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Cell Communication and Signaling: CCS

Neha Kaushik, Min-Jung Kim, Nagendra Kumar Kaushik, Jae Kyung Myung, Mi-Young Choi, Jae-Hyeok Kang, Hyuk-Jin Cha, Cha-Soon Kim, Seon-Young Nam, Su-Jae Lee
BACKGROUND: The existence of differentiated thyroid cells is critical to respond radioactive iodide treatment strategy in thyroid cancer, and loss of the differentiated phenotype is a trademark of iodide-refractive thyroid disease. While high-dose therapy has been beneficial to several cancer patients, many studies have indicated this clinical benefit was limited to patients having BRAF mutation. BRAF-targeted paired box gene-8 (PAX8), a thyroid-specific transcription factor, generally dysregulated in BRAF-mutated thyroid cancer...
February 13, 2019: Cell Communication and Signaling: CCS
Feixia Wang, Yan Jia, Mengmeng Li, Ling Wang, Jiangjuan Shao, Qinglong Guo, Shanzhong Tan, Hai Ding, Anping Chen, Feng Zhang, Shizhong Zheng
BACKGROUND: Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here, we investigated how HSC contraction was affected by the natural compound oroxylin A, and elucidated the underlying mechanism. METHODS: Cell contraction and glycolysis were examined in cultured human HSCs and mouse liver fibrosis model upon oroxylin A intervention using diversified cellular and molecular assays, as well as genetic approaches...
February 11, 2019: Cell Communication and Signaling: CCS
Gernot Posselt, Maria Wiesauer, Bianca E Chichirau, Daniela Engler, Linda M Krisch, Gabriele Gadermaier, Peter Briza, Sabine Schneider, Francesco Boccellato, Thomas F Meyer, Cornelia Hauser-Kronberger, Daniel Neureiter, Anne Müller, Silja Wessler
BACKGROUND: Deregulated c-Abl activity has been intensively studied in a variety of solid tumors and leukemia. The class-I carcinogen Helicobacter pylori (Hp) activates the non-receptor tyrosine kinase c-Abl to phosphorylate the oncoprotein cytotoxin-associated gene A (CagA). The role of c-Abl in CagA-dependent pathways is well established; however, the knowledge of CagA-independent c-Abl processes is scarce. METHODS: c-Abl phosphorylation and localization were analyzed by immunostaining and immunofluorescence...
January 31, 2019: Cell Communication and Signaling: CCS
Yao Lin, Zerong Liang, Liping He, Mengliu Yang, Dongfang Liu, Harvest F Gu, Hua Liu, Zhiming Zhu, Hongting Zheng, Ling Li, Gangyi Yang
BACKGROUND: Ghrelin modulates many physiological processes. However, the effects of intestinal ghrelin on hepatic glucose production (HGP) are still unclear. The current study was to explore the roles of intestinal ghrelin on glucose homeostasis and insulin signaling in the liver. METHODS: The system of intraduodenal infusion and intracerebral microinfusion into the nucleus of the solitary tract (NTS) in the normal chow-diet rats and pancreatic-euglycemic clamp procedure (PEC) combined with [3-3 H] glucose as a tracer were used to analyze the effect of intestinal ghrelin...
January 25, 2019: Cell Communication and Signaling: CCS
Yu-Hong Yuan, Han-Yu Wang, Yu Lai, Wa Zhong, Wei-Ling Liang, Fu-de Yan, Zhong Yu, Jun-Kai Chen, Ying Lin
BACKGROUND: To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway. METHODS: Thirty-seven paired colon cancer and its adjacent samples from The Cancer Genome Atlas (TCGA) were analyzed. Chip Analysis Methylation Pipeline (ChAMP) analysis was employed for differential methylated points (DMPs) and the differential methylation regions (DMRs) screening. The HOXD10 mRNA expression and DNA methylation levels were detected by RT-PCR...
January 25, 2019: Cell Communication and Signaling: CCS
Huihui Xu, Tianshu Fang, Hongbo Yan, Linghuo Jiang
Through a genome-wide screen we have identified calcium-tolerant deletion mutants for five genes in the budding yeast Saccharomyces cerevisiae. In addition to CNB1 and RCN1 that are known to play a role in the calcium signalling pathway, the protein kinase gene CMK2, the sphingolipid homeostasis-related gene ORM2 and the gene SIF2 encoding the WD40 repeat-containing subunit of Set3C histone deacetylase complex are involved in the calcium sensitivity of yeast cells to extracellular calcium. Cmk2 and the transcription factor Crz1 have opposite functions in the response of yeast cells to calcium stress...
January 21, 2019: Cell Communication and Signaling: CCS
Shi-Cong Tao, Shang-Chun Guo
Throughout human life, bone is constantly in a delicate dynamic equilibrium of synthesis and resorption, hosting finely-tuned bone mineral metabolic processes for bone homeostasis by collaboration or symphony among several cell types including osteoclasts (OCs), osteoblasts (OBs), osteocytes (OYs), vascular endothelial cells (ECs) and their precursors. Beyond these connections, a substantial level of communication seems to occur between bone and other tissues, and together, they form an organic unit linked to human health and disease...
January 18, 2019: Cell Communication and Signaling: CCS
Theresa Lowinus, Florian H Heidel, Tanima Bose, Subbaiah Chary Nimmagadda, Tina Schnöder, Clemens Cammann, Ingo Schmitz, Ulrike Seifert, Thomas Fischer, Burkhart Schraven, Ursula Bommhardt
BACKGROUND: Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic targets in cancer therapy include voltage-gated Kv 1.3 potassium channels, but their role in acute leukemia is unclear. We reported that Kv 1.3 channels of lymphocytes are blocked by memantine, which is known as an antagonist of neuronal N-methyl-D-aspartate type glutamate receptors and clinically applied in therapy of advanced Alzheimer disease...
January 16, 2019: Cell Communication and Signaling: CCS
Long Zhang, Qi Wang, Yuzhen Zhou, Qianwen Ouyang, Weixing Dai, Jianfeng Chen, Peipei Ding, Ling Li, Xin Zhang, Wei Zhang, Xinyue Lv, Luying Li, Pingzhao Zhang, Guoxiang Cai, Weiguo Hu
BACKGROUND: As the first member of the metastasis-associated protein (MTA) family, MTA1 and another MTA family member, MTA2, have both been reported to promote breast cancer progression and metastasis. However, the difference and relationship between MTA1 and MTA2 have not been fully elucidated. METHODS: Transwell assays were used to assess the roles of MTA1 and MTA2 in the metastasis of ZR-75-30 luminal B breast cancer cells in vitro. Immunoblotting and qRT-PCR were used to evaluate the effect of MTA1 overexpression on MTA2...
January 14, 2019: Cell Communication and Signaling: CCS
Liu Liu, Yan Wu, Chunxiang Bian, Muhammad Farrukh Nisar, Mei Wang, Xiangyu Hu, Qingchun Diao, Weiqi Nian, Enwen Wang, Wei Xu, Julia Li Zhong
BACKGROUND: Despite therapeutic advancements (e.g. B-RAF inhibitors) targeting cutaneous melanoma, many cellular processes, including inducible heme oxygenase 1 (HO-1), counteract treatments for malignancies. So there is an urgent need to find biological treatment targets, develop new therapeutic approaches and achieve longer responses. This study aimed to explore the relationship of HO-1 and B-Raf via mediating ERK1/2 signaling on cell cycle in melanoma. METHODS: Immunohistochemistry was applied to evaluate the levels of HO-1 and B-Raf expression in melanoma tissues and adjacent healthy tissues...
January 11, 2019: Cell Communication and Signaling: CCS
Hongming Lv, Lihua Hong, Ye Tian, Changjiu Yin, Chao Zhu, Haihua Feng
BACKGROUND: Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor, is essential for alleviating APAP-induced hepatotoxicity. Corilagin (Cori) is a natural polyphenol compound that possesses effective antioxidant activity; however, the protective effect of Cori on APAP-induced hepatotoxicity is still unknown. The current study aimed to explore whether Cori could mitigate hepatotoxicity caused by APAP and the underlying molecular mechanisms of action...
January 10, 2019: Cell Communication and Signaling: CCS
Rui Chen, Xin Xu, Yuquan Tao, Zijun Qian, Yongchun Yu
Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cell communication has been extensively studied, showed that exosomes can deliver their functional RNAs and proteins to recipient cells, impacting transcription and translation of recipient cells. Emerging evidence suggests that hepatocellular carcinoma (HCC) cell-derived exosomes can construct a fertile environment to support HCC cells proliferation, grow, invasion and metastasis, development of drug resistance...
January 7, 2019: Cell Communication and Signaling: CCS
Sara Ortiz-Rivero, Cristina Baquero, Luis Hernández-Cano, Juan José Roldán-Etcheverry, Sara Gutiérrez-Herrero, Cristina Fernández-Infante, Víctor Martín-Granado, Eduardo Anguita, José María de Pereda, Almudena Porras, Carmen Guerrero
BACKGROUND: Megakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activator of Rap1 GTPases, is involved in platelet activation and regulates several differentiation processes. METHODS: We evaluated C3G function in megakaryopoiesis using transgenic mouse models where C3G and C3GΔCat (mutant lacking the GEF domain) transgenes are expressed exclusively in megakaryocytes and platelets...
December 19, 2018: Cell Communication and Signaling: CCS
Jin-Yong He, Xiao-Hui Wei, Si-Jing Li, Yang Liu, Hao-Lin Hu, Zheng-Zheng Li, Xin-Hong Kuang, Lai Wang, Xin Shi, Sheng-Tao Yuan, Li Sun
BACKGROUND: Adipocytes make up the major component of breast tissue, accounting for 90% of stromal tissue. Thus, the crosstalk between adipocytes and breast cancer cells may play a critical role in cancer progression. Adipocyte-breast cancer interactions have been considered important for the promotion of breast cancer metastasis. However, the specific mechanisms underlying these interactions are unclear. In this study, we investigated the mechanisms of adipocyte-mediated breast cancer metastasis...
December 18, 2018: Cell Communication and Signaling: CCS
Bin Dai, Xuan Zhang, Runze Shang, Jianlin Wang, Xisheng Yang, Hong Zhang, Qi Liu, Desheng Wang, Lin Wang, Kefeng Dou
BACKGROUND: The molecular signaling events involving in high malignancy and poor prognosis of hepatocellular carcinoma (HCC) are extremely complicated. Blockade of currently known targets has not yet led to successful clinical outcome. More understanding about the regulatory mechanisms in HCC is necessary for developing new effective therapeutic strategies for HCC patients. METHODS: The expression of Rho GTPase-activating protein 11A (ARHGAP11A) was examined in human normal liver and HCC tissues...
December 13, 2018: Cell Communication and Signaling: CCS
Junsong Zhou, Aizhen Yang, Yucan Wang, Fengwu Chen, Zhenzhen Zhao, Viralkumar Davra, Katsue Suzuki-Inoue, Yukio Ozaki, Raymond B Birge, Qingxian Lu, Yi Wu
BACKGROUND: Previously, several studies have shown that Tyro3, Axl, and Mertk (TAM) receptors participate in platelet activation and thrombosis. However, the role of individual receptors is not fully understood. METHODS: Using single receptor-deficient platelets from TAM knockout mice in the C57BL/6 J strain, we performed a knockout study using single TAM-deficient mice. We treated platelets isolated from TAM knockout mice with the Glycoprotein VI (GPVI) agonists convulxin, poly(PHG), and collagen-related triple-helical peptide (CRP), as well as thrombin for in-vitro experiments...
December 12, 2018: Cell Communication and Signaling: CCS
Xiaofan Yang, Pingping Xue, Xin Liu, Xiang Xu, Zhenbing Chen
BACKGROUND: Transforming growth factor beta 1 (TGF-β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration and muscle function in skeletal muscle diseases. Skeletal muscle atrophy, characterized by the loss of muscle strength and mass, is one of the pathological conditions regulated by TGF-β1, but the underlying mechanism involved in the atrophic effects of TGF-β1 is not fully understood. METHODS: Mice sciatic nerve transection model was created and gastrocnemius were analysed by western blot, immunofluorescence staining and fibre diameter quantification after 2 weeks...
December 7, 2018: Cell Communication and Signaling: CCS
Fereshteh Haghighi, Julia Dahlmann, Saeideh Nakhaei-Rad, Alexander Lang, Ingo Kutschka, Martin Zenker, George Kensah, Roland P Piekorz, Mohammad Reza Ahmadian
BACKGROUND: Human pluripotent stem cells (PSCs) open new windows for basic research and regenerative medicine due to their remarkable properties, i.e. their ability to self-renew indefinitely and being pluripotent. There are different, conflicting data related to the role of basic fibroblast growth factor (bFGF) in intracellular signal transduction and the regulation of pluripotency of PSCs. Here, we investigated the effect of bFGF and its downstream pathways in pluripotent vs. differentiated human induced (hi) PSCs...
December 5, 2018: Cell Communication and Signaling: CCS
Yangguang Hao, Shichao Yu, Fangzhou Luo, Li Hua Jin
BACKGROUND: The regulatory mechanisms of hematopoiesis and cellular immunity show a high degree of similarity between insects and mammals, and Drosophila has become a good model for investigating cellular immune responses. Jumeau (Jumu) is a member of the winged-helix/forkhead (FKH) transcription factor family and is required for Drosophila development. Adult jumu mutant flies show defective hemocyte phagocytosis and a weaker defense capability against pathogen infection. Here, we further investigated the role of jumu in the regulation of larval hemocyte development and phagocytosis...
December 5, 2018: Cell Communication and Signaling: CCS
Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Tsukasa Oikawa, Hisataka Sabe
BACKGROUND: TP53 mutations in cancer cells often evoke cell invasiveness, whereas fibroblasts show invasiveness in the presence of intact TP53. AMAP1 (also called DDEF1 or ASAP1) is a downstream effector of ARF6 and is essential for the ARF6-driven cell-invasive phenotype. We found that AMAP1 levels are under the control of p53 (TP53 gene product) in epithelial cells but not in fibroblasts, and here addressed that molecular basis of the epithelial-specific function of p53 in suppressing invasiveness via targeting AMAP1...
December 4, 2018: Cell Communication and Signaling: CCS
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