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Liver International: Official Journal of the International Association for the Study of the Liver

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https://read.qxmd.com/read/30773766/the-effect-of-oral-contraceptive-pill-cessation-on-hepatocellular-adenoma-diameter-a-retrospective-cohort-study
#1
Martijn P D Haring, Annette S H Gouw, Robbert J de Haas, Frans J C Cuperus, Koert P de Jong, Vincent E de Meijer
BACKGROUND & AIMS: Hepatocellular Adenomas (HCA) are rare, hormone driven, benign liver tumors. HCA >50mm are associated with hemorrhage and malignant transformation. Guidelines recommend cessation of oral contraceptive pills (OCP) for size reduction, however, it is currently unknown how HCA respond to cessation of OCP. We sought to investigate the effect of OCP cessation on HCA size. METHODS: A retrospective cohort study was performed including HCA patients who stopped OCP intake within six months of imaging between 2005-2018...
February 18, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30770636/molecular-epidemiology-of-acute-hcv-infection-in-hiv-positive-patients-from-hong-kong-taipei-tokyo
#2
Hsin-Yun Sun, Haruka Uemura, Ngai-Sze Wong, Denise Pui-Chung Chan, Bonnie Chun-Kwan Wong, Pi-Han Lin, Li-Hsin Su, Chien-Ching Hung, Shinichi Oka, Sui-Yuan Chang, Shui-Shan Lee
BACKGROUND: Acute hepatitis C virus (HCV) infections have been increasingly reported among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in the Asia-Pacific region. It remains unknown whether international network of HCV transmission has occurred in this region. METHODS: HIV-positive patients with acute HCV infection, defined as HCV seroconversion within a year or documented acute hepatitis with seroconversion, diagnosed in Hong Kong, Taipei, and Tokyo during 2010-2016 were included in this molecular epidemiology study...
February 16, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30753752/long-term-outcomes-of-patients-with-hepatitis-b-virus-related-acute-on-chronic-liver-failure-an-observational-cohort-study
#3
Su Lin, Kai Zhang, Zhang Junchao, Mingfang Wang, Velani Bharat, Yueyong Zhu
BACKGROUND AND AIMS: The long-term outcomes of patients with hepatitis B virus -related acute-on-chronic liver failure (HBV-ACLF) remain unclear. The main aims of study was to compare the 5-year survival rate and incidence rate of hepatocellular carcinoma (HCC) between patients with HBV-ACLF and HBV-cirrhosis. METHODS: Clinical data of patients with ACLF, compensated cirrhosis and decompensated cirrhosis who survived more than 3 months after diagnosis were collected...
February 12, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30746903/use-of-dual-x-ray-absorptiometry-in-men-with-advanced-cirrhosis-to-predict-sarcopenia-associated-mortality-risk
#4
Marie Sinclair, Rudolf Hoermann, Adam Peterson, Adam Testro, Peter W Angus, Penelope Hey, Brooke Chapman, Paul J Gow
INTRODUCTION: Reduced muscle area on CT scan is an independent predictor of mortality in cirrhosis. We examine for the first time the relationship between Dual Energy X-ray Absorptiometry (DEXA) lean mass parameters on outcomes in cirrhotic men awaiting liver transplantation. MATERIALS AND METHODS: We retrospectively reviewed DEXA scans performed during transplant assessment between 2001 and 2016. Baseline data including presence of ascites and MELD score were recorded...
February 12, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30739387/collagen-type-iv-remodeling-gender-specifically-predicts-mortality-in-decompensated-liver-cirrhosis
#5
Jennifer Lehmann, Michael Praktiknjo, Mette Juul Nielsen, Robert Schierwagen, Carsten Meyer, Daniel Thomas, Francesco Violi, Christian P Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten Asser Karsdal, Diana Julie Leeming, Jonel Trebicka
BACKGROUND: Remodeling of extracellular matrix (ECM) is crucial in progressive liver fibrosis. Collagen type III desposition has been shown in acute decompensation. ECM is compiled of deposition of various components. The role of basement membrane collagen type IV in advanced liver cirrhosis and acute decompensation is unclear and investigated in this study. METHODS: Patients with decompensated liver cirrhosis from the prospective NEPTUN cohort (ClinicalTrialsgov Identifier: NCT03628807), who underwent TIPS procedure were included...
February 9, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30735608/autotaxin-bile-acid-profile-and-effect-of-ibat-inhibition-in-primary-biliary-cholangitis-patients-with-pruritus
#6
Vinod S Hegade, Alexandros Pechlivanis, Julie Ak McDonald, Douglas Rees, Margaret Corrigan, Gideon M Hirschfield, Simon D Taylor-Robinson, Elaine Holmes, Julian R Marchesi, Stuart Kendrick, David E Jones
BACKGROUND &AIMS: Pruritus is a common symptom in patients with primary biliary cholangitis (PBC) for which ileal bile acid transporter (IBAT) inhibition is emerging as a potential therapy. We explored the serum metabonome and gut microbiota profile in PBC patients with pruritus and investigated the effect of GSK2330672, an IBAT inhibitor. METHODS: We studied fasting serum bile acids (BAs), autotaxin and faecal microbiota in 22 PBC patients with pruritus at baseline and after two weeks of GSK2330672 treatment...
February 8, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30721572/randomized-trial-comparing-effects-of-weight-loss-by-liraglutide-with-lifestyle-modification-in-non-alcoholic-fatty-liver-disease
#7
Joan Khoo, John C Hsiang, Ranu Taneja, Seok-Hwee Koo, Gaik-Hong Soon, Carmen J Kam, Ngai-Moh Law, Tiing-Leong Ang
AIMS: We compared the effects of weight loss induced with the glucagon-like peptide-1 agonist liraglutide, with that of lifestyle modification, followed by weight maintenance after discontinuing intervention, in obese adults with NAFLD. METHODS: Thirty obese (mean age 40.7 ± 9.1 years, BMI 33.2 ± 3.6 kg/m2 , 90% male) adults with NAFLD defined as liver fat fraction (LFF) > 5% on magnetic resonance imaging without other causes of hepatic steatosis, were randomized to a supervised program of energy restriction plus moderate-intensity exercise to induce ≥ 5% weight loss (DE group, n= 15), or liraglutide 3 mg daily (LI group, n= 15) for 26 weeks, followed by 26 weeks with only advice to prevent weight regain...
February 5, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30721564/the-concomitant-loss-of-apc-and-hnf4%C3%AE-in-adult-hepatocytes-does-not-contribute-to-hepatocarcinogenesis-driven-by-%C3%AE-catenin-activation
#8
Chiara Sartor, Laura Bachelot, Cécile Godard, Franck Lager, Gilles Renault, Frank J Gonzalez, Christine Perret, Angélique Gougelet, Sabine Colnot
BACKGROUND/AIMS: Loss of hepatocyte nuclear factor-4α (HNF4α), a critical factor driving liver development and differentiation, is frequently associated with hepatocellular carcinoma (HCC). Our recent data revealed that HNF4α level was decreased in mouse and human HCCs with activated β-catenin signaling. In addition, increasing HNF4α level by miR-34a inhibition slowed tumor progression of β-catenin activated HCC in mice. METHODS: We generated a Hnf4aflox/flox/ Apcflox/flox /TTR-CreERT 2 (Hnf4a/Apc∆Hep ) mouse line and evaluated the impact of Hnf4a disruption on HCC development and liver homeostasis...
February 5, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30721562/microrna-30b-regulates-insulin-sensitivity-by-targeting-serca2b-in-non-alcoholic-fatty-liver-disease
#9
Li-Li Dai, Shu-De Li, Yi-Cheng Ma, Jun-Rui Tang, Jun-Yan Lv, Yuan-Qing Zhang, Ying-Lei Miu, Yan-Qiong Ma, Chun-Mei Li, Yi-You Chu, Kun-Hua Wang, Lan-Qing Ma, Cheng-Gang Zou
BACKGROUND & AIMS: Insulin resistance is strongly associated with nonalcoholic fatty liver disease, a chronic, obesity-related liver disease. Increased endoplasmic reticulum stress plays an important role in the development of insulin resistance. In this study, we investigated the roles of miRNAs in regulating ER stress in the liver of rats with obesity. METHODS: We used miRNA microarray to determine the miRNA expression profiles in the liver of rats fed a high fat diet (HFD)...
February 5, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30721553/tcr%C3%AE-repertoire-of-memory-t-cell-reveals-potential-role-for-e-coli-in-the-pathogenesis-of-primary-biliary-cholangitis
#10
Xianliang Hou, Yida Yang, Jianing Chen, Hongyu Jia, Ping Zeng, Longxian Lv, Yingfeng Lu, Xiangdong Liu, Hongyan Diao
BACKGROUND: Primary biliary cholangitis (PBC) is an organ-specific, T cell mediated autoimmune disease which is characterized by the breakdown of self-tolerance to the highly conserved pyruvate dehydrogenase complex, especially the pyruvate dehydrogenase E2 complex (PDC-E2). However, the molecular mechanism of breakdown of self-tolerance is still unclear. METHODS: A combination of multiplex-PCR and immune repertoire sequencing (IR-seq) was used for a standardized analysis of memory T cell receptor (TCR) β-chain repertoire of PBC patient and healthy volunteers...
February 5, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30716203/autoimmune-hepatitis-current-and-future-therapeutic-options
#11
Iliana Doycheva, Kymberly D Watt, Aliya F Gulamhusein
Autoimmune hepatitis (AIH) is a rare immune-mediated liver disease with few major advances in treatment options over the last several decades. Available options are effective in most patients albeit are imprecise in their mechanisms. Novel and more tolerable induction regimens and alternative options for management of patients intolerant or with suboptimal response to traditional therapies including in the post-transplant setting remain an important unmet need. This review aims to summarize recent data on pharmacological options and investigational drugs in development for patients with AIH...
February 4, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30716200/second-line-chemotherapy-in-biliary-tract-cancer-outcome-and-prognostic-factors
#12
Nora Schweitzer, Martha M Kirstein, Anna-Maria Kratzel, Young-Seon Mederacke, Mareike Fischer, Michael P Manns, Arndt Vogel
BACKGROUND & AIMS: The prognosis of biliary tract cancer (BTC) is poor. Standard treatment for advanced BTC is a chemotherapy (CT) with gemcitabine and cisplatin. Phase-III evidence for a second line (2L) CT is lacking. We aimed to investigate the feasibility of a 2L CT, to estimate the outcome and to identify prognostic markers. METHODS: Patients of our institution with advanced BTC between 2000 and 2015 receiving CT were included. Data were analyzed in univariate and multivariate analysis...
February 4, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30712318/ideal-cardiovascular-health-metrics-and-the-risk-of-nonalcoholic-fatty-liver-disease-a-cross-sectional-study-in-northern-china
#13
Huamin Liu, Yan Yao, Youxin Wang, Likun Ma, Xuezhen Liu, Shasha Guo, Xia Feng, Yanru Chen, Xueyu Chen, Zhongni Liu, Long Ji, Dong Li, Yong Zhou
BACKGROUND AND PURPOSE: The components of ideal cardiovascular health (CVH) metrics have been shown to be associated with nonalcoholic fatty liver disease (NAFLD). The present study aimed to determine the association between ideal CVH metrics and NAFLD. METHODS: A total of 10,511 participants (47.26% men) aged 18 to 92 years were selected from the Jidong and Kailuan communities. Ideal CVH was based on 7 ideal CVH metrics: smoking, body mass index (BMI), physical activity, diet, total cholesterol, blood pressure, and fasting blood glucose...
February 3, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30712284/impact-of-antiretroviral-therapy-containing-tenofovir-disoproxil-fumarate-on-the-survival-of-patients-with-hbv-and-hiv-coinfection
#14
Wan-Chen Tsai, Wei-Ting Hsu, Wang-Da Liu, Hsin-Yun Sun, Yu-Chung Chuang, Yu-Shan Huang, Aristine Cheng, Kuan-Yin Lin, Yi-Chia Huang, Guan-Jhou Chen, Sung-Hsi Huang, Wang-Huei Sheng, Szu-Min Hsieh, Chien-Ching Hung, Shan-Chwen Chang
BACKGROUND: Tenofovir disoproxil fumarate (TDF) is active against both HBV and HIV. Whether introduction of TDF-containing combination antiretroviral therapy (cART) has improved the outcome of HIV/HBV-coinfected patients remains unclear in areas of higher HBV endemicity. METHODS: We retrospectively reviewed medical records of newly diagnosed antiretroviral-naïve HIV-infected patients between 2007 and 2015. Four groups of patients were defined, according to the HBV status and availability of TDF for HIV treatment in Taiwan in 2011...
February 3, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30703293/injury-pattern-recognition-to-discriminate-competing-causes-of-liver-injury
#15
Nizar Talaat, Hans Tillmann
BACKGROUND: Competing causes of liver injury may be difficult to discriminate. Characterization of the typical phenotype of each injury defined by latency, time to improvement and biochemical pattern, could be helpful to identify the most likely of competing causes. METHODS: Liver injury characteristics of both bortezomib associated drug-induced liver injury (DILI) and hepatitis B virus (HBV) reactivation associated with bortezomib are derived from PubMed listed publications...
January 31, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30698907/klotho-beta-and-fibroblast-growth-factor-19-expression-correlates-with-early-recurrence-of-resectable-hepatocellular-carcinoma
#16
Zhong-Zhe Lin, Chiun Hsu, Yung-Ming Jeng, Fu-Chang Hu, Hung-Wei Pan, Yao-Ming Wu, Hey-Chi Hsu, Ann-Lii Cheng
BACKGROUND AND AIMS: Fibroblast growth factor 19 (FGF19) and fibroblast growth factor receptor 4 (FGFR4) signaling play critical roles in hepatocarcinogenesis. This study explored the potential of FGF19 and FGFR4 related biomarkers in predicting early tumor recurrence (ETR) and survival in patients with resectable hepatocellular carcinoma (HCC). METHODS: We examined the mRNA expressions of FGF19, FGFR4, klotho-beta (KLB), cyclin D1 (CCND1), and FGF4 in 151 surgically resected, primary unifocal HCCs through quantitative real-time polymerase chain reaction...
January 30, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30697898/the-interaction-of-nonalcoholic-fatty-liver-disease-and-smoking-on-mortality-among-adults-in-the-united-states
#17
Karn Wijarnpreecha, Melissa Scribani, Donghee Kim, W Ray Kim
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease in Western countries. Smoking and diabetes mellitus (DM) have been shown to increase mortality, however, whether NAFLD adds to the detrimental effect of smoking in DM and non-DM patients is unknown. We evaluated the possible interactive effect of NAFLD and smoking on mortality risk in a U.S. population-based sample. METHODS: Cross-sectional data from 11,205 participants in the third National Health and Nutrition Examination Survey were analyzed...
January 29, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30690862/long-lasting-persistence-of-large-b-cell-clones-in-hcv-cured-patients-with-complete-response-of-mixed-cryoglobulinemia-vasculitis
#18
Marcella Visentini, Martina Del Padre, Stefania Colantuono, Baoran Yang, Ylenia Aura Minafò, Silvia Antonini, Myriam Carnovale, Adriano De Santis, Alessandro Pulsoni, Giuseppe Maria De Sanctis, Laura Gragnani, Anna Linda Zignego, Massimo Fiorilli, Milvia Casato
BACKGROUND & AIMS: Hepatitis C virus (HCV)-related mixed cryoglobulinemia vasculitis (MCV) is characterized by the expansion of rheumatoid factor-producing B-cell clones. The aim of this study was to assess whether B-cell clones may persist in these patients after the clearance of the virus with antiviral therapy, and whether their persistence influences clinical outcomes. METHODS: 45 HCV-cured MCV patients were followed-up for a median of 18.5 (range 9-38) months after the clearance of HCV...
January 28, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30688401/nationwide-estimates-and-risk-factors-of-hospital-readmission-in-patients-with-cirrhosis-in-the-united-states
#19
Abdel-Aziz Shaheen, Henry H Nguyen, Stephen E Congly, Gilaad G Kaplan, Mark G Swain
BACKGROUND: The burden of cirrhosis on the healthcare system is substantial and growing. Our objectives were to estimate the readmission rates and hospitalization costs, as well as to identify risk factors for 90-day readmission in patients with cirrhosis. METHODS: We conducted a weighted analysis of the 2014 Nationwide Readmission Database to identify adult patients with cirrhosis-related complications in the United States and assessed readmission rates at 30, 60, and 90 days post-index hospitalization...
January 28, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/30667576/review-article-stopping-immunosuppressive-treatment-in-autoimmune-hepatitis-aih-is-it-justified-and-in-whom-and-when
#20
Laura Harrison, Dermot Gleeson
BACKGROUND: Initial treatment of autoimmune hepatitis (AIH) with prednisolone +/- azathioprine is based on randomised controlled trials. Many patients receive long-term immunosuppressive treatment to prevent disease relapse; this strategy has a weaker evidence base. AIM: To consider whether immunosuppressive treatment (IST) withdrawal in AIH is justified and to develop a rationale for patient selection. METHODS: We reviewed published papers between 1972-2018, which addressed the outcomes of IST withdrawal and/or complications of IST in AIH...
January 22, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
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