journal
https://read.qxmd.com/read/38609994/the-effects-of-telehealth-delivered-mindfulness-meditation-cognitive-therapy-and-behavioral-activation-for-chronic-low-back-pain-a-randomized-clinical-trial
#1
JOURNAL ARTICLE
Melissa A Day, Marcia A Ciol, M Elena Mendoza, Jeffrey Borckardt, Dawn M Ehde, Andrea K Newman, Joy F Chan, Sydney A Drever, Janna L Friedly, John Burns, Beverly E Thorn, Mark P Jensen
BACKGROUND: Chronic low back pain (CLBP) is a significant problem affecting millions of people worldwide. Three widely implemented psychological techniques used for CLBP management are cognitive therapy (CT), mindfulness meditation (MM), and behavioral activation (BA). This study aimed to evaluate the relative immediate (pre- to post-treatment) and longer term (pre-treatment to 3- and 6-month follow-ups) effects of group, videoconference-delivered CT, BA, and MM for CLBP. METHODS: This is a secondary analysis of a three-arm, randomized clinical trial comparing the effects of three active treatments-CT, BA, and MM-with no inert control condition...
April 12, 2024: BMC Medicine
https://read.qxmd.com/read/38609982/prex2-contributes-to-radiation-resistance-by-inhibiting-radiotherapy-induced-tumor-immunogenicity-via-cgas-sting-ifns-pathway-in-colorectal-cancer
#2
JOURNAL ARTICLE
Mingzhou Li, Jianbiao Xiao, Shasha Song, Fangyi Han, Hongling Liu, Yang Lin, Yunfei Ni, Sisi Zeng, Xin Zou, Jieqiong Wu, Feifei Wang, Shaowan Xu, You Liang, Peishuang Xu, Huirong Hong, Junfeng Qiu, Jianing Cao, Qin Zhu, Li Liang
BACKGROUND: Colorectal cancer (CRC) lacks established biomarkers or molecular targets for predicting or enhancing radiation response. Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2) exhibits intricate implications in tumorigenesis and progression. Nevertheless, the precise role and underlying mechanisms of PREX2 in CRC radioresistance remain unclear. METHODS: RNA-seq was employed to identify differentially expressed genes between radioresistant CRC cell lines and their parental counterparts...
April 12, 2024: BMC Medicine
https://read.qxmd.com/read/38609953/cervical-lymph-node-metastasis-prediction-from-papillary-thyroid-carcinoma-us-videos-a-prospective-multicenter-study
#3
JOURNAL ARTICLE
Ming-Bo Zhang, Zhe-Ling Meng, Yi Mao, Xue Jiang, Ning Xu, Qing-Hua Xu, Jie Tian, Yu-Kun Luo, Kun Wang
BACKGROUND: Prediction of lymph node metastasis (LNM) is critical for individualized management of papillary thyroid carcinoma (PTC) patients to avoid unnecessary overtreatment as well as undesired under-treatment. Artificial intelligence (AI) trained by thyroid ultrasound (US) may improve prediction performance. METHODS: From September 2017 to December 2018, patients with suspicious PTC from the first medical center of the Chinese PLA general hospital were retrospectively enrolled to pre-train the multi-scale, multi-frame, and dual-direction deep learning (MMD-DL) model...
April 12, 2024: BMC Medicine
https://read.qxmd.com/read/38609939/identification-and-support-of-autistic-individuals-within-the-uk-criminal-justice-system-a-practical-approach-based-upon-professional-consensus-with-input-from-lived-experience
#4
JOURNAL ARTICLE
Emma Woodhouse, Jack Hollingdale, Lisa Davies, Zainab Al-Attar, Susan Young, Luke P Vinter, Kwaku Agyemang, Carla Bartlett, Colleen Berryessa, Eddie Chaplin, Quinton Deeley, Ian Freckelton, Felicity Gerry, Gisli Gudjonsson, Katie Maras, Michelle Mattison, Jane McCarthy, Richard Mills, Peter Misch, David Murphy, Clare Allely
BACKGROUND: Autism spectrum disorder (hereafter referred to as autism) is characterised by difficulties with (i) social communication, social interaction, and (ii) restricted and repetitive interests and behaviours. Estimates of autism prevalence within the criminal justice system (CJS) vary considerably, but there is evidence to suggest that the condition can be missed or misidentified within this population. Autism has implications for an individual's journey through the CJS, from police questioning and engagement in court proceedings through to risk assessment, formulation, therapeutic approaches, engagement with support services, and long-term social and legal outcomes...
April 12, 2024: BMC Medicine
https://read.qxmd.com/read/38609914/assessing-causal-links-between-age-at-menarche-and-adolescent-mental-health-a-mendelian-randomisation-study
#5
JOURNAL ARTICLE
Adrian Dahl Askelund, Robyn E Wootton, Fartein A Torvik, Rebecca B Lawn, Helga Ask, Elizabeth C Corfield, Maria C Magnus, Ted Reichborn-Kjennerud, Per M Magnus, Ole A Andreassen, Camilla Stoltenberg, George Davey Smith, Neil M Davies, Alexandra Havdahl, Laurie J Hannigan
BACKGROUND: The timing of puberty may have an important impact on adolescent mental health. In particular, earlier age at menarche has been associated with elevated rates of depression in adolescents. Previous research suggests that this relationship may be causal, but replication and an investigation of whether this effect extends to other mental health domains is warranted. METHODS: In this Registered Report, we triangulated evidence from different causal inference methods using a new wave of data (N = 13,398) from the Norwegian Mother, Father, and Child Cohort Study...
April 12, 2024: BMC Medicine
https://read.qxmd.com/read/38589871/characterizing-the-polygenic-overlap-and-shared-loci-between-rheumatoid-arthritis-and-cardiovascular-diseases
#6
JOURNAL ARTICLE
Xiaohui Sun, Yu Qian, Weiqiu Cheng, Ding Ye, Bin Liu, Dan Zhou, Chengping Wen, Ole A Andreassen, Yingying Mao
BACKGROUND: Despite substantial research revealing that patients with rheumatoid arthritis (RA) have excessive morbidity and mortality of cardiovascular disease (CVD), the mechanism underlying this association has not been fully known. This study aims to systematically investigate the phenotypic and genetic correlation between RA and CVD. METHODS: Based on UK Biobank, we conducted two cohort studies to evaluate the phenotypic relationships between RA and CVD, including atrial fibrillation (AF), coronary artery disease (CAD), heart failure (HF), and stroke...
April 8, 2024: BMC Medicine
https://read.qxmd.com/read/38589864/patterns-of-comorbidities-in-patients-with-atrial-fibrillation-and-impact-on-management-and-long-term-prognosis-an-analysis-from-the-prospective-global-gloria-af-registry
#7
JOURNAL ARTICLE
Giulio Francesco Romiti, Bernadette Corica, Davide Antonio Mei, Arnaud Bisson, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V Huisman, Marco Proietti, Gregory Y H Lip
BACKGROUND: Clinical complexity, as the interaction between ageing, frailty, multimorbidity and polypharmacy, is an increasing concern in patients with AF. There remains uncertainty regarding how combinations of comorbidities influence management and prognosis of patients with atrial fibrillation (AF). We aimed to identify phenotypes of AF patients according to comorbidities and to assess associations between comorbidity patterns, drug use and risk of major outcomes. METHODS: From the prospective GLORIA-AF Registry, we performed a latent class analysis based on 18 diseases, encompassing cardiovascular, metabolic, respiratory and other conditions; we then analysed the association between phenotypes of patients and (i) treatments received and (ii) the risk of major outcomes...
April 8, 2024: BMC Medicine
https://read.qxmd.com/read/38589855/canadians-use-of-cannabis-for-therapeutic-purposes-since-legalization-of-recreational-cannabis-a-cross-sectional-analysis-by-medical-authorization-status
#8
JOURNAL ARTICLE
Lynda G Balneaves, Ashleigh Brown, Matthew Green, Erin Prosk, Lucile Rapin, Max Monahan-Ellison, Eva McMillan, Jonathan Zaid, Michael Dworkind, Cody Z Watling
BACKGROUND: There has been a precipitous decline in authorizations for medical cannabis since non-medical cannabis was legalized in Canada in 2018. This study examines the demographic and health- and medical cannabis-related factors associated with authorization as well as the differences in medical cannabis use, side effects, and sources of medical cannabis and information by authorization status. METHODS: Individuals who were taking cannabis for therapeutic purposes completed an online survey in early 2022...
April 8, 2024: BMC Medicine
https://read.qxmd.com/read/38581003/interventions-on-gender-equity-in-the-workplace-a-scoping-review
#9
JOURNAL ARTICLE
Andrea C Tricco, Amanda Parker, Paul A Khan, Vera Nincic, Reid Robson, Heather MacDonald, Rachel Warren, Olga Cleary, Elaine Zibrowski, Nancy Baxter, Karen E A Burns, Doug Coyle, Ruth Ndjaboue, Jocalyn P Clark, Etienne V Langlois, Sofia B Ahmed, Holly O Witteman, Ian D Graham, Wafa El-Adhami, Becky Skidmore, France Légaré, Janet Curran, Gillian Hawker, Jennifer Watt, Ivy Lynn Bourgeault, Jeanna Parsons Leigh, Karen Lawford, Alice Aiken, Christopher McCabe, Sasha Shepperd, Reena Pattani, Natalie Leon, Jamie Lundine, Évèhouénou Lionel Adisso, Santa Ono, Linda Rabeneck, Sharon E Straus
BACKGROUND: Various studies have demonstrated gender disparities in workplace settings and the need for further intervention. This study identifies and examines evidence from randomized controlled trials (RCTs) on interventions examining gender equity in workplace or volunteer settings. An additional aim was to determine whether interventions considered intersection of gender and other variables, including PROGRESS-Plus equity variables (e.g., race/ethnicity). METHODS: Scoping review conducted using the JBI guide...
April 5, 2024: BMC Medicine
https://read.qxmd.com/read/38561783/a-practical-evidence-based-approach-to-management-of-type-2-diabetes-in-children-and-young-people-cyp-uk-consensus
#10
JOURNAL ARTICLE
Billy White, S M Ng, J C Agwu, T G Barrett, N Birchmore, M Kershaw, J Drew, F Kavvoura, J Law, C Moudiotis, E Procter, P Paul, F Regan, P Reilly, P Sachdev, R Sakremath, C Semple, K Sharples, M Skae, A Timmis, E Williams, N Wright, A Soni
BACKGROUND: Type 2 diabetes in young people is an aggressive disease with a greater risk of complications leading to increased morbidity and mortality during the most productive years of life. Prevalence in the UK and globally is rising yet experience in managing this condition is limited. There are no consensus guidelines in the UK for the assessment and management of paediatric type 2 diabetes. METHODS: Multidisciplinary professionals from The Association of Children's Diabetes Clinicians (ACDC) and the National Type 2 Diabetes Working Group reviewed the evidence base and made recommendations using the Grading Of Recommendations, Assessment, Development and Evaluation (GRADE) methodology...
April 2, 2024: BMC Medicine
https://read.qxmd.com/read/38561764/blood-leukocytes-as-a-non-invasive-diagnostic-tool-for-thyroid-nodules-a-prospective-cohort-study
#11
JOURNAL ARTICLE
Feihang Wang, Danyang Zhao, Wang-Yang Xu, Yiying Liu, Huiyi Sun, Shanshan Lu, Yuan Ji, Jingjing Jiang, Yi Chen, Qiye He, Chengxiang Gong, Rui Liu, Zhixi Su, Yi Dong, Zhiping Yan, Lingxiao Liu
BACKGROUND: Thyroid nodule (TN) patients in China are subject to overdiagnosis and overtreatment. The implementation of existing technologies such as thyroid ultrasonography has indeed contributed to the improved diagnostic accuracy of TNs. However, a significant issue persists, where many patients undergo unnecessary biopsies, and patients with malignant thyroid nodules (MTNs) are advised to undergo surgery therapy. METHODS: This study included a total of 293 patients diagnosed with TNs...
April 2, 2024: BMC Medicine
https://read.qxmd.com/read/38561754/inpatient-level-care-at-home-delivered-by-virtual-wards-and-hospital-at-home-a-systematic-review-and-meta-analysis-of-complex-interventions-and-their-components
#12
JOURNAL ARTICLE
Chunhu Shi, Jo Dumville, Fernando Rubinstein, Gill Norman, Akbar Ullah, Saima Bashir, Peter Bower, Emma R L C Vardy
BACKGROUND: Technology-enabled inpatient-level care at home services, such as virtual wards and hospital at home, are being rapidly implemented. This is the first systematic review to link the components of these service delivery innovations to evidence of effectiveness to explore implications for practice and research. METHODS: For this review (registered here https://osf.io/je39y ), we searched Cochrane-recommended multiple databases up to 30 November 2022 and additional resources for randomised and non-randomised studies that compared technology-enabled inpatient-level care at home with hospital-based inpatient care...
April 2, 2024: BMC Medicine
https://read.qxmd.com/read/38561738/real-world-performance-of-indobufen-versus-aspirin-after-percutaneous-coronary-intervention-insights-from-the-aspiration-registry
#13
JOURNAL ARTICLE
Chunfeng Dai, Muyin Liu, Zheng Yang, Youran Li, You Zhou, Danbo Lu, Yan Xia, Ao Chen, Chenguang Li, Hao Lu, Yuxiang Dai, Jianying Ma, Zhangwei Chen, Juying Qian, Junbo Ge
BACKGROUND: Indobufen is widely used in patients with aspirin intolerance in East Asia. The OPTION trial launched by our cardiac center examined the performance of indobufen based dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). However, the vast majority of patients with acute coronary syndrome (ACS) and aspirin intolerance were excluded. We aimed to explore this question in a real-world population. METHODS: Patients enrolled in the ASPIRATION registry were grouped according to the DAPT strategy that they received after PCI...
April 2, 2024: BMC Medicine
https://read.qxmd.com/read/38561734/childhood-urbanicity-is-associated-with-emotional-episodic-memory-related-striatal-function-and-common-variation-in-ntrk2
#14
JOURNAL ARTICLE
Xiao Zhang, Yuyanan Zhang, Hao Yan, Hao Yu, Dai Zhang, Venkata S Mattay, Hao Yang Tan, Weihua Yue
BACKGROUND: Childhoods in urban or rural environments may differentially affect the risk of neuropsychiatric disorders, possibly through memory processing and neural response to emotional stimuli. Genetic factors may not only influence individuals' choices of residence but also modulate how the living environment affects responses to episodic memory. METHODS: We investigated the effects of childhood urbanicity on episodic memory in 410 adults (discovery sample) and 72 adults (replication sample) with comparable socioeconomic statuses in Beijing, China, distinguishing between those with rural backgrounds (resided in rural areas before age 12 and relocated to urban areas at or after age 12) and urban backgrounds (resided in cities before age 12)...
April 2, 2024: BMC Medicine
https://read.qxmd.com/read/38532468/comparing-the-clinical-practice-and-prescribing-safety-of-locum-and-permanent-doctors-observational-study-of-primary-care-consultations-in-england
#15
JOURNAL ARTICLE
Christos Grigoroglou, Kieran Walshe, Evangelos Kontopantelis, Jane Ferguson, Gemma Stringer, Darren M Ashcroft, Thomas Allen
BACKGROUND: Temporary doctors, known as locums, are a key component of the medical workforce in the NHS but evidence on differences in quality and safety between locum and permanent doctors is limited. We aimed to examine differences in the clinical practice, and prescribing safety for locum and permanent doctors working in primary care in England. METHODS: We accessed electronic health care records (EHRs) for 3.5 million patients from the CPRD GOLD database with linkage to Hospital Episode Statistics from 1st April 2010 to 31st March 2022...
March 27, 2024: BMC Medicine
https://read.qxmd.com/read/38532472/association-between-genetic-risk-and-adherence-to-healthy-lifestyle-for-developing-age-related-hearing-loss
#16
JOURNAL ARTICLE
Sang-Hyuk Jung, Young Chan Lee, Manu Shivakumar, Jaeyoung Kim, Jae-Seung Yun, Woong-Yang Park, Hong-Hee Won, Dokyoon Kim
BACKGROUND: Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association among genetics, lifestyle/environmental factors, and adherence to healthy lifestyle for risk of ARHL. We aimed to assess the association between ARHL genetic variants, lifestyle/environmental factors, and adherence to healthy lifestyle as pertains to risk of ARHL. METHODS: This case-control study included 376,464 European individuals aged 40 to 69 years, enrolled between 2006 and 2010 in the UK Biobank (UKBB)...
March 26, 2024: BMC Medicine
https://read.qxmd.com/read/38532458/a-phase-ii-study-of-belumosudil-for-chronic-graft-versus-host-disease-in-patients-who-failed-at-least-one-line-of-systemic-therapy-in-china
#17
MULTICENTER STUDY
Ying Wang, Depei Wu, Xiang Zhang, Yuhua Li, Yanjie He, Qifa Liu, Li Xuan, Zhenyu Li, Kunming Qi, Yuqian Sun, Shunqing Wang, Wenjian Mo, Lei Gao, Ye Hua, Yu Wang, Ying Zhang
BACKGROUND: Chronic graft-versus-host disease (cGVHD) is an immune-related disorder that is the most common complication post-allogenic hematopoietic stem cell transplant. Corticosteroids with or without calcineurin inhibitors (CNIs) remain the mainstay of cGVHD treatment for first-line therapy. However, for many patients, cGVHD symptoms cannot be effectively managed and thus require second-line therapy. Currently, there is no approved treatment for second-line cGVHD treatment in China...
March 26, 2024: BMC Medicine
https://read.qxmd.com/read/38532381/sars-cov-2-influenza-a-b-and-respiratory-syncytial-virus-positivity-and-association-with-influenza-like-illness-and-self-reported-symptoms-over-the-2022-23-winter-season-in-the-uk-a-longitudinal-surveillance-cohort
#18
JOURNAL ARTICLE
Elisabeth Dietz, Emma Pritchard, Koen Pouwels, Muhammad Ehsaan, Joshua Blake, Charlotte Gaughan, Eric Haduli, Hugh Boothe, Karina-Doris Vihta, Tim Peto, Nicole Stoesser, Philippa Matthews, Nick Taylor, Ian Diamond, Ruth Studley, Emma Rourke, Paul Birrell, Daniela De Angelis, Tom Fowler, Conall Watson, David Eyre, Thomas House, Ann Sarah Walker
BACKGROUND: Syndromic surveillance often relies on patients presenting to healthcare. Community cohorts, although more challenging to recruit, could provide additional population-wide insights, particularly with SARS-CoV-2 co-circulating with other respiratory viruses. METHODS: We estimated the positivity and incidence of SARS-CoV-2, influenza A/B, and RSV, and trends in self-reported symptoms including influenza-like illness (ILI), over the 2022/23 winter season in a broadly representative UK community cohort (COVID-19 Infection Survey), using negative-binomial generalised additive models...
March 26, 2024: BMC Medicine
https://read.qxmd.com/read/38528552/associations-between-maternal-pre-pregnancy-bmi-and-infant-striatal-mean-diffusivity
#19
JOURNAL ARTICLE
Aylin Rosberg, Harri Merisaari, John D Lewis, Niloofar Hashempour, Minna Lukkarinen, Jerod M Rasmussen, Noora M Scheinin, Linnea Karlsson, Hasse Karlsson, Jetro J Tuulari
BACKGROUND: It is well-established that parental obesity is a strong risk factor for offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring's brain in a manner that confers future obesity risk. Here, we investigated how pre-pregnancy maternal weight status influences the reward-related striatal areas of the offspring's brain during in utero development. METHODS: We used diffusion tensor imaging to quantify the microstructure of the striatal brain regions of interest in neonates (N = 116 [66 males, 50 females], mean gestational weeks at birth [39...
March 25, 2024: BMC Medicine
https://read.qxmd.com/read/38528543/evaluation-of-a-hospital-initiated-tobacco-dependence-treatment-service-uptake-smoking-cessation-readmission-and-mortality
#20
JOURNAL ARTICLE
John Robins, Irem Patel, Ann McNeill, John Moxham, Arran Woodhouse, Gareth Absalom, Buljana Shehu, Geraldine Bruce, Amy Dewar, Alanna Molloy, Stephanie Duckworth Porras, Michael Waring, Andrew Stock, Debbie Robson
BACKGROUND: The National Health Service in England aims to implement tobacco dependency treatment services in all hospitals by 2024. We aimed to assess the uptake of a new service, adapted from the Ottawa Model of Smoking Cessation, and its impact on 6-month quit rates and readmission or death at 1-year follow-up. METHODS: We conducted a pragmatic service evaluation of a tobacco dependency service implemented among 2067 patients who smoked who were admitted to 2 acute hospitals in London, England, over a 12-month period from July 2020...
March 25, 2024: BMC Medicine
journal
journal
40551
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.