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World Journal of Surgical Oncology

Hiroshi Matsuoka, Zenichi Morise, Chihiro Tanaka, Takahiro Hayashi, Yoshiaki Ikeda, Koutarou Maeda, Koji Masumori, Yoshikazu Koide, Hidetoshi Katsuno, Yoshinao Tanahashi, Sanae Nakajima, Tsunekazu Hanai, Yutaro Kato, Atsushi Sugioka, Ichiro Uyama
BACKGROUND: Although hepatectomy for metastatic colorectal cancer (mCRC) prolongs survival in up to 40% of people, recurrence rates approach 70%. We used a multidisciplinary approach to treat recurrent liver metastases, including chemotherapy, surgery, and palliative care. On the other hand, development of chemotherapeutic agents is remarkable and improves long-term survival. However, whether chemotherapy and repeat hepatectomy combination therapy improve survival or not is still unclear...
February 15, 2019: World Journal of Surgical Oncology
Jianjian Xiang, Huaqing Yan, Jiangfeng Li, Xiao Wang, Hong Chen, Xiangyi Zheng
BACKGROUND: Because conventional prostate biopsy has some limitations, optimal variations of prostate biopsy strategies have emerged to improve the diagnosis rate of prostate cancer. We conducted the systematic review to compare the diagnosis rate and complications of transperineal versus transrectal prostate biopsy. We searched for online publications published through June 27, 2018, in PubMed, Scopus, Web of Science, and Chinese National Knowledge Infrastructure databases. The relative risk and 95% confidence interval were utilized to appraise the diagnosis and complication rate...
February 13, 2019: World Journal of Surgical Oncology
Rieko Nakamura, Tai Omori, Shuhei Mayanagi, Tomoyuki Irino, Norihito Wada, Hirofumi Kawakubo, Kaori Kameyama, Yuko Kitagawa
BACKGROUND: Endoscopic resection (ER) has come to be recognized as a standard treatment for early gastric cancer (EGC). While its adoption is expanding, ER remains restricted to cases of EGC without lymph node metastasis for the treatment of local resection. On the other hand, histopathological analyses of surgically resected specimens of EGC have revealed the presence of lymph node (LN) metastasis in some cases of mucosal gastric cancer (MGC) and undifferentiated MGC (UD-MGC) is considered to have higher risk of nodal metastases than differentiated MGC (D-MGC)...
February 13, 2019: World Journal of Surgical Oncology
Shi Deng, Sheng Yin He, Pan Zhao, Peng Zhang
BACKGROUND: Oncostatin M receptor (OSMR) represents a part of the interleukin-six (IL6) cytokine group that was discovered recently to be closely associated with cell's growth and differentiation, inflammation, and enhancement of metastatic capacity. A comprehensive study suggests a close relationship between OSMR and papillary thyroid cancer, colorectal cancer, breast cancer, and other tumors. However, the relationship between OSMR and bladder cancer has yet to be determined. METHODS: Three hundred six patients (including 142 patients with muscle-invasive bladder cancer and 164 patients with non-muscle-invasive bladder cancer) as well as 459 normal controls were included in this study...
February 12, 2019: World Journal of Surgical Oncology
Dingyuan Hu, Daniel Ansari, Qimin Zhou, Agata Sasor, Katarzyna Said Hilmersson, Roland Andersson
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense stroma, which has a fundamental role in tumor progression. Fibronectin (FN1) is the main constituent of the tumor stroma in pancreatic cancer. This study aimed to explore the association between FN1 and clinicopathological characteristics and disease survival. METHODS: Formalin-fixed paraffin-embedded tissue samples from 138 patients with PDAC were constructed into a tissue microarray, followed by immunohistochemical analysis with a recombinant monoclonal FN1 antibody...
February 8, 2019: World Journal of Surgical Oncology
Pengfei Yu, Yian Du, Zhiyuan Xu, Ling Huang, Xiangdong Cheng
BACKGROUND: The optimal extent of lymph node (LN) dissection for advanced distal gastric cancer remains controversial. The present study compared the safety and efficacy of extended LN dissection (D2 plus) with standard D2 radical surgery for advanced distal gastric cancer. METHODS: Eligible patients were enrolled and randomly assigned into two groups: D2 group and D2 plus group. Patients in the D2 group received standard D2 LN dissection, while patients in the D2 plus group received an additional nos...
February 6, 2019: World Journal of Surgical Oncology
G Houvenaeghel, M Bannier, S Rua, J Barrou, M Heinemann, A Van Troy, E Lambaudie, M Cohen
BACKGROUND: Few studies of robotic nipple sparing mastectomy (NSM) were reported. We report feasibility of robotic NSM and determine standard surgical procedure and learning curve threefold. METHODS: A cohort of patients with robotic NSM for breast cancer was analyzed. Complications and post-operative hospitalization stay were reported. The same technic was used for all patients except for skin and nipple areolar complex (NAC) dissection. Differences between three surgical procedures of NAC dissection were analyzed: group 1, dissection with robotic scissors using coagulation; group 2, dissection with robotic scissors without coagulation; and group 3, dissection with non-robotic scissors and then robotic dissection...
February 6, 2019: World Journal of Surgical Oncology
Yonatan Lessing, Niv Pencovich, Nadav Nevo, Nir Lubezky, Yaacov Goykhman, Richard Nakache, Guy Lahat, Joseph M Klausner, Ido Nachmany
BACKGROUND: Reoperation following PD is a surrogate marker for a complex post-operative course and may lead to devastating consequences. We evaluate the indications for early reoperation following PD and analyze its effect on short- and long-term outcome. METHODS: Four hundred and thirty-three patients that underwent PD between August 2006 and June 2016 were retrospectively analyzed. RESULTS: Forty-eight patients (11%; ROp group) underwent 60 reoperations within 60 days from PD...
January 31, 2019: World Journal of Surgical Oncology
Cheng Xiao, Yonglian Huang, Qiyuan Gao, Zijian Feng, Qi Li, Zhen Liu
BACKGROUND: The abnormal expression of activator protein-1(AP-1) has recently been investigated in a variety of tumors. While the relationship between AP-1 and thyroid cancer is poorly studied, our study was to evaluate the protein expression and clinical value of AP-1 in papillary thyroid carcinoma (PTC). METHODS: The expression of AP-1 was examined by immunohistochemistry on paraffin-embedded tissues obtained from PTC and correspondent paracancerous tissues of 82 patients...
January 31, 2019: World Journal of Surgical Oncology
Tsukuru Amano, Tokuhiro Chano, Takahiro Isono, Fuminori Kimura, Ryoji Kushima, Takashi Murakami
BACKGROUND: Endometrioid ovarian carcinoma and clear cell ovarian carcinoma are both classified as endometriosis-associated ovarian cancers (EAOCs). Despite the high rates of recurrence and mortality of EAOC, only a few prognostic biomarkers have been reported. Mitochondrial superoxide dismutase (SOD2) plays an important role in maintaining mitochondrial function through oxidative stress tolerance and contributes to chemotherapeutic resistance. METHODS: To clarify the clinical significance of SOD2 in EAOC, SOD2 expression was semi-quantitatively investigated by immunohistochemical analysis in 61 primary EAOC cases, and the correlations between SOD2 expression and clinicopathological data and survival were analyzed...
January 30, 2019: World Journal of Surgical Oncology
Kai Shi, Sheng-Lin Wang, Bin Shen, Feng-Qiang Yu, Dan-Feng Weng, Jian-Hua Lin
BACKGROUND: Osteosarcoma is a malignant bone tumor with a high potential for lung metastasis, and the prognosis for patients with metastatic disease is very poor. The interaction between fibronectin (FN) and integrin αvβ3 in soft-tissue sarcoma promotes cell migration, invasion, and lung metastasis. This study aimed to investigate the prognostic significance of FN and αvβ3 in osteosarcoma. METHODS: Immunohistochemistry and western blotting were used to detect the expression of FN and αvβ3 in 60 osteosarcoma specimens and in 30 osteochondroma specimens...
January 28, 2019: World Journal of Surgical Oncology
Yazid Maghrabi, Maher E Kurdi, Saleh S Baeesa
BACKGROUND: Congenital intracranial tumors are very rare and account for less than 2% of all childhood brain tumors. Teratomas constitute about one third to one half of these, predominantly located midline in the supratentorial region. Posterior fossa location rarely occurs and, based on the cases reported in the literature, commonly has a poor prognosis. CASE PRESENTATION: A newborn female, diagnosed prenatally with hydrocephalus, is presented at birth with increasing head circumference and Parinaud's syndrome...
January 19, 2019: World Journal of Surgical Oncology
Xinger Lv, Hong Yu, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Yu Wang, Zhenning Wang
BACKGROUND: Bowel obstruction (BO) is a complication that commonly affects patients with colorectal cancer (CRC). BO causes severe outcomes, and its treatment leads to a dilemma for many surgeons. Moreover, the factors correlated to BO in preoperative CRC patients remain unclear. The objectives of this study were to investigate the clinical characteristics of BO to identify risk predictors and to construct a BO prediction model with preoperative CRC patients. METHODS: A large-scale, retrospective cohort, population-based study analyzed the data of 11,814 patients obtained from the Surveillance, Epidemiology, and End Results and Medicare claims-linked databases (SEER-M database)...
January 18, 2019: World Journal of Surgical Oncology
Peter C Ambe, Konstantinos Zarras, Maciej Stodolski, Ingfu Wirjawan, Hubert Zirngibl
BACKGROUND: Anastomotic leakage (AL) following colorectal resection is a serious issue. AL in oncologic patients might negatively affect the overall survival. Recently, mechanical bowel preparation with additive oral antibiotics (MBP + AB) prior to surgery has been suggested as a means of reducing AL. However, it is unclear whether this positive effect is secondary to MBP alone or secondary to the additive oral antibiotic (MBP + AB). The aim of this study was to investigate the effect of mechanical bowel preparation with additive oral antibiotics (MBP + AB) and without additive oral antibiotics (MBP - AB) on the rate of AL following colorectal resection for cancer...
January 16, 2019: World Journal of Surgical Oncology
Manoj Pandey, Jyoti Swain, Hema Malini Iyer, Mridula Shukla
BACKGROUND: Gastrointestinal tract is the most frequent site of extranodal lymphoma accounting for approximately 40% of all extranodal lymphomas; out of these, non-Hodgkin's lymphoma (NHL) comprises 4% of total cases. Primary lymphoma arising in the colon is very rare comprising only 0.2-1% of all colonic malignancy. PATIENTS AND METHODS: We report two cases of 13- and 20-year-old boys with NHL of colon presenting with abdominal pain and weight loss and discuss the approach to colonic lymphoma after a review of world literature to provide an overview on colonic lymphoma...
January 15, 2019: World Journal of Surgical Oncology
Bin-Shuai Wang, Run-Zhuo Ma, Yu-Qing Liu, Zhuo Liu, Li-Yuan Tao, Min Lu, Guo-Liang Wang, Shu-Dong Zhang, Jian Lu, Lu-Lin Ma
OBJECTIVE: To define preoperative clinical and radiographic risk factors for the need of inferior vena cava (IVC) resection in patients with renal cell carcinoma (RCC) and IVC tumor thrombus. METHODS: We reviewed data of 121 patients with renal cell carcinoma and venous tumor thrombus receiving radical nephrectomy and thrombectomy at our institution between 2015 and 2017, and 86 patients with Mayo I-IV level tumor thrombus were included in the final analysis. Clinical features, operation details, and pathology data were collected...
January 15, 2019: World Journal of Surgical Oncology
Nozomi Karakuchi, Manabu Shimomura, Kazuhiro Toyota, Takao Hinoi, Hideki Yamamoto, Seiji Sadamoto, Koichi Mandai, Hiroyuki Egi, Hideki Ohdan, Tadateru Takahashi
BACKGROUND: Spontaneous regression (SR) of colorectal cancer (CRC) is extremely rare, and only few cases have been reported. Although it is not yet clarified, a plausible mechanism for SR of CRC is an immunological event. CASE PRESENTATION: In this report, we present the case of SR of primary CRC in a 78-year-old man. Preoperative colonoscopy was performed, and a type 2 tumor measuring 30 mm in diameter in the transverse colon was detected. The biopsy revealed a poorly differentiated adenocarcinoma...
January 15, 2019: World Journal of Surgical Oncology
Chuying Wu, Kai Ye, Yiyang Wu, Qiwei Chen, Jianhua Xu, Jianan Lin, Wengui Kang
BACKGROUND: This study aimed to analyze right colonic vascular variability. METHODS: The study included 60 consecutive patients who underwent laparoscopic radical right colectomy and D3 lymph node dissection for malignant colonic cancer on the ileocecal valve, ascending colon or hepatic flexure (March 2013 to October 2016). The videos of the 60 surgical procedures were collected. Variations of right colonic vascular anatomy were retrospectively analyzed based on 60 high-resolution surgical videos of laparoscopic surgery...
January 12, 2019: World Journal of Surgical Oncology
M Leimkühler, P H J Hemmer, A K L Reyners, D J A de Groot, R J van Ginkel, L B Been, G H de Bock, B L van Leeuwen
BACKGROUND: Standard treatment for colorectal peritoneal carcinomatosis typically involves cytoreductive surgery, hyperthermic intraperitoneal chemotherapy (HIPEC), and if possible, postoperative adjuvant chemotherapy. However, a substantial percentage of patients never receive adjuvant chemotherapy because of postoperative complications. Neoadjuvant chemotherapy could be beneficial in this setting, so we assessed its feasibility and safety when used before cytoreductive surgery and HIPEC...
January 11, 2019: World Journal of Surgical Oncology
Sajith Babu Thavarool, Geetha Muttath, Sangeetha Nayanar, Karthickeyan Duraisamy, Prasanth Bhat, Kalpita Shringarpure, Priyakanta Nayak, Jaya Prasad Tripathy, Alfonso Thaddeus, Sairu Philip, Satheesan B
BACKGROUND: Oral cancer is very common in India. The reported 5-year survival of such patients is around 50% after treatment with surgery and radiotherapy, much lower than most of the developed countries. METHODS: A retrospective study of a prospective database of oral cancer patients undergoing surgery from June 2009 to June 2013 was conducted. Follow-up details were updated from case records and by phone calls. Data were double entered in EpiData Entry version 3...
January 11, 2019: World Journal of Surgical Oncology
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