journal
https://read.qxmd.com/read/38651347/seasonal-and-circadian-variation-of-non-volatile-metabolites-in-lippia-alba-leaves
#1
JOURNAL ARTICLE
Angélica Ferraz Gomes, Girlane Oliveira Rocha, Caroline Scabini, Jayne Ferreira da Silva Oliveira, Déborah Neres Oliveira, Luise Carvalho Mota, Brenda Novais Almeida Neves, Amanda Menezes Dos Santos, Urias Santos Araújo, Bruno Oliveira Moreira, Flávio Mendes de Souza, Maiara Prates de Almeida, Juliano Geraldo Amaral, Jorge Maurício David
The present study describes the seasonal and circadian variations of the major compounds from Lippia alba leaves. SPSS was used to identify, quantify, and associate the variations in the secondary metabolites of this species through HPLC/DAD analysis of the leaves hydroethanolic extracts of six selected L. alba specimens. For the circadian study, the samples were collected at four different daily hours in each year's season. For the seasonal study, the samples were collected monthly from the same individuals for two consecutive years (2018 and 2019)...
April 23, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38651315/exploring-steroidal-saponin-composition-and-morphometric-characteristics-of-rhizomes-from-trillium-govanianum-wall-ex-d-don-inference-for-medicinal-properties-and-genetic-stock-improvement
#2
JOURNAL ARTICLE
Surendra Singh Bisht, R K Meena, Maneesh Bhandari, Prithvi Pal Singh, Upendra Pal Sharma, Aman Bisht, P K Verma
Trillium govanianum, a medicinal herb, exhibiting diverse morphometric traits and phytochemicals across developmental stages of plants. The changes in the chemical profile and steroidal saponin levels in the rhizome of T. govanianum across different developmental stages were previously unknown. This study categorizes rhizomes into three types based on scar presence: juvenile (5-10 scars, Type I), young (11-19 scars, Type II), and mature (21-29 scars, Type III). Rhizomes show varying sizes (length 1.2-4.7 cm, girth 0...
April 23, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38646830/oleanane-type-triterpene-glycosides-from-camellia-phanii-and-their-%C3%AE-glucosidase-inhibitory-activity
#3
JOURNAL ARTICLE
Hoang Thi Tuyet Lan, Vu Thi Xuan, Bui Thi Mai Anh, Nguyen Thi Mai, Nguyen Viet Dung, Bui Huu Tai, Nguyen Thi Minh Hang, Vu Mai Thao, Nguyen Xuan Nhiem
Three new oleanane-type triterpene saponins, named camphanosides A-C (1-3), along with five known compounds, chikusetsusaponin IVa (4), spinasaponin A 28-O-glucoside (5), (-)-epicatechin (6), (--)-epicatechin 3-O-gallate (7), and (-)-epigallocatechin 3-O-gallate (8) were isolated from the leaves Camellia phanii Hakoda & Ninh. Their structures were established by 1D and 2D-NMR and mass spectral analysis and chemical methods. Moreover, compounds 1-5 were also evaluated for α-glucosidase inhibitory activity...
April 22, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38640439/a-new-insight-into-the-huisgen-reaction-heterogeneous-copper-catalyzed-azide-alkyne-cycloaddition-for-the-synthesis-of-1-4-disubstitutedtriazole-from-2018-2023
#4
JOURNAL ARTICLE
Shivani Kasana, Vaibhav Nigam, Surbhi Singh, Balak Das Kurmi, Preeti Patel
The Huisgen cycloaddition, often referred to as 1,3-Dipolar cycloaddition, is a well-established method for synthesizing 1,4-disubstituted triazoles. Originally conducted under thermal conditions [3+2] cycloaddition reactions were limited by temperature, prolonged reaction time, and regioselectivity. The copper catalyzed azide-alkyne cycloaddition (CuAAC) has emerged as a prominent method for producing 1,2,3-triazole with excellent yields and exceptional regioselectivity. Copper catalysts conventionally facilitate azide-alkyne cycloadditions, but challenges include instability and recycling issues...
April 19, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38640089/comparison-of-the-secondary-metabolism-of-the-basidiomycetes-armillaria-mellea-and-desarmillaria-ectypa
#5
JOURNAL ARTICLE
Jacklyne Chepkemoi, Sebastian Pfütze, Njogu M Kimani, Josphat C Matasyoh, Marc Stadler
During the course of our ongoing studies on the secondary metabolism of cultures of Basidiomycota, a new meroterpenoid named 10, 15-dihydroxydihydromelleolide (1) was isolated along with the known armillaridin (2) and arnamiol (3) from cultures of the rare saprotrophic species, Desarmillaria ectypa. These are the first secondary metabolites that were ever isolated from the latter species. A concurrently studied strain of the common pathogenic A. mellea yielded other melleolides, with 5'-O-methylmelledonal (4), melledonal C (5), 10 α-hydroxydihydromelleolide (6) and melledonal (7)...
April 19, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38639576/nervogenic-acid-derivatives-and-phenanthrenes-from-liparis-nervosa-and-their-antimicrobial-and-immunosuppressive-activities
#6
JOURNAL ARTICLE
Hong Jiang, Yang Liu, Bo Ren, Yi Lai, Hu-Lan Chen, Li-Mei Li
Two new nervogenic acid derivatives liparisnervosides Q (1) and R (5), as well as five known nervogenic acid derivatives (2-4, 6, 7) and four phenanthrenes (8-11) were isolated from the whole plant of Liparis nervosa (Thunb. ex A. Murray) Lindl.. Their structures were detremined using extensive spectroscopic techniques, including 1D, 2D NMR, and HR-ESI-MS, and acid hydrolysis. Furthermore, their antimicrobial and immunosuppressive activities were evaluated. Nervosine Ⅶ (3) exhibited antimicrobial activity against Staphylococcus aureus with an MIC of 62...
April 19, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38639566/withanicandrin-isolated-from-datura-ferox-promotes-antinociception-by-modulating-the-asics-and-trps-channels-and-anti-inflammation-in-adult-zebrafish
#7
JOURNAL ARTICLE
Jéssica Bezerra Maciel, Hortência Ribeiro Liberato, Antônio Wlisses da Silva, João Pedro Vieira da Silva, Francisco das Chagas L Pinto, Emanuela de Lima Rebouças, Francisco Sydney Henrique da Silva, Maria Kuerislene Amâncio Ferreira, Marcia Machado Marinho, Emmanuel Silva Marinho, Otília Deusdênia Loiola Pessoa, Paulo Goberlânio de Barros Silva, Andrelina Noronha Coelho de-Souza, Maria Izabel Florindo Guedes, Andreia Ferreira de Castro Gomes, Jane Eire Silva Alencar de Menezes, Helcio Silva Dos Santos
This is the first study to analyze the anti-inflammatory and antinociceptive effect of withanicandrin, isolated from Datura Ferox leaves, and the possible mechanism of action involved in adult zebrafish (ZFa). To this end, the animals were treated intraperitoneally (i.p.) with withanicandrin (4; 20 and 40 mg/kg; 20 μL) and subjected to locomotor activity and acute toxicity. Nociception tests were also carried out with chemical agents, in addition to tests to evaluate inflammatory processes induced by κ-Carrageenan 1...
April 19, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38635369/synthesis-of-some-novel-1h-phenanthro-9-10-d-imidazole-derivatives-and-their-antibacterial-and-molecular-docking-investigation
#8
JOURNAL ARTICLE
Nosrat O Mahmoodi, Anahita Rajabi, Hadiseh Yazdani Nyaki, Hossein Taherpour Nahzomi
In this study, several imidazole derivatives in one pot multicomponent reaction from various aldehydes (1(a-z)), 9,10-phenanthrenequinone, or benzyl (2), and ammonium acetate (3) were synthesized in the presence of acetic acid (AcOH) under reflux conditions at 120°C. Also, the photochromic properties of synthesized compounds were investigated in AcOH as a solvent under laboratory conditions at a temperature of 120°C. Moreover, the antibacterial and antioxidant activity of the synthesized compounds was investigated...
April 18, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38634813/phytochemical-composition-antioxidant-and-antimicrobial-activity-of%C3%A2-three-monarda-species-m-%C3%A2-bradburiana%C3%A2-l-%C3%A2-c-%C3%A2-beck-%C3%A2-m-%C3%A2-%C3%A3-%C3%A2-media%C3%A2-willd-%C3%A2-and-m-punctata-l
#9
JOURNAL ARTICLE
Łukasz Gontar, Anna Geszprych, Andżelika Drutowska, Ewa Osińska
Plants of the genus Monarda receive growing interest as the sources of herbal raw materials with wide range of potential applications in food, cosmetics, and phytopharmaceutical industry. This study aimed to evaluate the differences in chemical characteristics and biological activity among different organs of plants representing three underinvestigated species of this genus: Monarda bradburiana L. C. Beck, Monarda × media Willd., and Monarda punctata L. The content of phenolic compounds and the antioxidant activity of leaves, stems, and inflorescences were determined...
April 18, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38634793/two-new-phenylpropanoid-compounds-from-lilium-brownii%C3%A2-and-their-anti-monoamine-oxidase-activity
#10
JOURNAL ARTICLE
Chengcheng Hui, Shuaibo He, Mengshan Ji, Yuhang Zhang, Haibo Wang, Xiaowei Wang, Tao Guo
Baihe is a commonly used Chinese medicine for the treatment of neurological disorders. Clinically, the bulbs of Lilium brownii are used to act as Baihe. In the study, two new phenylpropanoid compounds including 3-O-acetyl-1-O-caffeoylglycerol (1) and 3-O-acetyl-1-O-p-coumaroylglycerol (2) were isolated from the bulbs of L. brownii. Their structures were identified by spectroscopic method and the effect on monoamine oxidase activity was determined using an enzyme labeling method. The results show 1 and 2 have anti-monoamine oxidase activity with 20...
April 18, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38634752/flavonoids-from-the-aerial-parts-of-sophora-tonkinensis-and-their-potential-anti-inflammatory-activities
#11
JOURNAL ARTICLE
Qing-Qing Yang, Yan-Fei Yang, Xuan-Qin Chen, Rong-Tao Li, Zhi-Jun Zhang
Four undescribed prenylated flavonoids, sophoratones A-D (1-4), and 17 known flavonoids, were obtained from the aerial parts of Sophora tonkinensis. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and ECD calculations. Meanwhile, the ability of these compounds to inhibit the release of nitric oxide (NO) by a lipopolysaccharide induced mouse in RAW 264.7 cells was assayed. The results indicated that some compounds exhibited clear inhibitory effects, with IC50 ranging from 19...
April 18, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38634186/synergistic-inhibitions-of-gram-negative-bacteria-by-combination-treatment-with-ciprofloxacin-and-a-novel-glucolipid
#12
JOURNAL ARTICLE
Liyuan Yang, Qingqing Zhang, Deng Yu, Weiming Zhu, Yi Wang
Psychrophilic fungus Pseudogymnoascus sp. OUCMDZ-4032 derived from Antarctica was cultivated under 16 ℃ to produce a new glucolipid compound (1). Its structure was elucidated by analysis of detailed spectroscopic data, acid hydrolysis and 1-phenyl-3-methyl-5-pyrazolone precolumn derivatization, and 13C NMR quantum chemical calculations. Though compound 1 did not show inhibitory activity against bacteria, it can reduce the minimum inhibitory concentration (MIC) of ciprofloxacin against Gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli, and Salmonella paratyphi by 1024, 256 and 256-fold...
April 17, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38629893/bioactives-of-melipona-rufiventris-propolis-exploring-its-antimicrobial-anti-inflammatory-and-antioxidant-activities
#13
JOURNAL ARTICLE
Amanda Tristao Santini, Rayra Annara Otacílio Pinto, Josy Goldoni Lazarini, Daniel Vieira de Morais, Anna Maria Alves de Piloto Fernandes, Marcelo Franchin, Patricia Lunardelli Negreiros de Carvalho, Carolina Girotto Pressete, Pedro Luiz Rosalen, Severino Matias de Alencar, Patricia de Oliveira Carvalho, Marisa Ionta, Masaharu Ikegaki
This study explores the potential of propolis from Melipona rufiventris species. With its composition encompassing resin, wax, pollen, and soil, propolis holds historical significance in traditional medicine within tropical regions. This research is driven by the scarcity of information surrounding M. rufiventris propolis, prompting an investigation into its chemical constituents, in vivo toxicity, and antimicrobial, antioxidant, and anti-inflammatory properties. This exploration could potentially uncover novel applications for this natural product, bolstering both meliponiculture practices and the preservation of native bee populations...
April 17, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38628065/further-polycyclic-quinones-of-micromonospora-sp
#14
JOURNAL ARTICLE
Otilia Deusdenia Loiola Pessoa, Hozana Patricia Silva de Freitas Cesário, Francisco das Chagas Lima Pinto, Kirley Marques Canuto, Ediberto Rocha Silveira, Diego Veras Wilke, Elthon Gois Ferreira, Aluísio Marques da Fonseca, Mayron Alves de Vasconcelos, Edson Holanda Teixeira
The crude acetone extract of a marine Micromonospora sp. strain associated with Eudistoma vannnamei was fractioned with hexane and ethyl acetate. The crude extract and both soluble fractions were assayed against several bacteria strains. The new polycyclic quinones 12-hydroxy-9-propyltetracene-6,1-dione (1), 5,12-dihydroxy-4-methoxy-9-propyltetracene-5,12-dione (2), and  4,6-dihydroxy-3-methoxycarbonyl- methyl-6a-(oxobutyl)-5,12-anthraquinone (3), along with the known 4,6-dihydroxy-3-methoxycarbonyl-methyl-6a-(oxo-3-methyl-butyl)-5,12-anthraquinone (4) and 4,6-dihydroxy-3-methoxycarbonyl-methyl-6a-(oxopentyl)-5,12-anthraquinone (5) were isolated from the hexane-soluble fraction, while from the active ethyl acetate fraction were isolated the known 4,6,11-trihydroxy-9-propyltetracene-5,12-dione (6), 4-methoxy-9-propyltetracene-6,11-dione (7), 7,8,9,10-tetrahydro-9-hydroxy-4-methoxy-9-propyltetracene-6,11-dione (8), and 10b-carbomethoxy-7,8,9,10-tetrahydro-4,6,7a,9a,11-pentahydroxy-9-propyltetracene-5,12-dione (9)...
April 16, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38623912/untargeted-metabolomic-to-access-chemical-differences-induced-by-dual-endophyte-cultures-isolated-from-euphorbia-umbellata
#15
JOURNAL ARTICLE
Amanda Santos Gusmão, João Carlos Silva Conceição, Stefane Moreira de Queiros Santos, Cecilia Lima Sampaio Pereira, Douglas Siqueira de Almeida Chaves, Karen de Jesus Nicácio, Daniela Aparecida Chagas-Paula, Eliane Oliveira Silva
Endophytic fungi live asymptomatically inside vegetal tissues, and such uncommon habitat contributes to their exceptional chemical diversity. Isolating natural products from endophytic fungi could fail due to silent biosynthetic gene clusters under ordinary in vitro culture conditions, and co-culturing has been assayed to trigger their metabolism. We carried out single and dual cultures with 13 endophyte strains isolated from Euphorbia umbellata leaves. Multivariate statistics applied to untargeted metabolomics compared the chemical profiles of all endophyte cultures...
April 16, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38623839/computational-exploration-of-naturally-occurring-flavonoids-as-tgf-%C3%AE-inhibitors-in-breast-cancer-insights-from-docking-and-molecular-dynamics-simulations-and-in-vitro-cytotoxicity-study
#16
JOURNAL ARTICLE
Umang Shah, Niyati Patel, Mehul Patel, Shishir Rohit, Nilay Solanki, Ashish Patel, Swayamprakash Patel, Vishwa Patel, Rajvi Patel, Rahul D Jawarkar
Breast cancer is a global health concern, demanding innovative treatments. Targeting the Transforming Growth Factor-beta (TGF-β) signaling pathway, pivotal in breast cancer, is a promising approach. TGF-β inhibits proliferation via G1 phase cell cycle arrest, acting as a suppressor initially, but in later stages, it promotes progression by enhancing motility, invasiveness, and metastasis formation. This study explores naturally occurring flavonoids' interactions with TGF-β. Using molecular docking against the protein's crystal structure (PDB Id: 1PY5), Gossypin showed the highest docking score and underwent molecular dynamics simulation, revealing complex flexibility and explaining how flavonoids impede TGF-β signaling in breast cancer...
April 16, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38619505/unveiling-the-biomedical-applications-of-novel-coumarins-isolated-from-capsicum-annuum-l-seeds-by-a-multivariate-extraction-technique
#17
JOURNAL ARTICLE
Areej Hazem Fakri Younes, Yasser Fakri Mustafa
For the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required the application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, and 1.6 T), time interval (30, 60, and 90 min), and temperature (45, 55, and 65°C). Numerous phytochemical categories were detected in the 81 crude chloroform extracts of green sweet bell pepper seeds that were collected, according to phytochemical analysis. Nine extracts were discovered to be linked to the coumarin chemical class and to have the same two extraction parameters: a 90-minute extraction duration and a 55°C extraction temperature...
April 15, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38619074/ring-contracted-artemisinin-derivatives-as-novel-cdk4-6-inhibitors-synthesis-and-anti-breast-cancer-evaluation
#18
JOURNAL ARTICLE
Junjie Zhu, Yi Ai, Junhui Wu, Changgaung Zeng, Zhen Cui, Zhengping Zhang, Jiayi Zhu, Changqi Wang, Hang Zhong
The endoperoxide group of artemisinins is a universally accepted essential group for their anti-cancer effects. In this work, a series of D-ring-contracted artemisinin derivatives were constructed by combining ring-contracted artemisinin core with the fragments of functional heterocyclic molecules or classical CDK4/6 inhibitors to identify more efficacious breast cancer treatment agents. Twenty-six novel hybridized molecules were synthesized and characterized by HRMS, IR, 1H NMR and 13C NMR data. In antiproliferative activities and kinase inhibitory effects assays, we found that the antiproliferative effects of B01 were close to positive controls Palbociclib, with GI50 values of 4...
April 15, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38616167/synthesis-and-antifungal-activity-of-norbornene-carboxamide-sulfonamide-derivatives-as-potential-fungicides-targeting-laccase
#19
JOURNAL ARTICLE
Zi-Hui Yang, Yi-Gui Qiu, Dao-Jun Jin, Yi-Ming Zheng, Jia Li, Wen Gu
To explore more potential fungicides with new scaffolds, thirty-seven norbornene carboxamide/sulfonamide derivatives were designed, synthesized, and assayed for inhibitory activity against six plant pathogenic fungi and oomycetes. The preliminary antifungal assay suggested that the title derivatives showed moderate to good antifungal activity against six plant pathogens. Especially, compound 6e presented excellent in vitro antifungal activity against Sclerotinia sclerotiorum (EC50 = 0.71 mg/L), which was substantially stronger than pydiflumetofen...
April 14, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38616166/porphysome-engineered-with-specific-protein-binding-sites-as-a-multimodal-theranostic-nanocarrier-for-targeted-protein-delivery
#20
JOURNAL ARTICLE
Niloofar Ayyari, Zahra Vaezi, Zeinab Fotouhi Ashin, Elham Karimi, Fatemeh Mohsenzadeh Haji, Maryam Nikkhah, Hossein Naderi-Manesh
The immobilization of proteins on the surface of carriers is challenging due to the loss of protein structure and function in this process. Here, we report the development of the protein immobilization on the surface of the metallated-porphyrin complex in the porphysome nanocarrier. The conjugated Ni-porphyrin to fatty acid (as a tail) has been synthesized and independently placed at the depth of the bilayer center of Dipalmitoylphosphatidylcholine (DPPC) in which the Ni-porphyrin was at the polar region of the membrane and is thus superficial...
April 14, 2024: Chemistry & Biodiversity
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