journal
https://read.qxmd.com/read/38796496/genetic-susceptibility-to-optic-neuropathy-in-patients-with-alcohol-use-disorder
#1
JOURNAL ARTICLE
Camille Delibes, Marc Ferré, Marine Rozet, Valérie Desquiret-Dumas, Alexis Descatha, Bénédicte Gohier, Philippe Gohier, Patrizia Amati-Bonneau, Dan Milea, Pascal Reynier
BACKGROUND: The pathophysiology of toxico-nutritional optic neuropathies remains debated, with no clear understanding of the respective roles played by the direct alcohol toxicity, smoking and the often associated vitamin deficiencies, which are risk factors for optic neuropathy. Our aim was to investigate genetic susceptibility in patients with bilateral infraclinical optic neuropathy associated with chronic alcohol use disorder. METHODS: This retrospective cohort study included 102 visually asymptomatic patients with documented alcohol use disorder from a French reference center...
May 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38796441/fecal-coprococcus-hidden-behind-abdominal-symptoms-in-patients-with-small-intestinal-bacterial-overgrowth
#2
JOURNAL ARTICLE
Huaizhu Guo, Yuzhu Chen, Wenxin Dong, Siqi Lu, Yanlin Du, Liping Duan
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is the presence of an abnormally excessive amount of bacterial colonization in the small bowel. Hydrogen and methane breath test has been widely applied as a non-invasive method for SIBO. However, the positive breath test representative of bacterial overgrowth could also be detected in asymptomatic individuals. METHODS: To explore the relationship between clinical symptoms and gut dysbiosis, and find potential fecal biomarkers for SIBO, we compared the microbial profiles between SIBO subjects with positive breath test but without abdominal symptoms (PBT) and healthy controls (HC) using 16S rRNA amplicon sequencing...
May 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38796431/platelet-rich-fibrin-as-an-apical-barrier-for-mta-placement-in-the-treatment-of-teeth-with-open-apices-a-pilot-study
#3
JOURNAL ARTICLE
Van-Khoa Pham, Tran-Lan-Khue Pham, An-Tran Pham, Hoang-Lan-Anh Le, Thi-Bich-Van Tran, Kim-Khang Huynh, Nguyen-Minh-Hieu Tran, Thuan-Loc Tran, Minh-Hong Tran, Thi-Anh-Thu Tran, Thi-Tam-Duyen Nguyen, Ngoc-Phuc Nguyen
OBJECTIVE: The aim of the present pilot study was to assess the effectiveness of the platelet-rich fibrin (PRF) apical barrier for the placement of MTA for the treatment of teeth with periapical lesions and open apices. METHODS: A total of thirty teeth on twenty-eight patients with open apices and periapical periodontitis were enrolled and divided into two groups in the present pilot study. In the PRF group (fourteen teeth in thirteen patients), nonsurgical endodontic treatment was performed using PRF as an apical matrix, after which the apical plug of the MTA was created...
May 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38796415/wtap-mediated-m-6-a-modification-of-lncrna-snhg1-improves-myocardial-ischemia-reperfusion-injury-via-mir-361-5p-opa1-dependent-mitochondrial-fusion
#4
JOURNAL ARTICLE
Linlin Liu, Jiahong Wu, Cheng Lu, Yan Ma, Jiayi Wang, Jie Xu, Xiaoli Yang, Xuan Zhang, Hua Wang, Jieyu Xu, Jiehan Zhang
BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) is caused by reperfusion after ischemic heart disease. LncRNA Snhg1 regulates the progression of various diseases. N6-methyladenosine (m6 A) is the frequent RNA modification and plays a critical role in MIRI. However, it is unclear whether lncRNA Snhg1 regulates MIRI progression and whether the lncRNA Snhg1 was modified by m6 A methylation. METHODS: Mouse cardiomyocytes HL-1 cells were utilized to construct the hypoxia/reoxygenation (H/R) injury model...
May 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38796413/atox1-regulates-macrophage-polarization-in-intestinal-inflammation-via-ros-nlrp3-inflammasome-pathway
#5
JOURNAL ARTICLE
MingXian Chen, Yu Chen, Rui Fu, SaiYue Liu, HaiXia Li, TangBiao Shen
BACKGROUND: Inflammation and oxidative stress play an important role in the pathophysiology of inflammatory bowel disease (IBD). This study aimed to explore the effects of copper chaperone Antioxidant-1 (Atox1) on macrophages in a mouse model of intestinal inflammation. METHODS: A mouse model of TNBS-induced colitis was established and verified using the disease activity index. Atox1 conditional knockout mice were applied. The proportion of macrophages in colonic lamina propria mononuclear cells and ROS production were analyzed using flow cytometry...
May 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38790051/il-37-ameliorates-myocardial-fibrosis-by-regulating-mtdna-enriched-vesicle-release-in-diabetic-cardiomyopathy-mice
#6
JOURNAL ARTICLE
Qingyu Huang, Tongqing Chen, Jian Li, Yiming Wang, Huairui Shi, Yifei Yu, Qingwei Ji, Xiaoyan Shen, Tao Sun, Haiming Shi, Xinping Luo, Bo Jin, Yan You, Bangwei Wu
BACKGROUND: Diabetic cardiomyopathy (DCM), a serious complication of diabetes, leads to structural and functional abnormalities of the heart and ultimately evolves to heart failure. IL-37 exerts a substantial influence on the regulation of inflammation and metabolism. Whether IL-37 is involved in DCM is unknown. METHODS: The plasma samples were collected from healthy controls, diabetic patients and DCM patients, and the level of IL-37 and its relationship with heart function were observed...
May 24, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38790026/horizontal-mitochondrial-transfer-as-a-novel-bioenergetic-tool-for-mesenchymal-stromal-stem-cells-molecular-mechanisms-and-therapeutic-potential-in-a-variety-of-diseases
#7
REVIEW
Roberto Iorio, Sabrina Petricca, Vincenzo Mattei, Simona Delle Monache
Intercellular mitochondrial transfer (MT) is a newly discovered form of cell-to-cell signalling involving the active incorporation of healthy mitochondria into stressed/injured recipient cells, contributing to the restoration of bioenergetic profile and cell viability, reduction of inflammatory processes and normalisation of calcium dynamics. Recent evidence has shown that MT can occur through multiple cellular structures and mechanisms: tunneling nanotubes (TNTs), via gap junctions (GJs), mediated by extracellular vesicles (EVs) and other mechanisms (cell fusion, mitochondrial extrusion and migrasome-mediated mitocytosis) and in different contexts, such as under physiological (tissue homeostasis and stemness maintenance) and pathological conditions (hypoxia, inflammation and cancer)...
May 24, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38790013/the-biological-function-of-the-n6-methyladenosine-reader-ythdc2-and-its-role-in-diseases
#8
REVIEW
Xudong Wu, Hui Chen, Kai Li, Hong Zhang, Kai Li, Haoyu Tan
N6-methyladenosine (m6A) stands as the most prevalent modified form of RNA in eukaryotes, pivotal in various biological processes such as regulating RNA stability, translation, and transcription. All members within the YT521-B homology (YTH) gene family are categorized as m6A reading proteins, capable of identifying and binding m6A modifications on RNA, thereby regulating RNA metabolism and functioning across diverse physiological processes. YTH domain-containing 2 (YTHDC2), identified as the latest member of the YTH family, has only recently started to emerge for its biological function...
May 24, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38789992/efficacy-and-safety-of-autologous-or-allogeneic-mesenchymal-stromal-cells-from-adult-adipose-tissue-expanded-and-combined-with-tricalcium-phosphate-biomaterial-for-the-surgical-treatment-of-atrophic-nonunion-of-long-bones-a-phase-ii-clinical-trial
#9
MULTICENTER STUDY
Lluís Orozco Delclós, Robert Soler Rich, Rafael Arriaza Loureda, Alonso Moreno García, Enrique Gómez Barrena
BACKGROUND: Autologous bone grafting is the standard treatment for the surgical management of atrophic nonunion of long bones. Other solutions, such as bone marrow mesenchymal stem cells (BM-MSC) combined with phospho-calcium material, have also been used. Here we evaluate the safety and early efficacy of a novel procedure using autologous or allogenic adipose tissue mesenchymal stromal cells (AT-MSC) seeded in a patented tricalcium phosphate-based biomaterial for the treatment of bone regeneration in cases of atrophic nonunion...
May 24, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38789990/a-scheme-to-underpin-key-mediator-s-in-salinosporamide-s-against-pan-tumor-via-systems-biology-concept
#10
LETTER
Ki-Kwang Oh, Sang-Jun Yoon, Seol Hee Song, Jeong Ha Park, Jeong Su Kim, Min Ju Kim, Dong Joon Kim, Ki-Tae Suk
No abstract text is available yet for this article.
May 24, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38778315/mild-therapeutic-hypothermia-upregulates-the-o-glcnacylation-level-of-cox10-to-alleviate-mitochondrial-damage-induced-by-myocardial-ischemia-reperfusion-injury
#11
JOURNAL ARTICLE
Wei Deng, Yixuan Chen, Jing Zhang, Jitao Ling, Zhou Xu, Zicheng Zhu, Xiaoyi Tang, Xiao Liu, Deju Zhang, Hong Zhu, Haili Lang, Lieliang Zhang, Fuzhou Hua, Shuchun Yu, Kejian Qian, Peng Yu
OBJECTIVE: Mild therapeutic hypothermia (MTH) is an important method for perioperative prevention and treatment of myocardial ischemia-reperfusion injury (MIRI). Modifying mitochondrial proteins after protein translation to regulate mitochondrial function is one of the mechanisms for improving myocardial ischemia-reperfusion injury. This study investigated the relationship between shallow hypothermia treatment improving myocardial ischemia-reperfusion injury and the O-GlcNAcylation level of COX10...
May 22, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38773651/mesenchymal-stromal-cell-derived-extracellular-vesicles-therapy-openings-new-translational-challenges-in-immunomodulating-acute-liver-inflammation
#12
REVIEW
Alexandre Sitbon, Pierre-Romain Delmotte, Valéria Pistorio, Sébastien Halter, Jérémy Gallet, Jérémie Gautheron, Antoine Monsel
Inflammation plays a critical role in conditions such as acute liver failure, acute-on-chronic liver failure, and ischemia-reperfusion-induced liver injury. Various pathogenic pathways contribute to liver inflammation, involving inflammatory polarization of macrophages and Küpffer cells, neutrophil infiltration, dysregulation of T cell subsets, oxidative stress, and activation of hepatic stellate cells. While mesenchymal stromal cells (MSCs) have demonstrated beneficial properties, their clinical translation is limited by their cellular nature...
May 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38773621/adherence-to-the-mediterranean-diet-and-its-association-with-gastric-cancer-health-benefits-from-a-planeterranean-perspective
#13
REVIEW
Claudia Reytor-González, Ana Karina Zambrano, Martha Montalvan, Evelyn Frias-Toral, Alison Simancas-Racines, Daniel Simancas-Racines
The Mediterranean Diet (MD) has garnered increasing attention for its potential protective effects against gastric cancer (GC). The MD's rich content of antioxidants, polyphenols, and other bioactive compounds contributes to its ability to modulate gene expression, inhibit tumor growth, and regulate apoptosis. Studies have shown significant reductions in inflammatory markers such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) among individuals adhering to the MD, suggesting its pivotal role in mitigating chronic inflammation-associated with cancer development...
May 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38773615/lactate-facilitated-mitochondrial-fission-derived-ros-to-promote-pulmonary-fibrosis-via-erk-drp-1-signaling
#14
JOURNAL ARTICLE
Zhiheng Sun, Zhihua Ji, Huiwen Meng, Wanyu He, Bin Li, Xiaoyue Pan, Yanlin Zhou, Guoying Yu
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung diseases, which mainly existed in middle-aged and elderly people. The accumulation of reactive oxygen species (ROS) is a common characteristic of IPF. Previous research also shown that lactate levels can be abnormally elevated in IPF patients. Emerging evidence suggested a relationship between lactate and ROS in IPF which needs further elucidation. In this article, we utilized a mouse model of BLM-induced pulmonary fibrosis to detect alterations in ROS levels and other indicators associated with fibrosis...
May 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38773612/trim26-inhibits-clear-cell-renal-cell-carcinoma-progression-through-destabilizing-etk-and-thus-inactivation-of-akt-mtor-signaling
#15
JOURNAL ARTICLE
Di Zheng, Jinzhuo Ning, Hao Deng, Yuan Ruan, Fan Cheng
BACKGROUND: Tripartite motif-containing 26 (TRIM26), a member of the TRIM protein family, exerts dual function in several types of cancer. Nevertheless, the precise role of TRIM26 in clear cell renal cell carcinoma (ccRCC) has not been investigated. METHODS: The expression of TRIM26 in ccRCC tissues and cell lines were examined through the use of public resources and experimental validation. The impacts of TRIM26 on cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) process were determined via CCK-8, colony formation, EdU incorporation, wound healing, Transwell invasion, Western blot, and Immunofluorescence assays...
May 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38773607/unraveling-resistance-mechanisms-in-anti-cd19-chimeric-antigen-receptor-t-therapy-for-b-all-a-novel-in-vitro-model-and-insights-into-target-antigen-dynamics
#16
JOURNAL ARTICLE
Hongzhe Li, Yuwen Wang, Rongrong Liu, Xiaoxiao Li, Ping Zhang, Ping Chen, Ning Zhao, Bing Li, Jie Wang, Yongmin Tang
BACKGROUND: Cellular immunotherapy, represented by the chimeric antigen receptor T cell (CAR-T), has exhibited high response rates, durable remission, and safety in vitro and in clinical trials. Unfortunately, anti-CD19 CAR-T (CART-19) treatment alone is prone to relapse and has a particularly poor prognosis in relapsed/refractory (r/r) B-ALL patients. To date, addressing or reducing relapse remains one of the research priorities to achieve broad clinical application. METHODS: We manufactured second generation CART-19 cells and validated their efficacy and safety in vitro and in vivo...
May 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38773604/in-silico-analysis-of-the-wild-type-and-mutant-type-of-brca2-gene
#17
JOURNAL ARTICLE
Jingjing Li, Rui Ge, Guanming Lu, Yuanxuan Cai, Yuan Teng, Zhe Fan, Liangyan Liao, Lingjie Kong, Jinze Zhang, Tao Wei, Qian Li, Tianzhu Long, Hongyan Yu, Jie Li
BACKGROUND: The aim of this study was to conduct an in silico analysis of a novel compound heterozygous variant in breast cancer susceptibility gene 2 (BRCA2) to clarify its structure-function relationship and elucidate the molecular mechanisms underlying triple-negative breast cancer (TNBC). METHODS: A tumor biopsy sample was obtained from a 42-year-old Chinese woman during surgery, and a maxBRCA™ test was conducted using the patient's whole blood. We obtained an experimentally determined 3D structure (1mje...
May 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38773585/plasma-derived-extracellular-matrix-for-xenofree-and-cost-effective-organoid-modeling-for-hepatocellular-carcinoma
#18
JOURNAL ARTICLE
Azza M El-Derby, Mennatallah A Khedr, Nehal I Ghoneim, Mahmoud M Gabr, Sherry M Khater, Nagwa El-Badri
BACKGROUND: Hepatocellular carcinoma (HCC) causes significant cancer mortality worldwide. Cancer organoids can serve as useful disease models by high costs, complexity, and contamination risks from animal-derived products and extracellular matrix (ECM) that limit its applications. On the other hand, synthetic ECM alternatives also have limitations in mimicking native biocomplexity. This study explores the development of a physiologically relevant HCC organoid model using plasma-derived extracellular matrix as a scaffold and nutritive biomatrix with different cellularity components to better mimic the heterogenous HCC microenvironment...
May 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38773576/mogroside-v-reduced-the-excessive-endoplasmic-reticulum-stress-and-mitigated-the-ulcerative-colitis-induced-by-dextran-sulfate-sodium-in-mice
#19
JOURNAL ARTICLE
Yue-Rong Tan, Si-Yang Shen, Xin-Yi Li, Peng-Fei Yi, Ben-Dong Fu, Lu-Yuan Peng
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory condition of the colon, characterized by repeated attacks, a lack of effective treatment options, and significant physical and mental health complications for patients. The endoplasmic reticulum (ER) is a vital intracellular organelle in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) is induced when the body is exposed to adverse external stimuli. Numerous studies have shown that ERS-induced apoptosis plays a vital role in the pathogenesis of UC...
May 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38773518/ubxn1-promotes-liver-tumorigenesis-by-regulating-mitochondrial-homeostasis
#20
JOURNAL ARTICLE
Kun Jiao, Guiqin Xu, Yun Liu, Zhaojuan Yang, Lvzhu Xiang, Zehong Chen, Chen Xu, You Zuo, Zhibai Wu, Ningqian Zheng, Wangjie Xu, Li Zhang, Yongzhong Liu
BACKGROUND: The maintenance of mitochondrial homeostasis is critical for tumor initiation and malignant progression because it increases tumor cell survival and growth. The molecular events controlling mitochondrial integrity that facilitate the development of hepatocellular carcinoma (HCC) remain unclear. Here, we report that UBX domain-containing protein 1 (UBXN1) hyperactivation is essential for mitochondrial homeostasis and liver tumorigenesis. METHODS: Oncogene-induced mouse liver tumor models were generated with the Sleeping Beauty (SB) transposon delivery system...
May 21, 2024: Journal of Translational Medicine
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