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Bosnian Journal of Basic Medical Sciences

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https://read.qxmd.com/read/30726701/intervertebral-disc-tissue-engineering-a-brief-review
#1
REVIEW
Janja Stergar, Lidija Gradisnik, Tomaz Velnar, Uros Maver
Intervertebral disc (IVD) degeneration (IDD) is associated with low back pain and significantly affects the patient's quality of life. Degeneration of the IVD alters disk height and the mechanics of the spine, leading to chronic segmental spinal instability. The pathophysiology of IVD disease is still not well understood. Current therapies for IDD include conservative and invasive approaches, but none of those treatments are able to restore the disc structure and function. Recently, tissue engineering techniques emerged as a possible approach to treat IDD, by replacing a damaged IVD with scaffolds and appropriate cells...
January 31, 2019: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30684951/feasibility-and-accuracy-of-a-voxel-based-neuronavigation-system-with-3d-image-rendering-in-preoperative-planning-and-as-a-learning-tool-for-young-neurosurgeons-exemplified-by-the-anatomical-localization-of-the-superior-sagittal-sinus
#2
Guenther C Feigl, Firas Thaher, Sören Danz, Marcos Tatagiba, Anne K Hickmann, Antje Fahrig, Tomaz Velnar, Marcel Kullmann
It is essential for a neurosurgeon to know individual anatomy and the corresponding anatomical landmarks before starting a surgery. Continuous training, especially of young neurosurgeons, is crucial for understanding complex neuroanatomy. In this study, we used a neuronavigation system with 3D volumetric image rendering to determine the anatomical relationship between the sagittal suture and the superior sagittal sinus (SSS) in patients with intracranial lesions. Furthermore, we discussed the applicability of such system in preoperative planning, residency training, and research...
January 27, 2019: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30684952/clinical-outcomes-after-intentional-replantation-of-permanent-teeth-a-systematic-review
#3
Lin Wang, Hua Jiang, Yang Bai, Qiang Luo, Hao Wu, Hongchen Liu
This study aimed to systematically assess the outcomes of intentional replantation (IR) of teeth and to determine the survival rate, success rate, and prognostic factors related to the treatment. A search was conducted for all relevant English language articles published from January 2000 to October 2017. The search terms included "intentional replantation" and "teeth" according to the inclusion criteria. The Methodological Index for Non-randomized Studies (MINORS) was used to assess the methodological quality of included studies...
January 17, 2019: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30684953/limb-girdle-muscular-dystrophy-due-to-gmppb-mutations-a-case-report-and-comprehensive-literature-review
#4
LiuQing Sun, DingGuo Shen, Ting Xiong, Zhibin Zhou, Xianghui Lu, Fang Cui
Mutations in the guanosine diphosphate mannose (GDP-mannose) pyrophosphorylase B (GMPPB) gene are rare. To date, 72 cases with GMPPB gene mutations have been reported. Herein, we reported a case of a 29-year-old Chinese male presenting with limb-girdle muscular dystrophy (LGMD) who was found to have two heterozygous GMPPB mutations. The patient had a progressive limb weakness for 19 years. His parents and elder brother were normal. On examination he had a waddling gait, and absent tendon reflexes in all four limbs...
January 16, 2019: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30640591/circrna_014511-affects-the-radiosensitivity-of-bone-marrow-mesenchymal-stem-cells-by-binding-to-mir-29b-2-5p
#5
Yanjie Wang, Junhua Zhang, Jian Li, Rong Gui, Xinmin Nie, Rong Huang
Hematopoietic stem cell transplantation is commonly used in patients with certain hematological or bone marrow tumors. Total body irradiation combined with chemotherapy is part of the preconditioning protocol that was the most commonly used before hematopoietic stem cell transplantation. However, total body irradiation preconditioning damages other normal cells in bone marrow. Therefore, exploring the mechanism of radiation resistance in bone marrow mesenchymal stem cells is of great significance for recovering the hematopoietic function after cell transplantation...
January 14, 2019: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30640590/neurostructural-correlates-of-strength-decrease-following-total-knee-arthroplasty-a-systematic-review-of-the-literature-with-meta-analysis
#6
REVIEW
Armin H Paravlic, Simon Kovač, Rado Pisot, Uros Marusic
Recent literature suggests that alterations in both neural and structural components of the neuromuscular system are major determinants of knee extensor muscle weakness after total knee arthroplasty (TKA). Therefore, the goal of this study was to investigate the maximal voluntary strength (MVS), voluntary muscle activation (VMA), and the cross-sectional area (CSA) of the muscle, up to 33 months after the TKA.  We searched relevant scientific databases and literature for outcomes of interest, including quadriceps MVS, VMA, and CSA...
January 14, 2019: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30640592/adjunct-corticosteroid-treatment-in-patients-with-pneumonia-a-precision-medicine-approach
#7
REVIEW
Srdjan Gavrilovic, Ana Andrijevic, Aida Mujakovic, Yewande Odeyemi, Belma Paralija, Ognjen Gajic
Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids...
January 12, 2019: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30599115/decreased-heart-rate-recovery-may-predict-a-high-syntax-score-in-patients-with-stable-coronary-artery-disease
#8
Sadık Volkan Emren, Rahman Bilal Gediz, Oktay Şenöz, Uğur Karagöz, Ersin Çağrı Şimşek, Fatih Levent, Emre Özdemir, Mustafa Ozan Gürsoy, Cem Nazlı
An impaired heart rate recovery (HRR) has been associated with increased risk of cardiovascular events, cardiovascular, and all-cause mortality. However, the diagnostic ability of HRR for the presence and severity of coronary artery disease (CAD) has not been clearly elucidated. Our aim was to investigate the relationship between HRR and the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score in patients with stable CAD (SCAD). A total of 406 patients with an abnormal treadmill exercise test and ≥50% coronary stenosis on coronary angiography were included...
January 1, 2019: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30599090/micrornas-recent-insights-towards-their-role-in-male-infertility-and-reproductive-cancers
#9
REVIEW
Muhammad Babar Khawar, Rabia Mehmood, Nabila Roohi
Spermatogenesis is a tightly controlled, multi-step process in which mature spermatozoa are produced. Disruption of regulatory mechanisms in spermatogenesis can lead to male infertility, various diseases of male reproductive system, or even cancer. The spermatogenic impairment in infertile men can be associated with different etiologies, and the exact molecular mechanisms are yet to be determined. MicroRNAs (miRNAs) are a type of non-protein coding RNAs, about 22 nucleotides long, with an essential role in post-transcriptional regulation of gene expression...
January 1, 2019: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30591008/teucrium-polium-plant-extract-provokes-substantial-cytotoxicity-at-the-early-stage-of-embryonic-development
#10
Shaikha S Al-Qahdi, Nada Alzohari, Abrar Y Alsaid, Anas A Ashour, Tahar Aboulkassim, Semir Vranic, Ala-Eddin Al Moustafa, Ashraf A Khalil
The aim of this study is to explore the outcome of Teucrium polium (TP) medicinal plant consumption on the early stage of fetal development.  We used the chicken embryo at three days of incubation as a model to evaluate the effect of TP plant extract during embryogenesis. Additionally, quantitative polymerase chain reaction (qPCR) was applied to explore the expression of six genes related to cell proliferaton, apoptosis, survival, angiogenesis and migration. Our data revealed that TP-exposure inhibits angiogenesis of the chicken embryo and its chorioallantoic membrane (CAM)...
December 28, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30589402/predictors-of-acute-kidney-injury-aki-in-high-risk-st-elevation-myocardial-infarction-stemi-patients-a-single-center-retrospective-observational-study
#11
Andreja Sinkovič, Klara Masnik, Matic Mihevc
Acute kidney injury (AKI) is a frequent complication in ST-elevation myocardial infarction (STEMI) patients. Factors other than contrast exposure have been suggested as major contributors to renal dysfunction in patients undergoing primary percutaneous coronary intervention (PPCI). Our aim was to assess the incidence and risk factors of AKI in high-risk STEMI patients, mostly treated by PPCI with implemented measures to prevent contrast-induced AKI. We retrospectively analyzed data of 245 STEMI patients (165 men, mean age 63...
December 27, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30589401/review-of-first-clinical-experiences-with-a-1-5-tesla-ceiling-mounted-moveable-intraoperative-mri-system-in-europe
#12
REVIEW
Guenther C Feigl, Stefan Heckl, Marcel Kullmann, Zoltan Filip, Karlheinz Decker, Jan Klein, Ulrike Ernemann, Marcos Tatagiba, Tomaz Velnar, Rainer Ritz
High-field intraoperative MRI (iMRI) systems provide excellent imaging quality and are used for resection control and update of image guidance systems in a number of centers. A ceiling-mounted intraoperative MRI system has several advantages compared to a conventional iMRI system. In this article, we report on first clinical experience with using such a state-of-the-art, the 1.5T iMRI system, in Europe. A total of 50 consecutive patients with intracranial tumors and vascular lesions were operated in the iMRI unit...
December 27, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30579324/vascular-endothelial-growth-factor-vegf-related-polymorphisms-rs10738760-and-rs6921438-are-not-risk-factors-for-proliferative-diabetic-retinopathy-pdr-in-patients-with-type-2-diabetes-mellitus-t2dm
#13
Jana Sajovic, Ines Cilenšek, Sara Mankoč, Špela Tanjšek, Tanja Kunej, Daniel Petrovič, Mojca Globočnik Petrovič
Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and has been investigated as a candidate gene in a number of conditions, including diabetes and its microvascular complications (e.g., retinopathy and nephropathy). Several VEGF-related polymorphisms have been shown to contribute to nearly half of the variability in circulating VEGF levels in healthy individuals. Our aim was to assess the association between VEGF-related rs10738760 and rs6921438 polymorphisms and proliferative diabetic retinopathy (PDR) in Slovenian patients with type 2 diabetes mellitus (T2DM)...
December 23, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30579323/how-latent-viruses-cause-breast-cancer-an-explanation-based-on-the-microcompetition-model
#14
REVIEW
Hanan Polansky, Hava Schwab
Most breast cancer cases show a decrease in the concentration of the breast cancer type 1 susceptibility protein (BRCA1). However, only a small portion of these cases have a mutated BRCA1 gene. Although many attempts have been made to identify the reason for the decrease in BRCA1 expression in sporadic, non-heritable breast cancer cases, the cause is still unknown. In this review, we use the Microcompetition Model to explain how certain latent viruses, which are frequently detected in breast cancer tumors, can decrease the expression of the BRCA1 gene and cause the development of breast tumors...
December 23, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30579325/analysis-of-multidrug-resistant-bacteria-in-3223-patients-with-hospital-acquired-infections-hai-from-a-tertiary-general-hospital-in-china
#15
Meng Wang, Hongyan Wei, Yaxin Zhao, Linlin Shang, Linlin Di, Chuanfeng Lyu, Jun Liu
The frequency of antimicrobial resistance has increased globally due to misuse and overuse of antibiotics, and multi-drug resistant (MDR) bacteria are now recognized as a major cause of hospital-acquired infections (HAI). Our aim was to investigate the prevalence, distribution, and antimicrobial susceptibility rates of MDR bacteria in patients with HAI from a tertiary hospital in China. We retrospectively evaluated all patients with a confirmed diagnosis of bacterial infection at a tertiary general hospital in Jining, for the period between January 2012 and December 2014...
December 17, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30501608/acute-phenibut-withdrawal-a-comprehensive-literature-review-and-illustrative-case-report
#16
REVIEW
Matthew I Hardman, Juraj Sprung, Toby N Weingarten
Phenibut is a glutamic acid derivative with activity on the γ-aminobutyric acid (GABA) B and A, and β-phenethylamine receptors. It is prescribed in former Communist Bloc countries for anxiolysis and related psychiatric disorders. It can be easily obtained in Western countries, and is thought to have abuse potential. Abrupt discontinuation has been reported to precipitate an abstinence syndrome. A review of the literature identified 22 reported cases, many of which were notable for severe psychomotor agitation and requirements for aggressive pharmacologic treatment...
December 3, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30465705/review-of-the-therapeutic-neurofeedback-method-using-electroencephalography-eeg-neurofeedback
#17
REVIEW
Nina Omejc, Bojan Rojc, Piero Paolo Battaglini, Uros Marusic
Electroencephalographic neurofeedback (EEG-NFB) represents a broadly used method that involves a real-time EEG signal measurement, immediate data processing with the extraction of the parameter(s) of interest, and feedback to the individual in a real-time. Using such a feedback loop, the individual may gain better control over the neurophysiological parameters, by inducing changes in brain functioning and, consequently, behavior. It is used as a complementary treatment for a variety of neuropsychological disorders and improvement of cognitive capabilities, creativity or relaxation in healthy subjects...
November 20, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30172250/induction-of-epithelial-mesenchymal-transition-emt-and-gli1-expression-in-head-and-neck-squamous-cell-carcinoma-hnscc-spheroid-cultures
#18
Nesrine Essid, Jean Claude Chambard, Amel Benammar Elgaaïed
Tumor microenvironment provides a specialized niche in which a population of stem-like cells is enriched and contributes to cancer progression. Moreover, cancer stem cell (CSC) phenotype has been associated with epithelial-mesenchymal transition (EMT). Here we investigated the effect of tumor microenvironment on the phenotypic characteristics of head and neck cancer cells and expression of CSC markers using a three-dimensional (3D), spheroid, culture system of CAL33 cell line from human tongue squamous cell carcinoma...
November 7, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/30054999/upregulation-of-mir-210-promotes-differentiation-of-mesenchymal-stem-cells-mscs-into-osteoblasts
#19
Ali Asgharzadeh, Shaban Alizadeh, Mohammad Reza Keramati, Masoud Soleimani, Amir Atashi, Mahdi Edalati, Zahra Kashani Khatib, Mohammad Rafiee, Mohyedin Barzegar, Hengamehsadat Razavi
Numerous studies indicated that microRNAs are critical in the regulation of cellular differentiation, by controlling the expression of underlying genes. The aim of this study was to investigate the effect of miR-210 upregulation on differentiation of human umbilical cord blood (HUCB)-derived mesenchymal stem cells (MSCs) into osteoblasts. MSCs were isolated from HUCB and confirmed by their adipogenic/osteogenic differentiation and flow cytometric analysis of surface markers. Pre-miR-210 was amplified from human DNA, digested and ligated with plenti-III-mir-green fluorescent protein (GFP) vector, and cloned in STBL4 bacteria...
November 7, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/29984676/simple-reliable-and-time-efficient-colorimetric-method-for-the-assessment-of-mitochondrial-function-and-toxicity
#20
Faraz Ahmad, Widyan Alamoudi, Shafiul Haque, Mohammad Salahuddin, Khaldoon Alsamman
Mitochondria are organelles involved in the production of cellular energy, regulation of Ca2+ and redox signaling, and are critical for normal functioning of eukaryotic cells. The dysfunction of mitochondria has been implicated in a wide range of diseases, including metabolic and neurodegenerative disorders and different types of cancers. To better understand the role of mitochondria in healthy and disease states, the development of efficient and reliable tools for the assessment of mitochondrial function is particularly important...
November 7, 2018: Bosnian Journal of Basic Medical Sciences
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