Laura de R Casagrande, Germano D Porto, Mateus C Colares, Ligia M Venturini, Gustavo de B Silveira, Carolini Mendes, Maria Eduarda A B Corrêa, Igor R Lima, Paulo E Feuser, Ricardo A Machado-de-Ávila, Paulo C L Silveira
This study aimed to investigate the effect of intranasal treatment of gold nanoparticles (GNPs) and Curcumin (Cur) on the lipopolysaccharide (LPS)-induced acute pulmonary inflammatory response. A single intraperitoneal injection of LPS (0.5 mg/Kg) was performed, and the animals in the Sham group were injected with 0.9% saline. Treatment was daily intranasally with GNPs (2.5 mg/L), Cur (10 mg/kg) and GNP-Cur started 12 hours after LPS administration and ended on the seventh day. The results show that the treatment performed with GNP-Cur was the most effective to attenuate the action of pro-inflammatory cytokines, and a lower leukocyte count in the bronchoalveolar lavage, in addition to positively regulating anti-inflammatory cytokines in relation to other groups...
March 7, 2023: Basic & Clinical Pharmacology & Toxicology