journal
https://read.qxmd.com/read/36927608/atorvastatin-pretreated-mesenchymal-stem-cell-derived-extracellular-vesicles-promote-cardiac-repair-after-myocardial-infarction-via-shifting-macrophage-polarization-by-targeting-microrna-139-3p-stat1-pathway
#1
JOURNAL ARTICLE
Yu Ning, Peisen Huang, Guihao Chen, Yuyan Xiong, Zhaoting Gong, Chunxiao Wu, Junyan Xu, Wenyang Jiang, Xiaosong Li, Ruijie Tang, Lili Zhang, Mengjin Hu, Jing Xu, Jun Xu, Haiyan Qian, Chen Jin, Yuejin Yang
BACKGROUND: Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (MSCs) pretreated with atorvastatin (ATV) (MSCATV -EV) have a superior cardiac repair effect on acute myocardial infarction (AMI). The mechanisms, however, have not been fully elucidated. This study aims to explore whether inflammation alleviation of infarct region via macrophage polarization plays a key role in the efficacy of MSCATV -EV. METHODS: MSCATV -EV or MSC-EV were intramyocardially injected 30 min after coronary ligation in AMI rats...
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36927576/relative-role-of-border-restrictions-case-finding-and-contact-tracing-in-controlling-sars-cov-2-in-the-presence-of-undetected-transmission-a-mathematical-modelling-study
#2
JOURNAL ARTICLE
Rachael Pung, Hannah E Clapham, Timothy W Russell, Vernon J Lee, Adam J Kucharski
BACKGROUND: Understanding the overall effectiveness of non-pharmaceutical interventions to control the COVID-19 pandemic and reduce the burden of disease is crucial for future pandemic planning. However, quantifying the effectiveness of specific control measures and the extent of missed infections, in the absence of early large-scale serological surveys or random community testing, has remained challenging. METHODS: Combining data on notified local COVID-19 cases with known and unknown sources of infections in Singapore with a branching process model, we reconstructed the incidence of missed infections during the early phase of the wild-type SARS-CoV-2 and Delta variant transmission...
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36927554/one-size-does-not-fit-all-working-towards-increasing-participation-of-minority-groups-in-cancer-screening-programmes
#3
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36927541/the-efficacy-and-safety-of-apatinib-plus-capecitabine-in-platinum-refractory-metastatic-and-or-recurrent-nasopharyngeal-carcinoma-a-prospective-phase-ii-trial
#4
JOURNAL ARTICLE
Lin-Quan Tang, Xiao-Yun Li, Zhi-Ming Li, Zhi-Gang Liu, Miao-Zhen Lin, Huan Zhou, Qi-Wen Yu, Jian Zhou, Chong Zhao, Ze-Bin Chen, Xi-Cheng Wang, Jia-Yu Peng, Qiu-Yan Chen, Wen-Feng Fang, Yun-Peng Yang, Bei Zhang, Liang-Ping Xia, Pi-Li Hu, Wei-Han Hu, Yi-Jie Li, Hai-Qiang Mai, Xiu-Yu Cai
BACKGROUND: Previous studies have shown that monotherapy with apatinib, an oral tyrosine kinase inhibitor, has promising efficacy for treating recurrent or metastatic (RM) nasopharyngeal carcinoma (NPC) patients. In this study, we aimed to assess the efficacy and safety of apatinib combined with capecitabine as a second-line therapy or beyond for treating RM-NPC patients who failed the first-line platinum-based chemotherapy. METHODS: In this single-arm, phase II study, we enrolled RM-NPC patients who had at least one measurable lesion according to the Response Evaluation Criteria in Solid Tumors (RECIST v1...
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36927443/light-at-night-and-cause-specific-mortality-risk-in-mainland-china-a-nationwide-observational-study
#5
JOURNAL ARTICLE
Yao Lu, Peng Yin, Jie Wang, Yiping Yang, Fei Li, Hong Yuan, Shenxin Li, Zheng Long, Maigeng Zhou
BACKGROUND: While epidemiological studies have found correlations between light at night (LAN) and health effects, none has so far investigated the impacts of LAN on population mortality yet. We aimed to estimate the relative risk for mortality from exposure to LAN in Mainland China. METHODS: This time-stratified case-crossover nationwide study used NPP-VIIRS to obtain daily LAN data of Mainland China between 2015 and 2019. The daily mortality data were obtained from the Disease Surveillance Point System in China...
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36927437/strategies-to-interrupt-rabies-transmission-for-the-elimination-goal-by-2030-in-china-strategic-a-modelling-study
#6
JOURNAL ARTICLE
Qiulan Chen, Qiuping Liu, Chao Gong, Wenwu Yin, Di Mu, Yu Li, Shujun Ding, Yifang Liu, Hao Yang, Shuwu Zhou, Sa Chen, Zhongfa Tao, Yanping Zhang, Xun Tang
BACKGROUND: A global plan has been set to end human deaths from dog-mediated rabies by 2030 ("Zero-by-30"), but whether it could be achieved in some countries, such as China, remains unclear. Although elimination strategies through post-exposure prophylaxis (PEP) use, dog vaccination, and patient risk assessments with integrated bite case management (IBCM) were proposed to be cost-effective, evidence is still lacking in China. We aim to evaluate the future burdens of dog-mediated human rabies deaths in the next decade and provide quantitative evidence on the cost-effectiveness of different rabies-control strategies in China...
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36927420/safety-tolerability-pharmacokinetics-and-antiviral-activity-of-the-novel-core-protein-allosteric-modulator-zm-h1505r-canocapavir-in-chronic-hepatitis-b-patients-a-randomized-multiple-dose-escalation-trial
#7
JOURNAL ARTICLE
Haiyan Jia, Jiajia Mai, Min Wu, Hong Chen, Xiaojiao Li, Cuiyun Li, Jingrui Liu, Chengjiao Liu, Yue Hu, Xiaoxue Zhu, Xiuhong Jiang, Bo Hua, Tian Xia, Gang Liu, Aiyun Deng, Bo Liang, Ruoling Guo, Hui Lu, Zhe Wang, Huanming Chen, Zhijun Zhang, Hong Zhang, Junqi Niu, Yanhua Ding
BACKGROUND: Hepatitis B virus (HBV) core protein-targeting antivirals (CpTAs) are promising therapeutic agents for treating chronic hepatitis B (CHB). In this study, the antiviral activity, pharmacokinetics (PK), and tolerability of ZM-H1505R (Canocapavir), a chemically unique HBV CpTA, were evaluated in patients with CHB. METHODS: This study was a double-blind, randomized, placebo-controlled phase 1b trial in Chinese CHB patients. Noncirrhotic and treatment-naive CHB patients were divided into three cohorts (10 patients per cohort) and randomized within each cohort in a ratio of 4:1 to receive a single dose of 50, 100, or 200 mg of Canocapavir or placebo once a day for 28 consecutive days...
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36927416/exploring-preconception-signatures-of-metabolites-in-mothers-with-gestational-diabetes-mellitus-using-a-non-targeted-approach
#8
JOURNAL ARTICLE
Ling-Jun Li, Ximeng Wang, Yap Seng Chong, Jerry Kok Yen Chan, Kok Hian Tan, Johan G Eriksson, Zhongwei Huang, Mohammad L Rahman, Liang Cui, Cuilin Zhang
BACKGROUND: Metabolomic changes during pregnancy have been suggested to underlie the etiology of gestational diabetes mellitus (GDM). However, research on metabolites during preconception is lacking. Therefore, this study aimed to investigate distinctive metabolites during the preconception phase between GDM and non-GDM controls in a nested case-control study in Singapore. METHODS: Within a Singapore preconception cohort, we included 33 Chinese pregnant women diagnosed with GDM according to the IADPSG criteria between 24 and 28 weeks of gestation...
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36927351/life-expectancy-among-older-adults-with-or-without-frailty-in-china-multistate-modelling-of-a-national-longitudinal-cohort-study
#9
JOURNAL ARTICLE
Junling Gao, Yujie Wang, Jixiang Xu, Junjia Jiang, Shitong Yang, Qianyi Xiao
BACKGROUND: Little is known about life expectancy (LE) with or without frailty. We aimed to estimate the total LE and duration of the state of frailty in China. METHODS: This study included older adults aged 65 years and older from the Chinese Longitudinal Healthy Longevity Study (CLHLS). Frailty status was classified into robust, pre-frailty and frailty based on a cumulative deficit model. Total and specific frailty state LEs at 65 years of age were estimated and stratified by demographic characteristics, behaviours, and psychosocial factors using continuous-time multistate modelling...
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36922820/exogenous-mitochondrial-transplantation-improves-survival-and-neurological-outcomes-after-resuscitation-from-cardiac-arrest
#10
JOURNAL ARTICLE
Kei Hayashida, Ryosuke Takegawa, Yusuke Endo, Tai Yin, Rishabh C Choudhary, Tomoaki Aoki, Mitsuaki Nishikimi, Atsushi Murao, Eriko Nakamura, Muhammad Shoaib, Cyrus Kuschner, Santiago J Miyara, Junhwan Kim, Koichiro Shinozaki, Ping Wang, Lance B Becker
BACKGROUND: Mitochondrial transplantation (MTx) is an emerging but poorly understood technology with the potential to mitigate severe ischemia-reperfusion injuries after cardiac arrest (CA). To address critical gaps in the current knowledge, we test the hypothesis that MTx can improve outcomes after CA resuscitation. METHODS: This study consists of both in vitro and in vivo studies. We initially examined the migration of exogenous mitochondria into primary neural cell culture in vitro...
March 16, 2023: BMC Medicine
https://read.qxmd.com/read/36918901/-willpower-is-not-enough-time-for-a-new-approach-to-public-health-policy-to-prevent-obesity
#11
LETTER
Susan A Jebb, Paul Aveyard
No abstract text is available yet for this article.
March 15, 2023: BMC Medicine
https://read.qxmd.com/read/36915130/mediterranean-diet-adherence-is-associated-with-lower-dementia-risk-independent-of-genetic-predisposition-findings-from-the-uk-biobank-prospective-cohort-study
#12
JOURNAL ARTICLE
Oliver M Shannon, Janice M Ranson, Sarah Gregory, Helen Macpherson, Catherine Milte, Marleen Lentjes, Angela Mulligan, Claire McEvoy, Alex Griffiths, Jamie Matu, Tom R Hill, Ashley Adamson, Mario Siervo, Anne Marie Minihane, Graciela Muniz-Tererra, Craig Ritchie, John C Mathers, David J Llewellyn, Emma Stevenson
BACKGROUND: The identification of effective dementia prevention strategies is a major public health priority, due to the enormous and growing societal cost of this condition. Consumption of a Mediterranean diet (MedDiet) has been proposed to reduce dementia risk. However, current evidence is inconclusive and is typically derived from small cohorts with limited dementia cases. Additionally, few studies have explored the interaction between diet and genetic risk of dementia. METHODS: We used Cox proportional hazard regression models to explore the associations between MedDiet adherence, defined using two different scores (Mediterranean Diet Adherence Screener [MEDAS] continuous and Mediterranean diet Pyramid [PYRAMID] scores), and incident all-cause dementia risk in 60,298 participants from UK Biobank, followed for an average 9...
March 14, 2023: BMC Medicine
https://read.qxmd.com/read/36907864/depression-cardiometabolic-disease-and-their-co-occurrence-after-childhood-maltreatment-an-individual-participant-data-meta-analysis-including-over-200-000-participants
#13
JOURNAL ARTICLE
Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W V Jaddoe, Anja Lok, Bas B van Rijn, Henry Völzke, Charlotte A M Cecil, Janine F Felix, Hans J Grabe, Tilo Kircher, Karim Lekadir, Margreet Ten Have, Esther Walton, Brenda W J H Penninx
BACKGROUND: Childhood maltreatment is associated with depression and cardiometabolic disease in adulthood. However, the relationships with these two diseases have so far only been evaluated in different samples and with different methodology. Thus, it remains unknown how the effect sizes magnitudes for depression and cardiometabolic disease compare with each other and whether childhood maltreatment is especially associated with the co-occurrence ("comorbidity") of depression and cardiometabolic disease...
March 13, 2023: BMC Medicine
https://read.qxmd.com/read/36907857/unravelling-the-potential-of-social-prescribing-in-individual-level-type-2-diabetes-prevention-a-mixed-methods-realist-evaluation
#14
JOURNAL ARTICLE
Sara Calderón-Larrañaga, Trish Greenhalgh, Megan Clinch, John Robson, Isabel Dostal, Fabiola Eto, Sarah Finer
BACKGROUND: Social prescribing (SP) usually involves linking patients in primary care with services provided by the voluntary and community sector. Preliminary evidence suggests that SP may offer a means of connecting patients with community-based health promotion activities, potentially contributing to the prevention of long-term conditions, such as type 2 diabetes (T2D). METHODS: Using mixed-methods realist evaluation, we explored the possible contribution of SP to individual-level prevention of T2D in a multi-ethnic, socio-economically deprived population in London, UK...
March 13, 2023: BMC Medicine
https://read.qxmd.com/read/36907851/vaginal-and-neonatal-microbiota-in-pregnant-women-with-preterm-premature-rupture-of-membranes-and-consecutive-early-onset-neonatal-sepsis
#15
MULTICENTER STUDY
Luiz Gustavo Dos Anjos Borges, Jana Pastuschek, Yvonne Heimann, Kristin Dawczynski, Ekkehard Schleußner, Dietmar H Pieper, Janine Zöllkau
BACKGROUND: Preterm premature rupture of membranes (PPROM), which is associated with vaginal dysbiosis, is responsible for up to one-third of all preterm births. Consecutive ascending colonization, infection, and inflammation may lead to relevant neonatal morbidity including early-onset neonatal sepsis (EONS). The present study aims to assess the vaginal microbial composition of PPROM patients and its development under standard antibiotic therapy and to evaluate the usefulness of the vaginal microbiota for the prediction of EONS...
March 13, 2023: BMC Medicine
https://read.qxmd.com/read/36894970/alpha-2-macroglobulin-is-involved-in-the-occurrence-of-early-onset-pre-eclampsia-via-its-negative-impact-on-uterine-spiral-artery-remodeling-and-placental-angiogenesis
#16
JOURNAL ARTICLE
Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li, Xuesong Yang
BACKGROUND: Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiological mechanism by which A2M is involved in PE development is not yet understood. METHODS: Human placenta samples, serum, and corresponding clinical data of the participants were collected to study the pathophysiologic mechanism underlying PE. Pregnant Sprague-Dawley rats were intravenously injected with an adenovirus vector carrying A2M via the tail vein on gestational day (GD) 8...
March 9, 2023: BMC Medicine
https://read.qxmd.com/read/36882868/assessing-the-impacts-of-covid-19-vaccination-programme-s-timing-and-speed-on-health-benefits-cost-effectiveness-and-relative-affordability-in-27-african-countries
#17
JOURNAL ARTICLE
Yang Liu, Simon R Procter, Carl A B Pearson, Andrés Madriz Montero, Sergio Torres-Rueda, Elias Asfaw, Benjamin Uzochukwu, Tom Drake, Eleanor Bergren, Rosalind M Eggo, Francis Ruiz, Nicaise Ndembi, Justice Nonvignon, Mark Jit, Anna Vassall
BACKGROUND: The COVID-19 vaccine supply shortage in 2021 constrained roll-out efforts in Africa while populations experienced waves of epidemics. As supply improves, a key question is whether vaccination remains an impactful and cost-effective strategy given changes in the timing of implementation. METHODS: We assessed the impact of vaccination programme timing using an epidemiological and economic model. We fitted an age-specific dynamic transmission model to reported COVID-19 deaths in 27 African countries to approximate existing immunity resulting from infection before substantial vaccine roll-out...
March 8, 2023: BMC Medicine
https://read.qxmd.com/read/36882828/circulating-levels-of-micronutrients-and-risk-of-infections-a-mendelian-randomization-study
#18
JOURNAL ARTICLE
Helene M Flatby, Anuradha Ravi, Jan K Damås, Erik Solligård, Tormod Rogne
BACKGROUND: Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized controlled trials of micronutrients and infections are limited. We performed Mendelian randomization (MR) analyses to evaluate the effect of blood levels of eight micronutrients (copper, iron, selenium, zinc, beta-carotene, vitamin B12, vitamin C, and vitamin D) on the risk of three infections (gastrointestinal infections, pneumonia, and urinary tract infections)...
March 8, 2023: BMC Medicine
https://read.qxmd.com/read/36882820/the-long-term-and-short-term-effects-of-ambient-air-pollutants-on-sleep-characteristics-in-the-chinese-population-big-data-analysis-from-real-world-by-sleep-records-of-consumer-wearable-devices
#19
JOURNAL ARTICLE
Peining Zhou, Jing Ma, Xueying Li, Yixue Zhao, Kunyao Yu, Rui Su, Rui Zhou, Hui Wang, Guangfa Wang
Several studies on long-term air pollution exposure and sleep have reported inconsistent results. Large-scale studies on short-term air pollution exposures and sleep have not been conducted. We investigated the associations of long- and short-term exposure to ambient air pollutants with sleep in a Chinese population based on over 1 million nights of sleep data from consumer wearable devices. Air pollution data including particulate matter (PM2.5 , PM10 ), nitrogen dioxide (NO2 ), sulfur dioxide (SO2 ), carbon monoxide (CO), and ozone (O3 ) were collected from the Ministry of Ecology and Environment...
March 8, 2023: BMC Medicine
https://read.qxmd.com/read/36882775/comparing-a-pd-l1-inhibitor-plus-chemotherapy-to-chemotherapy-alone-in-neoadjuvant-therapy-for-locally-advanced-escc-a-randomized-phase-ii-clinical-trial-a-randomized-clinical-trial-of-neoadjuvant-therapy-for-escc
#20
RANDOMIZED CONTROLLED TRIAL
Yong Li, Aiping Zhou, Shuoyan Liu, Ming He, Keneng Chen, Ziqiang Tian, Yin Li, Jianjun Qin, Zhen Wang, Haiquan Chen, Hui Tian, Yue Yu, Wang Qu, Liyan Xue, Shun He, Shuhang Wang, Fenglong Bie, Guangyu Bai, Bolun Zhou, Zhaoyang Yang, Huiyao Huang, Yan Fang, Benjamin Li, Xiangrong Dai, Shugeng Gao, Jie He
BACKGROUND: A Phase II study was undertaken to evaluate the safety and efficacy of the neoadjuvant socazolimab, a novel PD-L1 inhibitor, in combination with nab-paclitaxel and cisplatin for locally advanced esophageal squamous cell carcinoma (ESCC). METHODS: Sixty-four patients were randomly divided between the Socazolimab + nab-paclitaxel + cisplatin (TP) arm (n = 32) and the control arm (n = 32), receiving either socazolimab (5 mg/kg intravenously (IV), day 1) or a placebo with nab-paclitaxel (125 mg/m2 IV, day 1/8) and cisplatin (75 mg/m2 IV, day 1) repeated every 21 days for four cycles before surgery...
March 8, 2023: BMC Medicine
journal
journal
40551
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.