Agnieszka Jazwa, Paulina Kucharzewska, Justyna Leja, Anna Zagorska, Aleksandra Sierpniowska, Jacek Stepniewski, Magdalena Kozakowska, Hevidar Taha, Takahiro Ochiya, Rafal Derlacz, Elisa Vahakangas, Seppo Yla-Herttuala, Alicja Jozkowicz, Jozef Dulak
BACKGROUND: Impaired wound healing in diabetes is related to decreased production of growth factors. Hence, gene therapy is considered as promising treatment modality. So far, efforts concentrated on single gene therapy with particular emphasis on vascular endothelial growth factor-A (VEGF-A). However, as multiple proteins are involved in this process it is rational to test new approaches. Therefore, the aim of this study was to investigate whether single AAV vector-mediated simultaneous transfer of VEGF-A and fibroblast growth factor 4 (FGF4) coding sequences will improve the wound healing over the effect of VEGF-A in diabetic (db/db) mice...
2010: Genetic Vaccines and Therapy