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Journals Liver International : Official...

Liver International : Official Journal of the International Association for the Study of the Liver

https://read.qxmd.com/read/37724792/liver-stiffness-is-associated-with-all-cause-mortality-in-patients-with-nafld-a-systematic-review-and-meta-analysis
#1
REVIEW
Stefano Ciardullo, Emanuele Muraca, Francesca Zerbini, Gianluca Perseghin
BACKGROUND AND AIMS: Several studies reported an association between liver stiffness measurement (LSM) obtained through vibration-controlled transient elastography (VCTE) and all-cause mortality in patients with nonalcoholic fatty liver disease (NAFLD). The objective of this systematic review and meta-analysis was to summarize available evidence on the nature and magnitude of this association. METHODS: We systematically searched PubMed-MEDLINE and Scopus up to April 2023 for observational cohort studies in which LSM was measured with VCTE in patients with NAFLD or in general population settings, with a follow-up ≥1 year and with available data on all-cause mortality...
September 19, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37724776/the-non-invasive-evaluation-of-liver-involvement-in-patients-with-cystic-fibrosis-a-prospective-study
#2
JOURNAL ARTICLE
Elton Dajti, Federico Ravaioli, Giulia Paiola, Sonia Volpi, Luigi Colecchia, Alberto Ferrarese, Luigina Vanessa Alemanni, Caterina Cusumano, Anna Rita Di Biase, Giovanni Marasco, Amanda Vestito, Davide Festi, Pierre-Emmanuel Rautou, Marco Cipolli, Antonio Colecchia
BACKGROUND AND AIMS: Porto-sinusoidal vascular disease (PSVD) has been described as the prominent pathology in liver explants of patients with cystic fibrosis (CF), but data outside the transplant setting are lacking. We aimed to investigate the prevalence of portal hypertension (PH) in CF-associated liver disease (CFLD) and develop an algorithm to classify liver involvement in CF patients. METHODS: This is a cross-sectional study of consecutive paediatric and adult patients in a tertiary centre between 2018 and 2019, who underwent ultrasound, liver (LSM) and spleen stiffness (SSM) measurement...
September 19, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37724775/predicting-post-resection-early-recurrence-of-hepatocellular-carcinoma-defining-the-role-of-microvascular-invasion
#3
LETTER
Teh-Ia Huo, Shu-Yein Ho, Jia-I Liao
No abstract text is available yet for this article.
September 19, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37718933/a-prospective-study-on-the-prevalence-of-masld-in-people-with-type-2-diabetes-in-the-community-cost-effectiveness-of-screening-strategies
#4
JOURNAL ARTICLE
Roberta Forlano, Tijana Stanic, Sahan Jayawardana, Benjamin Harvey Mullish, Michael Yee, Elias Mossialos, Robert Goldin, Salvatore Petta, Emmanouil Tsochatzis, Mark Thursz, Pinelopi Manousou
BACKGROUND AND AIMS: As screening for the liver disease and risk-stratification pathways are not established in patients with type-2 diabetes mellitus (T2DM), we evaluated the diagnostic performance and the cost-utility of different screening strategies for MASLD in the community. METHODS: Consecutive patients with T2DM from primary care underwent screening for liver diseases, ultrasound, ELF score and transient elastography (TE). Five strategies were compared to the standard of care: ultrasound plus abnormal liver function tests (LFTs), Fibrosis score-4 (FIB-4), NAFLD fibrosis score, Enhanced liver fibrosis test (ELF) and TE...
September 18, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37718732/the-genetics-of-portal-hypertension-recent-developments-and-the-road-ahead
#5
REVIEW
Sarah Shalaby, Luisa Ronzoni, Virginia Hernandez-Gea, Luca Valenti
Portal hypertension (PH), defined as a pathological increase in the portal vein pressure, has different aetiologies and causes. Intrahepatic PH is mostly secondary to the presence of underlying liver disease leading to cirrhosis, characterized by parenchymal changes with deregulated accumulation of extracellular matrix and vascular abnormalities; liver sinusoidal endothelial cells and hepatic stellate cells are key players in PH progression, able to influence each other. However, PH may also develop independently of parenchymal damage, as occur in portosinusoidal vascular disorder (PSVD), a group of clinical and histological entities characterized by portal vasculature dysfunctions...
September 18, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37718730/predictors-of-clinical-trajectories-of-patients-with-acutely-decompensated-cirrhosis-an-external-validation-of-the-predict-study
#6
JOURNAL ARTICLE
Enrico Pompili, Maurizio Baldassarre, Giorgio Bedogni, Giacomo Zaccherini, Giulia Iannone, Clara De Venuto, Dario Pratelli, Francesco Palmese, Marco Domenicali, Paolo Caraceni
BACKGROUND AND AIMS: The PREDICT study recently showed that acutely decompensated (AD) patients with cirrhosis can present three different clinical phenotypes in the 90 days after admission: (1) pre-ACLF, developing acute-on-chronic liver failure (ACLF); (2) unstable decompensated cirrhosis (UDC), being re-admitted for AD without ACLF and (3) stable decompensated cirrhosis (SDC), not presenting readmission or ACLF. This study aimed to externally validate the existence of these three distinct trajectories and to identify predictors for the occurrence of each trajectory...
September 18, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37718533/patients-hospitalized-with-alcohol-related-liver-disease-and-prior-bariatric-surgery-are-more-prone-to-develop-acute-on-chronic-liver-failure
#7
JOURNAL ARTICLE
Louis Onghena, Yves Van Nieuwenhove, Laurissa Demeulenaere, Lindsey Devisscher, Xavier Verhelst, Helena Degroote, Sarah Raevens, Hans Van Vlierberghe, Sander Lefere, Anja Geerts
BACKGROUND & AIMS: Patients with a history of bariatric surgery (BS) are susceptible to developing alcohol use disorder. We and others have previously shown that these patients can develop severe alcohol-related liver disease (ARLD). Our aim was to describe the demographics, co-morbidities and mortality of a hospitalized population diagnosed with alcohol-related liver disease, in relation to BS. METHODS: We included 299 patients hospitalized with ARLD at the Ghent University Hospital between 1 January 2018 and 31 December 2022...
September 17, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37718515/socio-economic-factors-associated-with-loss-to-follow-up-among-individuals-with-hcv-a-dutch-nationwide-cross-sectional-study
#8
JOURNAL ARTICLE
Marleen van Dijk, Anders Boyd, Sylvia M Brakenhoff, Cas J Isfordink, Rosan A van Zoest, Mark D Verhagen, Robert J de Knegt, Joost P H Drenth, Marc van der Valk
BACKGROUND AND AIMS: The path to hepatitis C virus (HCV) elimination is complicated by individuals who become lost to follow-up (LTFU) during care, particularly before receiving effective HCV treatment. We aimed to determine factors contributing to LTFU and whether LTFU is associated with mortality. METHODS: In this secondary analysis, we constructed a database including individuals with HCV who were either LTFU (data from the nationwide HCV retrieval project, CELINE) or treated with directly acting antivirals (DAA) (data from Statistics Netherlands) between 2012 and 2019...
September 17, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37715608/mechanisms-and-treatment-approaches-for-aclf
#9
REVIEW
Salvatore Piano, Nadim Mahmud, Paolo Caraceni, Marta Tonon, Rajeshwar Prosad Mookerjee
Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome characterized by decompensation of cirrhosis, severe systemic inflammation and organ failures. ACLF is frequently triggered by intra- and/or extrahepatic insults, such as bacterial infections, alcohol-related hepatitis or flares of hepatic viruses. The imbalance between systemic inflammation and immune tolerance causes organ failures through the following mechanisms: (i) direct damage of immune cells/mediators; (ii) worsening of circulatory dysfunction resulting in organ hypoperfusion and (iii) metabolic alterations with prioritization of energetic substrates for inflammation and peripheral organ 'energetic crisis'...
September 16, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37715606/von-willebrand-factor-is-an-independent-predictor-of-short-term-mortality-in-acutely-ill-patients-with-cirrhosis
#10
JOURNAL ARTICLE
Bente P van den Boom, Marilena Stamouli, Jennifer Timon, William Bernal, Annabel Blasi, Jelle Adelmeijer, Javier Fernandez, Ton Lisman, Vishal C Patel
BACKGROUND AND AIMS: Levels of von Willebrand factor (VWF) are elevated in patients with cirrhosis, and correlate well with disease severity. In patients with decompensated cirrhosis (DC), plasma VWF is associated with mortality. The value of VWF in predicting short-term mortality risk in patients with acute-on-chronic liver failure (ACLF) is, however, unclear. METHODS: We included patients with DC (n = 111) and ACLF (n = 105). We measured VWF levels and correlated these with other laboratory parameters and prediction models for mortality...
September 16, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37715524/a-territory-wide-opportunistic-hospital-based-hcv-screening-in-the-general-population-from-northern-italy-the-1969-1989-birth-cohort
#11
JOURNAL ARTICLE
Roberta D'Ambrosio, Sara Piccinelli, Benedetta Beccalli, Angiola Spinetti, Massimo Puoti, Stefano Fagiuoli, Carlo Federico Magni, Andrea Vavassori, Paolo Sacchi, Silvana Castaldi, Giulia Bombardieri, Claudio Farina, Sabrina Buoro, Alessandro Amorosi, Matteo Corradin, Danilo Cereda, Pietro Lampertico
BACKGROUND AND AIM: The World Health Organization (WHO) goal of Hepatitis C Virus (HCV) elimination by 2030 rose awareness about the need of screening plans, worldwide. In Italy, graduated screening starting from people born in 1969-1989 might be the most-effective strategy. We performed an opportunistic HCV screening study in the general population attending health facilities in Lombardy region, Northern Italy. METHODS: This is a prospective, multicenter, territory-wide, opportunistic study supported by the Regional Government of Lombardy, Italy...
September 16, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37698034/metabolic-dysfunction-associated-steatotic-liver-disease-in-older-adults-is-associated-with-frailty-and-social-disadvantage
#12
JOURNAL ARTICLE
Daniel Clayton-Chubb, William W Kemp, Ammar Majeed, John S Lubel, Robyn L Woods, Cammie Tran, Joanne Ryan, Alexander Hodge, Hans G Schneider, John J McNeil, Stuart K Roberts
BACKGROUND & AIMS: The burden of metabolic dysfunction-associated steatotic liver disease (MASLD) is growing rapidly, as is the number of older adults globally. However, relatively few studies have been performed evaluating the prevalence and risk factors for MASLD in older adults. As such, we aimed to identify the prevalence of MASLD in older adults, as well as sociodemographic, clinical, functional and biochemical associations. METHODS: The study population included older adults without a history of cardiovascular disease, dementia or independence-limiting functional impairment who had participated in the ASPirin in Reducing Events in the Elderly (ASPREE) randomised trial...
September 12, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37697960/association-of-thyroid-function-with-non-alcoholic-fatty-liver-disease-in-recent-onset-diabetes
#13
JOURNAL ARTICLE
Nina Saatmann, Martin Schön, Oana-Patricia Zaharia, Maximilian Huttasch, Klaus Strassburger, Sandra Trenkamp, Yuliya Kupriyanova, Vera Schrauwen-Hinderling, Sabine Kahl, Volker Burkart, Robert Wagner, Michael Roden
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) has been linked to type 2 diabetes (T2D), but also to hypothyroidism. Nevertheless, the relationship between thyroid function and NAFLD in diabetes is less clear. This study investigated associations between free thyroxine (fT4) or thyroid-stimulating hormone (TSH) and NAFLD in recent-onset diabetes. METHODS: Participants with recent-onset type 1 diabetes (T1D, n = 358), T2D (n = 596) or without diabetes (CON, n = 175) of the German Diabetes Study (GDS), a prospective longitudinal cohort study, underwent Botnia clamp tests and assessment of fT4, TSH, fatty liver index (FLI) and in a representative subcohort 1 H-magnetic resonance spectroscopy...
September 12, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37680048/authors-reply-to-zou-et-al
#14
LETTER
Stefano Ciardullo, Marco Carbone, Pietro Invernizzi, Gianluca Perseghin
No abstract text is available yet for this article.
September 7, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37665175/letter-to-the-editor-regarding-exploring-the-landscape-of-steatotic-liver-disease-in-the-general-us-population
#15
LETTER
Haoxuan Zou, Yan Xie
No abstract text is available yet for this article.
September 4, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37665132/response-to-letter-to-the-editor-child-turcotte-pugh-score-as-a-model-for-organ-allocation-in-liver-transplantation-perhaps-old-is-still-gold
#16
LETTER
Quirino Lai, Ilaria Lenci, Valerio Giannelli, Giuseppe Marrone
No abstract text is available yet for this article.
September 4, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37650363/diagnostic-and-prognostic-performance-of-the-safe-score-in-non-alcoholic-fatty-liver-disease
#17
JOURNAL ARTICLE
Guanlin Li, Huapeng Lin, Pimsiri Sripongpun, Lilian Y Liang, Xinrong Zhang, Vincent W S Wong, Grace L H Wong, W Ray Kim, Terry C F Yip
BACKGROUND & AIMS: The steatosis-associated fibrosis estimator (SAFE) score was developed to detect clinically significant liver fibrosis in patients with NAFLD in the United States. We compare the performance of the SAFE score and other non-invasive tests to diagnose liver fibrosis and to correlate the scores with liver-related outcomes in patients with NAFLD in Hong Kong. METHODS: This was a retrospective cohort study involving two data sets. The first cohort was a biopsy cohort of NAFLD patients (n = 279), and the second was a territory-wide cohort of NAFLD patients (n = 4603) retrieved from a territory-wide electronic healthcare database in Hong Kong...
August 31, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37650333/child-turcotte-pugh-score-as-a-model-for-organ-allocation-in-liver-transplantation-perhaps-old-is-still-gold
#18
LETTER
Abdulrahman Qatomah, Aorn Hass, Philip Wong, Marc Deschenes
No abstract text is available yet for this article.
August 31, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37650211/investigating-the-role-of-lipid-genes-in-liver-disease-using-fatty-liver-models-of-alcohol-and-high-fat-in-zebrafish-danio-rerio
#19
JOURNAL ARTICLE
Fathima Shihana, Pradeep Manuneedhi Cholan, Stuart Fraser, Stefan H Oehlers, Devanshi Seth
BACKGROUND: Accumulation of lipid in the liver is the first hallmark of both alcohol-related liver disease (ALD) and non-alcohol-related fatty liver disease (NAFLD). Recent studies indicate that specific mutations in lipid genes confer risk and might influence disease progression to irreversible liver cirrhosis. This study aimed to understand the function/s of lipid risk genes driving disease development in zebrafish genetic models of alcohol-related and non-alcohol-related fatty liver...
August 31, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37649460/is-hcv-elimination-among-persons-living-with-hiv-feasible-data-from-the-noco-study-in-the-setting-of-the-icona-cohort
#20
JOURNAL ARTICLE
Antonella d'Arminio Monforte, Alessandro Tavelli, Roberto Rossotti, Roberta Gagliardini, Annalisa Saracino, Sergio Lo Caputo, Matteo Sala, Eugenia Quiros-Roldan, Cristina Mussini, Enrico Girardi, Alessandro Cozzi-Lepri, Andrea Antinori, Massimo Puoti
BACKGROUND AND AIMS: Whether the HCV test-and-treat strategy impacted on the rate of new HCV infections among PLWH in Italy is unknown. METHODS: Prospective study of PLWH in the ICONA network. At baseline, PLWH were tested for HCV-Ab; HCV-RNA (if HCV-Ab positive) and, if positive, treated with DAA. SVR12 indicated eradication. Seroconversions and re-infections were evaluated yearly in HCV-Ab neg and HCV-RNA neg at first screening. We estimated the following: HCV seroconversions, incidence of HCV reinfections, and access to DAA and SVR12 rates tighter with factors associated with each outcome...
August 31, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
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