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Journal of Circadian Rhythms

Julia M L Menon, Christ Nolten, E J Marijke Achterberg, Ruud N J M A Joosten, Maurice Dematteis, Matthijs G P Feenstra, W H Pim Drinkenburg, Cathalijn H C Leenaars
Disruption of the monoaminergic system, e.g. by sleep deprivation (SD), seems to promote certain diseases. Assessment of monoamine levels over the circadian cycle, during different sleep stages and during SD is instrumental to understand the molecular dynamics during and after SD. To provide a complete overview of all available evidence, we performed a systematic review. A comprehensive search was performed for microdialysis and certain monoamines (dopamine, serotonin, noradrenaline, adrenaline), certain monoamine metabolites (3,4-dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5-HIAA)) and a precursor (5-hydroxytryptophan (5-HTP)) in PubMed and EMBASE...
January 14, 2019: Journal of Circadian Rhythms
Xiaohan Li, Chengkang Zhang, Qun-Yong Zhou
In mammals, the master pacemaker driving circadian rhythms is thought to reside in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus. A clear view of molecular clock mechanisms within the SCN neurons has been elucidated. In contrast, much less is known about the output mechanism by which the SCN circadian pacemaker sends timing information for eventual control of physiological and behavioral rhythms. Two secreted molecules, prokineticin 2 (PK2) and vasopressin, that are encoded by respective clock-controlled genes, have been indicated as candidate SCN output molecules...
November 6, 2018: Journal of Circadian Rhythms
Cathalijn H C Leenaars, Jennifer Freymann, Koen Jakobs, Julia M L Menon, Thomas J Van Ee, Janneke Elzinga, Rosalie W M Kempkes, Bea Zoer, Pim W H I M Drinkenburg
Background: Microdialysis can be used to measure amino acids in the extracellular space in vivo, based on the principle of diffusion. Variations in experimental set-up result in variations in baseline levels of the compounds measured. Variations may also be due to circadian rhythms. Method: We systematically searched and mapped the literature on all studies reporting baseline microdialysis measurements of histamine and the amino acids asparagine, aspartate, GABA, glutamate, glutamine, glycine, proline and taurine...
October 9, 2018: Journal of Circadian Rhythms
Cathalijn H C Leenaars, Sergey A Savelyev, Stevie Van der Mierden, Ruud N J M A Joosten, Maurice Dematteis, Tarja Porkka-Heiskanen, Matthijs G P Feenstra
The neuroregulator adenosine is involved in sleep-wake control. Basal forebrain (BF) adenosine levels increase during sleep deprivation. Only a few studies have addressed the effect of sleep deprivation on extracellular adenosine concentrations in other brain regions. In this paper, we describe a microdialysis experiment as well as a meta-analysis of published data. The 64 h microdialysis experiment determined the extracellular adenosine and adenosine monophosphate (AMP) concentrations in the medial prefrontal cortex of rats before, during and after 12 h of sleep deprivation by forced locomotion...
October 9, 2018: Journal of Circadian Rhythms
Sajad Zare, Hossein Elahi Shirvan, Rasoul Hemmatjo, Mohammad Faridan, Masoud Hajghani, Behzad Fouladi Dehaghi
Introduction: Increasing population, the need for services, and industrialization of societies have led to a growing demand for shift work. Shiftwork causes several disorders, and determining the weight of each disorders is important for their prevention and treatment. Therefore, the purpose of the present study was to use Analytic Network Process (ANP) to prioritize and weigh shift work disorders among the personnel of hospitals of Kerman University of Medical Sciences. Methods: This cross-sectional, descriptive-analytical study was conducted in 2017 among 300 shift work personnel of 10 public hospitals affiliated with Kerman University of Medical Sciences...
October 4, 2018: Journal of Circadian Rhythms
Taleb Askaripoor, Majid Motamedzadeh, Rostam Golmohammadi, Maryam Farhadian, Mohammad Babamiri, Mehdi Samavati
Fatigue and sleepiness are one of the main causes of human errors and accidents in the workplace. The empirical evidence has approved that, in addition to stimulating the visual system, light elicits brain responses, which affect physiological and neurobehavioral human functions, known as the non-image forming (NIF) effects of light. As recent evidences have shown the positive effects of red or low correlated color temperature white light on alertness and performance, we investigated whether exposure to 2564 K light could improve subjective and objective measures of alertness and performance compared with 7343 K, 3730 K, and dim light (DL) conditions during the daytime...
September 12, 2018: Journal of Circadian Rhythms
Austin Anderson, Gillian Murray, Meaghan Herlihy, Chloe Weiss, Jacob King, Ellen Hutchinson, Neil Albert, Krista K Ingram
Although individual athletic performance generally tends to peak in the evening, individuals who exhibit a strong diurnal preference perform better closer to their circadian peak. Time-of-day performance effects are influenced by circadian phenotype (diurnal preference and chronotype-sleep-wake patterns), homeostatic energy reserves and, potentially, genotype, yet little is known about how these factors influence physiological effort. Here, we investigate the effects of time of day, diurnal preference, chronotype, and PER3 (a circadian clock gene) genotype on both effort and performance in a population of Division I collegiate swimmers (n = 27)...
August 3, 2018: Journal of Circadian Rhythms
Isabella M Hower, Sara A Harper, Thomas W Buford
Human circadian rhythmicity is driven by a circadian clock comprised of two distinct components: the central clock, located in the suprachiasmatic nucleus (SCN) within the hypothalamus, and the peripheral clocks, located in almost all tissues and organ systems in the body. Entrainment, or alignment, of circadian rhythmicity is dependent upon time of day and can occur through environmental influences such as light cues and physical activity exerted on skeletal muscle. Entrainment of the circadian clock through exercise has been reported to improve health by reducing risk of conditions such as cardiovascular disease (CVD), but further research is still needed...
July 12, 2018: Journal of Circadian Rhythms
Abdullah Mashhour, Zainab Al Mansour, Al Shaima Al Hallaj, Rizwan Ali, Thadeo Trivilegio, Mohamed Boudjelal
In mammals, circadian rhythmicity is sustained via a transcriptional/translational feedback loop referred to as the canonical molecular circadian clock. Circadian rhythm is absent in undifferentiated embryonic stem cells; it begins only after differentiation. We used pluripotent P19 embryonal carcinoma stem cells to check the biological clock before and after differentiation into neurons using retinoic acid. We show that the central clock genes ARNTL (Bmal), Per2 and Per3 , and the peripheral clock genes Rev-erb-α and ROR-α , oscillate before and after differentiation, as does the expression of the neuronal differentiation markers Hes5 , β-3-tubulin (Tubb3) and Stra13 , but not Neurod1 ...
May 18, 2018: Journal of Circadian Rhythms
Hiroshi Kawai, Natsumi Kodaira, Chika Tanaka, Takuya Ishibashi, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumoto
The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar-Hannover rats were administered imipramine acutely or chronically in the morning or in the evening. The antidepressant action of imipramine was analyzed using the forced swim test (FST). A single dose of imipramine (30 mg/kg) in the morning, but not in the evening, reduced immobility and increased climbing in the FST...
May 10, 2018: Journal of Circadian Rhythms
Ramanujam Karthikeyan, David Warren Spence, Gregory M Brown, Seithikurippu R Pandi-Perumal
In recent years, there has been an increased prevalence of type 2 diabetes mellitus (T2DM) and depression across the world. This growing public health problem has produced an increasing socioeconomic burden to the populations of all affected countries. Despite an awareness by public health officials and medical researchers of the costs associated with these diseases, there still remain many aspects of how they develop that are not understood. In this article, we propose that the circadian clock could be a factor that coordinates both the neurobehavioral and metabolic processes that underlie depression and T2DM...
April 18, 2018: Journal of Circadian Rhythms
Karyn Geralyn Butler
Affective disorders impact women's health, with a lifetime prevalence of over twelve per cent. They have been correlated with reproductive cycle factors, under the regulation of hormonal circadian rhythms. In affective disorders, circadian rhythms may become desynchronized. The circadian rhythms of cortisol and estradiol may play a role in affective disorders. The purpose of this study was to explore the temporal relationship between the rhythms of cortisol and estradiol and its relationship to affect. It was hypothesized that a cortisol-estradiol phase difference (PD) exists that correlates with optimal affect...
February 21, 2018: Journal of Circadian Rhythms
Mathias Adamsson, Thorbjörn Laike, Takeshi Morita
The purpose of the study was to investigate seasonal variation in mood and behavior among a group of office workers in Sweden (56°N). Thirty subjects participated in this longitudinal study. The subjects kept a weekly log that included questionnaires for ratings of psychological wellbeing and daily sleep-activity diaries where they also noted time spent outdoors. The lighting conditions in the offices were subjectively evaluated during one day, five times over the year. There was a seasonal variation in positive affect and in sleep-activity behavior...
February 21, 2018: Journal of Circadian Rhythms
Reza Kazemi, Sajad Zare, Rasoul Hemmatjo
Introduction: A two-shift work schedule with different rotations is common among firefighters in Iranian petrochemical companies. This study compared salivary melatonin and sleepiness on the last night before turning to day shift at 19:00, 23:00, 3:00, and 7:00 among petrochemical firefighters (PFFs) working seven and four consecutive night shifts. Methods: Sixty four PFFs working in the petrochemical industry were selected. To measure melatonin, saliva samples were taken, whereas the KSS index was used to assess sleepiness...
February 21, 2018: Journal of Circadian Rhythms
Juri Olkkonen, Vesa-Petteri Kouri, Elina Kuusela, Mari Ainola, Dan Nordström, Kari K Eklund, Jami Mandelin
The expression of clock genes ARNTL2, NPAS2 and DEC2 are disturbed in rheumatoid arthritis, an autoimmune disease with circadian variation of symptoms. We have shown that TNF is a potent inducer of these genes. We investigated the regulation of ARNTL2 and NPAS2 by TNF and elucidated their effect on other clock gene expressions. Additionally, we studied the effect of DEC1 and DEC2 on ARNTL, ARNTL2 and NPAS2 . Cultured primary human fibroblasts were stimulated with TNF and the effects on ARNTL2 and NPAS2 were studied with RT-qPCR and immunofluorescence staining...
August 11, 2017: Journal of Circadian Rhythms
Harold Kuta Makeri, Joseph Olusegun Ayo, Tagang Aluwong, Ndazo Salka Minka
Several studies carried out on humans and other mammals show that the temporal organisation of haematological parameters in the blood exhibit daily rhythms; however, such studies have been rare in poultry reared under a natural photoperiod. The present study investigated the occurrence of daily rhythms in blood parameters of broiler chickens kept under tropical climatic conditions. Ten 6-7-week-old broiler chickens served as subjects of the study. They were kept in standard individual cages under natural light-dark cycle and given access to feed and water ad libitum ...
August 10, 2017: Journal of Circadian Rhythms
Isaac Chayo, Mercedes Fernandez, Samantha Sandor, Jaime L Tartar
Previous work from our laboratory has shown that a measure of attention to emotionally-charged stimuli, the late positive potential (LPP) event related potential (ERP), distinguished neutral from emotional pictures on a baseline day, but not after sleep deprivation. Here we sought to extend these findings and address the uncertainty about the effect of time-of-day on emotion processing by testing a morning group (8:00-10:00 a.m., n = 30) and an evening group (8:00-10:00 p.m., n = 30). We also examined the extent of diurnal changes in cortisol related to the emotion processing task...
May 23, 2017: Journal of Circadian Rhythms
Sabhi Rahman, Al-Shaimaa Al-Hallaj, Atef Nedhi, Gmal Gmati, Khadega Ahmed, Haya Al Jama, Thadeo Trivilegio, Abdullah Mashour, Ahmad Al Askar, Mohamed Boudjelal
Disregulation of genes making up the mammalian circadian clock has been associated with different forms of cancer. This study aimed to address how the circadian clock genes behave over the course of treatment for both the acute and chronic forms of leukemia and whether any could be used as potential biomarkers as a read-out for therapeutic efficacy. Expression profiling for both core and ancillary clock genes revealed that the majority of clock genes are down-regulated in acute myeloid leukemia patients, except for Cry2, which is up-regulated towards the end of treatment...
April 28, 2017: Journal of Circadian Rhythms
Ray Norbury
Bibliometric indices are a widely used measure of research impact. The aim of the current study was to identify and characterise the top one hundred most-cited research articles in the topic of chronotype research. A search of the Thomson Reuters Web of Science database returned 974 eligible articles (published between 1990 and 2016). Citations for the 100 most-cited articles ranged between 438 and 29. The most represented journal was Chronobiology International ( n = 30). Nearly 50% of articles originated in Germany and the U...
January 27, 2017: Journal of Circadian Rhythms
Manuel Miranda-Anaya, Dalia Luna-Moreno, Agustín Carmona-Castro, Mauricio Díaz-Muñoz
Obesity is a growing problem worldwide with a clear impact on health status. It is also a condition that negatively affects circadian rhythms. When the mouse Neotomodon alstoni is fed a regular rodent chow, some individuals develop obesity, representing an opportunity to compare the effects of spontaneous obesity upon the circadian organization in this species with that observed in other rodents with induced obesity. We report differences in the free running circadian locomotor activity rhythm and in the effects of light pulses between lean and obese mice...
January 27, 2017: Journal of Circadian Rhythms
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