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Journals Transfusion Medicine and Hemot...

Transfusion Medicine and Hemotherapy

https://read.qxmd.com/read/38584699/increase-of-phosphoprotein-expressions-in-amotosalen-uva-treated-platelet-concentrates
#1
JOURNAL ARTICLE
Charlotte Muret, David Crettaz, Lorenzo Alberio, Michel Prudent
BACKGROUND: Pathogen inactivation treatment (PIT) has been shown to alter platelet function, phenotype, morphology and to induce a faster aging of platelet concentrates (PCs). Key pieces of information are still missing to understand the impacts of PITs at the cellular level. OBJECTIVES: This study investigated the impact of amotosalen/UVA on PCs, from a post-translational modifications (PTM) point of view. Phosphoproteomic analyses were conducted on resting platelets, right after the amotosalen/UVA treatment and compared with untreated PCs...
April 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38584698/indocyanine-green-labeled-platelets-for-survival-and-recovery-studies
#2
JOURNAL ARTICLE
Johannes-Moritz von Behren, Jan Wesche, Andreas Greinacher, Konstanze Aurich
INTRODUCTION: Before being implemented in daily clinical routine, new production strategies for platelet concentrates (PCs) must be validated for their efficacy. Besides in vitro testing, the establishment of new methods requires the labeling of platelets for in vivo studies of platelets' survival and recovery. Indocyanine green (ICG) is a Food and Drug Administration-approved near-infrared (NIR) fluorescent dye for diagnostic use in vivo, suitable for non-radioactive direct cell labeling of platelets...
April 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38584697/moleculargenetic-and-in-addition-partly-discrepant-infection-serological-malaria-testing-in-two-blood-donors
#3
Lutz Pichl, Katja Konietzko, Ludwig Hartmann, Bogdan Puscasu, Carlos Jiménez Klingberg
INTRODUCTION: According to the guidelines (GL) valid in Germany, persons born or raised in a malaria-endemic area or had continuously stayed in a malaria-endemic area for more than 6 months may only be admitted donating blood if, among other things, validated and quality-assured laboratory diagnostics show that there is no evidence of infectivity. In a statement of the Working Group "Blood" of the Federal Ministry of Health (WGB), a reduction of the deferral period from 4 to 3 years and an antibody test after the deferral period are recommended...
April 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38584696/growth-and-distribution-of-bacteria-in-contaminated-whole-blood-and-derived-blood-components
#4
JOURNAL ARTICLE
Ute Gravemann, Wiebke Handke, Torsten J Schulze, Axel Seltsam
INTRODUCTION: Bacterial contamination of blood products presumably occurs mainly during blood collection, starting from low initial concentrations of 10-100 colony-forming units (CFUs) per bag. As little is known about bacterial growth behavior and distribution in stored whole blood (WB) and WB-derived blood products, this study aims to provide data on this subject. METHODS: WB units were inoculated with transfusion-relevant bacterial species ( Acinetobacter baumannii, Bacillus cereus, Escherichia coli, Klebsiella pneumoniae, Listeria monocytogenes, Pseudomonas fluorescens, Serratia marcescens, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus dysgalactiae, Streptococcus pyogenes, Yersinia enterocolitica ; n = 12 for each species), stored for 22-24 h at room temperature, and then centrifuged for separation into plasma, red blood cells (RBCs), and buffy coats (BCs)...
April 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38584695/efficient-chimeric-antigen-receptor-t-cell-generation-starting-with-leukoreduction-system-chambers-of-thrombocyte-apheresis-sets
#5
JOURNAL ARTICLE
Stefani Xhaxho, Linping Chen-Wichmann, Sophie Kreissig, Roland Windisch, Adrian Gottschlich, Sayantan Nandi, Sophie Schabernack, Irmgard Kohler, Christian Kellner, Sebastian Kobold, Andreas Humpe, Christian Wichmann
INTRODUCTION: Primary human blood cells represent an essential model system to study physiology and disease. However, human blood is a limited resource. During healthy donor plateletpheresis, the leukoreduction system chamber (LRSC) reduces the leukocyte amount within the subsequent platelet concentrate through saturated, fluidized, particle bed filtration technology. Normally, the LRSC is discarded after apheresis is completed. Compared to peripheral blood, LRSC yields 10-fold mononuclear cell concentration...
April 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38584694/in-vitro-hemostatic-functions-of-cold-stored-platelets
#6
REVIEW
Johanna Kirschall, Günalp Uzun, Tamam Bakchoul, Irene Marini
BACKGROUND: Transfusion of platelets is a life-saving medical strategy used worldwide to treat patients with thrombocytopenia as well as platelet function disorders. SUMMARY: Until the end of 1960s, platelets were stored in the cold because of their superior hemostatic functionality. Cold storage of platelets was then abandoned due to better posttransfusion recovery and survival of room temperature (RT)-stored platelets, demonstrated by radioactive labeling studies...
April 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38584693/two-cases-of-anti-d-alloimmunization-in-d-negative-thai-patients-as-a-result-of-the-asian-type-del-on-transfused-red-cells
#7
Kanyapon Suksard, Komon Luangtrakool, Thongbai Rungroung, Sutthisak Chamsai, Pradermchai Saetam, Kulvara Kittisares, Parichart Permpikul, Janejira Kittivorapart
INTRODUCTION: DEL is known to be one of the weakest D variants, which can be detected by the adsorption-elution technique or by molecular study. Currently, in Thailand, we do not routinely test for DEL variants serologically or genetically among serologic RhD-negative blood donors. CASE PRESENTATION: We reported 2 cases of alloimmunization after transfused with Rh DEL, RHD*DEL1 allele, in the Thai population. The first case was a 73-year-old male with anemia who presented with post-cardiac arrest and septic shock...
April 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38584692/increased-responsiveness-of-stored-platelets-after-short-term-refrigeration
#8
JOURNAL ARTICLE
Julia Zeller-Hahn, Anna Kobsar, Marius Bittl, Angela Koessler, Katja Weber, Markus Boeck, Juergen Koessler
INTRODUCTION: Refrigeration of platelets is considered to provide advantages in therapy of acute hemorrhage due to increased platelet responsiveness. The alleviation of inhibitory signaling caused by cold temperature (CT) has been identified as an important mechanism contributing to enhanced platelet reactivity, detectable in freshly prepared platelets within 1 h of cold storage. The aim of this study was to confirm the effects of short-term refrigeration in platelets from apheresis-derived platelet concentrates (APC)...
April 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38584691/a-call-to-reinvent-platelet-products
#9
EDITORIAL
Stefan Handtke, Thomas Thiele
No abstract text is available yet for this article.
April 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314246/the-ratio-of-intraoperative-red-blood-cell-transfusion-to-blood-loss-associated-with-early-postoperative-complications-in-pediatric-liver-transplantation-patients
#10
JOURNAL ARTICLE
Yiming Ma, Cheng Li, Liying Sun, Xiaofei Li
INTRODUCTION: Liver transplantation (LT) is an operation purposed to save the lives of children with acute or chronic liver diseases, hepatic tumors, and some genetic and metabolic diseases. However, patients who underwent LT have a significant risk of intraoperative blood loss and red blood cell (RBC) transfusion, especially in pediatric patients. METHODS: In this study, 569 pediatric patients (<18 years old) who underwent LT at a tertiary university hospital between 2013 and 2020 were included...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314245/the-putative-role-of-the-transient-receptor-potential-ion-channel-of-vanilloid-type-2-in-red-blood-cell-storage-lesions
#11
JOURNAL ARTICLE
Nicoletta Murciano, Lars Kaestner
No abstract text is available yet for this article.
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314244/allogeneic-blood-transfusion-and-risk-of-postoperative-complications-in-patients-with-mild-and-moderate-anemia-of-any-cause-a-retrospective-cohort-study-in-total-revision-hip-surgery
#12
JOURNAL ARTICLE
Henning Uden, Franziska Büttner, Christian von Heymann, Michael Krämer, Lutz Kaufner, Gerald Vorderwülbecke, Sebastian Hardt, Jochen Kruppa, Felix Balzer, Claudia Spies
INTRODUCTION: Patients undergoing revision total hip surgery (RTHS) have a high prevalence of mild and moderate preoperative anemia, associated with adverse outcomes. The aim of this study was to investigate the association of perioperative allogeneic blood transfusions (ABT) and postoperative complications in preoperatively mild compared to moderate anemic patients undergoing RTHS who did not receive a diagnostic anemia workup and treatment before surgery. METHODS: We included 1,765 patients between 2007 and 2019 at a university hospital...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314243/impact-of-additional-administration-of-von-willebrand-factor-concentrates-to-thrombocyte-transfusion-in-perioperative-bleeding-in-cardiac-surgery
#13
JOURNAL ARTICLE
Katrin Ledergerber, Alexa Hollinger, Sibylle Zimmermann, Atanas Todorov, Maren Trutmann, Laura Gallachi, Lena Anna Gschwandtner, Lisa Andrea Ryser, Caroline Eva Gebhard, Daniel Bolliger, Andreas Buser, Dimitrios Athanasios Tsakiris, Martin Siegemund
BACKGROUND: Von Willebrand factor (vWF) is an important part of blood coagulation since it binds platelets to each other and to endothelial cells. In traumatic and surgical haemorrhage, both blood cells and plasmatic factors are consumed, leading to consumption coagulopathy and fluid resuscitation. This often results in large amounts of crystalloids and blood products being infused. Additional administration of vWF complex and platelets might mitigate this problem. We hypothesize that administration of vWF concentrate additionally to platelet concentrates reduces blood loss and the amount of blood products (platelets, red blood cells [RBC], fresh frozen plasma [FFP]) administered...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314242/validation-of-a-parvovirus-b19-nat-assay-for-screening-of-umbilical-cord-blood-for-allogenic-hematopoietic-stem-cell-donation
#14
JOURNAL ARTICLE
Philipp Steininger, Klaus Korn, Holger Hackstein, Erwin F Strasser
INTRODUCTION: Parvovirus B19 transmitted by umbilical cord blood (UCB) products may cause severe disease in allogenic hematopoietic stem cell transplant recipients. Thus, commercially available nucleic acid test (NAT) assays for highly sensitive detection of parvovirus B19 DNA validated for the specimen cord blood plasma (CBP) are required to avoid parvovirus B19 transmission by umbilical hematopoietic stem cell preparations. METHODS: The multiplex cobas DPX NAT assay was validated for detection of parvovirus B19 DNA in CBP derived from citrate anticoagulated UCB units which have been processed by the Rubinstein method...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314241/implementation-of-a-bleeding-management-algorithm-in-liver-transplantation-a-pilot-study
#15
JOURNAL ARTICLE
Ignacio A Sarmiento, María F Guzmán, Javier Chapochnick, Jens Meier
OBJECTIVES: The aims of the study were to compare the consumption of blood products before and after the implementation of a bleeding management algorithm in patients undergoing liver transplantation and to determine the feasibility of a multicentre, randomized study. BACKGROUND: Liver transplantation remains the only curative therapy for patients with end-stage liver disease, but it carries a high risk of surgical bleeding. MATERIALS AND METHODS: Retrospective study of patients treated before (group 1) and after (group 2) implementation of a haemostatic algorithm guided by viscoelastic testing, including use of lyophilized coagulation factor concentrates ( prothrombin complex and fibrinogen concentrates )...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314240/high-throughput-cd36-phenotyping-on-human-platelets-based-on-sandwich-elisa-and-mutant-gene-analysis
#16
JOURNAL ARTICLE
Honghong He, Longhai Tang, Yiming Jin, Yujue Wang, Hongmei Wang, Shaohua Ding, Yezhou Chen, Jingjing Tian, Mingyuan Wang, Shengbao Duan
BACKGROUND: CD36 deficiency is closely associated with fetal/neonatal alloimmune thrombocytopenia, platelet transfusion refractoriness, and other hemorrhage disorders, particularly in Asian and African populations. There is a clinical need for rapid and high-throughput methods of platelet CD36 (pCD36) phenotyping to improve the availability of CD36 typing of donors and assist clinical blood transfusions for patients with anti-CD36 antibodies. Such methods can also support the establishment of databases of pCD36-negative phenotypes...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314239/quartic-car-t-cell-bridging-to-twice-allo-hsct-therapy-in-a-patient-with-acute-lymphoblastic-leukemia
#17
Qing Zhang, Yi Dong, Zhimin Zhai, Qianshan Tao
INTRODUCTION: Chimeric antigen receptor T (CAR-T) cell therapy is an effective bridging treatment for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in relapsed or refractory acute lymphoblastic leukemia (ALL). However, repetitive CAR-T cell therapy and allo-HSCT can only be performed in a few patients because of technical difficulties and patients' physical, economic, and social conditions. CASE PRESENTATION: A 23-year-old female patient with second relapsed B-cell ALL (B-ALL) underwent human-murine chimeric CD19 CAR-T cell therapy twice, human-murine chimeric CD22 CAR-T cell therapy once, and humanized CD19 CAR-T cell therapy once...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38089498/patient-blood-management-we-still-have-work-to-do
#18
JOURNAL ARTICLE
Patrick Meybohm, Lotta Hof, Suma Choorapoikayil, Kai Zacharowski
No abstract text is available yet for this article.
December 2023: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38089497/a-german-wide-systematic-study-on-mobilization-and-collection-of-hematopoietic-stem-cells-in-poor-mobilizer-patients-with-multiple-myeloma-prior-to-autologous-stem-cell-transplantation
#19
JOURNAL ARTICLE
Max Bittrich, Katharina Kriegsmann, Carola Tietze-Stolley, Kamran Movassaghi, Matthias Grube, Vladan Vucinic, Daniela Wehler, Andreas Burchert, Martin Schmidt-Hieber, Andreas Rank, Heinz A Dürk, Bernd Metzner, Christoph Kimmich, Marcus Hentrich, Christian Kunz, Frank Hartmann, Cyrus Khandanpour, Maike de Wit, Udo Holtick, Michael Kiehl, Andrea Stoltefuß, Alexander Kiani, Ralph Naumann, Christian W Scholz, Hans-Joachim Tischler, Martin Görner, Franziska Brand, Martin Ehmer, Nicolaus Kröger
INTRODUCTION: In patients with a clinical indication for autologous hematopoietic stem cell transplantation (ASCT), sufficient mobilization of CD34+ precursor cells into peripheral blood is essential to ensure adequate hematopoietic stem cell (HSC) collection prior to intensive therapy. However, with standard granulocyte-colony stimulating factor (G-CSF)-based mobilization schemes, an important minority of patients fail to mobilize sufficient (e.g., >10/µL) CD34+ cell counts into the peripheral blood and are considered as poor mobilizers (PM)...
December 2023: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38089496/the-impact-of-pathogen-reduction-on-total-igg-and-igg-subclass-profiles-of-convalescent-plasma
#20
JOURNAL ARTICLE
Tomasz Wasiluk, Magdalena Sredzinska, Anna Rogowska, Magdalena Dzieniszewska, Agnieszka Zebrowska, Barbara Boczkowska-Radziwon, Katarzyna Gagola, Anna Stasiak-Barmuta, Marcus Picard-Maureau, Piotr Radziwon
INTRODUCTION: In case of newly emerging pathogens, convalescent plasma (CP) is often the only early available treatment option. It has been shown that different IgG subclasses contribute differently to CP neutralizing activity. As CP donors often have a risk profile like first-time donors, especially with respect to window-period viral transmission, pathogen reduction (PR) could mitigate that risk. The aim of our study, especially in the light of potential future pandemics, was to evaluate the impact of commercially available PR technologies on total IgG and IgG subclasses quantity and distribution in CP using COVID-19 CP (CCP) as surrogate for CP in a side-by-side comparison approach...
December 2023: Transfusion Medicine and Hemotherapy
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