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Acta Biochimica et Biophysica Sinica

Jingjie Sun, Yuping Du, Qiaoling Song, Jing Nan, Peizhu Guan, Jihui Guo, Xiao Wang, Jinbo Yang, Chenyang Zhao
Activation of transcription factor STAT3 is involved in cell proliferation, differentiation, and cell survival. Constitutive activation of STAT3 pathway has been associated with the oncogenesis of various types of cancers. It has been reported that STAT3 plays a key role in the G1 to S phase cell cycle transition induced by the cytokine receptor subunit gp130, through the upregulation of cyclins D1, D2, D3, A, and Cdc25A and the concomitant downregulation of p21 and p27. However, its role in mediating G2-M phase transition has not been studied...
February 6, 2019: Acta Biochimica et Biophysica Sinica
Zijian Li, Luming Zhou, Tianxia Jiang, Libin Fan, Xiaoying Liu, Xiaobo Qiu
The ubiquitin-proteasome system degrades most cellular proteins in eukaryotes. UCH37, also known as UCH-L5, is a deubiquitinase binding to Rpn13, a receptor for ubiquitinated substrates in the 26 S proteasome. But, it remains unclear how UCH37 influences the proteasomal degradation of the ubiquitinated substrates. Because deletion of UCH37 is embryonically lethal in mice, this study aims to investigate the role of UCH37 in proteasomal degradation by constructing the UCH37-deficient cell lines using CRISPR/Cas9 technology...
February 6, 2019: Acta Biochimica et Biophysica Sinica
Ruijie Liu, Christian Miller, Christiana D'Annibale, Kimberly Vo, Ashley Jacobs
Protein phosphatase 1 isoforms α, β, and γ (PP1α, PP1β, and PP1γ) are highly homologous in the catalytic domains but have distinct subcellular localizations. In this study, we utilized both primary cell culture and knockout mice to investigate the isoform-specific roles of PP1s in the heart. In both neonatal and adult cardiac myocytes, PP1β was mainly localized in the nucleus, compared to the predominant presence of PP1α and PP1γ in the cytoplasm. Adenovirus-mediated overexpression of PP1α led to decreased phosphorylation of phospholamban, which was not influenced by overexpression of either PP1β or PP1γ...
February 5, 2019: Acta Biochimica et Biophysica Sinica
Natalie Nemazannikova, Gregory L Blatch, Crispin R Dass, Rodney Sinclair, Vasso Apostolopoulos
No abstract text is available yet for this article.
January 22, 2019: Acta Biochimica et Biophysica Sinica
Rui Hao, Guoying Su, Xiaolin Sun, Xiangran Kong, Cuiying Zhu, Guohai Su
Adiponectin, an adipokine synthesized and secreted majorly by adipose tissue, is reported to exert cardioprotective properties via anti-inflammation and antiapoptosis. Lipopolysaccharide (LPS) is a common inflammation and apoptosis inducer of cardiomyocytes. However, few studies have reported the roles of adiponectin on LPS-induced inflammation as well as apoptosis of H9c2 cells, and the possible mechanisms of these effects. In the present study, we found that adiponectin significantly relieved LPS-induced cytotoxicity including decreased viability and elevated LDH release, inhibited LPS-triggered inflammation, which is evidenced by increases in release of TNF-α, IL-1β as well as IL-6, and attenuated the enhanced rates of apoptotic cells as well as increased caspase-3 activity caused by LPS in H9c2 cells...
January 22, 2019: Acta Biochimica et Biophysica Sinica
Hongbin Liu, Fan Wu, Xiaoqin Wu, Jianren Ye
Pine wilt disease (PWD) caused by the pine wood nematode (PWN), Bursaphelenchus xylophilus, is a devastating disease for Pinus spp. The virulence and resilience of PWN are closely linked to the spread and development of PWD. Numerous studies have shown that autophagy has important physiological and pathological functions in eukaryotes. But little is known about the relationships between autophagy and PWNs' virulence and resistance. In this study, through observation under the microscope and recording, we found the induction of autophagy by rapamycin could dramatically improve movement ability of PWNs with different virulence, and the highly virulent AMA3 isolate moved more than the low virulent YW4 isolate when autophagy was over-induced...
January 22, 2019: Acta Biochimica et Biophysica Sinica
Wei Wu, Weiping Li, Jiaojiao Wei, Chunsheng Wang, Yunliang Yao, Weihua Zhu, Weimei He, Weimei Zhou, Jiang Liu
In the present study, we aimed to investigate the role of endoplasmic reticulum stress (ERS) and its related inflammation and angiogenesis in liver fibrosis in a rat model of combined hypoxia and nonalcoholic steatohepatitis (NASH) and to confirm whether the intervention of hypoxia-inducible factor 1α (HIF1α) can improve fibrosis. Liver histological changes and biochemical indices, HIF1α, inflammatory factors, ERS-related parameters (GRP78, CHOP, caspase-3, and caspase-12), and angiogenesis indices (VEGFA, VEGFR2, and CD34) were evaluated...
January 22, 2019: Acta Biochimica et Biophysica Sinica
Pingbo Yao, Hong Zhao, Jiangang Cao, Linxi Chen
No abstract text is available yet for this article.
January 22, 2019: Acta Biochimica et Biophysica Sinica
Wenyan Zhu, Xiaoyan Wu, Bo Yang, Xiaodong Yao, Xiaomei Cui, Pan Xu, Xiaodong Chen
Keloids (KDs) and hypertrophic scars (HSs), two forms of pathological scars, seriously affect the physical and psychological health of patients. Despite many similarities with HSs, KDs are characterized by invasion and a high rate of recurrence after surgery, features they share in common with tumors. The underlying molecular mechanisms of this phenomenon have not been fully elucidated. In this study, we used microRNA (miRNA) array analysis to search for invasion-associated miRNAs in KDs. The expression of miR-188-5p in KDs, HSs, normal skin (NS) tissues, and cell lines was measured by quantitative real-time polymerase chain reaction...
January 21, 2019: Acta Biochimica et Biophysica Sinica
Li Huang, Jing Su, Liping Bu, Jiabin Tong, Jinghui Wang, Yufang Yang, Zishan Wang, Haoyue Wang, Heng Li, Yuanyuan Ma, Mei Yu, Jian Fei, Fang Huang
Stress is a potent risk factor for depression. Chronic stress can exacerbate and induce symptoms of depression. Clinical studies suggested that depressive patients are more likely to develop coronary artery diseases. However, the causal relationship between depression and heart failure progression remains unclear. In this study, we aimed to explore the relevance between stress and heart failure (HF) in a mouse model subjected to chronic restraint stress and left anterior descending coronary artery (LAD) ligation...
January 11, 2019: Acta Biochimica et Biophysica Sinica
Juanjuan Yang, Jing Hong, Ling Luo, Ke Liu, Chun Meng, Zhi-Liang Ji, Donghai Lin
Mycobacterium tuberculosis (Mtb) is the key devastating bacterial pathogen responsible for tuberculosis. Increasing emergence of multi-drug-resistant, extensively drug-resistant, and rifampicin/isoniazid-resistant strains of Mtb makes the discovery of validated drug targets an urgent priority. As a vital translational component of the protein biosynthesis system, elongation factor Tu (EF-Tu) is an important molecular switch responsible for selection and binding of the cognate aminoacyl-tRNA to the acceptor site on the ribosome...
January 7, 2019: Acta Biochimica et Biophysica Sinica
Jing Wang, Jie Qi, Qichao Wu, Hui Jiang, Yuehao Yin, Yan Huan, Yanjun Zhao, Minmin Zhu
Perioperative hyperglycemia is a common metabolic disorder in clinic settings. Hyperglycemia leads to endothelial inflammation, endothelial cell apoptosis, and dysfunction, thus resulting in endothelial injury. Propofol (2,6-diisopropylphenol) is a widely used intravenous anesthetic in clinic settings. Our previous study indicated that propofol inhibits mitochondrial reactive oxygen species (ROS) production via down-regulation of phosphatase A2 (PP2A) expression, inhibition of Ser36-p66shc dephosphorylation and mitochondrial translocation, thus improving high glucose-induced endothelial injury...
December 27, 2018: Acta Biochimica et Biophysica Sinica
Shaopei Qi, Lixue Wang, Xiao Chang, Yanfen Zhang, Yong Zhang, Ming-Qing Gao
Monocyte chemoattractant protein-induced protein 1 (MCPIP1) is a kind of zinc finger RNA binding protein, which exerts immune responses in a variety of cell types. However, the role of MCPIP1 in bovine mammary epithelial cells during mastitis has not been studied. In this study, we explored the functions of MCPIP1 in the inflammatory process induced by virulence factors of pathogens in bovine mammary alveolar cell-T (MAC-T) cell line. Our results showed that MCPIP1 was significantly highly expressed both in the mammary tissue of dairy cows with mastitis and in inflammatory MAC-T cells induced by lipopolysaccharide (LPS) or lipoteichoic acid (LTA)...
December 26, 2018: Acta Biochimica et Biophysica Sinica
Jianping Cao, Lan She, Yanghui Song
No abstract text is available yet for this article.
December 26, 2018: Acta Biochimica et Biophysica Sinica
Hui Zhou, Zixu Gao, Fusheng Wan
Long non-coding RNAs (lncRNAs) are a class of RNAs whose transcripts are more than 200 nucleotides in length and lack protein-coding ability. Taurine-upregulated gene 1 (TUG1), a novel cancer-related lncRNA, has been documented to be abnormally expressed in various types of cancers and act as an oncogene or anti-oncogene. It has been considered previously that TUG1 is closely related to the cell proliferation, invasion, metastasis, and apoptosis of cancer. In recent years, it has been found that TUG1 acts as a microRNA (miRNA) sponge to indirectly regulate the expression of the miRNA target gene and dominates cancer progression in several types of cancers...
December 26, 2018: Acta Biochimica et Biophysica Sinica
Yujie Liu, Yuan Fang, Yongxiang Liu, Zhaowei Wang, Bao Lyu, Yuanyang Hu, Xi Zhou
Translin/TRAX complex, also named as C3PO, is evolutionarily conserved and participates in diverse cellular processes in different organisms from yeast to human. C3PO plays a critical role in the activation of RNA-induced silencing complexes by promoting the unwinding and degradation of passenger strand of exogenous siRNAs (exo-siRNAs) in Drosophila and human. Moreover, human C3PO (hC3PO) has been found to broadly repress miRNAs by degrading miRNA precursors. However, the effect of Drosophila melanogaster C3PO (dmC3PO) on endogenous siRNA (endo-siRNA) and miRNA pathways remains unknown...
December 20, 2018: Acta Biochimica et Biophysica Sinica
Jiangrong Chen, Chunchao Zhu, Chaojie Wang, Xiaodan Zhang, Jian Ni, Daniel M Czajkowsky, Bingya Liu, Yan Guo
No abstract text is available yet for this article.
December 20, 2018: Acta Biochimica et Biophysica Sinica
Zhe Wang, Min Wang, Chengyan Wang, Boyang Lu
Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most common pattern, and mutations in FERM domain-containing protein 7 (FRMD7) are the major cause. Here, we recruited a four-generation Chinese family with X-linked ICN for the causative mutational screening of FRMD7. A novel missense variant, c.805 A > C, was identified in the proband. The mutation was confirmed in all the affected individuals but was not detected in unaffected family members or 100 unrelated Chinese male controls...
December 20, 2018: Acta Biochimica et Biophysica Sinica
Junhua Ma, Xuemei Zhao, Jichen Zhang, Fei Sun, Jiancan Lu, Hongling Zhu, Mingjun Gu, Jingnan Wang, Xiangqi Li
No abstract text is available yet for this article.
December 20, 2018: Acta Biochimica et Biophysica Sinica
Junquan Gu, Zhoujing Ji, Dong Li, Qirong Dong
Simultaneous silencing of multiple upregulated genes is an attractive and viable treatment strategy for many incurable diseases including cancer. Herein we used a dual gene-targeted siRNA conjugate composed of VEGF and Survivin siRNA sequences in the same backbone to inhibit proliferation and angiogenesis in two human osteosarcoma cell lines. We synthesized siRNA sequences targeting the VEGF and Survivin genes individually (VEGF siRNA and Survivin siRNA) or simultaneously (one-chain-double-target siRNA: dual siRNA)...
December 19, 2018: Acta Biochimica et Biophysica Sinica
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