Rejuvenation Research

This Scientometric study aimed to provide state-of-the-art information on research growth and trends, areas of potential growth and development in genomics in India, and identify the key players (organizations or institutions, and funding agencies). It was found that the number of publications and citations related to genomics research has been steadily increasing over the years, indicating a growing interest and investment in the field as the Indian Council of Agricultural Research was the leading contributor to the field...

Intestinal aging contributes to the physiological decline of intestine and induces age-associated intestinal diseases. Therefore, the intestine is a vital target to delay intestinal aging and extend healthy lifespan. Alginate oligosaccharides (AOS) have a wide range of biological and pharmacological activities. However, there are no related reports of AOS on intestinal aging. Our study aimed to investigate the effect of AOS on hydrogen peroxide (H2O2)-induced senescent intestinal epithelial cells (IEC-6) and its anti-aging mechanism...

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The current understanding of skin aging is that senescent fibroblasts accumulate within the dermis and subcutaneous fat to cause abnormal tissue remodeling and extracellular matrix dysfunction, triggering a senescence-associated secretory phenotype (SASP). A novel therapeutic approach to prevent skin aging is to specifically eliminate senescent dermal fibroblasts; this requires the identification of specific protein markers for senescent cells. Apolipoprotein D (ApoD) is involved in lipid metabolism and antioxidant responses and is abundantly expressed in tissues affected by age-related diseases such as Alzheimer's disease and atherosclerosis...

Ischemia stroke is thought to be one of vascular risks associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Hydroxysafflor yellow A (HSYA) has been reported to protect against stroke and AD, while the underlying mechanism remains unclear. In this study, SH-SY5Y cell model treated with oxygen glucose deprivation/reperfusion (OGD/R) was used to explore the potential mechanism of HSYA. Results from CCK-8 showed that 10μM HSYA restored the cell viability after OGD 2 h/R 24 h. HSYA reduced the levels of malondialdehyde and ROS, while improved the levels of superoxide dismutase and glutathione peroxidase...

OBJECTIVE: This study aimed to establish a complement-tolerance test as a marker of protein fragility and discuss its clinical significance. METHODS: Total complement activity (TCA) of serum was measured using a self-hemolysis colorimetric method. Human O-erythrocytes and rabbit anti-human O-erythrocyte antibodies were used to replace sheep erythrocytes and the corresponding hemolysin for the hemolysis test, respectively. The antigen-antibody specific binding activated the classical pathway of complement, generating a membrane attack complex (MAC), and the red blood cells rupture...

No abstract text is available yet for this article.

Data regarding plant extracts with antiaging properties, particularly via the biological process involving telomeres and telomerase, are limited. Thus, the present study aimed to investigate the effects of Acanthopanax senticosus extract (ASE) supplementation on leukocyte telomere length (LTL), telomerase, and inflammatory and metabolic markers in adult animal models. A freeze-dried product of ethanol extracts was prepared using a mixture product of stem and root ASE. In a 24-week experiment that included 24-week-old Sprague Dawley male rats, experimental rats (n = 10) were administrated with 7 mg/day of ASE dissolved in saline and control rats (n = 10) with saline...

Increasing age is the single largest risk factor for a variety of chronic illnesses. As a result, the capability to target the aging process has the potential to lead to increased health span. A lack of appropriate glucoregulatory control is a recurring issue associated with aging and chronic illness, even though many longevity therapies result in the preservation of glucoregulatory control. In this study, we suggest that targeting glucose metabolism to improve regulatory control can help to slow the aging process...

Acute pulmonary thromboembolism (APTE) has become a non-negligible clinical concern due to its high mortality and complex symptoms. Early diagnosis and prognostic assessment of APTE are of great significance for the long-term benefits of patients, especially elderly patients. Elderly patients with pulmonary embolism (n=250) who presented to our hospital from January 2018 to July 2021 were recruited into this study. In addition, 50 healthy elderly people with no history of allergies were selected as the control group...

No abstract text is available yet for this article.

Chronic senescence, such as aging, contributes to age-related tissue dysfunction and disease development. The accumulation of senescent fibroblasts and the senescence-associated secretory phenotype are particularly implicated in this process. Removal of senescent cells has been reported to prevent tissue dysfunction and extend life span during aging. ABT-263 (navitoclax), which inhibits antiapoptotic proteins, is a leading antiaging drug; however, its role in human skin aging is unclear. This study aimed to determine the rejuvenating effects of ABT-263 on aging skin using a human skin graft mouse model...

The work investigated effects of plant polyphenolic compounds (PPs) on responses of cultured human HaCaT keratinocytes to ultraviolet radiation in the C range (UV-C). The experimental data obtained indicate a cytoprotective effect of the PPs added immediately after UV-C exposure. The efficiency of PPs was lowered in the order: acacetin ≥ silybin > quercetin. It was also studied the influence of PPs on phosphorylation of histones H2AX and the number of single-strand DNA breaks in the nuclei of keratinocytes...

Oncogene-induced senescence (OIS), characterized by irreversible cell cycle arrest by oncogene activation, plays an important role in the pathogenesis of aging and age-related diseases. Recent research indicates that OIS is driven by activation of mitogen-activated protein kinase (MAPK). However, it is not apparent whether MAPK inhibition helps to recover senescence. In our previous study, we uncovered p38 MAPK inhibitor, SB203580, as an effective agent to reduce ROS and increase proliferation in premature senescent cells...

Constipation is one of the most common gastrointestinal disorders, whose incidence increasing with age. As one of the main components, Astragalus polysaccharide (APS) has been used to treat a variety of diseases. This study aimed to explore the effects of APS on the improvement of gastrointestinal function and learning memory in elderly rats with constipation. In this study, both 16S rRNA sequencing-based microbiome and 1NMR-based metabolomics were applied to demonstrate the effects of APS on host metabolism and gut microbiota of the elderly rats with constipation...

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BACKGROUND: Huntington's disease is an inherited neurodegenerative disease. 3- nitropropionic acid (3-NP) causes increased ROS production and neuroinflammation. Centella asiatica (CA) is a strong antioxidant. AIM: To investigate the effect of hydroalcoholic extract of Centella asiatica (HA-CA) in 3-nitro propionic acid-induced Huntington's disease in adult zebrafish. MATERIAL AND METHOD: Adult zebrafish (approximately 5-6 months old), weighing from 470-530 mg were used and treated with 3-NP (5 mg/kg i...

Considering that telomere length can be determined not only by issues related to cell biology, but also by aspects related to social factors and environmental exposures, studies on the relationship between social aspects and telomere length can help to better understand the still little-known aspects of the human aging process. Thus, this research seeks to verify whether social support network is associated with telomere length in older adults. This is a cross-sectional study conducted with 448 individuals aged 60 years or older living in the urban area of a municipality in Brazil's countryside...

Cisplatin is widely used in chemotherapies in cervical cancer (CC). Nevertheless, drug resistance in cancer patients poses a major threat to efficacy of treatment. To explore the underlying modulatory mechanism of SOX21-AS1 in cisplatin resistance in CC cell and mice models，Gepia database was referred for SOX21-AS1 expression in cancer tissues and normal ones. RT-qPCR was used to measure the differential expression of SOX21-AS1 in parental Siha cells and cisplatin-resistant Siha/DDP cells. Luciferase reporter gene assays were conducted to verify putative bindings between SOX21-AS1 and miR-9-3p...

The inflammatory response is the stress reactions to infection or injury so as to help the body return to normal as soon as possible. In central nervous system, the over activated immune system causes irreversible damage to neurons and synapses,which results in cognitive impairment. Berberine,an isoquinoline alkaloid extracted from Coptidis Rhizoma,plays a powerful role in anti-inflammation.It has been reported that berberine significantly improved the decline of cognitive ability.Therefore,we carried out this work to find out the specific mechanism...