiated thyroid cancer (DTC) has relatively favorable course, factors predicting the course of the disease are intensively searched. The aim of the study was to identify the clinical factors determining incomplete response to radioiodine therapy in patients with differentiated thyroid cancer. METHODS: We retrospectively analyzed 385 consecutive patients with DTC treated and followed-up at a single tertiary reference center. We investigated clinical factors detectable during first hospitalization 3-6 months following total thyroidectomy due to DTC, which may serve as prognostic factors determining response to DTC therapy in a long-term follow-up...
September 13, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/29869489/investigational-pet-tracers-for-high-grade-gliomas
#18
REVIEW
Gagandeep Choudhary, Karl-Josef Langen, Norbert Galldiks, Jonathan McConathy
High-grade gliomas (HGGs) are the most common primary malignant tumors of the brain, with glioblastoma (GBM) constituting over 50% of all the gliomas in adults. The disease carries very high mortality, and even with optimal treatment, the median survival is 2-5 years for anaplastic tumors and 1-2 years for GBMs. Neuroimaging is critical to managing patients with HGG for diagnosis, treatment planning, response assessment, and detecting recurrent disease. Magnetic resonance imaging (MRI) is the cornerstone of imaging in neuro-oncology, but molecular imaging with positron emission tomography (PET) can overcome some of the inherent limitations of MRI...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/29869488/radiomics-derived-from-amino-acid-pet-and-conventional-mri-in-patients-with-high-grade-gliomas
#19
REVIEW
Philipp Lohmann, Martin Kocher, Jan Steger, Norbert Galldiks
Radiomics is a technique that uses high-throughput computing to extract quantitative features from tomographic medical images such as MRI and PET that usually are beyond visual perception. Importantly, the radiomics approach can be performed using neuroimages that have already been acquired during the routine follow-up of the patients allowing an additional data evaluation at low cost. In Neuro-Oncology, these features can potentially be used for differential diagnosis of newly diagnosed cerebral lesions suggestive for brain tumors or for the prediction of response to a neurooncological treatment option...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/29781593/neuroimaging-in-patients-with-high-grade-gliomas
#20
EDITORIAL
Norbert Galldiks
No abstract text is available yet for this article.
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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