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Chinese Journal of Integrative Medicine

Fu-Ming Yang, Lin Yao, Shen-Jun Wang, Yi Guo, Zhi-Fang Xu, Chien-Hung Zhang, Kuo Zhang, Yu-Xin Fang, Yang-Yang Liu
The scientific evidence of acupuncture studies has been improved in recent years, and one of the important manifestations is that more and more acupuncture clinical trials and mechanism researches have been published in the source periodicals of Science Citation Index (SCI). This study summarized the dominant diseases of acupuncture focusing on of acupuncture efficacy and mechanisms, and discussed the existing problems, highlighting the direction of future developments. Most clinical studies were published in journals with journal impact factor (JIF) score of 10 or above, and majority of the basic researches had JIF scores of 5 to 10...
February 1, 2019: Chinese Journal of Integrative Medicine
Ming-Tai Chen, Ruo-Lan Huang, Li-Jun Ou, Ying-Nan Chen, Ling Men, Xiao Chang, Ling Wang, Yu-Zhu Yang, Zhong Zhang
OBJECTIVE: To test the hypothesis that the inhibition of endoplasmic reticulum (ER) stress-induced apoptosis in oxidized low-density lipoproteins (ox-LDL)-induced human aortic-vascular smooth muscle cells (HA-VSMCs) was associated with suppression of the protein kinase RNA-like ER kinase (PERK)-eukaryotic translation initiation factor 2α (eIF2α)-activating transcription factor 4 (ATF4)-CCAAT/enhancer binding protein homologous protein (CHOP) signaling pathway by Pollen Typhae total flavone (PTF)...
February 1, 2019: Chinese Journal of Integrative Medicine
Li Su, Miao-Miao Wang, Meng-Ran Xu, Xiao Wang, Hong-Zhen Xia, Mei Zhang, Lei Zheng, Yao-Dong Zhu, Ming-Qi Wang, Ping Li
No abstract text is available yet for this article.
February 1, 2019: Chinese Journal of Integrative Medicine
Hai-Yong Chen, Nong-Yu Liu
OBJECTIVE: To investigate the immediate analgesic effect of sinew acupuncture for patients with soft-tissue injuries (STIs). METHODS: Two hundreds eligible adult patients suffering from STIs were recruited and received sinew acupuncture with flexible treatment schedules. The number of treatment sessions was pragmatically decided by each patient on the basis of their pain relief. The outcome measurement was the change of pain rating in the Visual Analogue Scale (VAS) during the first 5 sessions...
January 18, 2019: Chinese Journal of Integrative Medicine
Xiang Wang, Yan-Gang Wang
Gout is a crystal-related arthropathy resulting from the deposition of monosodium urate. Identifying appropriate treatments and novel drugs to decrease serum uric acid (SUA) levels and gout risk has been a major focus. By performing extensive literature review on the pathogenesis and Chinese and Western medicine treatment of gout, this paper aimed to identify novel targets for effective control of acute gout attacks and long-term reduction of SUA. In addition, we aimed to provide new directions for the improvement of therapeutic measures and the development of drugs...
January 18, 2019: Chinese Journal of Integrative Medicine
Guang-Wen Wu, Jun Chen, Yun-Mei Huang, Cai-Bin Pan, Wen-Lie Chen, Shi-Mao Zhang, Wei Lin, Xian-Xiang Liu, Ming-Xia Wu
OBJECTIVE: To illustrate the molecular mechanisms underlying the therapeutic effects of electroacupuncture (EA) on knee osteoarthritis (OA). METHODS: Twenty-seven six-month-old New Zealand white rabbits were allocated into three groups in accordance with a random number table: normal group (no surgery-induced OA; without treatment), model group (surgery-induced OA; without treatment) and EA group [surgery-induced OA; received treatment with EA at acupoints Dubi (ST 35) and Neixiyan (EX-LE 5), 30 min twice a day]...
January 17, 2019: Chinese Journal of Integrative Medicine
Chan Jiang, Xi Wang, Song Dang, Xin Wang, Qing Deng, Juan Hu, Cong-Xin Huang
OBJECTIVE: To investigate the effect of Chinese compound Shensong Yangxin Capsule ( , SSYX) on myocardial microcirculation in myocardial-infarcted rabbits. METHODS: Myocardial infarction (MI) was established in rabbits by ligation of the left circumflfl ex coronary. Thirty rabbits were randomly divided into the control group, the MI group (model), and the MI treated with SSYX group (MI+SSYX) by a random number table method. After 4 weeks of administration, low-energy real-time myocardial contrast echocardiography (RT-MCE) was conducted to assess the microcirculatory perfusion...
January 9, 2019: Chinese Journal of Integrative Medicine
Qian Zhang, Xiao-Chun Liang
Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of peripheral nervous system with high energy requirement. The adenosine monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) axis plays a key role in regulating mitochondrial energy metabolism. Increasing preclinical evidences have shown that inhibition of AMPK/PGC-1α pathway leading to mitochondrial dysfunction in neurons or Schwann cells contributes to neuron apoptosis, distal axonopathy and nerve demyelination in DPN...
January 9, 2019: Chinese Journal of Integrative Medicine
Liang Wang, Hui Shi, Jin-Ling Huang, Shan Xu, Pei-Pei Liu
OBJECTIVE: To investigate the inhibitory effect of Linggui Zhugan Decoction (LZD, ) on the ventricular remodeling (VR) after acute myocardial infarction (AMI) and related mRNA and proteins expression in transforming growth factor-beta 1 (TGF-β1 )/Smad signaling pathway, and explain its putative mechanism. METHODS: A VR model was generated by ligation of coronary artery in mice. Two weeks after surgery, 60 mice were randomly divided into the model group, the sham-operation group (distilled water), the positive control group (2...
January 9, 2019: Chinese Journal of Integrative Medicine
Shuai Yan, Yin-Zi Yue, Yang Zong, Li Zeng
Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine (TMP), one of the most widely used medicinal compound isolated from traditional Chinese herb, is usually employed for anti-oxidation, anti-inflammation, anti-platelet aggregation, anti-lipid, anti-fibrosis, as well as activating blood, removing stasis, dilating small arteries, improving microcirculation and antagonizing calcium. In the present paper, the anti-adhesion effect of TMP were reviewed...
January 9, 2019: Chinese Journal of Integrative Medicine
Bao-Fang Jin, Wen-Tao Yang, Da-Lin Sun, Hong-Jun Li
The development of Chinese medicine and Western medicine andrology is based on different social background and academic systems, either Chinese medicine or Western medicine andrology has their limitations, therefore, integration of Chinese and Western medicine (ICWM) andrology is in a great need. After more than 30 years of development, andrology has made great achievements in the construction of specialized academic association, holding academic conferences and publication of academic monographs, and the research progress on this field is mainly in the combination of disease and syndrome, microdifferentiation of symptoms and signs and basic research development...
January 9, 2019: Chinese Journal of Integrative Medicine
Xiao Kang, Hua-Jun Zhou, Jian Yang, Jian-Hua Zhong, Tao Tang, Han-Jin Cui Cui, Jing-Hua Zhou, Zhi-Gang Mei
OBJECTIVE: To evaluate the effect of Buyang Huanwu Decoction (, BYHWD) on glial scar after intracerebral hemorrhage (ICH) and investigate the underlying mechanism. METHODS: Collagenase type VII (0.5 U) was injected stereotaxically into right globus pallidus to induce ICH model. One hundred and twenty Sprague-Dawley rats were randomly divided into 3 groups according to a random number table, including normal group (n=40), ICH model group (n=40) and BYHWD group (n=40), respectively...
December 28, 2018: Chinese Journal of Integrative Medicine
Tian-Wei Cui, Mao Qin, Bao-Xing Liu, Yun-Xiao Gao, Wen-Jing Ma, Xiu-Ping Zhang
OBJECTIVE: To assess the effect of electroacupuncture (EA) on expression of cytoskeletal proteins from Sertoli cells (SCs) and spermatogenesis in rats with oligozoospermia of insufficiency of Shen (Kidney) essence syndrome (OIKES). METHODS: Twenty healthy male Sprague-Dawley rats were randomly assigned to four groups using a random number table: control, tripterygium glycosides (TG) treatment, sham and EA groups (n=5 in each group). A rat model of OIKES was established by oral gavage with TG...
December 28, 2018: Chinese Journal of Integrative Medicine
Wen-Xiu Xin, Qing-Lin Li, Luo Fang, Li-Ke Zhong, Xiao-Wei Zheng, Ping Huang
OBJECTIVE: To observe the effect and molecular mechanism of ethyl acetate extract of Sceptridium ternatum (STE) on the monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). METHODS: The main chemical components of Sceptridium ternatum were determined, and the effects in PAH rats were observed. A total of 140 Sprague Dawley rats were randomly and equally divided into the normal group, the model group, the Bosentan group, and the STE groups (2.5, 5, 10 g/kg) by the random number table method...
December 28, 2018: Chinese Journal of Integrative Medicine
Ming Jin, Chang-Jiang Xue, Yu Wang, Fang Dong, Yuan-Yuan Peng, Ya-Dan Zhang, Bao-Xia Zang, Li Tan
OBJECTIVE: To investigate the attenuating effect of Hydroxysafflor yellow A (HSYA) on inflammatory injury in chronic obstructive pulmonary disease (COPD). METHODS: Rats were randomly assigned to 7 groups according to body weight including normal control group, HSYA blank group (76.8 mg/kg), COPD group, COPD+HSYA (30, 48, 76.8 mg/kg) groups and COPD+dexamethasone (2 mg/kg), 10 in each group. Passive cigarette smoke and intratracheal instillation of lipopolysaccharides were used to establish a COPD model in rats...
December 27, 2018: Chinese Journal of Integrative Medicine
Susana Seca, Diana Miranda, Daniela Cardoso, Bernice Nogueira, Henry J Greten, António Cabrita, Manuel Alves Rodrigues
OBJECTIVE: To identify and synthesize the most recent available evidence of effectiveness of acupuncture on pain, physical function and health-related quality of life (HRQoL) in patients with rheumatoid arthritis (RA). METHODS: A comprehensive search of 12 Western and Chinese databases was undertaken from their inception up to end of 2016. Randomized controlled trials (RCTs), concerning patients with RA treated with needle acupuncture, written in English, Portuguese, German or Chinese were included...
December 19, 2018: Chinese Journal of Integrative Medicine
Feng Hu, Yu Yan, Chu-Wang Wang, Yu Liu, Jing-Jing Wang, Fang Zhou, Qing-Hai Zeng, Xiao Zhou, Jia Chen, Ai-Jun Wang, Jian-da Zhou
OBJECTIVE: To investigate the effects of Ganoderma lucidum polysaccharides (GL-PS) on human fifi broblasts and skin wound healing in Kunming male mice and to explore the putative molecular mechanism. METHODS: Primary human skin fifi broblasts were cultured. The viability of fifi broblasts treated with 0, 10, 20, 40, 80, and 160 μg/mL of GL-PS, respectively were detected by 3-4,5-dimethyl-2-thiazolyl-2,5-diphenyl-2-Htetrazolium bromide (MTT). The migration ability of fifi broblasts treated with 0, 10, 20, and 40 μg/mL of GL-PS were measured by transwell assay...
December 15, 2018: Chinese Journal of Integrative Medicine
Song-Zi Wang, Min Wu, Ke-Ji Chen, Yue Liu, Jing Sun, Zhuo Sun, He Ma, Long-Tao Liu
OBJECTIVE: To determine the effects of hawthorn extract on serum lipid levels, pathological changes in aortic atherosclerosis plaque, inflammatory factors, and apoptosis-related protein and mRNA expression in apolipoprotein E gene knockout (ApoE-/- ) mice. METHODS: Thirty-six ApoE-/- mice were fed with a high-fat diet starting at the age of 8 weeks. Mice were randomly divided into 3 groups by a random number table including model group, hawthorn extract group, and simvastatin group, 12 mice in each group...
December 5, 2018: Chinese Journal of Integrative Medicine
Ming Dong, Wen-Qian Wang, Juan Chen, Mi-Hui Li, Fei Xu, Jie Cui, Jing-Cheng Dong, Ying Wei
OBJECTIVE: To evaluate the involvement of different CD4+ T cell subtypes in the anti-asthmatic effects of acupuncture in asthmatic mice. METHODS: BALB/c mice were challenged by ovalbumin (OVA) for the establishment of experimental asthma model. Mice were divided into 4 groups by a random number table including the normal control, asthma model, acupuncture and sham acupuncture groups (14 per group). Acupoints Dazhui (GV 14), bilateral Fengmen (BL 12) and Feishu (BL 13) were selected for manual acupuncture treatment every other day for 4 weeks and Huantiao (GB 30) was selected for sham acupuncture...
December 5, 2018: Chinese Journal of Integrative Medicine
Guo-Hua Zheng, Xin Zheng, Jun-Zhe Li, Ting-Jin Duan, Jing Tao, Li-Dian Chen
OBJECTIVE: To evaluate the effect of tai chi exercise on cardiac and static lung function for older community-dwelling adults at risk of ischemic stroke. METHODS: A total of 170 older community-dwelling adults (aged 55-75 years old) at risk of ischemic stroke were allocated to either tai chi training group (85 cases, five 60-min sessions of tai chi training per week for 12 weeks) or control group (85 cases, usual pbysical activity for 12 weeks) using a computer-generated randomization...
December 5, 2018: Chinese Journal of Integrative Medicine
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