Yiqun Zhou, Nabin Kandel, Mattia Bartoli, Leonardo F Serafim, Ahmed E ElMetwally, Sophia M Falkenberg, Xavier E Paredes, Christopher J Nelson, Nathan Smith, Elisa Padovano, Wei Zhang, Keenan J Mintz, Braulio C L B Ferreira, Emel Kirbas Cilingir, Jiuyan Chen, Sujit K Shah, Rajeev Prabhakar, Alberto Tagliaferro, Chunyu Wang, Roger M Leblanc
Due to the numerous failed clinical trials of anti-amyloid drugs, microtubule associated protein tau (MAPT) now stands out as one of the most promising targets for AD therapy. In this study, we report for the first time the structure-dependent MAPT aggregation inhibition of carbon nitride dots (CNDs). CNDs have exhibited great promise as a potential treatment of Alzheimer's disease (AD) by inhibiting the aggregation of MAPT. In order to elucidate its structure-activity relationship, CNDs were separated via column chromatography and five fractions with different structures were obtained that were characterized by multiple spectroscopy methods...
June 30, 2022: Carbon