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Experimental and Clinical Transplantation

https://read.qxmd.com/read/38511988/response-to-letter-to-the-editor-monkeypox-in-a-kidney-transplant-recipient
#1
LETTER
Hinpetch Daungsupawong, Viroj Wiwanitkit
No abstract text is available yet for this article.
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511987/successful-anesthesia-management-of-pediatric-living-donor-liver-transplant-with-mild-bilateral-pulmonary-artery-stenosis-due-to-alagille-syndrome-a-case-report
#2
Nedim Çekmen, Ahmed Uslu, Adnan Torgay, Coşkun Araz, Emre Karakaya, Sedat Yildirim, Kürşad Tokel, Mehmet Haberal
Alagille syndrome is an autosomal-dominantinherited disease characterized by intrahepatic bile duct involvement, congenital heart disease, eye anomalies, skeletal and central nervous system involvement, kidney anomalies, and facial appearance. Liver transplant is the only treatment option for patients with end-stage liver disease and Alagille syndrome. Bilateral peripheral pulmonary artery stenosis is a contraindication for liver transplant due to high mortality, and the decision for liver transplant in patients with bilateral peripheral pulmonary artery stenosis is extremely challenging for anesthesiologists andtransplant surgeons...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511986/laparoscopic-nephrectomy-via-the-retroperitoneal-approach-for-autosomal-dominant-polycystic-kidney-disease-after-renal-transplant-a-case-report
#3
Kazuro Kikkawa, Hiraku Yamamoto, Yasuo Kohjimoto, Isao Hara
We report a case of laparoscopic nephrectomy via the retroperitoneal approach for autosomal dominant polycystic kidney disease after renal transplant. A 54-year-old male patient with end-stage renal failure because of autosomal dominant polycystic kidney disease underwent a living donor renal transplant and right nephrectomy via open surgery through a median abdominal incision 5 years previously. However, the left kidney gradually became enlarged. We performed laparoscopic left nephrectomy via the retroperitoneal approach...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511985/mir96-has-good-potential-to-differentiate-human-bone-marrow-derived-mesenchymal-stem-cells-into-photoreceptor-like-cells
#4
JOURNAL ARTICLE
Mohammad-Reza Mahmoudian-Sani, Najmeh Fattahi, Morteza Hashemzadeh Chaleshtori, Samira Asgharzade
OBJECTIVES: MicroRNAs play an important role in the development and function of neuron cells. Among these, the miRNA known as MIR96 is abundantly expressed in mammalian retina and significantly affects differentiation, maturation, and survival of human photoreceptor cells. In this study, a mimic to miRNA-96 was transfected into human bone marrowderived mesenchymal stem cells to explore the biological functions of MIR96 at differentiation processing. MATERIALS AND METHODS: A mimic to miRNA-96 and a competitive control were transfected into human bone marrow-derived mesenchymal stem cells using Lipofectamine...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511984/implications-of-an-altered-gut-microbiome-in-rat-experimental-vascularized-composite-transplantation
#5
JOURNAL ARTICLE
Ashti M Shah, Ali M Aral, Derek A Barclay, Jinling Yin, Ruben Zamora, Vijay Gorantla, Yoram Vodovotz
OBJECTIVES: Vascularized composite allotransplantation is a reconstructive option after severe injury but is fraught with complications, including transplant rejection due to major histocompatibility complex mismatch in the context of allogeneic transplant, which in turn is due to altered immuno-inflammation secondary to transplant. The immunosuppressant tacrolimus can prevent rejection. Because tacrolimus is metabolized predominantly by the gut, this immunosuppressant alters the gut microbiome in multiple ways, thereby possibly affecting immunoinflammation...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511983/effects-of-extracellular-calcium-concentration-on-hepatic-ischemia-reperfusion-injury-in-a-rat-model
#6
JOURNAL ARTICLE
Eun Ji Lee, Hyun Ji Hwang, Justin S Ko, MiHye Park
OBJECTIVES: Hypocalcemia is frequently identified during liver transplant. However, supplementation of extracellular calcium could induce increased intracellular calcium concentration, as a potential factor for injury to the liver graft. We evaluated the effects of regulating extracellular calcium concentrations on hepatic ischemia-reperfusion injury. MATERIALS AND METHODS: We randomly divided 24 Sprague-Dawley rats into 3 groups: group C received normal saline (n = 8), group L received citrate to induce hypocalcemia (n = 8), and group L-Co received citrate followed by calcium gluconate to ameliorate hypocalcemia (n = 8)...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511982/factors-associated-with-chronic-rejection-in-liver-transplant-recipients-a-retrospective-cohort-study-from-shiraz-organ-transplant-center
#7
JOURNAL ARTICLE
Alireza Shamsaeefar, Shabnam Shojaei, Hamed Nikoupour, Kourosh Kazemi, Mehrab Sayadi, Amirali Mashhadiagha, Seyed Ali Moosavi, Nasrin Motazedian, Bita Geramizadeh, Seyed Ali Malekhosseini
OBJECTIVES: Identification of chronic rejection risk factors in liver transplant recipients is critical for early detection and prevention of further graft loss. We investigated characteristics of liver transplant recipients who had experienced chronic rejection and the associated risk factors versus patients without chronic rejection. MATERIALS AND METHODS: Data from 3022 adult liver transplant recipients between 2011 and 2018 were analyzed; of these, 80 patients had experienced chronic rejection...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511981/effect-of-body-composition-on-graft-function-and-cardiovascular-outcomes-in-normotensive-renal-transplant-recipients
#8
JOURNAL ARTICLE
Bahar Gurlek Demirci, Mine Sebnem Karakan
OBJECTIVES: We evaluated the effects of body composition on graft function and cardiovascular outcomes in normotensive renal transplant recipients. MATERIALS AND METHODS: In this cross-sectional study, we analyzed ambulatory blood pressure monitoring data from 136 renal transplant recipients with stable allograft function after living related donor transplant. We enrolled 87 normotensive recipients. We analyzed left ventricular mass index, renal resistive index, and body composition of recipients...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511980/renal-transplant-in-elderly-end-stage-renal-disease-patients-impact-of-comorbidities-and-posttransplant-adverse-events-on-outcomes
#9
JOURNAL ARTICLE
Mohamed Yehia Hamdy, Hayam El Aggan, Iman El Gohary, Ahmed Halawa
OBJECTIVES: Elderly renal transplant continues to be debated because of age-related factors affecting transplant success and long-term prognosis. We investigated the effects ofrecipient age and predictors of renal transplant outcomes in elderly renal transplant recipients. MATERIALS AND METHODS: We retrospectively analyzed 506 patients who had a first renal transplant between January 2010 and December 2020; there were 165 recipients aged ≥60 years (elderly) and 341 recipients aged <60 years (young)...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511979/an-overview-of-liver-transplantation-current-status-recent-techniques-and-challenges-perspectives-from-a-center-in-china
#10
REVIEW
Zhihong Zheng, Lijin Zhao
Liver transplantation is the best way to treat end-stage liver disease.With benefits from enhanced techniques, refined management, and advanced medications, liver transplant boasts a commendable 5-year survival rate for recipients. Nevertheless, acquiring the perioperative management and surgical skills essential for liver transplant is a time-consuming process for new surgeons. In addition, COVID-19 has also affected the field. Based on our actual situation in China, we have provided an overview of donor evaluation,recipient selection,transplant procedures, postoperative complications and management, longterm management, and pandemic strategies to guide new clinical surgeons in the field...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385595/a-different-perspective-of-covid-19-pandemic-efficacy-and-safety-of-mrna-vaccines-in-immunocompetent-and-immunocompromised-individuals-part-3
#11
REVIEW
Antoine Barbari
Shortly after the declaration of the pandemic, several anti-SARS-CoV-2 vaccines entered phase 3 clinical trials. One year later, Pfizer-BioNTech and Moderna published their initial trial results, encompassing a 2-month follow-up. The studies were only designed to test whether the vaccines were effective and safe on the short-term.The vaccine's efficacy in the 2 trials was defined as relative risk reduction instead of absolute risk reduction, a more accurate determinant of vaccine effectiveness in the real world...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385594/a-different-perspective-on-the-covid-19-pandemic-validity-of-covid-19-testing-and-protective-nonpharmaceutical-interventions-part-2
#12
REVIEW
Antoine Barbari
The causative agent for COVID-19 was identified by next-generation sequencing from samples received from several pneumonia patients. The detection of the coronavirus was done through real-time polymerase chain reaction analyses performed from plasma sample. Ribonucleic acid extracted from a patient's bronchoalveolar lavage fluid was used as a template to clone and sequence a genome from lineage B of the betacoronavirus. A polymerase chain reaction test was considered positive using cycle threshold above 34 for detected samples...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385593/a-different-perspective-on-the-covid-19-pandemic-origin-of-the-outbreak-part-1
#13
REVIEW
Antoine Barbari
In December 2019, an outbreak caused by novel coronavirus 2019 (COVID-19) started in Wuhan, China. After extensive speculation about a causative agent, a novel betacoronavirus, in the same family as SARS-CoV and MERS-CoV, was identified via next-generation sequencing from samples received from several pneumonia patients. Ribonucleic acid extracted from the patient's bronchoalveolar lavage fluid was used as a template to clone and sequence the genome of SARS-CoV-2. Shortly after, the World Health Organization announced a worldwide pandemic...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385427/drug-drug-interaction-between-tacrolimus-and-fluconazole-in-a-kidney-transplant-recipient
#14
Khouloud Ferchichi, Syrine Ben Hammamia, Mouna Ben Sassi, Hanene El Jebari, Rim Charfi, Riadh Daghfous, Emna Gaies, Sameh Trabelsi
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385426/interaction-between-tacrolimus-and-proton-pump-inhibitor-in-a-kidney-transplant-recipient
#15
Khouloud Ferchichi, Syrine Ben Hammamia, Mouna Ben Sassi, Hanene El Jebari, Rim Charfi, Riadh Daghfous, Emna Gaies, Sameh Trabelsi
We aimed to present a drug monitoring profile of tacrolimus and proton pump inhibitor coadministration in a 23-year-old male patient with a history of high blood pressure who underwent kidney transplant. The patient's serum trough levels of tacrolimus were in the therapeutic range until omeprazole 20 mg daily was prescribed. Tacrolimus trough serum level increased to 29.5 ng/mL under the same daily dose and to 13.9 ng/mL after tacrolimus daily dose was decreased to 6 mg/day. This increase in tacrolimus serum level was behind a renal function alteration...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385425/kidney-transplant-recipient-with-cerebral-paradoxical-embolism-following-recurrent-idiopathic-deep-vein-thrombosis-and-pulmonary-embolism-case-report-and-review-of-the-literature
#16
REVIEW
Osama Gheith, Hassanen Abo Atya, Ayman Maher Nagib, Ahmed Sami, Prasad Nair, Medhat Alawady, Khaja M Sharfuddin, Ahmed Fathy, Wesam Mattar, Ahmed Abass, Abdulwahab Mahmoud, Mohamed Al Ajmi, Torki Al Otaibi
Paradoxical embolism occurs when a thrombus crosses an intracardiac defect into the systemic circulation. Here, we present the case of a 35-yearold male kidney transplant recipient with a cerebral paradoxical embolism associated with a spontaneous venous thromboembolism. This patient had recurrent deep venous thrombosis and showering emboli to the lung and paradoxically to the brain through patent foramen ovale, and we treated him successfully. The role of bubble echocardiography was essential in diagnosis to avoid contrast-induced nephropathy...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385424/anesthetic-management-for-kidney-transplant-in-a-young-patient-with-mitral-regurgitation-case-report
#17
Juan Carlos Delgado Márquez
Patients with chronic kidney disease who are candidates for transplant may experience changes in capillary permeability, coagulation, and the endocrine system; alterations in the pulmonary vasculature; and cardiac structural and functional changes. Patients with renal replacement by hemodialysis have a mortality rate 30 times higher than those who do not have uremia. According to the onset, duration, and severity of chronic kidney disease, cardiovascular disease will be reflected in baseline function and response to stress...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385423/a-rare-reason-for-severe-hypocalcemia-following-kidney-transplant-denosumab-treatment
#18
Muride Aktas, Hayriye Nur Oray Unlu, Murat Karatas, Gokalp Okut, Berna Eren, Adam Uslu, Erhan Tatar
Deviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyperphosphatemia cause the development of secondary hyperparathyroidism...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385422/management-of-tacrolimus-induced-toxicity-with-normal-serum-levels-after-liver-transplant
#19
Zain Majid, Shoaib Ahmed Khan, Farina M Hanif, Mudassir Laeeq, Abbas Ali Tasneem, Nasir Hassan Luck, Muhammad Mubarak
Drug-induced liver injury after liver transplant occurs in 1.7% of patients. Tacrolimus is an effective immunosuppressant that is used to treat acute rejection. Although rare, it can cause toxicity, which is demonstrated by cholestatic liver injury. Here, we present a case of a young male patient who was diagnosed with Wilson disease, had penicillaminechelating therapy, and underwent living related liver transplant. Within 1 month posttransplant, he developed deranged, predominantly cholestatic pattern liver function tests...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38385421/tacrolimus-associated-posterior-reversible-encephalopathy-syndrome-in-renal-transplant-recipient-in-early-posttransplant-period-case-report
#20
Syed Mohd Azhar Hassan
Posterior reversible encephalopathy syndrome is an emergency medical condition with varied causes presenting as reversible subcortical vasogenic brain edema caused by endothelial injury, resulting from changes in blood pressure or direct effects of cytokines on endothelium. Posterior reversible encephalopathy syndrome is manifested by neurologic symptoms. Common causes include hypertensive emergency, renal disease, preeclampsia, eclampsia, and immunosuppressive drugs. In this case report, a 17-year-old female patient on hemodialysis as a result of lupus nephritis who had previously undergone deceased donor organ transplant and was on triple immunosuppression presented with neurological symptoms of posterior reversible encephalopathy syndrome in the early posttransplant period...
January 2024: Experimental and Clinical Transplantation
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