Kyong-Oh Shin, Kenya Ishida, Hisashi Mihara, Yerim Choi, Jae-Ho Park, Soo-Hyun Park, Jin-Taek Hwang, Joan S Wakefield, Yasuko Obata, Yoshikazu Uchida, Kyungho Park
INTRODUCTION: Diesel particulate matter (DPM) emitted from diesel engines is a major source of air pollutants. DPM is composed of elemental carbon, which adsorbs organic compounds including toxic polycyclic aromatic hydrocarbons (PAH). The skin, as well as airways, are directly exposed to DPM, and association of atopic dermatitis, psoriasis flares, and premature skin aging with air pollutant levels has been documented. In skin, the permeation of DPM and DPM-adsorbed compounds is primarily blocked by the epidermal permeability barrier deployed in the stratum corneum...
May 20, 2024: Skin Pharmacology and Physiology
Joachim W Fluhr, Agnès Voisard, Dessyslava G Nikolaeva, Leonie Herzog, Georg Wiora, Jeremias Gayer, Nicolas J Lehmann, Razvigor Darlenski
INTRODUCTION AND AIMS: Non-invasive measurement of the stratum corneum hydration (SCH) with capacitance-based instrumentation is established in dermatological and cosmetic studies. We wanted to test the reliability of non-invasive self-measurements for SCH performed under real-life conditions by volunteers with a Bluetooth-based (wireless) probe Corneometer® (CM825i) transmitting the data via a smartphone application to a central server. Probes and smartphones communicated using Bluetooth Low Energy (BLE)...
May 18, 2024: Skin Pharmacology and Physiology
Yu Yan, Shuzheng Huang, Yu Zeng, Siyuan Yue, Tong Wang, Lin Yuan, Junhui Nie
INTRODUCTION: Disinfectants play a critical role in reducing healthcare-associated infections by eliminating microorganisms on surfaces. However, prolonged use of disinfectants may adversely affect the skin microflora, essential for skin health and infection prevention. This study investigates the impact of disinfection on the skin microbiota and metabolites of medical personnel in operating rooms, aiming to provide a scientific foundation for safeguarding their skin health. METHODS: We conducted 16S sequencing and metabolomic analysis to assess the effects of disinfection on the skin microbiota and metabolites of medical personnel...
May 6, 2024: Skin Pharmacology and Physiology
Guilherme Muzy
No abstract text is available yet for this article.
May 3, 2024: Skin Pharmacology and Physiology
Dongyun Lei, Li Ye, Si Wen, Junling Zhang, Litao Zhang, Mao-Qiang Man
BACKGROUND: The skin, particularly the epidermis, is subjected to various external stresses, including ultraviolet [UV] irradiation. UV irradiation, mainly UVB at wavelength of 280-315 nm, can alter several epidermal functions, including cutaneous inflammation, epidermal hyperproliferation, DNA damage, disruption of epidermal permeability barrier and reduction in stratum corneum hydration levels. Because of the negative impacts of UVB irradiation on epidermal functions, great efforts have been made to develop regimens for the protection of alterations in epidermal function induced by UV irradiation...
April 12, 2024: Skin Pharmacology and Physiology
Yumi Touma, Mayumi Ichikawa, Masatake Kishi, Tomomi Yokota, Akio Fujisawa
INTRODUCTION: Percutaneous drug delivery systems are attractive not only as a therapeutic strategy but also for cosmetic treatment. Iontophoresis is a well-recognized method for promoting transdermal absorption of ionized compounds. Franz cells are generally used to estimate drug permeation of skin by iontophoresis. However, methods using Franz cells are less versatile; for instance, the method is unsuited for use with a portable electric facial care device having a working probe of a certain size and weight...
February 17, 2024: Skin Pharmacology and Physiology
Catharina Braren-von Stülpnagel, Matthias Augustin, Rachel Sommer, Lukas Westphal
BACKGROUND: Atopic dermatitis (AD) is a physical, emotional and social burden for patients. Most suffer from itching, pain and dry skin as well as sleep disturbances, experienced stigmatization, anxiety or depression. Therefore, it is important to consider the psychosocial well-being and also stigmatization in the treatment of people with AD. OBJECTIVE: The aim of this study was to compare clinical and psychosocial parameters between patients with different severity of AD and to analyse the effect of an Omega-6-fatty-acid-skin therapy...
February 7, 2024: Skin Pharmacology and Physiology
Mily Constanza Moreno Ramos, Maria Valeria Robles Velasco, Mariana Bueno, Maria de La Ó Ramalho Veríssimo
INTRODUCTION: Compared to adults, newborns' skin has thinner epidermis and stratum corneum with decreased hydration level, higher transepidermal water loss, and pH variation between 5.5 and 7.5. These characteristics can predispose the occurrence of dryness, infections, and dermatological conditions. Water and liquid soap with adequate formulation have shown to be beneficial and safe for newborns' skin. However, studies evaluating the effect of bar soap, products widely used in Brazil and Latin America, are unknown...
January 23, 2024: Skin Pharmacology and Physiology
Bor Hrvatin Stancic, Jurr Boer, Mateja Dolenc-Voljč, Gregor B E Jemec
No abstract text is available yet for this article.
January 4, 2024: Skin Pharmacology and Physiology
Rainer C Görne, Nils Günnewich, Hilde Huber, Britta Wallmen, Christian Zimmermann
INTRODUCTION: Folliculitis is a painful infection and inflammation of hair follicles, mostly caused by bacterial, fungal or, more rarely, viral infections. Turpentine derivatives have been used traditionally to treat various skin infections and could thus also be effective in treating folliculitis. We carried out an open, prospective, randomized, placebo- and comparator-controlled multicenter trial to evaluate the efficacy and safety of an ointment containing pine turpentine oil, larch turpentine, and eucalyptus oil in the treatment of acute folliculitis...
December 15, 2023: Skin Pharmacology and Physiology
Philip W Wertz
BACKGROUND: Linoleate-containing acylglucosylceramide (GLC-CER[EOx], where x = sphingosine (S), dihydrosphingosine (dS), phytosphingosine (P) or 6-hydroxysphingosine (H)) in the viable epidermis serve as the precursors to the linoleate-containing acylceramides (CER[EOx]) in the stratum corneum (SC) and the cornified lipid envelope (CLE), both of which are essential for the barrier function of the skin. SUMMARY: CLE formation and envelope maturation takes place across the SC...
November 30, 2023: Skin Pharmacology and Physiology
Ritamaria Di Lorenzo, Federica Forgione, Antonietta Bernardi, Antonia Sacchi, Sonia Laneri, Giovanni Greco
BACKGROUND: Curcumin is a polyphenolic compound present in turmeric (Curcuma longa). Curcumin, turmeric powder, and extracts are widely used in traditional Indian medicine and are active ingredients of dietary supplements and cosmeceutical products. The pharmacological properties of curcumin/turmeric as well as the studies performed in vitro, in animal models and in volunteers to assess its effectiveness have been the objects of a vast literature. Most of the clinical studies report on the effects of curcumin/turmeric administered orally while only a few describe its topical applications...
November 26, 2023: Skin Pharmacology and Physiology
Géraldine Aimond, Stéphane Nicolle, Romain Debret, Valérie Oréa, Audrey Josset-Lamaugarny, Jean-François Palierne, Pascal Sommer, Dominique Sigaudo-Roussel, Bérengère Fromy
INTRODUCTION: Elastic skin fibers lose their mechanical properties during aging due to enzymatic degradation, lack of maturation or post-translational modifications. Dill extract has been observed to increase elastin protein expression and maturation in a 3D skin model, to improve mechanical properties of skin, to increase elastin protein expression in vascular smooth muscle cells, to preserve aortic elastic lamella and to prevent glycation. OBJECTIVE: The aim of the study was to highlight dill actions on elastin fibers during ageing thanks to elastase digestion model and the underlying mechanism...
October 3, 2023: Skin Pharmacology and Physiology
Yves Poumay, Emilie Faway
BACKGROUND: For one half-century, cultures of human epidermal keratinocytes have opened new paths of research in skin biology and dermatology. Either performed with serum and feeder-layer, in serum-free conditions, or in autocrine conditions, cells cultured as monolayers became research materials for basic science and dermatology, as well as a source for grafting, particularly to treat severely burned patients. More recently tissue reconstruction at air-liquid interface has opened new perspectives for in vitro toxicology, studies of epidermal barrier, and modeling skin diseases...
September 16, 2023: Skin Pharmacology and Physiology
Jeffrey Rajkumar, Neha Chandan, Peter Lio, Vivian Shi
BACKGROUND: The anatomic layers of the skin are well-described; recent research into the barrier capabilities of the skin has led to the development of a functional model of the skin barrier. Moisturization has been consistently recommended for use in conditions such as atopic dermatitis, in which barrier disruption plays a key role in disease. This review aims to analyze the skin barrier in the context of this function model, with a focus on the mechanisms by which moisturizers support each of the functional layers of the skin barrier to promote homeostasis and repair...
September 15, 2023: Skin Pharmacology and Physiology
(no author information available yet)
No abstract text is available yet for this article.
August 31, 2023: Skin Pharmacology and Physiology
Tingting Zhu, Shuyun Yang, Theodora M Mauro, Mao-Qiang Man
Background Obesity is a condition defined by an excess amount of body fat, with body mass index of 30 and higher. It is associated with a number of other medical conditions, including insulin resistance, diabetes mellitus, and cardiovascular diseases, as well as dyslipidemia, and it is also associated with several cutaneous disorders such as atopic dermatitis, psoriasis, intertriginous dermatitis, acanthosis nigricans, and skin infections. Summary Evidence suggests a link between obesity and epidermal dysfunction...
August 28, 2023: Skin Pharmacology and Physiology
Stella Hofmeyer, Frank Weber, Sandra Gerds, Steffen Emmert, Alexander Thiem
INTRODUCTION: Rosacea is a common, facial, chronic inflammatory skin disease. Due to its complex pathogenesis, adequate therapy of rosacea can be challenging. An innovative recent therapeutic tool is cold atmospheric plasma (CAP), which is already established in the treatment of chronic wounds and promising in different other skin diseases. METHODS: In a split-face pilot study we investigated dielectric-barrier-discharged CAP in erythemato-telangiectatic (ETR) and/or papulopustular rosacea (PPR)...
July 25, 2023: Skin Pharmacology and Physiology
AKira Koda, Yuko Ishii, Ayu Kashiwagi, Mika Fujikawa, Keisuke Kikuchi, Ryota Hashimoto, Yuhki Ueda, Takaaki Doi
INTRODUCTION: The long-term use of topical corticosteroids (TCS) is associated with side effects such as skin atrophy and barrier deterioration. Moisturizers, such as mucopolysaccharide polysulfate (MPS), have been reported to prevent relapses in atopic dermatitis (AD) when used in combination with TCS. However, the mechanisms underlying the positive effects of MPS in combination with TCS in AD are poorly understood. In the present study, we investigated the effects of MPS in combination with clobetasol 17-propionate (CP) on tight junction (TJ) barrier function in human epidermal keratinocytes (HEKa) and 3D skin models...
March 25, 2023: Skin Pharmacology and Physiology
Joachim Fluhr, Katarina Stevanovic, Priyanka Joshi, Karl-Christian Bergmann, Leonie S Herzog, Yasmeen Alwaheed, Shirina Al Sowaidi, Torsten Zuberbier
INTRODUCTION: Along with climate changes, we see an increase in allergic symptoms and the number of pollen-allergic patients in many countries. Increased allergic symptoms are associated with an elevated ozone exposure which may be linked by impaired epithelial barrier function. This study aimed to quantify the clinical effect of ozone and pollen double exposure (DE). We tested whether ozone impairs barrier-related skin physiology and mucosal functions under double exposure with pollen ozone in grass pollen-allergic patients versus healthy controls...
March 16, 2023: Skin Pharmacology and Physiology
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