Journals Cell Communication and Signali...

Cell Communication and Signaling : CCS
Elmira Mahdinia, Nafiseh Shokri, Abdolkarim Talebi Taheri, Sahar Asgharzadeh, Mohammad Elahimanesh, Mohammad Najafi
Atherosclerosis is an underlying pathology of many vascular diseases as a result of cellular, structural and molecular dysfunctions within the sub-endothelial space. This review deals with the events involved in the formation, growth and remodeling of plaque, including the cell recruitment, cell polarization, and cell fat droplets. It also describes cross talking between endothelial cells, macrophages, and vascular smooth muscle cells, as well as the cellular pathways involved in plaque development in the plaque microenvironment...
May 30, 2023: Cell Communication and Signaling: CCS
Yu Zhang, Jun Zhou, Ling Hua, Pan Li, Jiaqi Wu, Shenglan Shang, Fei Deng, Jing Luo, Mengling Liao, Nuoyan Wang, Xichun Pan, Yue Yuan, Yue Zheng, Yonglin Lu, Yasi Huang, Jiang Zheng, Xin Liu, Xiaoli Li, Hong Zhou
It is unclear whether membrane vitamin D receptor (mVDR) exists on the macrophage membrane or whether mVDR is associated with lipopolysaccharide (LPS) tolerance. Herein, we report that interfering with caveolae and caveolae-dependent lipid rafts inhibited the formation of LPS tolerance. VDR was detected as co-localized with membrane molecular markers. VDR was detected on the cell membrane and its level was higher in LPS-tolerant cells than that in only LPS treatment cells. Anti-VDR antibodies could abolish the effect of artesunate (AS) to reverse LPS tolerance, and the wild-type peptides (H397 and H305) of VDR, but not the mutant peptide (H397D and H305A), led to the loss of AS's effect...
May 29, 2023: Cell Communication and Signaling: CCS
Bowen Liu, Jinling Cao, Biting Wu, Kaixuan Hao, Xiangyun Wang, Xin Chen, Zhifa Shen
BACKGROUND: It is well-established that most Hepatocellular carcinoma (HCC) patients die of metastasis, yet the potential mechanisms orchestrating metastasis remain poorly understood. Current evidence suggests that the dysregulation of METTL3-mediated m6A methylation modification is closely associated with cancer progression. STAT3 is an oncogenic transcription factor that reportedly plays a central role in the occurrence and development of HCC. However, the relationship between METTL3 and STAT3 in HCC metastasis remains unclear...
May 25, 2023: Cell Communication and Signaling: CCS
Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
BACKGROUND: Idiosyncratic drug-induced liver injury (IDILI) is common in hepatology practices and, in some cases, lethal. Increasing evidence show that tricyclic antidepressants (TCAs) can induce IDILI in clinical applications but the underlying mechanisms are still poorly understood. METHODS: We assessed the specificity of several TCAs for NLRP3 inflammasome via MCC950 (a selective NLRP3 inhibitor) pretreatment and Nlrp3 knockout (Nlrp3-/- ) BMDMs. Meanwhile, the role of NLRP3 inflammasome in the TCA nortriptyline-induced hepatotoxicity was demonstrated in Nlrp3-/- mice...
May 25, 2023: Cell Communication and Signaling: CCS
Aleksandra Gedaj, Dominika Zukowska, Natalia Porebska, Marta Pozniak, Mateusz Krzyscik, Aleksandra Czyrek, Daniel Krowarsch, Malgorzata Zakrzewska, Jacek Otlewski, Lukasz Opalinski
Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis of the human body. Most of FGFs are released by cells using the conventional secretory pathway and are N-glycosylated, yet the role of FGFs glycosylation is largely unknown. Here, we identify N-glycans of FGFs as binding sites for a specific set of extracellular lectins, galectins - 1, -3, -7 and - 8. We demonstrate that galectins attract N-glycosylated FGF4 to the cell surface, forming a reservoir of the growth factor in the extracellular matrix...
May 25, 2023: Cell Communication and Signaling: CCS
Klara Hanelova, Martina Raudenska, Monika Kratochvilova, Jiri Navratil, Tomas Vicar, Maria Bugajova, Jaromir Gumulec, Michal Masarik, Jan Balvan
Extracellular vesicles (EVs) are important mediators of intercellular communication in the tumour microenvironment. Many studies suggest that cancer cells release higher amounts of EVs exposing phosphatidylserine (PS) at the surface. There are lots of interconnections between EVs biogenesis and autophagy machinery. Modulation of autophagy can probably affect not only the quantity of EVs but also their content, which can deeply influence the resulting pro-tumourigenic or anticancer effect of autophagy modulators...
May 24, 2023: Cell Communication and Signaling: CCS
Leilei Wu, Zhenshan Zhang, Menglin Bai, Yujie Yan, Jinming Yu, Yaping Xu
Until the advent of immune checkpoint inhibitors (ICIs), definitive radiotherapy (RT) concurrently with chemotherapy was recommended for unresectable, locally advanced non-small cell lung cancer (LA-NSCLC). The trimodality paradigm with consolidation ICIs following definitive concurrent chemoradiotherapy has been the standard of care since the PACIFIC trial. Preclinical evidence has demonstrated the role of RT in the cancer-immune cycle and the synergistic effect of RT combined with ICIs (iRT). However, RT exerts a double-edged effect on immunity and the combination strategy still could be optimized in many areas...
May 23, 2023: Cell Communication and Signaling: CCS
Gloria Stoyanova, Sidra Jabeen, Joselyn Landazuri Vinueza, Sounak Ghosh Roy, Richard A Lockshin, Zahra Zakeri
BACKGROUND: Zika virus (ZIKV), an arbovirus of global concern, has been associated with neurological complications including microcephaly in newborns and Guillain-Barré syndrome in adults. Like other flaviviruses, ZIKV depends on cholesterol to facilitate its replication; thus, cholesterol has been proposed as a therapeutic target to treat the infection using FDA-approved statins. Cholesterol is stored in intracellular lipid droplets (LD) in the form of cholesterol esters and can be regulated by autophagy...
May 19, 2023: Cell Communication and Signaling: CCS
Ting Yuan, Qingzhu Jia, Bo Zhu, Degao Chen, Haixia Long
Cancer-associated anemia promotes tumor progression, leads to poor quality of life in patients with cancer, and even obstructs the efficacy of immune checkpoint inhibitors therapy. However, the precise mechanism for cancer-associated anemia remains unknown and the feasible strategy to target cancer-associated anemia synergizing immunotherapy needs to be clarified. Here, we review the possible mechanisms of cancer-induced anemia regarding decreased erythropoiesis and increased erythrocyte destruction, and cancer treatment-induced anemia...
May 19, 2023: Cell Communication and Signaling: CCS
Leila Salimi, Fatemehsadat Seyedaghamiri, Mohammad Karimipour, Halimeh Mobarak, Narges Mardi, Maryam Taghavi, Reza Rahbarghazi
Blood-brain barrier (BBB) interface with multicellular structure controls strictly the entry of varied circulating macromolecules from the blood-facing surface into the brain parenchyma. Under several pathological conditions within the central nervous system, the integrity of the BBB interface is disrupted due to the abnormal crosstalk between the cellular constituents and the recruitment of inflammatory cells. Exosomes (Exos) are nano-sized extracellular vesicles with diverse therapeutic outcomes. These particles transfer a plethora of signaling molecules with the potential to modulate target cell behavior in a paracrine manner...
May 19, 2023: Cell Communication and Signaling: CCS
Sicheng Wan, Guanghui Zhang, Ruochen Liu, Muhammad Nadeem Abbas, Hongjuan Cui
Glioma is a common primary tumor of the central nervous system (CNS), with glioblastoma multiforme (GBM) being the most malignant, aggressive, and drug resistant. Most drugs are designed to induce cancer cell death, either directly or indirectly, but malignant tumor cells can always evade death and continue to proliferate, resulting in a poor prognosis for patients. This reflects our limited understanding of the complex regulatory network that cancer cells utilize to avoid death. In addition to classical apoptosis, pyroptosis, ferroptosis, and autophagy are recognized as key cell death modalities that play significant roles in tumor progression...
May 19, 2023: Cell Communication and Signaling: CCS
Chuwen Jiang, Zhengting Jiang, Gengyu Sha, Daorong Wang, Dong Tang
Metastasis, the spread of a tumor or cancer from the primary site of the body to a secondary site, is a multi-step process in cancer progression, accounting for various obstacles in cancer treatment and most cancer-related deaths. Metabolic reprogramming refers to adaptive metabolic changes that occur in cancer cells in the tumor microenvironment (TME) to enhance their survival ability and metastatic potential. Stromal cell metabolism also changes to stimulate tumor proliferation and metastasis. Metabolic adaptations of tumor and non-tumor cells exist not only in the TME but also in the pre-metastatic niche (PMN), a remote TME conducive for tumor metastasis...
May 19, 2023: Cell Communication and Signaling: CCS
Genmao Cao, Xuezhen Xuan, Yaling Li, Jie Hu, Ruijing Zhang, Haijiang Jin, Honglin Dong
BACKGROUND AND OBJECTIVES: Phenotypic switching in vascular smooth muscle cells (VSMCs) has been linked to aortic aneurysm, but the phenotypic landscape in aortic aneurysm is poorly understood. The present study aimed to analyse the phenotypic landscape, phenotypic differentiation trajectory, and potential functions of various VSMCs phenotypes in aortic aneurysm. METHODS: Single-cell sequencing data of 12 aortic aneurysm samples and 5 normal aorta samples (obtained from GSE166676 and GSE155468) were integrated by the R package Harmony...
May 15, 2023: Cell Communication and Signaling: CCS
Tanja Buchacher, Astrid Digruber, Markus Kanzler, Giorgia Del Favero, Monika Ehling-Schulz
BACKGROUND: Extracellular vesicles (EVs) from Gram-positive bacteria have gained considerable importance as a novel transport system of virulence factors in host-pathogen interactions. Bacillus cereus is a Gram-positive human pathogen, causing gastrointestinal toxemia as well as local and systemic infections. The pathogenicity of enteropathogenic B. cereus has been linked to a collection of virulence factors and exotoxins. Nevertheless, the exact mechanism of virulence factor secretion and delivery to target cells is poorly understood...
May 15, 2023: Cell Communication and Signaling: CCS
Katrin Laakmann, Jorina Mona Eckersberg, Moritz Hapke, Marie Wiegand, Jeff Bierwagen, Isabell Beinborn, Christian Preußer, Elke Pogge von Strandmann, Thomas Heimerl, Bernd Schmeck, Anna Lena Jung
BACKGROUND: Sepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysregulated host response and endothelial cell (EC) dysfunction. Ribonuclease 1 (RNase1) acts as a protective factor of vascular homeostasis and is known to be repressed by massive and persistent inflammation, associated to the development of vascular pathologies. Bacterial extracellular vesicles (bEVs) are released upon infection and may interact with ECs to mediate EC barrier dysfunction...
May 15, 2023: Cell Communication and Signaling: CCS
Sareh Kakavandi, Iman Zare, Maryam VaezJalali, Masoud Dadashi, Maryam Azarian, Abdullatif Akbari, Marzieh Ramezani Farani, Hamidreza Zalpoor, Bahareh Hajikhani
Coronavirus disease 2019 (COVID-19) is caused by a new member of the Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are structural and non-structural proteins (NSPs) in the genome of this virus. S, M, H, and E proteins are structural proteins, and NSPs include accessory and replicase proteins. The structural and NSP components of SARS-CoV-2 play an important role in its infectivity, and some of them may be important in the pathogenesis of chronic diseases, including cancer, coagulation disorders, neurodegenerative disorders, and cardiovascular diseases...
May 15, 2023: Cell Communication and Signaling: CCS
Yuhong Jian, Xiao Zhou, Wenju Shan, Cheng Chen, Wei Ge, Jun Cui, Wei Yi, Yang Sun
Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death worldwide. Acute MI (AMI) inflicts massive injury to the coronary microcirculation, causing large-scale cardiomyocyte death due to ischemia and hypoxia. Inflammatory cells such as monocytes and macrophages migrate to the damaged area to clear away dead cells post-MI. Macrophages are pleiotropic cells of the innate immune system, which play an essential role in the initial inflammatory response that occurs following MI, inducing subsequent damage and facilitating recovery...
May 11, 2023: Cell Communication and Signaling: CCS
Inigo Martinez-Zubiaurre, Turid Hellevik
BACKGROUND: The primary goal of radiotherapy (RT) is to induce cellular damage on malignant cells; however, it is becoming increasingly recognized the important role played by the tumor microenvironment (TME) in therapy outcomes. Therapeutic irradiation of tumor lesions provokes profound cellular and biological reconfigurations within the TME that ultimately may influence the fate of the therapy. MAIN CONTENT: Cancer-associated fibroblasts (CAFs) are known to participate in all stages of cancer progression and are increasingly acknowledged to contribute to therapy resistance...
May 11, 2023: Cell Communication and Signaling: CCS
Eun-Su Ko, Seung Hee Choi, Minwook Lee, Kyung-Soon Park
BACKGROUND: Ex vivo cultivation is a promising strategy for increasing the number of NK cells and enhancing their antitumor activity prior to clinical application. Recent studies show that stimulation with 25KDa branched polyethylenimine (25KbPEI) generates NK cells with enhanced antitumor activity. To better understand how 25KbPEI primes NK cells, we explored the mechanism underlying increase in production of IFN-γ. METHODS: Chemical priming was performed on NK-92MI cells by incubating them with 5 μg/ml of 25KbPEI...
May 9, 2023: Cell Communication and Signaling: CCS
Dong Lin, Yijia Chen, Ali Riza Koksal, Srikanta Dash, Yucel Aydin
BACKGROUND: Chronic hepatitis C virus (HCV) infection causes hepatocellular carcinoma (HCC). The HCC risk, while decreased compared with active HCV infection, persists in HCV-cured patients by direct-acting antiviral agents (DAA). We previously demonstrated that Wnt/β-catenin signaling remained activated after DAA-mediated HCV eradication. Developing therapeutic strategies to both eradicate HCV and reverse Wnt/β-catenin signaling is needed. METHODS: Cell-based HCV long term infection was established...
May 8, 2023: Cell Communication and Signaling: CCS
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