Jens Witsch, Quy Cao, Jae W Song, Yunshi Luo, Kelly L Sloane, Aaron Rothstein, Christopher G Favilla, Brett L Cucchiara, Scott E Kasner, Steve R Messé, Huimahn A Choi, Louise D McCullough, Stephan A Mayer, Aaron M Gusdon
BACKGROUND: Although larger hematoma volume is associated with worse outcome after intracerebral hemorrhage (ICH), the association between perihematomal edema (PHE) volume and outcome remains uncertain, as does the impact of sex on PHE and outcome. Here we aimed to determine whether larger PHE volume is associated with worse outcome and whether PHE volume trajectories differ by sex. METHODS: We conducted a post hoc analysis of the Factor VIIa for Acute Hemorrhagic Stroke Treatment (FAST) trial, which randomized patients with ICH to receive recombinant activated factor VIIa or placebo...
February 20, 2024: Neurocritical Care