Bruno Crestani, Sylvain Marchand-Adam, Christophe Quesnel, Laurent Plantier, Keren Borensztajn, Joelle Marchal, Arnaud Mailleux, Paul Soler, Monique Dehoux
Idiopathic pulmonary fibrosis is currently believed to be driven by alveolar epithelial cells, with abnormally activated alveolar epithelial cells accumulating in an attempt to repair injured alveolar epithelium (1). Thus, targeting the alveolar epithelium to prevent or inhibit the development of pulmonary fibrosis might be an interesting therapeutic option in this disease. Hepatocyte growth factor (HGF) is a growth factor for epithelial and endothelial cells, which is secreted by different cell types, especially fibroblasts and neutrophils...
July 2012: Proceedings of the American Thoracic Society