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Journals Clinical & Developmental Immun...

Clinical & Developmental Immunology

https://read.qxmd.com/read/24348675/effect-of-selective-serotonin-reuptake-inhibitors-and-immunomodulator-on-cytokines-levels-an-alternative-therapy-for-patients-with-major-depressive-disorder
#61
JOURNAL ARTICLE
María Eugenia Hernandez, Danelia Mendieta, Mayra Pérez-Tapia, Rafael Bojalil, Iris Estrada-Garcia, Sergio Estrada-Parra, Lenin Pavón
Major depressive disorder (MDD) is a psychiatric illness that presents as a deficit of serotonergic neurotransmission in the central nervous system. MDD patients also experience alterations in cortisol and cytokines levels. Treatment with selective serotonin reuptake inhibitors (SSRIs) is the first-line antidepressant regimen for MDD. The aim of this study was to determine the effect of a combination of SSRIs and an immunomodulator-human dialyzable leukocyte extract (hDLE)-on cortisol and cytokines levels. Patients received SSRIs or SSRIs plus hDLE...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348674/modulatory-effect-of-1-25-dihydroxyvitamin-d-3-on-il1-%C3%AE-induced-rankl-opg-tnf-%C3%AE-and-il-6-expression-in-human-rheumatoid-synoviocyte-mh7a
#62
JOURNAL ARTICLE
Xiaoke Feng, Chengyin Lv, Fang Wang, Ke Gan, Miaojia Zhang, Wenfeng Tan
Receptor activator of nuclear factor κ B ligand (RANKL) plays a crucial role in the bone erosion of rheumatoid arthritis (RA) by prompting osteoclastogenesis. Considering that 1,25(OH)2D3 has been suggested as a potent inducer of RANKL expression, it should clarify whether vitamin D supplement could result in RANKL overexpression and thereby facilitate excessive osteoclastogenesis and bone resorption in RA. Here, we investigated modulatory effect of 1,25(OH)2D3 on the expression of RANKL and its decoy receptor osteoprotegerin (OPG) in an inflammatory condition of human rheumatoid synoviocyte MH7A...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348673/haemophilus-parasuis-subunit-vaccines-based-on-native-proteins-with-affinity-to-porcine-transferrin-prevent-the-expression-of-proinflammatory-chemokines-and-cytokines-in-pigs
#63
JOURNAL ARTICLE
R Frandoloso, S Martínez-Martínez, E F Rodríguez-Ferri, S Yubero, D Rodríguez-Lázaro, M Hernández, C B Gutiérrez-Martín
The expression of chemokines (CCL-2 and CXCL-8) and cytokines (IL-1 α , IL-1 β , IL-6, TNF- α , and IL-10) was evaluated by RT-qPCR in colostrum-deprived pigs vaccinated and challenged with Haemophilus parasuis serovar 5. Two vaccines containing native proteins with affinity to porcine transferrin (NPAPTim and NPAPTit) were tested, along with two control groups: one inoculated with PBS instead of antigen (challenge group (CHG)), and another one nonimmunized and noninfected (blank group). The use of NPAPTim and NPAPTit resulted in complete protection against H...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24324511/design-of-peptide-immunotherapies-for-mhc-class-ii-associated-autoimmune-disorders
#64
REVIEW
Masha Fridkis-Hareli
Autoimmune disorders, that occur when autoreactive immune cells are induced to activate their responses against self-tissues, affect one percent of the world population and represent one of the top 10 leading causes of death. The major histocompatibility complex (MHC) is a principal susceptibility locus for many human autoimmune diseases, in which self-tissue antigens providing targets for pathogenic lymphocytes are bound to HLA molecules encoded by disease-associated alleles. In spite of the attempts to design strategies for inhibition of antigen presentation targeting the MHC-peptide/TCR complex via generation of blocking antibodies, altered peptide ligands (APL), or inhibitors of costimulatory molecules, potent therapies with minimal side effects have yet to be developed...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24324510/efficacy-of-abatacept-for-arthritis-in-patients-with-an-overlap-syndrome-between-rheumatoid-arthritis-and-systemic-lupus-erythematosus
#65
JOURNAL ARTICLE
Kei Ikeda, Yoshie Sanayama, Sohei Makita, Junichi Hosokawa, Mieko Yamagata, Daiki Nakagomi, Katsuhiko Takabayashi, Hiroshi Nakajima
INTRODUCTION: This study aimed to investigate the efficacy of abatacept for arthritis in patients with rhupus, an overlap syndrome between rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). METHODS: Patients who fulfilled both the 2010 ACR/EULAR criteria for RA classification and the 1997 ACR revised criteria for classification of SLE and received abatacept treatment for arthritis were retrospectively studied. RESULTS: Six rhupus patients who fulfilled the inclusion criteria above were identified...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24324509/notch-signaling-and-t-helper-cells-in-eae-ms
#66
REVIEW
Ribal Bassil, William Orent, Wassim Elyaman
The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in embryogenesis, tissue homeostasis, angiogenesis, and immunoregulation. Multiple sclerosis (MS) is an incurable yet treatable autoimmune chronic inflammatory disease of the central nervous system. The aim of this review is to provide a brief description of the Notch signaling pathway, and summarize the current literature implicating Notch in the pathogenesis of MS...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24324508/influence-of-the-cholinergic-system-on-the-immune-response-of-teleost-fishes-potential-model-in-biomedical-research
#67
REVIEW
G A Toledo-Ibarra, A E Rojas-Mayorquín, M I Girón-Pérez
Fishes are the phylogenetically oldest vertebrate group, which includes more than one-half of the vertebrates on the planet; additionally, many species have ecological and economic importance. Fish are the first evolved group of organisms with adaptive immune mechanisms; consequently, they are an important link in the evolution of the immune system, thus a potential model for understanding the mechanisms of immunoregulation. Currently, the influence of the neurotransmitter acetylcholine (ACh) on the cells of the immune system is widely studied in mammalian models, which have provided evidence on ACh production by immune cells (the noncholinergic neuronal system); however, these neuroimmunomodulation mechanisms in fish and lower vertebrates are poorly studied...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24324507/modification-of-intestinal-microbiota-and-its-consequences-for-innate-immune-response-in-the-pathogenesis-of-campylobacteriosis
#68
REVIEW
Wycliffe Omurwa Masanta, Markus M Heimesaat, Stefan Bereswill, Abdul Malik Tareen, Raimond Lugert, Uwe Groß, Andreas E Zautner
Campylobacter jejuni is the leading cause of bacterial food-borne gastroenteritis in the world, and thus one of the most important public health concerns. The initial stage in its pathogenesis after ingestion is to overcome colonization resistance that is maintained by the human intestinal microbiota. But how it overcomes colonization resistance is unknown. Recently developed humanized gnotobiotic mouse models have provided deeper insights into this initial stage and host's immune response. These studies have found that a fat-rich diet modifies the composition of the conventional intestinal microbiota by increasing the Firmicutes and Proteobacteria loads while reducing the Actinobacteria and Bacteroidetes loads creating an imbalance that exposes the intestinal epithelial cells to adherence...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24324506/role-of-toll-like-receptor-4-on-lupus-lung-injury-and-atherosclerosis-in-lps-challenge-apoe%C3%A2-%C3%A2-mice
#69
JOURNAL ARTICLE
Jing-qin Ni, Qiufang Ouyang, Ling Lin, Ziyang Huang, Huixia Lu, Xiaoqing Chen, Huili Lin, Zhenhua Wang, Dongming Xu, Yun Zhang
To investigate the pathologic mechanisms of toll-like receptor 4 (TLR4) in lung injury and atherosclerosis, ApoE⁻/⁻ or wild-type mice were intraperitoneally administered saline, lipopolysaccharides (LPS), or LPS plus TAK-242 (TLR4 inhibitor), respectively, twice a week for 4 weeks. Serum autoantibody of antinuclear antibody (ANA), anti-double-stranded DNA (anti-dsDNA), and cytokines of interferon-gamma (IFN-γ), tumor necrosis factor (TNF-α ), and interleukin-1 (IL-1β) were assessed by ELISA. Hematoxylin and eosin (HE) and Perl's stains for lung pathomorphology as well as HE staining for atherosclerosis were employed...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24324505/allergenic-characterization-of-new-mutant-forms-of-pru-p-3-as-new-immunotherapy-vaccines
#70
JOURNAL ARTICLE
C Gómez-Casado, M Garrido-Arandia, P Gamboa, N Blanca-López, G Canto, J Varela, J Cuesta-Herranz, L F Pacios, A Díaz-Perales, L Tordesillas
Nowadays, treatment of food allergy only considered the avoidance of the specific food. However, the possibility of cross-reactivity makes this practice not very effective. Immunotherapy may exhibit as a good alternative to food allergy treatment. The use of hypoallergenic molecules with reduced IgE binding capacity but with ability to stimulate the immune system is a promising tool which could be developed for immunotherapy. In this study, three mutants of Pru p 3, the principal allergen of peach, were produced based on the described mimotope and T cell epitopes, by changing the specific residues to alanine, named as Pru p 3...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24324504/mesoporous-silicon-microparticles-enhance-mhc-class-i-cross-antigen-presentation-by-human-dendritic-cells
#71
JOURNAL ARTICLE
A Jiménez-Periáñez, B Abos Gracia, J López Relaño, C M Diez-Rivero, P A Reche, E Martínez-Naves, E Matveyeva, M Gómez del Moral
The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24324503/association-of-human-leukocyte-antigen-class-i-polymorphism-with-spontaneous-clearance-of-hepatitis-b-surface-antigen-in-qidong-han-population
#72
JOURNAL ARTICLE
Fengqin Miao, Hang Sun, Ning Pan, Jinhuan Xu, Jie Qiu, Yuqing Shen, Wei Xie, Jianqiong Zhang
AIM: To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population. METHODS: We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT). All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24319469/immunological-demyelination-triggers-macrophage-microglial-cells-activation-without-inducing-astrogliosis
#73
JOURNAL ARTICLE
Frank Cloutier, Ilse Sears-Kraxberger, Krista Keachie, Hans S Keirstead
The glial scar formed by reactive astrocytes and axon growth inhibitors associated with myelin play important roles in the failure of axonal regeneration following central nervous system (CNS) injury. Our laboratory has previously demonstrated that immunological demyelination of the CNS facilitates regeneration of severed axons following spinal cord injury. In the present study, we evaluate whether immunological demyelination is accompanied with astrogliosis. We compared the astrogliosis and macrophage/microglial cell responses 7 days after either immunological demyelination or a stab injury to the dorsal funiculus...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24319468/therapeutic-potential-of-tolerogenic-dendritic-cells-in-ibd-from-animal-models-to-clinical-application
#74
REVIEW
Raquel Cabezón, Daniel Benítez-Ribas
The gut mucosa undergoes continuous antigenic exposure from food antigens, commensal flora derived ligands, and pathogens. This constant stimulation results in controlled inflammatory responses that are effectively suppressed by multiple factors. This tight regulation, necessary to maintain intestinal homeostasis, is affected during inflammatory bowel diseases (IBD) resulting in altered immune responses to harmless microorganisms. Dendritic cells (DCs) are sentinels of immunity, located in peripheral and lymphoid tissues, which are essential for homeostasis of T cell-dependent immune responses...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24319467/enumeration-and-characterization-of-human-memory-t-cells-by-enzyme-linked-immunospot-assays
#75
REVIEW
Sandra A Calarota, Fausto Baldanti
The enzyme-linked immunospot (ELISPOT) assay has advanced into a useful and widely applicable tool for the evaluation of T-cell responses in both humans and animal models of diseases and/or vaccine candidates. Using synthetic peptides (either individually or as overlapping peptide mixtures) or whole antigens, total lymphocyte or isolated T-cell subset responses can be assessed either after short-term stimulation (standard ELISPOT) or after their expansion during a 10-day culture (cultured ELISPOT). Both assays detect different antigen-specific immune responses allowing the analysis of effector memory T cells and central memory T cells...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24319466/persistent-suppression-of-type-1-diabetes-by-a-multicomponent-vaccine-containing-a-cholera-toxin-b-subunit-autoantigen-fusion-protein-and-complete-freund-s-adjuvant
#76
JOURNAL ARTICLE
Béla Dénes, István Fodor, William H R Langridge
Data presented here demonstrate multifunctional vaccination strategies that harness vaccinia virus mediated delivery of a gene encoding an immunoenhanced diabetes autoantigen in combination with complete Freund's adjuvant (CFA) that can maintain safe and durable immunologic homeostasis in NOD mice. Systemic coinoculation of prediabetic mice with recombinant vaccinia virus rVV-CTB::GAD and undiluted or 10-fold diluted CFA demonstrated a significant decrease in hyperglycemia and pancreatic islet inflammation in comparison with control animals during 17-61 and 17-105 weeks of age, respectively...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24312131/an-elucidation-of-neutrophil-functions-against-mycobacterium-tuberculosis-infection
#77
JOURNAL ARTICLE
Devin Morris, Thien Nguyen, John Kim, Christine Kassissa, Melissa Khurasany, Jennifer Luong, Sarah Kasko, Shalin Pandya, Michael Chu, Po-Ting Chi, Judy Ly, Minette Lagman, Vishwanath Venketaraman
We characterized the functions of neutrophils in response to Mycobacterium tuberculosis (M. tb) infection, with particular reference to glutathione (GSH). We examined the effects of GSH in improving the ability of neutrophils to control intracellular M. tb infection. Our findings indicate that increasing the intracellular levels of GSH with a liposomal formulation of GSH (L-GSH) resulted in reduction in the levels of free radicals and increased acidification of M. tb containing phagosomes leading to the inhibition in the growth of M...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24312130/combination-of-human-leukocyte-antigen-and-killer-cell-immunoglobulin-like-receptor-genetic-background-influences-the-onset-age-of-hepatocellular-carcinoma-in-male-patients-with-hepatitis-b-virus-infection
#78
JOURNAL ARTICLE
Ning Pan, Jie Qiu, Hang Sun, Fengqin Miao, Qian Shi, Jinhuan Xu, Wei Jiang, Hui Jin, Wei Xie, Youji He, Jianqiong Zhang
To investigate whether killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) genetic background could influence the onset age of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection, one hundred and seventy-one males with HBV-related HCC were enrolled. The presence of 12 loci of KIR was detected individually. HLA-A, -B, and -C loci were genotyped with high resolution by a routine sequence-based typing method. The effect of each KIR locus, HLA ligand, and HLA-KIR combination was examined individually by Kaplan-Meier (KM) analysis...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24307909/liver-transplant-tolerance-and-its-application-to-the-clinic-can-we-exploit-the-high-dose-effect
#79
REVIEW
Eithne C Cunningham, Alexandra F Sharland, G Alex Bishop
The tolerogenic properties of the liver have long been recognised, especially in regard to transplantation. Spontaneous acceptance of liver grafts occurs in a number of experimental models and also in a proportion of clinical transplant recipients. Liver graft acceptance results from donor antigen-specific tolerance, demonstrated by the extension of tolerance to other grafts of donor origin. A number of factors have been proposed to be involved in liver transplant tolerance induction, including the release of soluble major histocompatibility (MHC) molecules from the liver, its complement of immunosuppressive donor leucocytes, and the ability of hepatocytes to directly interact with and destroy antigen-specific T cells...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24302959/lipoic-acid-treatment-after-brain-injury-study-of-the-glial-reaction
#80
JOURNAL ARTICLE
Brenda Rocamonde, Sara Paradells, Carlos Barcia, Angeles Garcia Esparza, José Miguel Soria
After trauma brain injury, oxidative substances released to the medium provoke an enlargement of the initial lesion, increasing glial cell activation and, occasionally, an influx of immune cells into the central nervous system, developing the secondary damage. In response to these stimuli, microglia are activated to perform upregulation of intracellular enzymes and cell surface markers to propagate the immune response and phagocytosis of cellular debris. The phagocytosis of debris and dead cells is essential to limit the inflammatory reaction and potentially prevent extension of the damage to noninjured regions...
2013: Clinical & Developmental Immunology
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