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Journals Liver International : Official...

Liver International : Official Journal of the International Association for the Study of the Liver

https://read.qxmd.com/read/36938759/biallelic-known-and-novel-dcdc2-variants-in-cholestatic-liver-disease-phenotype-genotype-observations-in-four-children
#1
JOURNAL ARTICLE
Aline Azabdaftari, Henrike L Sczakiel, Magdalena Danyel, Benno Kohlmaier, Christoph J Mache, Amelie Stalke, Eva-Doreen Pfister, Julia Thumfart, Stephan Henning, A S Knisely, Philip Bufler
Neonatal sclerosing cholangitis (NSC) is associated with progressing biliary fibrosis often requiring liver transplantation in childhood. Several recent studies have identified variants in DCDC2, encoding doublecortin domain-containing protein 2 (DCDC2), expressed in primary cilia, that accompany syndromic disease and NSC. We report 4 patients with hepatobiliary disease associated with two novel homozygous or compound heterozygous variants in DCDC2. Three patients with protein-truncating variants in DCDC2, expressing no DCDC2, presented with the originally described severe hepatic phenotype in infancy...
March 20, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36938749/associations-of-serum-uric-acid-levels-with-liver-disease-related-morbidity-and-mortality-a-prospective-cohort-study-of-the-uk-biobank
#2
JOURNAL ARTICLE
Zhening Liu, Hangkai Huang, Jiarong Xie, Chengfu Xu
BACKGROUND AND AIMS: The association of serum uric acid (SUA) levels with liver-related morbidity and mortality remains undetermined. Therefore, we aimed to explore the association of SUA levels with liver-related morbidity and mortality. METHODS: The present cohort study included 459,619 adults from the UK Biobank. Multivariable Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of SUA levels with morbidity and mortality of overall liver disease...
March 20, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36929682/third-dose-of-sars-cov2-mrna-vaccination-produces-robust-persistent-cellular-and-humoral-immune-responses-in-liver-transplant-recipients
#3
JOURNAL ARTICLE
Marzia Montalbano, Paola Piccolo, Raffaella Lionetti, Ubaldo Visco-Comandini, Chiara Agrati, Germana Grassi, Silvia Meschi, Giulia Matusali, Federica Conte, Federica Angelone, Giuseppe Maria Ettorre, Nicola Guglielmo, Fabrizio Maggi, Massimo Francalancia, Tiziana Mereu, Vincenzo Puro, Enrico Girardi, Gianpiero D'Offizi
Weaker responses have been described after two doses of anti-SARS-CoV2 vaccination in liver transplant recipients. At the Italian National Institute for Infectious Diseases, 122 liver transplant recipients (84% males, median age 64 years) were tested for humoral and cell-mediated immune response after a third doses of anti-SARS-CoV2 mRNA vaccines. Humoral response was measured by quantifying anti-receptor binding domain and neutralizing antibodies; cell-mediated response was measured by quantifying IFN-γ after stimulation of T cells with SARS-CoV-2-specific peptides...
March 17, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36924436/novel-urinary-protein-panels-for-the-non-invasive-diagnosis-of-nonalcoholic-fatty-liver-disease-and-fibrosis-stages
#4
JOURNAL ARTICLE
Gong Feng, Xiaoxun Zhang, Liangjun Zhang, Wen-Yue Liu, Shi Geng, Hai-Yang Yuan, Jun-Cheng Sha, Xiao-Dong Wang, Dan-Qin Sun, Giovanni Targher, Christopher D Byrne, Tian-Lei Zheng, Feng Ye, Ming-Hua Zheng, Jin Chai
BACKGROUND & AIMS: There is an unmet clinical need for non-invasive tests to diagnose nonalcoholic fatty liver disease (NAFLD) and individual fibrosis stages. We aimed to test whether urine protein panels could be used to identify NAFLD, NAFLD with fibrosis (stage F≥1), and NAFLD with significant fibrosis (stage F≥2). METHODS: We collected urine samples from 100 patients with biopsy-confirmed NAFLD and 40 healthy volunteers and proteomics and bioinformatics analyses were performed in this derivation cohort...
March 16, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36912787/high-accuracy-of-spleen-stiffness-measurement-in-diagnosing-clinically-significant-portal-hypertension-in-metabolic-associated-fatty-liver-disease
#5
JOURNAL ARTICLE
Aitor Odriozola, Ángela Puente, Antonio Cuadrado, Paula Iruzubieta, María Teresa Arias-Loste, Carlos Redondo, Coral Rivas, Emilio Fábrega, Javier Crespo, José Ignacio Fortea
BACKGROUND & AIMS: Spleen stiffness measurement (SSM) by transient elastography (VCTE) has been tested in a limited number of studies versus hepatic venous pressure gradient (HVPG), especially with the 100 Hz spleen specific module. The current study aims to evaluate the diagnostic performance of this novel module for detecting clinically significant portal hypertension (CSPH) in a cohort of compensated patients with metabolic-associated fatty liver disease (MAFLD) as the main etiology and to improve the performance of the Baveno VII criteria for CSPH diagnosis by including SSM...
March 13, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36912786/deficient-chaperone-mediated-autophagy-in-macrophage-aggravates-inflammation-of-nonalcoholic-steatohepatitis-by-targeting-nup85
#6
JOURNAL ARTICLE
Miao Zhang, Siyuan Tian, Shuoyi Ma, Xia Zhou, Xiaohong Zheng, Bo Li, Guanya Guo, Jiahao Yu, Rui Su, Fangfang Yang, Yinan Hu, Gang Ma, Hui Yang, Linhua Zheng, Changcun Guo, Yulong Shang, Jingbo Wang, Ying Han
BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH), a more severe subtype of non-alcoholic fatty liver disease, can cause cirrhosis and hepatocellular carcinoma. Macrophages play critical roles in initiating and maintaining NASH-induced liver inflammation and fibrosis. However, the underlying molecular mechanism of macrophage chaperone-mediated autophagy (CMA) in NASH remains unclear. We aimed to investigate the effects of macrophage-specific CMA on liver inflammation and identify a potential therapeutic target for NASH treatment...
March 13, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36897563/carvedilol-as-the-new-non-selective-beta-blocker-of-choice-in-patients-with-cirrhosis-and-portal-hypertension
#7
REVIEW
Laura Turco, Thomas Reiberger, Giovanni Vitale, Vincenzo La Mura
Portal hypertension (PH) is the most common complication of cirrhosis and represents the main driver of hepatic decompensation. The overarching goal of PH treatments in patients with compensated cirrhosis is to the reduce the risk of hepatic decompensation (i.e development of ascites, variceal bleeding and/or hepatic encephalopathy). In decompensated patients, PH-directed therapies aim at avoiding further decompensation (i.e. recurrent/refractory ascites, variceal rebleeding, recurrent encephalopathy, spontaneous bacterial peritonitis, or hepatorenal syndrome) and at improving survival...
March 10, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36892418/spermidine-suppresses-the-activation-of-hepatic-stellate-cells-to-cure-liver-fibrosis-through-autophagy-activator-map1s
#8
JOURNAL ARTICLE
Boyun Shi, Wei Wang, Mengting Ye, Min Liang, Ziyu Yu, Yingying Zhang, Zhaoyu Liu, Xue Liang, Jian Ao, Fengfeng Xu, Guibin Xu, Xianhan Jiang, Xinke Zhou, Leyuan Liu
BACKGROUND & AIMS: Liver diseases present a wide range of fibrosis, from fatty liver with no inflammation to steatohepatitis with varying degrees of fibrosis, to established cirrhosis leading to HCC. In a multivariate analysis, serum levels of spermidine were chosen as the top metabolite from 237 metabolites and its levels were drastically reduced along with progression to advanced steatohepatitis. Our previous studies that showed spermidine supplementation helps mice prevent liver fibrosis through MAP1S have prompted us to explore the possibility that spermidine can alleviate or cure already-developed liver fibrosis...
March 9, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36883784/fatty-liver-disease-heart-rate-and-cardiac-remodelling-evidence-from-the-uk-biobank
#9
JOURNAL ARTICLE
Oveis Jamialahmadi, Federica Tavaglione, Araz Rawshani, Charlotta Ljungman, Stefano Romeo
BACKGROUND & AIMS: Growing evidence supports an association between fatty liver disease (FLD) and cardiac dysfunction and remodelling, leading to cardiovascular disease and heart failure. Herein, we investigated the independent contribution of FLD to cardiac dysfunction and remodelling in participants from the UK Biobank with cardiac magnetic resonance (CMR) data available. METHODS: A total of 18,848 Europeans without chronic viral hepatitis and valvular heart diseases, with liver magnetic resonance imaging and CMR data were included in the analyses...
March 8, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36864668/the-use-of-current-knowledge-and-non-invasive-testing-modalities-for-predicting-at-risk-nonalcoholic-steatohepatitis-and-assessing-fibrosis
#10
REVIEW
Marcelo Kugelmas, Mazen Noureddin, Nadege Gunn, Kimberly Brown, Zobair Younossi, Manal Abdelmalek, Naim Alkhouri
There is ongoing recognition of the burden of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), with fibrosis being the most important histological feature that is associated with progression to cirrhosis and the occurrence of major adverse liver outcomes. Liver biopsy is the gold standard applied to detect NASH and determine the stage of fibrosis, but its use is limited. There is a need for non-invasive testing (NIT) techniques to identify patients considered at-risk NASH (NASH with NAFLD activity score > 4 and ≥F2 fibrosis)...
March 2, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36855842/the-utility-of-non-invasive-tests-to-assess-advanced-fibrosis-in-asian-subjects-with-chronic-hepatitis-b-and-concomitant-hepatic-steatosis
#11
JOURNAL ARTICLE
Weicong Kenneth Lin, Rajneesh Kumar, Feng Shen, Henry Lik-Yuen Chan, Grace Lai-Hung Wong, Rahul Kumar, Wan Cheng Chow, Su Lin, Vincent Wai-Sun Wong, Jian-Gao Fan, George Boon-Bee Goh
BACKGROUND: Chronic hepatitis B (CHB) is endemic to Asia and is a leading cause of liver-related morbidity. The prevalence of concomitant CHB and hepatic steatosis (HS) is increasing in Asia. Non-invasive tests (NITs) including FIB-4, NFS, and APRI assess fibrosis in populations with a single aetiology, but not in subjects with concomitant CHB and HS. AIM: To explore the accuracy of NITs in predicting advanced fibrosis in patients with concomitant CHB and HS. METHODOLOGY: This multicentre study of CHB patients who underwent liver biopsy explored clinical characteristics of these subjects, stratified by presence of HS...
February 28, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36843445/abdominal-obesity-and-alcohol-use-modify-the-impact-of-genetic-risk-for-incident-advanced-liver-disease-in-the-general-population
#12
JOURNAL ARTICLE
Panu K Luukkonen, Martti Färkkilä, Antti Jula, Veikko Salomaa, Satu Männistö, Annamari Lundqvist, Markus Perola, Fredrik Åberg
BACKGROUND & AIMS: Genetic variants, abdominal obesity and alcohol use are risk factors for incident liver disease (ILD). We aimed to study whether variants either alone or when aggregated into genetic risk scores (GRSs) associate with ILD, and whether waist-hip ratio (WHR) or alcohol use interacts with this risk. METHODS: Our study included 33,770 persons (mean age 50 yrs, 47% men) who participated in health-examination surveys (FINRISK 1992-2012 or Health 2000) with data on alcohol use, WHR and 63 genotypes associated with liver disease...
February 26, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36825358/global-treatment-rate-and-barriers-to-daa-therapy-a-systematic-review-and-meta-analysis-of-146-studies-and-1-760-352-hcv-patients
#13
JOURNAL ARTICLE
Vy H Nguyen, Daniel Q Huang, Michael H Le, Michelle Jin, Eunice Yewon Lee, Linda Henry, Sanjna Nilesh Nerurkar, Eiichi Ogawa, Khin Naing Thin, Margaret L P Teng, Kang Shiong Goh, Justin Chua Ying Kai, Connie Wong, Darren J H Tan, Le Thi Thanh Thuy, Hoang Hai, Masaru Enomoto, Ramsey Cheung, Mindie H Nguyen
BACKGROUND: Global data on the treatment rate with direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) are sparse. We aimed to evaluate the CHC treatment rate and barriers to treatment in the DAA era. METHODS: We searched PubMed, EMBASE, and Cochrane from inception to August 5, 2021, for relevant articles. Patients treated with DAAs without interferon (IFN) therapy were categorized as IFN-free DAAs. Patients receiving DAA with IFN or unclear IFN status were categorized as DAA/IFN...
February 24, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36825357/risk-of-severe-disease-and-mortality-of-covid-19-in-patients-with-budd-chiari-syndrome-a-population-based-matched-cohort-study
#14
LETTER
Arunkumar Krishnan, Carolin V Schneider, Jörn M Schattenberg, Saleh A Alqahtani
BACKGROUND & AIMS: Budd-Chiari syndrome (BCS) is a rare and potentially life-threatening disorder characterized by obstruction of the hepatic outflow tract. It is unknown whether patients with BCS represent a high risk for severe disease and mortality from coronavirus disease 2019 (COVID-19). Thus, we aimed to assess hospitalization rates, severe disease, all-cause mortality, intensive care unit (ICU) requirement and acute kidney injury (AKI) from COVID-19 diagnoses. METHODS & RESULTS: We identified 467 patients with BCS with COVID-19, 96 427 non-chronic liver disease (CLD) and 9652 non-BCS CLD...
February 24, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36825356/reply-to-the-letter-anti-hbc-level-predicting-virological-relapse-after-stopping-nucleos-t-ide-analogue-in-chronic-hepatitis-b
#15
LETTER
Valerie Ohlendorf, Benjamin Maasoumy
No abstract text is available yet for this article.
February 24, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36825353/long-term-outcome-of-liver-transplantation-for-autoimmune-hepatitis-a-french-nationwide-study-over-30%C3%A2-years
#16
JOURNAL ARTICLE
Yasmina Chouik, Olivier Chazouillères, Claire Francoz, Eleonora De Martin, Olivier Guillaud, Armand Abergel, Mario Altieri, Louise Barbier, Camille Besch, Filomena Conti, Christophe Corpechot, Sébastien Dharancy, François Durand, Christophe Duvoux, Jean Gugenheim, Jean Hardwigsen, Marie-Noëlle Hilleret, Pauline Houssel-Debry, Nassim Kamar, Delphine Maucort-Boulch, Anne Minello, Martine Neau-Cransac, Georges-Philippe Pageaux, Sylvie Radenne, Olivier Roux, Faouzi Saliba, Olivier Serée, Didier Samuel, Claire Vanlemmens, Marie-Lorraine Woehl-Jaegle, Vincent Leroy, Jean-Charles Duclos-Vallée, Jérôme Dumortier
BACKGROUND & AIMS: Autoimmune hepatitis (AIH) is a rare indication for liver transplantation (LT). The aims of this study were to evaluate long-term survival after LT for AIH and prognostic factors, especially the impact of recurrent AIH (rAIH). METHODS: A multicenter retrospective nationwide study including all patients aged ≥16 transplanted for AIH in France was conducted. Early deaths and retransplantations (≤ 6 months) were excluded...
February 24, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36810858/transcriptomics-confirm-the-establishment-of-a-liver-immune-dual-humanized-mouse-model-after-transplantation-of-a-single-type-of-human-bmsc
#17
JOURNAL ARTICLE
Suwan Sun, Hui Yang, Jiaojiao Xin, Heng Yao, Lunzhi Yuan, Keke Ren, Jing Jiang, Dongyan Shi, Jun Li, Qian Zhou, Zhanglu An, Beibei Guo, Jiaxian Chen, Lulu He, Xi Liang, Tong Cheng, Ningshao Xia, Jun Li
BACKGROUND & AIMS: Human bone marrow mesenchymal stem cells (hBMSCs) are important for developing a dual-humanized mouse model to clarify disease pathogenesis. We aimed to elucidate the characteristics of hBMSC transdifferentiation into liver and immune cells. METHODS: A single type of hBMSCs was transplanted into immunodeficient Fah-/- Rag2-/- IL-2Rγc-/- SCID (FRGS) mice with fulminant hepatic failure (FHF). Liver transcriptional data from the hBMSC-transplanted mice were analysed to identify transdifferentiation with traces of liver and immune chimerism...
February 21, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36809581/susceptibility-to-hepatitis-b-virus-infection-in-adults-living-in-spain
#18
JOURNAL ARTICLE
Vicente Soriano, Antonio Aguilera, Rafael Benito, Rocío González-Díez, Elisenda Miró, Paloma Liendo, Juan Carlos Rodríguez-Diaz, Teresa Cabezas, Alberto Richart, José Manuel Ramos, Luisa Barea, Carmen Álvarez, Ana Treviño, Félix Gómez-Gallego, Octavio Corral, Carmen de Mendoza
BACKGROUND: A protective hepatitis B virus (HBV) vaccine has been available for four decades. Universal HBV vaccination of infants is recommended by the WHO since the 90s. Furthermore, HBV immunization is advised to all adults with high-risk behaviors and no seroprotection. However, HBV vaccine coverage remains globally suboptimal. The advent of new more efficacious trivalent HBV vaccines has renewed the interest for HBV vaccination. At this time, the extent of current HBV susceptibility in adults remains unknown in Spain...
February 21, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36801835/subclinical-liver-traits-are-associated-with-structural-and-hemodynamic-brain-imaging-markers
#19
JOURNAL ARTICLE
Pinar Yilmaz, Louise J M Alferink, Lotte G M Cremers, Sarwa Darwish Murad, Wiro J Niessen, M Arfan Ikram, Meike W Vernooij
BACKGROUND & AIMS: Impaired liver function affects brain health and therefore understanding potential mechanisms for subclinical liver disease is essential. We assessed the liver-brain associations using liver measures with brain imaging markers, and cognitive measures in the general population. METHODS: Within the population-based Rotterdam Study, liver serum and imaging measures (ultrasound and transient elastography), metabolic dysfunction-associated fatty liver disease (MAFLD), non-alcoholic fatty liver disease (NAFLD) and fibrosis phenotypes, and brain structure were determined in 3,493 non-demented and stroke-free participants in 2009-2014...
February 21, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/36800487/potential-therapies-for-acute-on-chronic-liver-failure
#20
REVIEW
Maura A Morrison, Florent Artru, Francesca M Trovato, Evangelos Triantafyllou, Mark J McPhail
Acute-on-chronic liver failure (ACLF) is a syndrome that develops in approximately 30% of patients hospitalised with cirrhosis and is characterised by an acute decompensation of liver function associated with extra-hepatic organ failures and a high short-term mortality. At present, no specific therapies are available for ACLF, and current management is limited to treatment of the precipitating event and organ support. Given the high prevalence and high mortality of this severe liver disease, there is an urgent need for targeted treatments...
February 17, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
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