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Journals Journal of Drugs in Dermatolog...

Journal of Drugs in Dermatology : JDD

https://read.qxmd.com/read/38834229/an-open-label-study-to-investigate-the-efficacy-and-tolerability-of-dapsone-gel-7-5-in-the-treatment-of-acne-vulgaris-in-men-and-women-with-skin-of-color
#1
JOURNAL ARTICLE
Nour El-Kashlan, Ahuva Cices, Bridget Kaufman, Joel Correa Da Rosa, Ingrid Sanabria-Gonzalez, Saakshi Khattri, Andrew Alexis
INTRODUCTION: Acne vulgaris is a common skin disease prevalent in skin of color patients. Studies have demonstrated that dapsone gel, 7.5% (Aczone) used once daily is effective, safe, and well-tolerated for the treatment of acne in both men and women. However, minimal data are available in skin of color populations. This single-center, open-label clinical study investigated the efficacy and safety of dapsone gel, 7.5% in the treatment of moderate to severe acne vulgaris in patients with Fitzpatrick skin types IV-VI...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834228/treatment-of-bullous-pemphigoid-with-dupilumab-a-case-series-of-30-patients
#2
MULTICENTER STUDY
Austinn C Miller, Laurie A Temiz, Susuana Adjei, Miguel A Duran, Jeffrey Sassmannshausen, Arturo Dominguez, Cristina Thomas, Jimmy D Schmidt, Michael Bernhardt, Coley J Doolittle-Amieva, Ata S Moshiri, Anthony J Thompson, Penelope Pyoung Kim-Lim, Alexzandra V Mattia, Stephen K Tyring
Bullous pemphigoid is often difficult to treat with the limited therapies available. Here, we describe clinical outcomes among 30 adults with bullous pemphigoid patients treated with dupilumab. We performed a multicenter, retrospective case series between March 2020 to August 2022. Patients received a loading dose of dupilumab 600 mg, followed by 300 mg maintenance dose with varying administration frequency tailored to individual patient response. All patients experienced at least some improvement in blister formation and pruritus, with 23 (76...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834227/anifrolumab-for-the-dermatologist
#3
JOURNAL ARTICLE
Cleo Whiting, Sara Abdel Azim, Adam Friedman
No abstract text is available yet for this article.
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834226/triple-combination-clindamycin-phosphate-1-2-adapalene-0-15-benzoyl-peroxide-3-1-gel-for-acne-in-adult-and-pediatric-participants
#4
RANDOMIZED CONTROLLED TRIAL
Hilary Baldwin, Linda Stein Gold, Julie C Harper, Andrew F Alexis, Valerie D Callender, Leon Kircik, Eric Guenin, Lawrence F Eichenfield
BACKGROUND: Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel (CAB) is the first fixed-dose triple-combination approved for the treatment of acne. This post hoc analysis investigated the efficacy and safety of CAB in pediatric (<18 years) and adult (greater than or equal to 18 years) participants. METHODS: In two multicenter, double-blind, phase 3 studies (NCT04214639 and NCT04214652), participants greater than or equal to 9 years of age with moderate-to-severe acne were randomized (2:1) to 12 weeks of once-daily treatment with CAB or vehicle gel...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834225/investigating-the-relationship-between-acne-and-vasodilatory-medications-in-a-hospital-wide-adult-population
#5
JOURNAL ARTICLE
Paras Patel, Jennifer Wang, David Bitterman, Kayla Zafar, Margaret Kabakova, Marc Cohen, Evan Austin, Jared Jagdeo
Acne vulgaris is a common chronic dermatological condition characterized by obstruction and inflammation of pilosebaceous units. Recent research on a different dermatologic condition has demonstrated that the use of vasodilatory medications is associated with a decreased relative risk of rosacea. This finding is significant due to the overlapping inflammatory pathways involved in rosacea and acne. Herein, a retrospective cohort study was designed to determine the correlation between vasodilator usage and the risk of developing acne within 5 years, contrasting it with thiazide diuretics, chosen as a control due to its non-vasodilatory antihypertensive mechanism and availability of data...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834224/going-beyond-ceramides-in-moisturizers-the-role-of-natural-moisturizing-factors
#6
REVIEW
Hilary Baldwin, James Del Rosso
Xerosis is experienced by almost everyone at some time in their lives and the foundation of management of dry skin (both consumer- and healthcare professional--directed) rests on the use of moisturizers. Given the wide range of available moisturizers, counseling patients about selecting the optimum moisturizer for their individual situation relies on knowledge of ingredients and formulations. Traditionally, the main focus for many moisturizers centered on the core functional and structural role of ceramides within the epidermal barrier...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834223/topical-clindamycin-in-the-management-of-acne-vulgaris-current-perspectives-and-recent-therapeutic-advances
#7
REVIEW
James Q Del Rosso, Christopher G Bunick, Leon Kircik, Neal Bhatia
Clindamycin is a lincosamide-derivate antibiotic that has been widely used both systemically and topically for approximately 5 decades. The antimicrobial profile of clindamycin primarily covers several gram-positive bacteria and anaerobic bacteria, with multiple clinical applications supported in the literature and with widespread real-world use. Topical clindamycin has been used primarily for the treatment of acne vulgaris, with both monotherapy and combination therapy formulations available commercially. This article reviews the use of clindamycin as a topical agent with emphasis on therapy for acne vulgaris, and addresses modes of action, reported anti-inflammatory properties that may relate to therapeutic outcomes, recommendations to avoid the emergence of antibiotic-resistant bacteria, tolerability and safety considerations, and published data from clinical studies completed over a span of several years...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834222/sunscreen-practices-and-preferences-of-skin-of-color-patients
#8
JOURNAL ARTICLE
Jennifer Y Wang, Paras Patel, Raichel Philip, Margaret Kabakova, David Bitterman, Kayla Zafar, Sharon A Glick, Jared Jagdeo
Sunscreen is an essential way to protect against photodamage from ultraviolet (UV) radiation. Despite the recognized benefits of sunscreen in preventing skin damage from UV light, its use varies across different patient groups. This cross-sectional, questionnaire-based study aims to uncover the sunscreen usage patterns, preferences, and barriers among non-Hispanic White (NHW) and skin of color (SOC) individuals. Our findings demonstrate that NHW individuals are more likely to wear sunscreen daily (31% NHW vs 25% SOC) and reapply sunscreen at least once a day (76% NHW vs 45% SOC) compared with SOC individuals...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834221/lichen-sclerosus-a-survey-of-diagnosis-and-management-among-pediatric-dermatologists-and-gynecologists
#9
JOURNAL ARTICLE
Christine M Pennesi, Aneka Khilnani, Kalyani S Marathe, Tazim Dowlut-McElroy, Kaiane Habeshian
BACKGROUND/OBJECTIVES: Lichen sclerosus (LS) is a chronic condition that warrants close follow-up due to the risk of scarring. The optimal long-term management of pediatric vulvar and perianal lichen sclerosus (PVPLS) is unknown. This study aimed to identify diagnostic, treatment, and maintenance regimens among pediatric dermatologists and pediatric/adolescent gynecologists, as well as assess provider confidence and desire for guidance on long-term PVPLS management. METHODS: A cross-sectional 35-question survey was administered through the Pediatric Dermatology Research Alliance (PeDRA) and the North American Society for Pediatric and Adolescent Gynecology (NASPAG) between 7/13/2021 and 8/30/2021 to ascertain PVPLS diagnostic and management regimens...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834220/hypothalamic-pituitary-adrenal-axis-response-in-patients-with-acne-vulgaris-treated-with-clascoterone
#10
MULTICENTER STUDY
Neal Bhatia, Lawrence F Eichenfield, Alessandro Mazzetti, Luigi Moro, Nicholas Squittieri, Adelaide A Hebert
BACKGROUND: Clascoterone cream 1% is a topical androgen receptor inhibitor approved to treat acne vulgaris in patients =>12 years of age. This report provides details of patients who developed laboratory signs of hypothalamic-pituitary-adrenal (HPA) axis suppression without clinical signs of adrenal suppression during the clascoterone development program. METHODS: Two open-label, multicenter, Phase 2 trials evaluated HPA axis suppression in patients with moderate-to-severe acne vulgaris...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834219/steroids-used-to-treat-acne-vulgaris-a-review-of-efficacy-safety-and-clinical-considerations
#11
REVIEW
Wendy Cantrell, Loree Easley, Keri Squittieri
Acne vulgaris is prevalent among adolescents and adults worldwide and can significantly impact patients' quality of life. Steroidal molecules, including oral and intralesional corticosteroids, combined oral contraceptives (COCs), oral spironolactone, and topical clascoterone, are an important part of the acne treatment armamentarium. The recommended use, mechanism of action, and available evidence supporting the use of steroids for acne treatment are reviewed, and differences in acne clinical presentation and treatment approaches based on patient characteristics relevant to the selection of an appropriate steroid are also discussed...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834218/treatment-of-acne-scars-with-microneedling-and-chemical-reconstruction-of-scarred-skin-therapy-cross-using-penol-croton-oil-combination
#12
JOURNAL ARTICLE
Quita Lopez
BACKGROUND: Microneedling has been shown to release growth factors, which improves the appearance of acne scars by itself and in combination with different therapy modalities. Combining microneedling with Chemical Reconstruction of Scarred Skin (CROSS) therapy using a 60% phenol and 0.2% croton oil combination results in a significant improvement of acne scarring. OBJECTIVE: To assess the safety and efficacy of combination treatments using microneedling in combination with CROSS therapy that contains 60% phenol and 0...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834217/assessing-the-impact-of-prior-authorizations-on-dermatology-residents
#13
JOURNAL ARTICLE
Dillon Nussbaum, Jessica Kalen, Erika McCormick, Sapana Desai, Adam Friedman
INTRODUCTION: Prior authorizations (PAs) are administrative tasks commonly required by insurers to approve medications or therapies for patients. Dermatology practices frequently employ coordinators to focus on completing PAs, among other solutions. The degree to which this support is offered in academic centers and, importantly, how much time dermatology residents spend on PAs over educational pursuits is largely unknown. The authors sought to identify the impact of PAs on dermatology residents...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834216/factors-influencing-patient-selection-of-sunscreen
#14
JOURNAL ARTICLE
Joshua Burshtein, Danny Zakria, Milaan Shah, Darrell Rigel
Sunscreen is an essential component of sun protection. The most important characteristics for patient selection of sunscreens have not been evaluated. A cross-sectional survey study was performed at an academic dermatology office. The sunscreen characteristic chosen most frequently was SPF (75.2%). Fewer patients selected broad-spectrum (20.7%) and water-resistance (22.7%). There remains a gap in patient knowledge regarding AAD recommendations for sunscreen characteristics and educational initiatives may be required...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834215/disparities-in-state-medicaid-coverage-of-tretinoin-for-pigmentary-disorders-compared-to-acne-vulgaris
#15
COMPARATIVE STUDY
Priya Manjaly, Kanika Kamal, Sophia Ly, Katherine Sanchez, Ethiopia Getachew, Arash Mostaghimi, Nicholas Theodosakis
BACKGROUND: Melasma and post-inflammatory hyperpigmentation (PIH) are common cosmetic dermatologic conditions that predominantly affect patients with skin phototypes III-VI. Comparing treatment coverage for these pigmentary disorders to treatment coverage for acne vulgaris may demonstrate disparities in insurance coverage for diseases that primarily affect patients of color. OBJECTIVE: Describe differences in Medicaid coverage for topical tretinoin for melasma and PIH vs...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834214/sentiment-analysis-of-epsolay-microencapsulated-benzoyl-peroxide-5-on-reddit-pre-and-post-fda-approval
#16
JOURNAL ARTICLE
Asghar Shah, Surya Khatri, Sara Yumeen, Elie Saliba
No abstract text is available yet for this article.
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834213/heatmap-evaluation-of-facial-hydration-using-a-novel-python-program
#17
JOURNAL ARTICLE
Thu Q Nguyen, Christine Emesiani, Matthew Meckfessel
BACKGROUND: Evaluating cleansers and moisturizers provides important information to guide clinicians in the recommendation of these products. This project was performed to visualize skin hydration via heatmap after the use of a gentle skin cleanser (GSC) and moisturizing lotion (ML). METHODS: Half-face, intra-individual open-label study in healthy volunteers. Cleanser was administered in a single application that was then wiped off the face. Moisturizing lotion was applied at least once-daily for one week...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834212/consensus-statements-on-the-use-of-novel-formulations-of-isotretinoin-a-modified-delphi-process
#18
JOURNAL ARTICLE
Paige Kingston, Leon Kircik, Neal Bhatia, James Del Rosso, Seemal R Desai, Julie C Harper, Linda Stein Gold, Firas Hougeir, April W Armstrong
Oral isotretinoin remains a mainstay of treatment for severe, recalcitrant nodular acne. Novel formulations of isotretinoin have been developed over the past decade, including lidose isotretinoin and micronized isotretinoin. It is important to understand the differences between isotretinoin formulations to help guide clinical decision-making and selection of isotretinoin therapy. This study aims to provide evidence-based consensus statements regarding the use of novel formulations of isotretinoin for the treatment of moderate-to-severe acne...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834211/efficacy-and-safety-of-micronized-isotretinoin-administered-once-daily-without-food-in-patients-with-recalcitrant-nodular-acne
#19
JOURNAL ARTICLE
James Q Del Rosso, Leon Kircik
INTRODUCTION: Micronized isotretinoin 0.4 to 0.8 mg/kg/day administered in 2 divided doses with or without meals is approved for the treatment of severe nodular acne in patients aged 12 years or older. Although practitioners may suggest once-daily dosing to increase patient compliance, supporting data are limited. METHODS: In this pilot study, patients aged 12 years or older with severe nodular acne (Investigator's Global Assessment [IGA] =>4 and >5 facial nodules) received once-daily micronized isotretinoin 0...
June 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38834210/blue-light-effects-on-the-skin-a-post-2015-update
#20
REVIEW
Lauren Pupa, Ida F Orengo, Ted Rosen
The debate surrounding the benefits versus harms of blue light have become a topic of interest recently due to increased exposure. Blue light therapy has been utilized with some success in a variety of dermatologic conditions. However, potential harms have also been documented. Currently, there is no evidence to suggest a necessity for blue light photoprotection, but there are products available with proven efficacy for those desiring protection. J Drugs Dermatol. 2024;23(6):472-476.     doi:10...
June 1, 2024: Journal of Drugs in Dermatology: JDD
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