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Journal of Drugs in Dermatology: JDD

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https://read.qxmd.com/read/30681817/principles-of-moisturizer-product-design
#1
REVIEW
Christine Lee, John Bajor, Teanoosh Moaddel, Vivek Subramanian, Jian-Ming Lee, Diana Marrero, Sheila Rocha, Michael D. Tharp
Moisturizers provide significant benefit in dermatology – as adjuvant therapy for many clinical conditions, as a key player in anti-aging regimens, and as a core component in maintaining healthy skin barrier function. Although they have been a mainstay for decades, lotions and creams are no longer formulated with a one-size-fits-all approach, where thickness was the primary cue for efficacy. In fact, moisturizer design today has become an art as well as a science. Product efficacy, aesthetics, and packaging are all engineered in a variety of ways, to create an expansive market of products that meet many consumer needs...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681816/recent-advances-in-mild-and-moisturizing-cleansers
#2
REVIEW
K P Ananthapadmanabhan, James J. Leyden, Stacy S. Hawkins
Mild and moisturizing cleanser technologies, and the science underpinning them, have progressed significantly over the past decade. This includes introduction of amino-acid based milder surfactants into the cleansing arena, a deeper understanding of the roles of stratum corneum lipids and proteins in their interaction with cleanser surfactants, the role of pH in skin cleansing, and the development of improved methodologies for predicting skin irritation and drying potential of cleansers. In this paper, the recent advances in these areas as well as newer technologies are reviewed, and the future directions are outlined...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681814/the-importance-of-understanding-consumer-preferences-for-dermatologist-recommended-skin-cleansing-and-care-products
#3
REVIEW
Joanne Crudele, Elizabeth Kim, Karen Murray, Jamie Regan
Dermatologist recommendations of skin care products are critical to the management of compromised and healthy skin and appreciated by patients. Professionals must carefully weigh not only the safety and efficacy but also the aesthetics of products if they are to achieve the desired outcome of satisfied patients. This article elucidates the relevance of product sensory characteristics and consumer preferences, with specific focus on what appeals to men vs. women, those with self-perceived sensitive skin, and acne sufferers...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681812/the-spectrum-of-sensitive-skin-considerations-for-skin-care-in-vulnerable-populations
#4
Stacy S. Hawkins, Vickie Foy
Sensitive skin is a multifactorial condition, where the underlying pathology is not fully understood, and the clinical signs may not always be present or obvious. Despite this challenge, there has been recent progress to understand the different subtypes of sensitive skin, as well as new methods to measure the sensorial response that may not be obvious from visual examination. Similarly, there has been progress in understanding in the management of symptoms through skin care regimens designed for sensitive skin...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681811/skin-barrier-insights-from-bricks-and-mortar-to-molecules-and-microbes
#5
REVIEW
Carol A. Bosko
Recent advances in genomics, spectroscopy, and immunology have increased our understanding of the skin barrier. A new model of barrier lipid organization has emerged owing to the application of advanced modeling and microscopy techniques. The contribution of filaggrin gene mutations to atopic dermatitis has increased our appreciation of the role barrier perturbations play in inflammatory dermatoses. Next generation sequencing techniques have led to a greater understanding of the diversity of resident skin microorganisms and the close association between microbes and the host immune system...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681808/concurrent-scabies-incognito-and-crusted-scabies-with-scalp-lesions-masquerading-as-erythrodermic-dermatitis
#6
Philip R. Cohen
I read with interest the excellent report by Tolkachjhov et al1 that describes the delay in diagnosis of a scabies infestation in a 90-year-old woman. Her condition mimicked dermatitis not only on clinical presentation but also on evaluation of skin biopsies.
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681807/bullous-pemphigoid-associated-with-a-new-combination-checkpoint-inhibitor-immunotherapy
#7
Natalia M. Fontecilla, Trisha Khanna, Claire-Audrey Y. Bayan, Nina A. Antonov, Larisa J. Geskin
Novel immunotherapies including antibodies to programmed death ligand 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) have become common therapies for neoplasms including metastatic melanoma and non-small cell lung cancer (NSCLC). Dermatologic toxicity is the most common adverse event associated with these immunotherapies. We report a case of bullous pemphogoid (BP) in a patient receiving combination durvalumab and tremelimumab, two newer immunotherapy checkpoint inhibitors under investigation in phase III trials...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681806/managing-the-aesthetic-patient
#8
Alessandra Haddad, Ana Paula Gomes Meski, Camila Cazerta, Christine Guarnieri, Eliandre Palermo, Juliana Sarubi, Luciana Lourenço, Luiz Eduardo Avelar, Marcus Henrique Morais, Maria Alice Gabay, Meire Brasil Parada, Rodrigo Ferraz, Rodrigo Maia, Danielle Shitara
wide variety of therapeutic options, some challenges have arisen: designing an adequate treatment plan, electing the most suitable procedures for the patient, taking into consideration the rheological characteristics of the products, considering the amount needed to achieve a natural look, but also defining the safest way to deliver the treatment. Aging of the facial structural tissue layers occurs at a different pace and the requirements for the aesthetic approach of a 30-year-old patient are different from a 60-year-old patient...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681803/open-label-post-marketing-study-to-evaluate-the-performance-and-safety-of-calcium-hydroxylapatite-with-integral-lidocaine-to-correct-facial-volume-loss
#9
Gabriele F. Muti
Background: Calcium hydroxylapatite (CaHA, Radiesse®) with integral 0.3% lidocaine (CaHA(+)) has recently been approved for use in aesthetic medicine. This study assessed the performance of CaHA(+) in subjects undergoing treatment for facial volume loss and evaluated subject and physician satisfaction. Methods: In a prospective, open-label, post-marketing study, 25 women seeking treatment for age-related facial volume loss received CaHA(+) injections in 1–3 facial areas including the cheeks, marionette lines, prejowl sulcus, and jawline...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681802/cohort-using-a-ceramides-containing-cleanser-and-cream-with-salicylic-acid-for-dry-flaking-and-scaling-skin-conditions
#10
Ronald B. Vender, Anneke Andriessen, Benjamin Barankin, Anatoli Freiman, Dimitrios Kyritsis, Loukia-Maria Mistos, Jennifer Salsberg, Laetitia Amar
Introduction: The skin of subjects with dry, flaking, and/or scaling conditions is characterized by decreased water and skin lipids content among other findings. It is well understood that daily use of gentle cleansers and moisturizers may help to restore and maintain an optimal skin barrier function. A cohort study of patients with dry skin was developed to evaluate efficacy of daily use of a ceramide containing cleanser and cream that also has salicylic acid. Methods: Thirty-five adults with mild-to-moderate dry skin conditions were recruited from four dermatology centers in Canada...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681800/patient-satisfaction-following-treatment-with-microfocused-ultrasound-with-visualization-results-of-a-retrospective-cross-sectional-survey
#11
José Raúl Montes, Elizabeth Santos
Background: A device that uses microfocused ultrasound with visualization (MFU-V) is cleared in the United States and European Union as a noninvasive procedure that lifts and tightens the skin (Ultherapy® System; Merz North America, Raleigh, NC, USA). The objective of this patient survey was to obtain more in-depth information on patient satisfaction during the MFU-V treatment procedure and satisfaction with their aesthetic results. Methods: Survey participants had received MFU-V treatment and completed at least 6 months of follow-up...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681799/open-label-study-evaluating-efficacy-safety-and-effects-on-perception-of-age-after-injectable-20-mg-ml-hyaluronic-acid-gel-for-volumization-of-facial-temples
#12
Leslie S. Baumann, Edmund M. Weisberg, Melissa Mayans, Erika Arcuri
Objective: To study the safety, efficacy, optimal volume, and longevity of an injectable hyaluronic acid (HA) gel dermal filler to treat facial temporal fossa fat loss. Methods and materials: This open-label, single-site, 12-month study used 20 mg/mL HA gel to correct volume loss in both temples in 30 subjects. Touch-ups were allowed at week 2. At each visit, the investigator completed a Frontal Temporal Fossa Scale and a 7-point satisfaction scale. Subjects completed a 7-point satisfaction scale, Subject Global Aesthetic Improvement Scale (GAIS), and self-perception of age assessment...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681798/effectiveness-of-combining-high-intensity-focused-radiofrequency-and-non-ablative-fractional-laser-for-improving-the-appearance-of-the-aging-face-and-neck
#13
Amir Moradi, Steven F. Weiner
Background: The safety and effectiveness of high-intensity precision radiofrequency (RF) for rejuvenating the aging neck and face, and of fractional laser therapy for treating photodamaged skin have each been previously demonstrated. Objective: To assess the effects of combining high-intensity precision RF and fractional laser therapy for treating the aging face and neck. Methods and Materials: Subjects (N=19) with Fitzpatrick skin types I to VI and mild-to-moderate solar elastosis and sun or age-related pigmentation on the face and/or neck were sequentially treated with high-intensity precision RF and fractionated laser devices during the same session...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681794/incobotulinumtoxina-a-highly-purified-and-precisely-manufactured-botulinum-neurotoxin-type-a
#14
Martina Kerscher, Rungsima Wanitphakdeedecha, Ada Trindade de Almeida, Corey Maas, Jürgen Frevert
Aesthetic dermatologic applications of botulinum neurotoxin (BoNT), including treatment of glabellar lines, horizontal forehead lines, and crow’s feet, were the most common non-surgical cosmetic procedures in the US in 2017, with high levels of subject satisfaction. Since the first BoNT type A (BoNT-A) formulation was approved in 1989, the number of formulations available on the world’s commercial markets has increased and new approvals are expected. BoNT is produced by Clostridium botulinum in nature as part of a large protein complex...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681793/final-data-from-the-condition-of-submental-fullness-and-treatment-outcomes-registry-contour
#15
Melanie D. Palm, Joel Schlessinger, Valerie D. Callender, Steven Fagien, Kenneth Beer, Suzanne Magante, Sara Sangha
Perceptions of attractiveness can be negatively affected by submental fullness. Patients seeking to improve their submental contour have a variety of treatment options including surgical procedures, energy-based devices, and injectable treatment. The Condition of Submental Fullness and Treatment Outcomes Registry (CONTOUR) was designed to provide insights into the treatment of submental fat (SMF) in clinical practice. CONTOUR was a prospective observational study that enrolled 1029 adults at 91 sites in the United States and Canada...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681791/novel-tretinoin-0-05-lotion-for-once-daily-treatment-of-moderate-to-severe-acne-vulgaris-in-a-hispanic-population
#16
Fran E. Cook-Bolden, Susan H. Weinkle, Eric Guenin, Varsha Bhatt
Background: Acne vulgaris (acne) is the most common dermatologic disease seen in a racially, geographically, politically, culturally, and socioeconomically diverse Hispanic population. Despite their growing demographics in the US, there are few studies evaluating acne treatment in this population. Potential for skin irritation and dryness, as well as pigmentary changes are key concerns. The first lotion formulation of tretinoin was developed using novel polymerized emulsion technology to provide an important alternative option to treat these acne patients who may be sensitive to the irritant effects of other tretinoin formulations...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681790/a-novel-approach-to-enhancing-the-quality-and-appearance-of-photoaged-skin
#17
Zoe Diana Draelos
Background: Moisturizers create the illusion of smooth, soft skin by placing a temporary film over the skin surface or by imparting a transient hydration benefit that does not clinically improve the quality or appearance of skin. Objective: The objective of this 8-week study was to assess the clinically relevant effects of a 3-step facial treatment program to improve the multiple qualities of photoaged skin. Methods: Thirty-five female subjects were evaluated at baseline and after 2, 4, and 8 weeks. Measures included investigator and subject assessments and noninvasive measures of skin hydration, elasticity, sebum, and exfoliation...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681789/seborrheic-dermatitis-in-skin-of-color-clinical-considerations
#18
May Elgash, Ncoza Dlova, Temitayo Ogunleye, Susan C. Taylor
Seborrheic dermatitis is a common, relapsing, inflammatory skin condition of unclear etiology. The Malassezia yeast genus are believed to play a role. Seborrheic dermatitis commonly affects areas of the skin with high sebum production, including the scalp, nasolabial folds, glabella, eyebrows, beard, ears, retroauricular skin, sternum, and other skin folds. Seborrheic dermatitis may present differently in individuals with skin of color. Darker-skinned individuals may present with scaly, hypopigmented macules and patches in typical areas of involvement...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681788/update-in-herpes-zoster-prevention-and-the-role-of-dermatologists
#19
Kayla H. Feli, Constance E. Ediale, Amy J. McMichael
A recombinant vaccine (HZ/su) was approved in 2017 to prevent herpes zoster (HZ) infection and associated sequelae with greater efficacy and safety than its live precursor. Though dermatologists regularly encounter patients with HZ infection, recommendation of vaccination by dermatologists and other physicians has been minimal in past years. Overall patient awareness and utilization of the HZ vaccines has subsequently been low. While HZ/su touts several improvements over the live vaccine, dermatologists still face obstacles to vaccine recommendation and administration including concerns of efficacy, limited availability, and complex cost and reimbursement for administration...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30681787/oral-collagen-supplementation-a-systematic-review-of-dermatological-applications
#20
Franchesca D. Choi, Calvin T. Sung, Margit L.W. Juhasz, Natasha Atanaskova Mesinkovsk
Importance: The use of nutraceuticals such as collagen for skincare has been rising, but regulations are lacking on quality, absorption, and efficacy. To address this knowledge gap, clinical studies regarding the potential effects of collagen-based dietary supplements on skin are being completed. Objective: To review the literature and assess available randomized-controlled trials using collagen supplementation for treatment efficacy regarding skin quality, anti-aging benefits, and potential application in medical dermatology...
January 1, 2019: Journal of Drugs in Dermatology: JDD
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