Muhammad Sarfraz, Mubashir Aziz, Saira Afzal, Pervaiz Ali Channar, Bshra A Alsfouk, Ghulam Abbas Kandhro, Sidra Hassan, Ahlam Sultan, Asad Hamad, Mosab Arafat, Muhammad Naeem Qaiser, Aftab Ahmed, Farhan Siddique, Syeda Abida Ejaz
AKR1B1 and AKR1B10 are important members of aldo-keto reductase family which plays a significant role in cancer progression by modulating cellular metabolism. These enzymes are involved in various metabolic processes, including the synthesis and metabolism of hormones, detoxification of reactive aldehydes, and the reduction of various endogenous and exogenous compounds. This study aimed to explore the potential of strychnine as an anticancer agent by targeting AKR1B1 and AKR1B10 via drug repurposing approach...
November 8, 2023: Protein Journal