Hui-Han Ma, Jun-Ru Wen, Hao Fang, Shan Su, Can Wan, Chao Zhang, Fang-Mei Lu, Ling-Ling Fan, Guang-Liang Wu, Zi-Yi Zhou, Lijun Qiao, Shi-Jie Zhang, Ye-Feng Cai
Ischemia stroke is thought to be one of vascular risks associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Hydroxysafflor yellow A (HSYA) has been reported to protect against stroke and AD, while the underlying mechanism remains unclear. In this study, SH-SY5Y cell model treated with oxygen glucose deprivation/reperfusion (OGD/R) was used to explore the potential mechanism of HSYA. Results from CCK-8 showed that 10μM HSYA restored the cell viability after OGD 2 h/R 24 h. HSYA reduced the levels of malondialdehyde and ROS, while improved the levels of superoxide dismutase and glutathione peroxidase...
February 3, 2023: Rejuvenation Research