Razieh Mansoori, Sohrab Kazemi, Darya Almasi, Seyed Mohammad Hosseini, Bardia Karim, Majid Nabipour, Ali Akbar Moghadamnia
Nephrotoxicity and hepatotoxicity include increased oxidative stress and apoptosis; as a result, liver and kidney damage are related to its pathogenesis. These are significant side effects caused in cancer patients treated with 5-FU. In the research, 25 rats were divided into five groups, including control, 5-FU, and 5-FU + 2.5, 5, and 10 mg/Kg melatonin (MEL), and the protective impact of MEL against 5-FU-induced hepatorenal damage in rats was investigated. 5-FU caused significant harm, resulting in severe renal failure and histopathological changes...
December 21, 2023: Basic & Clinical Pharmacology & Toxicology