Takuya Hashimoto, Masayuki Tsuneki, Trenton R Foster, Jeans M Santana, Hualong Bai, Mo Wang, Haidi Hu, Jesse J Hanisch, Alan Dardik
Vascular diseases span diverse pathology, but frequently arise from aberrant signaling attributed to specific membrane-associated molecules, particularly the Eph-ephrin family. Originally recognized as markers of embryonic vessel identity, Eph receptors and their membrane-associated ligands, ephrins, are now known to have a range of vital functions in vascular physiology. Interactions of Ephs with ephrins at cell-to-cell interfaces promote a variety of cellular responses such as repulsion, adhesion, attraction, and migration, and frequently occur during organ development, including vessel formation...
March 2016: Birth Defects Research. Part C, Embryo Today: Reviews