journal
Journals Clinical & Developmental Immun...

Clinical & Developmental Immunology

https://read.qxmd.com/read/24369474/the-expression-of-netrin-1-in-the-thymus-and-its-effects-on-thymocyte-adhesion-and-migration
#41
JOURNAL ARTICLE
Xiao-Kai Guo, Yuan-Feng Liu, Yu Zhou, Xiu-Yuan Sun, Xiao-Ping Qian, Yu Zhang, Jun Zhang
Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still unknown. Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24368924/an-imbalance-between-frequency-of-cd4-cd25-foxp3-regulatory-t-cells-and-ccr4-and-ccr9-circulating-helper-t-cells-is-associated-with-active-perennial-allergic-conjunctivitis
#42
JOURNAL ARTICLE
J Galicia-Carreón, C Santacruz, J Ayala-Balboa, A Robles-Contreras, S M Perez-Tapia, Y Garfias, E Hong, M C Jiménez-Martínez
Allergic conjunctivitis (AC) is one of the most common eye disorders in ophthalmology. In mice models, it has been suggested that control of allergic conjunctivitis is a delicate balance between Tregs and inflammatory migrating effector cells. Our aim was to evaluate the frequency of Tregs and the frequency of homing receptors expressing cells in peripheral blood mononuclear cells (PBMC) from patients with perennial allergic conjunctivitis (PAC). The analyses of phenotypic markers on CD4+ T cells and both soluble or intracellular cytokines were performed by flow cytometry...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24367384/sleep-loss-as-a-factor-to-induce-cellular-and-molecular-inflammatory-variations
#43
REVIEW
Gabriela Hurtado-Alvarado, Lenin Pavón, Stephanie Ariadne Castillo-García, María Eugenia Hernández, Emilio Domínguez-Salazar, Javier Velázquez-Moctezuma, Beatriz Gómez-González
A reduction in the amount of time spent sleeping occurs chronically in modern society. Clinical and experimental studies in humans and animal models have shown that immune function is impaired when sleep loss is experienced. Sleep loss exerts a strong regulatory influence on peripheral levels of inflammatory mediators of the immune response. An increasing number of research projects support the existence of reciprocal regulation between sleep and low-intensity inflammatory response. Recent studies show that sleep deficient humans and rodents exhibit a proinflammatory component; therefore, sleep loss is considered as a risk factor for developing cardiovascular, metabolic, and neurodegenerative diseases (e...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24367383/evidence-of-stage-and-age-related-heterogeneity-of-non-hla-snps-and-risk-of-islet-autoimmunity-and-type-1-diabetes-the-diabetes-autoimmunity-study-in-the-young
#44
JOURNAL ARTICLE
Brittni N Frederiksen, Andrea K Steck, Miranda Kroehl, Molly M Lamb, Randall Wong, Marian Rewers, Jill M Norris
Previously, we examined 20 non-HLA SNPs for association with islet autoimmunity (IA) and/or progression to type 1 diabetes (T1D). Our objective was to investigate fourteen additional non-HLA T1D candidate SNPs for stage- and age-related heterogeneity in the etiology of T1D. Of 1634 non-Hispanic white DAISY children genotyped, 132 developed IA (positive for GAD, insulin, or IA-2 autoantibodies at two or more consecutive visits); 50 IA positive children progressed to T1D. Cox regression was used to analyze risk of IA and progression to T1D in IA positive children...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24363764/t-cell-vaccination-inhibits-th1-th17-tfh-frequencies-and-production-of-autoantibodies-in-collagen-induced-arthritis
#45
JOURNAL ARTICLE
Shan Li, Xiaoyin Niu, Yebin Xi, Shaohua Deng, Chengzhen Li, Qing Zhao, Guangjie Chen
The aim of this study is to determine whether the regulatory role of T cell vaccination (TCV) is through inhibition of Th1/Th17/Tfh and production of autoantibodies on collagen-induced arthritis (CIA). First, CIA mice were treated with TCV. After disease onset, the incidence and severity of change in joint histopathology were evaluated. Mice in the TCV-treated group showed less disease severity and less infiltration of inflammatory cells in the joint sections. TCV decreased the frequencies of Th1/Th17/Tfh cells and related cytokines...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24363762/stimulation-of-tlr4-by-lmw-ha-induces-metastasis-in-human-papillary-thyroid-carcinoma-through-cxcr7
#46
JOURNAL ARTICLE
Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu
In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower molecular weight hyaluronan fragments (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains to be elucidated. In this study, we found that receptor of LMW-HA, TLR4, was aberrantly overexpressed in PTC tissues and cell line W3. Exposure of W3 cells to LMW-HA promoted cell proliferation and migration via TLR4. Knockdown of TLR4 has provided evidence that TLR4 is essential for LMW-HA-induced CXCR7 expression, which is responsible for LMW-HA-induced proliferation and migration of W3 cells...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24363761/effects-of-rapamycin-combined-with-low-dose-prednisone-in-patients-with-chronic-immune-thrombocytopenia
#47
RANDOMIZED CONTROLLED TRIAL
Jiaming Li, Zhaoyue Wang, Lan Dai, Lijuan Cao, Jian Su, Mingqing Zhu, Ziqiang Yu, Xia Bai, Changgeng Ruan
We conducted this randomized trial to investigate the efficacy and safety of rapamycin treatment in adults with chronic immune thrombocytopenia (ITP). Eighty-eight patients were separated into the control (cyclosporine A plus prednisone) and experimental (rapamycin plus prednisone) groups. The CD4⁺CD25⁺CD127(low) regulatory T (Treg) cells level, Foxp3 mRNA expression, and the relevant cytokines levels were measured before and after treatment. The overall response (OR) was similar in both groups (experimental group versus control group: 58% versus 62%, P = 0...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24363760/the-effect-of-perioperative-immunonutrition-on-the-phagocytic-activity-of-blood-platelets-in-advanced-gastric-cancer-patients
#48
JOURNAL ARTICLE
Zbigniew Kamocki, Joanna Matowicka-Karna, Mariusz Gryko, Konrad Zareba, Boguslaw Kedra, Halina Kemona
BACKGROUND AND AIMS: Perioperative immunonutrition can influence the phagocytic activity of platelets in advanced gastric cancer. METHODS: 51 patients with stage IV gastric cancer divided into four groups depending on the clinical status and 40 normal donors were analyzed. Patients of groups I and II underwent palliative gastrectomy. Patients of groups III and IV had exploratory laparotomy. Perioperative immunonutrition was administered as follows: group I--TPN, II--oral arginine, peripheral TPN, III--TPN preoperatively, and IV--without nutrition...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24363759/helicobacter-pylori-infection-and-light-chain-gammopathy
#49
JOURNAL ARTICLE
José A Girón, Shawn L Shah
OBJECTIVE: Helicobacter pylori provokes a host of immune alterations upon colonizing the gastric mucosa. DESIGN: We report 22 individuals with confirmed Helicobacter pylori infection who were also managed for the concurrent elevation of immunoglobulin free light chain (kappa and lambda) levels. RESULT: Of the 22 patients, 15 patients (68.2%) had elevated free light chain levels: 6 patients (40%) had only kappa chain elevation, 2 patients (13...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24363758/potential-survival-benefit-of-anti-apoptosis-protein-survivin-derived-peptide-vaccine-with-and-without-interferon-alpha-therapy-for-patients-with-advanced-or-recurrent-urothelial-cancer-results-from-phase-i-clinical-trials
#50
JOURNAL ARTICLE
Toshiaki Tanaka, Hiroshi Kitamura, Ryuta Inoue, Sachiyo Nishida, Akari Takahashi-Takaya, Sachiyo Kawami, Toshihiko Torigoe, Yoshihiko Hirohashi, Taiji Tsukamoto, Noriyuki Sato, Naoya Masumori
We previously identified a human leukocyte antigen (HLA)-A24-restricted antigenic peptide, survivin-2B80-88, a member of the inhibitor of apoptosis protein family, recognized by CD8+cytotoxic T lymphocytes (CTL). In a phase I clinical trial of survivin-2B80-88 vaccination for metastatic urothelial cancer (MUC), we achieved clinical and immunological responses with safety. Moreover, our previous study indicated that interferon alpha (IFN α ) enhanced the effects of the vaccine for colorectal cancer. Therefore, we started a new phase I clinical trial of survivin-2B80-88 vaccination with IFN α for MUC patients...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24363757/epidemiology-of-human-respiratory-viruses-in-children-with-acute-respiratory-tract-infections-in-jinan-china
#51
JOURNAL ARTICLE
Yanqin Lu, Shifu Wang, Lehai Zhang, Chao Xu, Cuirong Bian, Zhaoxia Wang, Yanhui Ma, Ke Wang, Lixia Ma, Chen Meng, Caiyun Ni, Jiabei Tong, Gongchao Li, Jinxiang Han
The viral etiologies of UTRIs and LTRIs in children in Jinan city were investigated between July 2009 and June 2010. Nasal and throat swabs were collected from 397 children with URTIs and bronchoalveolar lavage fluid specimens were collected from 323 children with LRTIs. RT-PCR/PCR was used to examine all samples for IFV, PIV, RSV, RV, hMPV, HBoV, CoV, ADV, RSV, and EV. Viral pathogens were detected in 47.10% of URTI samples and 66.57% samples, and the incidence of viral coinfection was 5.29% and 21.05%, respectively...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348684/tumor-protective-activity-of-cd4-but-not-of-cd8-t-cells-in-dna-vaccinated-mice-challenged-with-bcr-abl-transformed-cells
#52
JOURNAL ARTICLE
Martina Petráčková, Vincent Lučanský, Vladimír Vonka
In the recent past, it has repeatedly been reported that CD4 cells play an important role in the immunology of chronic myeloid leukaemia. It was therefore of interest to test their activity in an animal model using bcr-abl-transformed cells. BALB/c mice were four times immunized with a DNA vaccine carrying the bcr-abl fusion gene. Two weeks after the last vaccine dose, the animals were challenged with syngeneic bcr-abl-transformed 12B1 cells which form solid tumors after subcutaneous administration. At the time of challenge, animals were treated with antibodies against the CD8+ T cells or CD4+ T cells...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348683/incidence-and-clinical-significance-of-de-novo-donor-specific-antibodies-after-kidney-transplantation
#53
REVIEW
Sophia Lionaki, Konstantinos Panagiotellis, Aliki Iniotaki, John N Boletis
Kidney transplantation has evolved over more than half a century and remarkable progress has been made in patient and graft outcomes. Despite these advances, chronic allograft dysfunction remains a major problem. Among other reasons, de novo formation of antibodies against donor human leukocyte antigens has been recognized as one of the major risk factors for reduced allograft survival. The type of treatment in the presence of donor specific antibodies (DSA) posttransplantation is largely related to the clinical syndrome the patient presents with at the time of detection...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348682/apache-iv-is-superior-to-meld-scoring-system-in-predicting-prognosis-in-patients-after-orthotopic-liver-transplantation
#54
JOURNAL ARTICLE
Yueyun Hu, Xianling Zhang, Yuan Liu, Jun Yan, Tiehua Li, Ailing Hu
This study aims to compare the efficiency of APACHE IV with that of MELD scoring system for prediction of the risk of mortality risk after orthotopic liver transplantation (OLT). A retrospective cohort study was performed based on a total of 195 patients admitted to the ICU after orthotopic liver transplantation (OLT) between February 2006 and July 2009 in Guangzhou, China. APACHE IV and MELD scoring systems were used to predict the postoperative mortality after OLT. The area under the receiver operating characteristic curve (AUC) and the Hosmer-Lemeshow C statistic were used to assess the discrimination and calibration of APACHE IV and MELD, respectively...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348681/potential-immune-modularly-role-of-glycine-in-oral-gingival-inflammation
#55
JOURNAL ARTICLE
Teresa Schaumann, Dominik Kraus, Jochen Winter, Michael Wolf, James Deschner, Andreas Jäger
Gingival epithelial cells (GECs) represent a physical barrier against bacteria and are involved in the processes of innate immunity. Recently, an anti-inflammatory and immune-modulatory effect of the amino acid glycine has been demonstrated. However, there is only little information about the immune-modulatory effects of glycine in oral tissues. This study aimed to investigate the existence and role of the glycine receptor in gingival tissue analyzing tissues/cells from extracted human molars via immunohistochemical analysis...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348680/interferon-alpha-association-with-neuromyelitis-optica
#56
JOURNAL ARTICLE
Nasrin Asgari, Anne Voss, Troels Steenstrup, Kirsten Ohm Kyvik, Egon Stenager, Soeren Thue Lillevang
Interferon-alpha (IFN- α ) has immunoregulatory functions in autoimmune inflammatory diseases. The goal of this study was to determine occurrence and clinical consequences of IFN- α in neuromyelitis optica (NMO) patients. Thirty-six NMO and 41 multiple sclerosis (MS) patients from a population-based retrospective case series were included. Expanded Disability Status Scale (EDSS) score and MRI findings determined disease activity. Linear regression was used to assess the effects of the level of IFN- α on disability (EDSS)...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348679/impaired-lymphocyte-profile-in-schistosomiasis-patients-with-periportal-fibrosis
#57
JOURNAL ARTICLE
Luciana Santos Cardoso, Andréia de Souza Rocha Barreto, Jamille Souza Fernandes, Ricardo Riccio Oliveira, Robson da Paixão de Souza, Edgar M Carvalho, Maria Ilma Araujo
The Th2 immune response in chronic schistosomiasis is associated with the development of periportal fibrosis. However, little is known about the phenotype and activation status of T cells in the process. Objective. To evaluate the profile of T cells in schistosomiasis patients with periportal fibrosis. Methods. It was a cross-sectional study, conducted in the village of Agua Preta, Bahia, Brazil, which included 37 subjects with periportal fibrosis determined by ultrasound. Peripheral blood mononuclear cells were obtained by the Ficcol-hypaque gradient and the frequency of T cells expressing the surface markers CD28, CD69, CD25, and CTLA-4 was determined by flow cytometry...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348678/modulation-of-lps-induced-cd4-t-cell-activation-and-apoptosis-by-antioxidants-in-untreated-asymptomatic-hiv-infected-participants-an-in-vitro-study
#58
JOURNAL ARTICLE
S Mburu, J L Marnewick, A Abayomi, H Ipp
Persistent immune activation characterises HIV infection and is associated with depletion of CD4+ T-cells and increased risk of disease progression. Early loss of gut mucosal integrity results in the translocation of microbial products such as lipopolysaccharide (LPS) into the systemic circulation. This is an important source of on-going immune stimulation. The purpose of this study was to determine levels of CD4+ T-cell activation (%CD25 expression) and apoptosis (% annexin V/7-AAD) in asymptomatic, untreated HIV infection at baseline and after stimulation with LPS and incubation with or without vitamin C and N-acetylcysteine...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348677/selection-of-conserved-epitopes-from-hepatitis-c-virus-for-pan-populational-stimulation-of-t-cell-responses
#59
JOURNAL ARTICLE
Magdalena Molero-Abraham, Esther M Lafuente, Darren R Flower, Pedro A Reche
The hepatitis C virus (HCV) is able to persist as a chronic infection, which can lead to cirrhosis and liver cancer. There is evidence that clearance of HCV is linked to strong responses by CD8 cytotoxic T lymphocytes (CTLs), suggesting that eliciting CTL responses against HCV through an epitope-based vaccine could prove an effective means of immunization. However, HCV genomic plasticity as well as the polymorphisms of HLA I molecules restricting CD8 T-cell responses challenges the selection of epitopes for a widely protective vaccine...
2013: Clinical & Developmental Immunology
https://read.qxmd.com/read/24348676/decreased-cd127-expression-on-cd4-t-cells-and-elevated-frequencies-of-cd4-cd25-cd127-t-cells-in-children-with-long-lasting-type-1-diabetes
#60
JOURNAL ARTICLE
Marcin Moniuszko, Barbara Glowinska-Olszewska, Malgorzata Rusak, Marta Jeznach, Kamil Grubczak, Danuta Lipinska, Robert Milewski, Anna Justyna Milewska, Milena Dabrowska, Ewa Jablonska, Adam Kretowski, Maria Gorska, Anna Bodzenta-Lukaszyk, Artur Bossowski
Pathobiology of type 1 diabetes (T1D) is predominantly associated with T-cell-related actions. Homeostasis of majority of T-cells is critically dependent on signals mediated by CD127 (interleukin-7 receptor, IL-7R). In contrast, regulatory T-cells express very little CD127 and thereby may be delineated by CD4+CD25+CD127- phenotype. Here we aimed to analyze CD127 expression on CD4+ and CD8+ T-cells and enumerate CD4+CD25+CD127- T-cells in long-lasting T1D. T-cells were analyzed by flow cytometry and immunologic data were correlated with vascular, metabolic, and inflammatory parameters...
2013: Clinical & Developmental Immunology
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