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Journals Liver International : Official...

Liver International : Official Journal of the International Association for the Study of the Liver

https://read.qxmd.com/read/38606676/targeted-inhibition-of-autophagy-in-hepatic-stellate-cells-by-hydroxychloroquine-an-effective-therapeutic-approach-for-the-treatment-of-liver-fibrosis
#1
JOURNAL ARTICLE
Li-Shuang Hou, Xiao-Pei Zhai, Yao-Wen Zhang, Jie-Hua Xing, Chen Li, Si-Yuan Zhou, Xiao-Hong Zhu, Bang-Le Zhang
BACKGROUND AND PURPOSE: Liver fibrosis is a wound-healing reaction which is the main cause of chronic liver diseases worldwide. The activated hepatic stellate cell (aHSC) is the main driving factor in the development of liver fibrosis. Inhibiting autophagy of aHSC can prevent the progression of liver fibrosis, but inhibiting autophagy of other liver cells has opposite effects. Hence, targeted inhibition of autophagy in aHSC is quite necessary for the treatment of liver fibrosis, which prompts us to explore the targeted delivery system of small molecule autophagy inhibitor hydroxychloroquine (HCQ) that can target aHSC and alleviate the liver fibrosis...
April 12, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38597738/impact-of-masld-and-metald-on-clinical-outcomes-a-meta-analysis-of-preliminary-evidence
#2
JOURNAL ARTICLE
Stefano Ciardullo, Alessandro Mantovani, Mario Luca Morieri, Emanuele Muraca, Pietro Invernizzi, Gianluca Perseghin
A recent Delphi consensus proposed a new definition for metabolic dysfunction associated steatotic liver disease (MASLD) and introduced a disease entity called MetALD, a condition in which steatotic liver disease (SLD), metabolic dysfunction and moderate alcohol intake coexist. Given the limited available data on the prognostic implications of these disease entities, we performed a systematic review and meta-analysis of available cohort studies to evaluate the association of MASLD and MetALD with hard clinical outcomes...
April 10, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38597373/loss-of-gcn5l1-exacerbates-damage-in-alcoholic-liver-disease-through-ferroptosis-activation
#3
JOURNAL ARTICLE
Chenxi Yang, Ye Yang, Xiuya Hu, Qiqi Tang, Jiaqi Zhang, Peiyu Zhang, Xin Lu, Juan Xu, Sai Li, Zhengni Dong, Lu Zhu, Lingdi Wang
BACKGROUND AND AIMS: Iron overload, oxidative stress and ferroptosis are associated with liver injury in alcohol-associated liver disease (ALD), however, the crosstalk among these regulatory pathways in ALD development is unclear. METHODS: ALD mouse model and general control of amino acid synthesis 5 like 1 (GCN5L1) liver knockout mice were generated to investigate the role of GCN5L1 in ALD development. Proteomic screening tests were performed to identify the key factors mediating GCN5L1 loss-induced ALD...
April 10, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38591767/cacs-ccta-and-mcad-lt-score-in-the-pre-transplant-assessment-of-coronary-artery-disease-and-the-prediction-of-post-transplant-cardiovascular-events
#4
JOURNAL ARTICLE
Giulia Pagano, Lydia Sastre, Annabel Blasi, Salvatore Brugaletta, Judit Mestres, Julia Martinez-Ocon, Jose T Ortiz-Pérez, Clara Viñals, Susanna Prat-Gonzàlez, Eva Rivas, Rosario J Perea, Sergio Rodriguez-Tajes, África Muxí, Emilio Ortega, Ada Doltra, Pablo Ruiz, Bàrbara Vidal, Graciela Martínez-Palli, Jordi Colmenero, Gonzalo Crespo
BACKGROUND: The optimal cardiovascular assessment of liver transplant (LT) candidates is unclear. We aimed to evaluate the performance of CT-based coronary tests (coronary artery calcium score [CACS] and coronary CT angiography [CCTA]) and a modification of the CAD-LT score (mCAD-LT, excluding family history of CAD) to diagnose significant coronary artery disease (CAD) before LT and predict the incidence of post-LT cardiovascular events (CVE). METHODS: We retrospectively analysed a single-centre cohort of LT candidates who underwent non-invasive tests; invasive coronary angiography (ICA) was performed depending on the results of non-invasive tests...
April 9, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38591751/prognosis-algorithms-for-acute-decompensation-of-cirrhosis-and-aclf
#5
REVIEW
Shantha R Valainathan, Qing Xie, Vicente Arroyo, Pierre-Emmanuel Rautou
Accurate prediction of survival in patients with cirrhosis is crucial, as patients who are unlikely to survive in the short-term need to be oriented to liver transplantation and to novel therapeutic approaches. Patients with acute decompensation of cirrhosis without or with organ dysfunction/failure, the so-called acute-on-chronic liver failure (ACLF), have a particularly high short-term mortality. Recognizing the specificity of this clinical situation, dedicated classifications and scores have been developed over the last 15 years, including variables (e...
April 9, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38588031/management-of-biliary-tract-cancers-in-early-onset-patients-a-nested-multicenter-retrospective-study-of-the-acabi-gercor-pronobil-cohort
#6
JOURNAL ARTICLE
Antoine Lebeaud, Leony Antoun, Jane-Rose Paccard, Julien Edeline, Hélène Bourien, Nadim Fares, Christophe Tournigand, Thierry Lecomte, David Tougeron, Vincent Hautefeuille, Angélique Viénot, Julie Henriques, Nicolas Williet, Jean-Baptiste Bachet, Cristina Smolenschi, Antoine Hollebecque, Teresa Macarulla, Florian Castet, David Malka, Cindy Neuzillet, Dewi Vernerey, Alice Boilève, Anthony Turpin
BACKGROUND & AIMS: Accumulating data has shown the rising incidence and poor prognosis of early-onset gastrointestinal cancers, but few data exist on biliary tract cancers (BTC). We aimed to analyse the clinico-pathological, molecular, therapeutic characteristics and prognosis of patients with early onset BTC (EOBTC, age ≤50 years at diagnosis), versus olders. METHODS: We analysed patients diagnosed with intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder adenocarcinoma between 1 January 2003 and 30 June 2021...
April 8, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38588014/macrophage-activation-markers-are-associated-with-infection-and-mortality-in-patients-with-acute-liver-failure
#7
JOURNAL ARTICLE
Anna Cavazza, Evangelos Triantafyllou, Roberto Savoldelli, Salma Mujib, Ellen Jerome, Francesca M Trovato, Florent Artru, Roosey Sheth, Xiao Hong Huang, Yun Ma, Francesco Dazzi, Tasneem Pirani, Charalambos G Antoniades, William M Lee, Mark J McPhail, Constantine J Karvellas
BACKGROUND AND AIMS: Acute liver failure is a multisystem disorder with a high mortality and frequent need for emergency liver transplantation. Following massive innate immune system activation, soluble markers of macrophage activation are released during liver damage and their association with disease severity and prognosis requires exploration. METHODS: Patients ALF from the United States Acute Liver Failure Study Group (USALFSG, n = 224) and King's College Hospital (n = 40) together with healthy controls (HC, n = 50) were recruited...
April 8, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38581233/upfront-multi-bipolar-radiofrequency-ablation-for-hcc-in-transplant-eligible-cirrhotic-patients-with-salvage-transplantation-in-case-of-recurrence
#8
JOURNAL ARTICLE
Carina Boros, Olivier Sutter, François Cauchy, Nathalie Ganne-Carrié, Pierre Nahon, Gisele N'kontchou, Marianne Ziol, Véronique Grando, Alix Demory, Lorraine Blaise, Fédérica Dondero, François Durand, Olivier Soubrane, Mickael Lesurtel, Alexis Laurent, Oliver Seror, Jean Charles Nault
INTRODUCTION: We aim to assess the long-term outcomes of percutaneous multi-bipolar radiofrequency (mbpRFA) as the first treatment for hepatocellular carcinoma (HCC) in transplant-eligible cirrhotic patients, followed by salvage transplantation for intrahepatic distant tumour recurrence or liver failure. MATERIALS AND METHODS: We included transplant-eligible patients with cirrhosis and a first diagnosis of HCC within Milan criteria treated by upfront mbp RFA. Transplantability was defined by age <70 years, social support, absence of significant comorbidities, no active alcohol use and no recent extrahepatic cancer...
April 6, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38578141/the-first-mash-drug-therapy-on-the-horizon-current-perspectives-of-resmetirom
#9
REVIEW
Salvatore Petta, Giovanni Targher, Stefano Romeo, Utpal B Pajvani, Ming-Hua Zheng, Alessio Aghemo, Luca V C Valenti
The rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) poses a significant global health challenge, affecting over 30% of adults worldwide. MASLD is linked to increased mortality rates and substantial healthcare costs, primarily driven by its progression to metabolic dysfunction-associated steatohepatitis (MASH), which can lead to severe liver complications including cirrhosis and hepatocellular carcinoma. Despite its growing burden, effective pharmacotherapy for MASLD/MASH has been lacking until the recent conditional approval of resmetirom by the FDA...
April 5, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38578107/changing-landscape-of-alcohol-associated-liver-disease-in-younger-individuals-women-and-ethnic-minorities
#10
REVIEW
Juan P Arab, Winston Dunn, Gene Im, Ashwani K Singal
Alcohol use is the most important determinant of the development of alcohol-associated liver disease (ALD) and of predicting long-term outcomes in those with established liver disease. Worldwide, the amount, type, and pattern of use of alcohol vary. Alcohol use and consequent liver disease have been increasing in certain ethnic groups especially Hispanics and Native Americans, likely due to variations in genetics, cultural background, socio-economic status, and access to health care. Furthermore, the magnitude and burden of ALD have been increasing especially in the last few years among females and young adults who are at the prime of their productivity...
April 5, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38573034/diagnostic-accuracy-of-non-invasive-tests-to-screen-for-at-risk-mash-an-individual-participant-data-meta-analysis
#11
JOURNAL ARTICLE
Ferenc E Mózes, Jenny A Lee, Yasaman Vali, Emmanuel A Selvaraj, Arjun N A Jayaswal, Jérôme Boursier, Victor de Lédinghen, Monica Lupșor-Platon, Yusuf Yilmaz, Wah-Kheong Chan, Sanjiv Mahadeva, Thomas Karlas, Johannes Wiegand, Shalimar, Emmanouil Tsochatzis, Antonio Liguori, Vincent Wai-Sun Wong, Dae Ho Lee, Adriaan G Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Hannes Hagström, Camilla Akbari, Masashi Hirooka, Dong Hyeon Lee, Won Kim, Takeshi Okanoue, Toshihide Shima, Atsushi Nakajima, Masato Yoneda, Paul J Thuluvath, Feng Li, Annalisa Berzigotti, Yuly P Mendoza, Mazen Noureddin, Emily Truong, Céline Fournier-Poizat, Andreas Geier, Theresa Tuthill, Carla Yunis, Quentin M Anstee, Stephen A Harrison, Patrick M Bossuyt, Michael Pavlides
BACKGROUND & AIMS: There is a need to reduce the screen failure rate (SFR) in metabolic dysfunction-associated steatohepatitis (MASH) clinical trials (MASH+F2-3; MASH+F4) and identify people with high-risk MASH (MASH+F2-4) in clinical practice. We aimed to evaluate non-invasive tests (NITs) screening approaches for these target conditions. METHODS: This was an individual participant data meta-analysis for the performance of NITs against liver biopsy for MASH+F2-4, MASH+F2-3 and MASH+F4...
April 4, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38567962/relationship-between-helicobacter-pylori-infection-and-risk-of-metabolic-dysfunction-associated-steatotic-liver-disease-an%C3%A2-updated-meta-analysis
#12
REVIEW
Alessandro Mantovani, Maria Giovanna Lando, Nicolò Borella, Enrico Scoccia, Barbara Pecoraro, Federico Gobbi, Zeno Bisoffi, Luca Valenti, Herbert Tilg, Christopher D Byrne, Giovanni Targher
BACKGROUND: Recent observational studies examining the association between Helicobacter pylori infection and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) have reported conflicting results. We performed a meta-analysis to quantify the magnitude of the association between H. pylori infection and the risk of MASLD. METHODS: We systematically searched three large electronic databases to identify eligible observational studies (published up to 30 November 2023) in which liver biopsy, imaging methods or blood-based biomarkers/scores were used for diagnosing MASLD...
April 3, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38563728/estimating-the-prevalence-of-hepatitis-delta-virus-infection-among-adults-in-the-united-states-a-meta-analysis
#13
JOURNAL ARTICLE
Robert J Wong, Carol Brosgart, Steven S Wong, Jordan Feld, Jeffrey Glenn, Saeed Hamid, Chari Cohen, Beatrice Zovich, John Ward, Heiner Wedemeyer, Cihan Yurdaydin, Robert Gish
BACKGROUND AND AIMS: Suboptimal awareness and low rates of hepatitis delta virus (HDV) testing contribute to underdiagnosis and gaps in accurate estimates of U.S. HDV prevalence. We aim to provide an updated assessment of HDV prevalence in the U.S. using a comprehensive literature review and meta-analysis approach. METHODS: A comprehensive literature review of articles reporting HBsAg seroprevalence and anti-HDV prevalence was conducted to calculate country-specific rates and pooled prevalence of CHB and HDV using meta-analyses...
April 2, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38560775/liver-stiffness-predicts-progression-to-liver-related-events-in-patients-with-chronic-liver-disease-a-cohort-study-of-14%C3%A2-414-patients
#14
JOURNAL ARTICLE
Hannes Hegmar, Axel Wester, Soo Aleman, Jens Backman, Erik Degerman, Håkan Ekvall, Katarina Lund, Åsa Lundgren, Patrik Nasr, Afshin Shahnavaz, Johan Vessby, Johan Westin, Kristina Önnerhag, Hannes Hagström
BACKGROUND & AIMS: Liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) is a non-invasive diagnostic biomarker of liver fibrosis. It is uncertain if LSM can predict risk for future liver-related outcomes in large, heterogenous populations. METHODS: This Swedish multi-centre cohort study included patients (n = 14 414) from 16 sites who underwent LSM by VCTE between 2008 and 2020. Outcomes were ascertained from national registers...
April 1, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38558221/severe-hepatic-steatosis-promotes-increased-liver-stiffness-in-the-early-stages-of-metabolic-dysfunction-associated-steatotic-liver-disease
#15
JOURNAL ARTICLE
Takashi Kumada, Hidenori Toyoda, Sadanobu Ogawa, Tatsuya Gotoh, Yasuaki Suzuki, Katsutoshi Sugimoto, Yuichi Yoshida, Hidekatsu Kuroda, Yoshihiro Kamada, Yoshio Sumida, Takanori Ito, Tomoyuki Akita, Junko Tanaka
BACKGROUND & AIMS: The predictors of progression from steatosis to more advanced stages of metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. We evaluated the association between the quantity of hepatic steatosis and longitudinal changes in liver stiffness measurements (LSMs) using magnetic resonance elastography (MRE) in patients with MASLD. METHODS: We retrospectively analysed patients with MASLD who underwent at least two serial MRE and magnetic resonance imaging-based proton density fat fraction (MRI-PDFF) examinations at least 1 year apart...
April 1, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38554051/shining-a-spotlight-on-sarcopenia-and-myosteatosis-in-liver-disease-and-liver-transplantation-potentially-modifiable-risk-factors-with-major-clinical-impact
#16
REVIEW
Sophie Reichelt, Uta Merle, Miriam Klauss, Christoph Kahlert, Georg Lurje, Arianeb Mehrabi, Zoltan Czigany
Muscle-wasting and disease-related malnutrition are highly prevalent in patients with chronic liver diseases (CLD) as well as in liver transplant (LT) candidates. Alterations of body composition (BC) such as sarcopenia, myosteatosis and sarcopenic obesity and associated clinical frailty were tied to inferior clinical outcomes including hospital admissions, length of stay, complications, mortality and healthcare costs in various patient cohorts and clinical scenarios. In contrast to other inherent detrimental individual characteristics often observed in these complex patients, such as comorbidities or genetic risk, alterations of the skeletal muscle and malnutrition are considered as potentially modifiable risk factors with a major clinical impact...
March 30, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38554045/histological-characterization-of-liver-involvement-in-systemic-mastocytosis
#17
JOURNAL ARTICLE
Julien Rossignol, Danielle Canioni, Achille Aouba, Cristina Bulai-Livideanu, Stéphane Barete, Charles Lancesseur, Laura Polivka, Marine Madrange, Thomas Ballul, Antoine Neuraz, Celine Greco, Julie Agopian, Fabienne Brenet, Patrice Dubreuil, Richard Lemal, Olivier Tournilhac, Louis Terriou, David Launay, Laurence Bouillet, Clément Gourguechon, Laurent Frenzel, Cécile Meni, Caroline Gaudy-Marqueste, Marie Gousseff, Edwige Le Mouel, Mohamed Hamidou, Antoine Neel, Dana Ranta, Roland Jaussaud, Philippe Guilpain, Thierry J Molina, Julie Bruneau, Ludovic Lhermitte, Nicolas Garcelon, Rose-Marie Javier, Fabien Pelletier, Florence Castelain, Frederique Retornaz, Quentin Cabrera, Patricia Zunic, Marie Pierre Gourin, Ewa Wierzbicka-Hainaut, Jean François Viallard, Christian Lavigne, Cyrille Hoarau, Isabelle Durieu, Maël Heiblig, Sophie Dimicoli-Salazar, Jose M Torregrosa-Diaz, Angèle Soria, Michel Arock, Olivier Lortholary, Christine Bodemer, Stanislas Pol, Vincent Mallet, Olivier Hermine, Ghandi Damaj
BACKGROUND AND AIMS: Systemic mastocytosis (SM) is characterized by the accumulation of atypical mast cells (MCs) in organs. Liver histology of SM has been marginally described and accurate histological classification is critical, given the consequences of aggressive SM diagnosis. We aimed to describe the histological features associated with liver SM using updated tools. METHODS: Using the database of the French Reference Centre for Mastocytosis, we retrospectively identified patients with a liver biopsy (LB) and a diagnosis of SM...
March 30, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38554044/fgf21-protects-against-ischaemia-reperfusion-injury-in-normal-and-fatty-livers
#18
JOURNAL ARTICLE
Yong Ma, Garima Singhal, Suzanne S Chan, Chaoqun Wang, Hongjun Yu, Bing Yin, Jing Pang, Grace Malvar, Imad Nasser, Marie L Mather, Eleftheria Maratos-Flier
BACKGROUND: Liver ischaemia/reperfusion (I/R) injury, which is an inevitable clinical problem of liver resection, liver transplantation and haemorrhagic shock. Fibroblast growth factor 21 (FGF21) was intimately coupled with multiple metabolic processes and proved to protect against apoptosis and inflammatory response in hepatocytes during hepatic I/R injury. However, the regulatory mechanisms of FGF21 in hepatic I/R injury remains unknown. Therefore, we hypothesize that FGF21 protects hepatic tissues from I/R injury...
March 30, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38554043/neurokinin-1-receptor-antagonist-aprepitant-regulates-autophagy-and-apoptosis-via-ros-jnk-in-intrahepatic-cholangiocarcinoma
#19
JOURNAL ARTICLE
Yang Yang, Xueyan Cao, Yuting Wang, Xinyu Wu, Ping Zhou, Lin Miao, Xueting Deng
BACKGROUND: Intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis and limited treatment options. Aprepitant, a selective NK-1R antagonist, can inhibit the growth of various tumours in vitro and in vivo. However, it remains unclear whether aprepitant has cytotoxic effects on iCCA. METHODS: We measured the expression of SP/NK-1R in clinical samples of iCCA by immunohistochemistry. Then, we detected the cytotoxic effects of aprepitant on iCCA cells via MTT, EdU and colony formation assay...
March 30, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38517286/impact-of-body-mass-index-on-the-prognosis-of-unresectable-hcc-patients-receiving-first-line-lenvatinib-or-atezolizumab-plus-bevacizumab
#20
JOURNAL ARTICLE
Margherita Rimini, Bernardo Stefanini, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Fabian Finkelmeier, Changhoon Yoo, José Presa, Elisabeth Amadeo, Virginia Genovesi, Maria Caterina De Grandis, Massimo Iavarone, Fabio Marra, Francesco Foschi, Emiliano Tamburini, Federico Rossari, Francesco Vitiello, Linda Bartalini, Caterina Soldà, Francesco Tovoli, Caterina Vivaldi, Sara Lonardi, Marianna Silletta, Takashi Kumada, Naoya Sakamoto, Hideki Iwamoto, Tomoko Aoki, Vera Himmelsbach, Margarida Montes, Atsushi Hiraoka, Takuya Sho, Takashi Niizeki, Naoshi Nishida, Christoph Steup, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Mara Persano, Silvia Camera, Silvia Foti, Luca Aldrighetti, Stefano Cascinu, Andrea Casadei-Gardini, Fabio Piscaglia
INTRODUCTION: Overweight is a negative prognostic factor in the general population in the long term. However, the role of body mass index (BMI) in the short-mid term in advanced tumours is unclear. The present analysis investigates the role of BMI weight classes in a large sample of patients affected by HCC and receiving atezolizumab plus bevacizumab or lenvatinib as first-line treatment. METHODS AND MATERIAL: The cohort included consecutive patients affected by BCLC-c and BCLC-B HCC patients from a multicenter international study group who received atezolizumab plus bevacizumab or lenvatinib as first-line therapy...
March 22, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
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