Kristine Hole, Sofie Gangsø, Åsa Tonette Jensstuen, Hanne Holte Ormøy, Maren Paulsen, Espen Molden, Tore Haslemo
Duloxetine is metabolized by cytochrome P450 (CYP)1A2 and CYP2D6. The aim of this study was to investigate the effect of CYP2D6 genotype on duloxetine serum concentration adjusting for age and sex. Patients were included retrospectively from a therapeutic drug monitoring service. Multiple linear regression analysis was used to investigate the effect of CYP2D6 genotype, age and sex on duloxetine concentration-to-dose (C/D) ratio. In total, 269 patients were included and assigned to the following genotype-predicted phenotype subgroups: CYP2D6 poor metabolizers (PMs, n = 23), intermediate metabolizers (IMs, n = 121), normal metabolizers (NMs, n = 120), and ultrarapid metabolizers (UMs, n = 5)...
October 20, 2023: Basic & Clinical Pharmacology & Toxicology