Muhammad Abrar, Shahid Ali, Irfan Hussain, Hizran Khatoon, Fatima Batool, Shakira Ghazanfar, Dylan Corcoran, Yasuhiko Kawakami, Amir Ali Abbasi
TRPS1 serves as the causative gene for tricho-rhino phalangeal syndrome, known for its craniofacial and skeletal abnormalities. The Trps1 gene encodes a protein that represses Wnt signaling through strong interactions with Wnt signaling inhibitors. The identification of genomic cis-acting regulatory sequences governing Trps1 expression is crucial for understanding its role in embryogenesis. Nevertheless, to date, no investigations have been conducted concerning these aspects of Trps1. To identify deeply conserved noncoding elements (CNEs) within the Trps1 locus, we employed a comparative genomics approach, utilizing slowly evolving fish such as coelacanth and spotted gar...
February 18, 2024: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution