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Journal of Applied Biomaterials & Biomechanics: JABB

María Dolores Paz, J Iñaki Álava, Leire Goikoetxea, Stefano Chiussi, Idoia Díaz-Güemes, Jesus Usón, Francisco Sánchez, Betty León
PURPOSE: To assess both the in vitro and in vivo biological response of a laser modified surface in an integrated manner. A combined innovative approach applies lasers to macrostructure as well as to oxidize the surface of titanium alloy implants. MATERIALS AND METHODS: A Nd:YAG marking and ArF excimer lasers were used for macrostructuring and UV-oxidizing the surface of Ti6Al4V discs, respectively. Human fetal osteoblastic cell culture and a sheep tibia model were used to assess the cell response and the osseogeneration capability of as-machined, laser macrostructured and laser macrostructured and oxidized surfaces...
September 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Gabriele Candiani, Barbara Del Curto, Chiara Malloggi, Alberto Cigada
PURPOSE: Since bacterial pollution is more troublesome than other nonbiologic air pollutants, the need to control airborne micro-organisms has led to renewed interest in filter media for air filtration in indoor environments. Although mechanical filtration of aerosols by HEPA systems is the most common method for particle removal, these filters characterized by high efficiency usually reveal a higher drop in pressure and noise and are very expensive. On this basis, we aimed to develop novel, very effective air filters for removal of airborne bacteria from confined environments...
September 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Davide Carnelli, Tomaso Villa, Dario Gastaldi, Giancarlo Pennati
PURPOSE: Experimental tests have played a major role in the assessment of fatigue endurance of orthopedic prostheses; however, cyclic tests on devices entail high costs. Here, a multiaxial fatigue criterion coupled with computational simulations and material properties measurements has been employed to predict fatigue life of the tibial component of a polymeric PMMA spacer. The ultimate aim is to obtain valid information on fatigue behavior avoiding fatigue tests on the device. METHODS: First, an accurate measurement of the static and fatigue properties of PMMA samples is performed...
September 2011: Journal of Applied Biomaterials & Biomechanics: JABB
James Chapman, Fiona Regan
AIM: In this work, we report the use of plasticized poly vinylchloride (PVC) as a potential antifouling coating material. The materials contain a variety of sebacic and succinic acid-derived plasticisers providing a variation in molecular shape and structure; diethyl succinate (DESn), di-(2-ethylhexyl sebacate) (DEHS), dibutyl sebacate (DBS), and diethyl sebacate (DES). Each plasticiser from the sebacate group possessed the same basic C10H16O4 moiety with varied dialkyl terminated groups, affording a different range of homologous series plasticisers...
September 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Serena Bertoldi, Silvia Farè, Maria Cristina Tanzi
A complete morphologic characterization of porous scaffolds for tissue engineering application is fundamental, as the architectural parameters, in particular porosity, strongly affect the mechanical and biological performance of the structures. Therefore, appropriate techniques for this purpose need to be selected. Several techniques for the assessment of scaffold porosity have been proposed, including Scanning Electron Microscopy observation, mercury and liquid extrusion porosimetry, gas pycnometry, and capillary flow porometry...
September 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Abdelwahed Barkaoui, Ridha Hambli
PURPOSE: The aim of this work is to develop a 3D finite elements model to study the nanomechanical behavior of mineralized collagen microfibrils, which consists of three phases, (i) collagen phase formed by five tropocollagen (TC) molecules linked together with cross-links, (ii) a mineral phase (Hydroxyapatite), and (iii) impure mineral phase, and to investigate the important role of individual properties of every constituent. METHODS: The mechanical and geometric properties (TC molecule diameter) of both tropocollagen and mineral were taken into consideration as well as cross-links, which was represented by spring elements with adjusted properties based on experimental data...
September 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Elisa Battistella, Elena Varoni, Andrea Cochis, Barbara Palazzo, Lia Rimondini
The use of biomaterials in dentistry is more widespread than in any other medical field in terms of both amount and variety. Most of them were not originally designed for dental applications but for other medical applications or, sometimes, for no medical purposes. Among these materials, biodegradable materials play an important role, especially in bone regeneration and in periodontal surgery. This paper briefly reviews some degradable polymers developed as tools for the treatment of periodontal and bone diseases...
September 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Li Xiao, Guixue Wang, Tao Jiang, Chaojun Tang, Xue Wu, Tin Sun
PURPOSE: The aim of this study was to screen specific adherent matrix for endothelial progenitor cells (EPCs), which can be used for antibody capturing stents. METHODS: In this study, the adhesion of EPCs on different matrices containing three different antibodies, VEGFR-2, CD34, CD133, was observed under shear stress in a flow chamber. Nitric oxide (NO) release, cell proliferation and the retention rate of EPCs, were measured separately. RESULTS: The results demonstrated that shear stress within a certain range can promote proliferation and NO secretion of EPCs...
September 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Antonio Gloria, Dante Ronca, Teresa Russo, Ugo D'Amora, Marianna Chierchia, Roberto De Santis, Luigi Nicolais, Luigi Ambrosio
Polymer-based composite materials are ideal for applications where high stiffness-to-weight and strength-to-weight ratios are required. From aerospace and aeronautical field to biomedical applications, fiber-reinforced polymers have replaced metals, thus emerging as an interesting alternative. As widely reported, the mechanical behavior of the composite materials involves investigation on micro- and macro-scale, taking into consideration micromechanics, macromechanics and lamination theory. Clinical situations often require repairing connective tissues and the use of composite materials may be suitable for these applications because of the possibility to design tissue substitutes or implants with the required mechanical properties...
May 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Hanna Trebacz, Artur Zdunek, Wojciech Dys, Tomasz Gieroba, Ewa Wlizlo
PURPOSE: Effects of in vitro induced nonenzymatic glycation of bone collagen on stiffness and fracture of demineralized bone matrix in unconfined compression were investigated. MATERIAL AND METHODS: Regular specimens from mid-shaft of bovine femur were grouped in pairs. One sample (R) from each pair was incubated in ribose solution, control samples (C) were incubated in a buffer solution. Samples were then demineralized in formic acid. Demineralized samples were axially compressed to failure (0...
May 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Erwin Chan, Dieter Cadosch, Oliver P Gautschi, Kai Sprengel, Luis Filgueira
BACKGROUND: There is mounting evidence to suggest the involvement of the immune system by means of activation by metal ions released via biocorrosion, in the pathophysiologic mechanisms of aseptic loosening of orthopedic implants. However, the detailed mechanisms of how metal ions become antigenic and are presented to T-lymphocytes, in addition to how the local inflammatory response is driven, remain to be investigated. METHODS: Human T-lymphocytes were cultured in the presence of a variety of metal ions before investigating functional and phenotypic changes using flow cytometric analysis...
May 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Stefano Santoro, Luisa Russo, Vincenzo Argenzio, Assunta Borzacchiello
AIM: Ha based dermal fillers in recent years aroused big interest in the area of cosmetic surgery for the rejuvenation of the dermis. There is not a ideal dermal filler (DF) for all applications and in commerce there are many types of DF that differ for their chemical-physical properties. So the aim of this paper is to correlate the rheological and physical properties of different DF to their clinical effectiveness. MATERIALS AND METHODS: In this frame the samples have been subjected to oscillation dynamic rheological and steady shear measurements...
May 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Andaç Barkin Bavbek, Arife Dogan, Murat Cavit Cehreli
PURPOSE: The purpose of this study was to explore the effects of implant angulation and its possible influence on prosthetic connection as regards implant/tooth strains in a combined implant and natural tooth abutment fixed partial denture. METHODS: A natural tooth was embedded between vertically-aligned and 17° angulated implants in a polymethyl methacrylate acrylic resin model. Three designs (Group 1: tooth and vertically-aligned implant; Group 2: tooth and 17° angulated implant, Group 3: tooth and vertically-aligned implant having a different prosthetic connection to Group 1) of tooth-implant supported prostheses (n=4) were fabricated...
May 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Gabriele Dubini, Davide Ambrosi, Paola Bagnoli, Federica Boschetti, Enrico G Caiani, Claudio Chiastra, Carlo A Conti, Chiara Corsini, Maria Laura Costantino, Carlo D'Angelo, Luca Formaggia, Roberto Fumero, Dario Gastaldi, Francesco Migliavacca, Stefano Morlacchi, Fabio Nobile, Giancarlo Pennati, Lorenza Petrini, Alfio Quarteroni, Alberto Redaelli, Marco Stevanella, Alessandro Veneziani, Christian Vergara, Emiliano Votta, Wei Wu, Paolo Zunino
Over the last twenty years major advancements have taken place in the design of medical devices and personalized therapies. They have paralleled the impressive evolution of three-dimensional, non invasive, medical imaging techniques and have been continuously fuelled by increasing computing power and the emergence of novel and sophisticated software tools. This paper aims to showcase a number of major contributions to the advancements of modeling of surgical and interventional procedures and to the design of life support systems...
May 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Linda Pattini, Riccardo Bertacco, Gabriele Candiani, Marco Masseroli, Stefano Servi
Genomics is the study of an organism's genome aimed at the functional specification of the different parts of the sequence that comprise the blueprint of the living cell to unveil the mechanisms of the physiology of the cell and its basic, developmental, and tissue-specific processes. Proteomics is the comprehensive study of the executive molecules of the cell coded by the genome, further raising the level of complexity, because of the large amplification in the number, going from genes to proteins, and to the sophisticated structural and functional characterization of protein products, which confer specific biochemical properties...
May 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Maria Cristina Tanzi, Sabrina Bozzini, Gabriele Candiani, Alberto Cigada, Luigi De Nardo, Silvia Farè, Fabio Ganazzoli, Dario Gastaldi, Marinella Levi, Pierangelo Metrangolo, Francesco Migliavacca, Roberto Osellame, Paola Petrini, Giuseppina Raffaini, Giuseppe Resnati, Pasquale Vena, Simone Vesentini, Paolo Zunino
The present article reviews on different research lines, namely: drug and gene delivery, surface modification/modeling, design of advanced materials (shape memory polymers and biodegradable stents), presently developed at Politecnico di Milano, Italy. For gene delivery, non-viral polycationic-branched polyethylenimine (b-PEI) polyplexes are coated with pectin, an anionic polysaccharide, to enhance the polyplex stability and decrease b-PEI cytotoxicity. Perfluorinated materials, specifically perfluoroether, and perfluoro-polyether fluids are proposed as ultrasound contrast agents and smart agents for drug delivery...
May 2011: Journal of Applied Biomaterials & Biomechanics: JABB
M Adelaide Asnaghi, Gabriele Candiani, Silvia Farè, Gianfranco B Fiore, Paola Petrini, Manuela T Raimondi, Monica Soncini, Sara Mantero
Regenerative medicine is a critical frontier in biomedical and clinical research. The major progresses in the last few years were driven by a strong clinical need which could benefit from regenerative medicine outcomes for the treatment of a large number of conditions including birth defects, degenerative and neoplastic diseases, and traumatic injuries. Regenerative medicine applies the principles of engineering and life sciences to enhance the comprehension of the fundamental biological mechanisms underlying the structure-function relationships in physiologic and pathologic tissues and to accomplish alternative strategies for developing in vitro biological substitutes which are able to restore, maintain, or improve tissue, and organ function...
May 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Maria Vittoria Diamanti, Barbara Del Curto, Mariapia Pedeferri
Titanium biomaterials are widely employed to produce medical components, such as hip and knee-joint prostheses, bone plates and screws, dental implants, pacemaker cases, surgical equipment, etc. Their diffusion is ascribed to the broad spectrum of optimal mechanical and surface properties, such as the corrosion resistance and correlated low ionic release, the biocompatibility, and especially, the enhanced osseointegration that can be achieved by surface modifications, particularly by suitable anodizing treatments...
January 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Livio Quagliarella, Nicola Sasanelli, Giuseppe Belgiovine, Domenico Accettura, Angela Notarnicola, Biagio Moretti
PURPOSE: The Counter Movement Jump (CMJ) is widely used as a field test to evaluate the muscular explosive power of lower limbs in various sports, including soccer. The aim of the present study was to verify the possibility to discriminate the effect of training level and age on young adult male soccer players, adopting the flight time, the peak force, or the peak power obtained from a countermovement jump. METHODS: One hundred and twenty three young male soccer players were enrolled in the study; the participants were split into groups according to Tanner's stages (pre- and post-pubertal) and training level (high and low activity)...
January 2011: Journal of Applied Biomaterials & Biomechanics: JABB
Fritz Thorey, Kerstin Weinert, Andreas Weizbauer, Frank Witte, Elmar Willbold, Ivonne Bartsch, Andrea Hoffmann, Gerhard Gross, Corinna Lorenz, Henning Menzel, Henning Windhagen
PURPOSE: In modern orthopedics aseptic loosening caused by the formation of micro-wear particles remains a problem for endoprosthetic joint replacements as revision surgery is necessary with corresponding costs and exertions by patients. This study is devoted to the question of how the osseous ingrowth of implants can be supported. It was investigated whether the developed copolymer, p-VBP-co-GMA, coated on the surface of the implants, supports bone healing. In addition, it was analyzed whether covalent linkage of Bone Morphogenetic Protein 2 (BMP-2) to the copolymer layer enhances bone formation...
January 2011: Journal of Applied Biomaterials & Biomechanics: JABB
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