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Journals Liver International : Official...

Liver International : Official Journal of the International Association for the Study of the Liver

https://read.qxmd.com/read/38488749/predictive-factors-for-transition-to-conversion-therapy-in-hepatocellular-carcinoma-using-atezolizumab-plus-bevacizumab
#1
JOURNAL ARTICLE
Tatsuya Kikuchi, Yasuto Takeuchi, Kazuhiro Nouso, Kazuya Kariyama, Kenji Kuwaki, Junichi Toshimori, Shota Iwado, Akio Moriya, Hiroaki Hagihara, Hiroyuki Takabatake, Toshifumi Tada, Tetsuya Yasunaka, Masahiro Sakata, Masahiko Sue, Nozomi Miyake, Takuya Adachi, Nozomu Wada, Hideki Onishi, Hidenori Shiraha, Akinobu Takaki, Motoyuki Otsuka
BACKGROUND: To identify predictive factors associated with successful transition to conversion therapy following combination therapy with atezolizumab and bevacizumab in the treatment of unresectable hepatocellular carcinoma (HCC). METHODS: In total, 188 patients with HCC, who received atezolizumab plus bevacizumab combination therapy as the first-line chemotherapy, were studied. Patients who achieved complete response (CR) with systemic chemotherapy alone were excluded...
March 15, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38488679/the-associations-between-fibrosis-changes-and-liver-related-events-in-patients-with-metabolic-dysfunction-associated-steatotic-liver-disease
#2
JOURNAL ARTICLE
Hye Won Lee, Kun Hee Kim, Sang Hoon Ahn, Han Chu Lee, Jonggi Choi
BACKGROUND: The prognosis of metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with liver fibrosis. We investigated the associations between changes in liver stiffness measurement (LSM) over 3-year period and the development of cirrhosis or hepatocellular carcinoma (HCC) in patients with MASLD. METHODS: This study involved patients with MASLD who underwent transient elastography at baseline and 3 years after baseline from 2012 to 2020...
March 15, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38483145/an-optimized-short-term-steroid-therapy-for-chronic-drug-induced-liver-injury-a-prospective-randomized-clinical-trial
#3
JOURNAL ARTICLE
Ang Huang, Yun Zhu, Shuhong Liu, Ying Sun, Zherui Liu, Qing-Sheng Liang, Jun Zhao, Bin-Xia Chang, Jing-Feng Bi, Jiang-Tao Liu, Xing-Ran Zhai, Huan Xie, Ning Li, Hui Tian, Lin Han, Yingjie Zhuang, Hongbin Ma, Guang-Ju Teng, Wei Zhang, Guruprasad P Aithal, Dong Ji, Jingmin Zhao, Zhengsheng Zou
BACKGROUND AND AIMS: The use of corticosteroids in chronic drug-induced liver injury (DILI) is an important issue. Our previous randomized controlled trial showed that patients with chronic DILI benefited from a 48-week steroid stepwise reduction (SSR) regimen. However, it remains unclear whether a shorter course of therapy can achieve similar efficacy. In this study, we aimed to assess whether a 36-week SSR can achieve efficacy similar to that of 48-week SSR. METHODS: A randomized open-label trial was performed...
March 14, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38456654/proactive-case-finding-of-alcohol-related-liver-disease-in-high-risk-populations-a-systematic-review
#4
REVIEW
Ann J Archer, Jennifer Phillips, Mohsan Subhani, Zoe Ward, Fiona H Gordon, Matthew Hickman, Ashwin D Dhanda, Kushala W M Abeysekera
BACKGROUND: Alcohol-related liver disease (ARLD) is often diagnosed at a late stage when mortality is unacceptably high. Earlier identification of ARLD may lead to reduced alcohol intake, participation in hepatocellular carcinoma surveillance and reduction in liver-related morbidity and mortality. People with alcohol use disorder (AUD) are at highest risk of ARLD. The aim of this systematic review was to understand the yield of proactive screening for ARLD amongst high-risk groups. METHODS: Embase, Medline, Scopus and grey literature were searched for studies describing proactive assessment for alcohol-related liver disease in people with a history of alcohol excess or diagnosed AUD...
March 8, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38456621/liver-transplantation-and-primary-liver-cancer-in-porphyria
#5
REVIEW
Mattias Lissing, Bruce Wang, Staffan Wahlin
The porphyrias are a heterogeneous group of metabolic disorders that result from defects in heme synthesis. The metabolic defects are present in all cells, but symptoms are mainly cutaneous or related to neuropathy. The porphyrias are highly relevant to hepatologists since patients can present with symptoms and complications that require liver transplantation (LT), and some porphyrias are associated with a high risk for primary liver cancer (PLC). Among the cutaneous porphyrias, erythropoietic protoporphyria (EPP) can lead to cholestatic liver failure where LT cures the liver disease but not the porphyria...
March 8, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38456620/tenofovir-alafenamide-or-tenofovir-disoproxil-fumarate-in-pregnancy-to-prevent-hbv-transmission-maternal-alt-trajectory-and-infant-outcomes
#6
JOURNAL ARTICLE
Huey-Ling Chen, Chien-Nan Lee, Chin-Hao Chang, Ming-Wei Lai, Ming-Chieh Tsai, Shu-Chi Mu, Chun-Jen Liu, Jin-Chung Shih, Wan-Hsin Wen, Rui-Ting Hu, Chun-Pin Huang, Kuang-Chun Hu, Chie-Pein Chen, Chyi-Long Lee, Rong-Nan Chien, Kai-Chi Chang, Hong-Yuan Hsu, Chien-Chang Lee, Yen-Hsuan Ni, Mei-Hwei Chang
BACKGROUND: The use of antiviral agents, specifically tenofovir disoproxil fumarate (TDF), in pregnant women to prevent mother-to-child HBV transmission is a key step towards hepatitis elimination. However, data on using tenofovir alafenamide (TAF) is insufficient. The frequent occurrence of postpartum ALT flares may impact the clinical implementation. METHODS: The maternal and infant outcomes were compared in multi-centre trials of high viral load HBsAg/HBeAg+ pregnant women receiving TAF or TDF from the third trimester until 2 weeks postpartum with intensive follow-ups...
March 8, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38451069/recipient-age-influences-survival-after-liver-transplant-results-of-the-french-national-cohort-2007-2017
#7
JOURNAL ARTICLE
Lea Lerosey, Elea Ksiasek, Michal Abrahamowicz, Corinne Antoine, Sébastien Dharancy, Jérôme Dumortier, Alexandre Doussot, Vincent Di Martino, Pauline Houssel-Debry, Filomena Conti, Claire Francoz, Georges-Philippe Pageaux, Ephrem Salame, François Faitot, Audrey Coilly, Jean Hardwigsen, Thomas Decaens, Faiza Chermak, Fabrice Muscari, Rodolphe Anty, Christophe Duvoux, Armand Abergel, Anne Minello, Thomas Mouillot, Christine Binquet, Marianne Latournerie
BACKGROUND: In recent years, age at liver transplantation (LT) has markedly increased. In the context of organ shortage, we investigated the impact of recipient age on post-transplantation mortality. METHODS: All adult patients who received a first LT between 2007 and 2017 were included in this cross-sectional study. Recipients' characteristics at the time of listing, donor and surgery data, post-operative complications and follow-up of vital status were retrieved from the national transplantation database...
March 7, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38451053/hepatic-organoids-move-from-adolescence-to-maturity
#8
REVIEW
Yuan Guan, Gary Peltz
Since organoids were developed 15 years ago, they are now in their adolescence as a research tool. The ability to generate 'tissue in a dish' has created enormous opportunities for biomedical research. We examine the contributions that hepatic organoids have made to three areas of liver research: as a source of cells and tissue for basic research, for drug discovery and drug safety testing, and for understanding disease pathobiology. We discuss the features that enable hepatic organoids to provide useful models for human liver diseases and identify four types of advances that will enable them to become a mature (i...
March 7, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38451034/drug-induced-liver-injury-dili-ascribed-to-non-steroidal-anti-inflammatory-drugs-nsaids-in-the-usa-update-with-genetic-correlations
#9
JOURNAL ARTICLE
Herbert L Bonkovsky, Marwan Ghabril, Paola Nicoletti, Andrew Dellinger, Robert J Fontana, Huiman Barnhart, Jiezhun Gu, Ann K Daly, Guruprasad P Aithal, Elizabeth J Phillips, David E Kleiner
OBJECTIVE: To describe patients with NSAID-DILI, including genetic factors associated with idiosyncratic DILI. METHODS: In DILIN, subjects with presumed DILI are enrolled and followed for at least 6 months. Causality is adjudicated by a Delphic approach. HLA sequencing of multiethnic NSAID-DILI patients and HLA allele imputation of matching population controls were performed following overall, class and drug-based association analysis. Significant results were tested in a non-Hispanic White (NHW) case-control replication cohort...
March 7, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38445848/impact-of-new-direct-acting-antiviral-therapy-on-the-prevalence-and-undiagnosed-proportion-of-chronic-hepatitis-c-infection
#10
JOURNAL ARTICLE
Farinaz Forouzannia, Abdullah Hamadeh, Ana Maria Passos-Castilho, Aysegul Erman, Amanda Yu, Zeny Feng, Naveed Z Janjua, Beate Sander, Christina Greenaway, William W L Wong
BACKGROUND: Patients with chronic hepatitis C (CHC) can be cured with the new highly effective interferon-free combination treatments (DAA) that were approved in 2014. However, CHC is a largely silent disease, and many individuals are unaware of their infections until the late stages of the disease. The impact of wider access to effective treatments and improved awareness of the disease on the number of infections and the number of patients who remain undiagnosed is not known in Canada...
March 6, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38441405/health-information-in-short-videos-about-metabolic-dysfunction-associated-steatotic-liver-disease-analysing-quality-and-reliability
#11
JOURNAL ARTICLE
Ruihao Ding, Qingzhou Kong, Longfei Sun, Xuyan Liu, Leiqi Xu, Yueyue Li, Xiuli Zuo, Yanqing Li
BACKGROUND & AIMS: Short videos, crucial for disseminating health information on metabolic dysfunction-associated steatotic liver disease (MASLD), lack a clear evaluation of quality and reliability. This study aimed to assess the quality and reliability of MASLD-related videos on Chinese platforms. METHODS: Video samples were collected from three platforms (TikTok, Kwai and Bilibili) during the period from November 2019 to July 2023. Two independent reviewers evaluated the integrity of the information contained therein by scoring six key aspects of its content: definition, epidemiology, risk factors, outcomes, diagnosis and treatment...
March 5, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38436551/multitask-deep-learning-for-prediction-of-microvascular-invasion-and-recurrence-free-survival-in-hepatocellular-carcinoma-based-on-mri-images
#12
JOURNAL ARTICLE
Fang Wang, Gan Zhan, Qing-Qing Chen, Hou-Yun Xu, Dan Cao, Yuan-Yuan Zhang, Yin-Hao Li, Chu-Jie Zhang, Yao Jin, Wen-Bin Ji, Jian-Bing Ma, Yun-Jun Yang, Wei Zhou, Zhi-Yi Peng, Xiao Liang, Li-Ping Deng, Lan-Fen Lin, Yen-Wei Chen, Hong-Jie Hu
BACKGROUND AND AIMS: Accurate preoperative prediction of microvascular invasion (MVI) and recurrence-free survival (RFS) is vital for personalised hepatocellular carcinoma (HCC) management. We developed a multitask deep learning model to predict MVI and RFS using preoperative MRI scans. METHODS: Utilising a retrospective dataset of 725 HCC patients from seven institutions, we developed and validated a multitask deep learning model focused on predicting MVI and RFS...
March 4, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38436538/long-term-oncological-results-of-percutaneous-radiofrequency-ablation-for-intrahepatic-cholangiocarcinoma
#13
JOURNAL ARTICLE
Clémentine Alitti, Agnès Rode, Hervé Trillaud, Philippe Merle, Jean-Frédéric Blanc, Lorraine Blaise, Alix Demory, Gisele Nkontchou, Véronique Grando, Marianne Ziol, Pierre Nahon, Nathalie Ganne-Carrié, Arthur Petit, Olivier Seror, Olivier Sutter, Jean-Charles Nault
INTRODUCTION: The effectiveness of percutaneous radiofrequency ablation (RFA) in intrahepatic cholangiocarcinomas (iCCA) remains insufficiently studied. METHODS: We conducted a retrospective study including patients with histologically proven iCCA within Milan criteria treated by percutaneous RFA from 2000 to 2022. The primary outcome was overall survival in treatment-naive patients and secondary outcomes included ablation completeness, adverse events, local and distant recurrence...
March 4, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38436529/progression-pattern-and-post-progression-survival-following-atezolizumab-and-bevacizumab-treatment-in-advanced-hepatocellular-carcinoma
#14
JOURNAL ARTICLE
Satoshi Kobayashi, Taito Fukushima, Makoto Ueno, Makoto Chuma, Kazushi Numata, Kota Tsuruya, Yoshitaka Arase, Shunji Hirose, Tatehiro Kagawa, Nobuhiro Hattori, Tsunamasa Watanabe, Kotaro Matsunaga, Haruki Uojima, Hisashi Hidaka, Chika Kusano, Manabu Morimoto, Shin Maeda
BACKGROUND: Although the combination of atezolizumab and bevacizumab (ATZ + BEV) is a standard treatment for advanced hepatocellular carcinoma (HCC), strategies for addressing treatment failure and prognostic factors of post-progression survival (PPS) remain unestablished. METHODS: We conducted a multicentre retrospective study to evaluate PPS following ATZ + BEV treatment in patients with advanced HCC. We classified the patients into three groups: BCLC stage B and BCLC stage C without or with new extrahepatic lesions (BCLCp-C1 and BCLCp-C2, respectively) at the time of progression...
March 4, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38426633/global-burden-of-acute-hepatitis-e-between-1990-and-2019-and-projections-until-2030
#15
JOURNAL ARTICLE
Guoqing Ouyang, Guangdong Pan, Qiuyun Li, Shuang Li, Tao Liu, Xiaolei Yi, Zhipeng Liu
BACKGROUND AND AIMS: Acute hepatitis E (AHE) is still a public health issue worldwide. Here, we report the global burden of AHE in 204 countries and territories from 1990 to 2019 by age, sex and socio-demographic index (SDI), and predict the future trends to 2030. METHODS: Data on AHE were collected from the Global Burden of Diseases, Injuries and Risk Factors Study 2019. The average annual percentage change (AAPC) and joinpoint analysis were used to determine the burden trend...
March 1, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38426626/artificial-replication-cohort-leveraging-ai-fabricated-data-for-genetic-studies
#16
JOURNAL ARTICLE
Wiktor Smyk, Krystian Adrych, Marcin Krawczyk
Recent advancements in artificial intelligence (AI) present both opportunities and challenges within the scientific community. This study explores the capability of AI to replicate findings from genetic research, focusing on findings from prior work. Using an AI model without exposing any raw data, we created a dataset that closely mirrors the results of our original study, illustrating the ease of fabricating datasets with authenticity. This approach highlights the risks associated with AI misuse in scientific research...
March 1, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38426611/serum-pro-c3-is-useful-for-risk-prediction-and-fibrosis-assessment-in-mafld-with-chronic-kidney-disease-in-an-asian-cohort
#17
JOURNAL ARTICLE
Liang-Jie Tang, Dan-Qin Sun, Sherlot Juan Song, Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, Pei-Wu Zhu, Sui-Dan Chen, Morten Karsdal, Diana Julie Leeming, Pei Jiang, Cong Wang, Qiang Chen, Christopher D Byrne, Giovanni Targher, Mohammed Eslam, Jacob George, Vincent Wai-Sun Wong, Ming-Hua Zheng
BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) is an emerging risk factor for chronic kidney disease (CKD). N-terminal propeptide of collagen type 3 (PRO-C3) is a biomarker of advanced fibrosis in MAFLD and PRO-C3 may be involved in renal fibrosis. We aimed to use PRO-C3 measurements to generate a new algorithmic score to test the prediction of MAFLD with chronic kidney disease (MAFLD-CKD). METHODS: A derivation and independent validation cohort of 750 and 129 Asian patients with biopsy-confirmed MAFLD were included...
March 1, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38426268/acute-and-non-acute-decompensation-of-liver-cirrhosis-47-130
#18
REVIEW
Martin S Schulz, Paolo Angeli, Jonel Trebicka
In the traditional view, the occurrence of cirrhosis-related complications, such as hepatic encephalopathy, formation of ascites or variceal haemorrhage, marks the transition to the decompensated stage of cirrhosis. Although the dichotomous stratification into a compensated and decompensated state reflects a prognostic water-shed moment and remains to hold its prognostic validity, it represents an oversimplification of clinical realities. A broadening understanding of pathophysiological mechanisms underpinning decompensation have led to the identification of distinct prognostic subgroups, associated with different clinical courses following decompensation...
March 1, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38426262/characteristics-and-outcome-of-anti-hepatitis-d-virus-positive-patients-with-hepatocellular-carcinoma
#19
JOURNAL ARTICLE
Edoardo G Giannini, Andrea Pasta, Giulia Pieri, Maria Corina Plaz Torres, Mariarosaria Marseglia, Filippo Pelizzaro, Angelo Sangiovanni, Giuseppe Cabibbo, Giorgia Ghittoni, Mariella Di Marco, Francesco Giuseppe Foschi, Maria Guarino, Elisabetta Biasini, Carlo Saitta, Claudia Campani, Gianluca Svegliati-Baroni, Antonio Gasbarrini, Maurizia Rossana Brunetto, Donatella Magalotti, Francesco Azzaroli, Andrea Mega, Rodolfo Sacco, Gerardo Nardone, David Sacerdoti, Alberto Masotto, Gianpaolo Vidili, Laura Bucci, Alessandro Vitale, Franco Trevisani
BACKGROUND & AIMS: Chronic hepatitis D virus (HDV) often leads to end-stage liver disease and hepatocellular carcinoma (HCC). Comprehensive data pertaining to large populations with HDV and HCC are missing, therefore we sought to assess the characteristics, management, and outcome of these patients, comparing them to patients with hepatitis B virus (HBV) infection. METHODS: We analysed the Italian Liver Cancer database focusing on patients with positivity for HBV surface antigen and anti-HDV antibodies (HBV/HDV, n = 107) and patients with HBV infection alone (n = 588)...
March 1, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38421084/combination-of-heterozygous-apob-gene-mutation-with-pnpla3-and-tm6sf2-variants-promotes-steatotic-liver-disease-cirrhosis-and-hcc-development
#20
LETTER
Yasmina Chouik, Mathilde Di Filippo, Sylvie Radenne, Jérôme Dumortier, Philippe Moulin, Massimo Levrero
No abstract text is available yet for this article.
February 29, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
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