Hirofumi Tenshin, Jesus Delgado-Calle, Jolene J Windle, G David Roodman, John M Chirgwin, Noriyoshi Kurihara
PURPOSE OF REVIEW: To describe the contributions of osteocytes to the lesions in Paget's disease, which are characterized by locally overactive bone resorption and formation. RECENT FINDINGS: Osteocytes, the most abundant cells in bone, are altered in Paget's disease lesions, displaying increased size, decreased canalicular length, incomplete differentiation, and less sclerostin expression compared to controls in both patients and mouse models. Pagetic lesions show increased senescent osteocytes that express RANK ligand, which drives osteoclastic bone resorption...
March 8, 2024: Current Osteoporosis Reports