Swati Singh, Zoltan Winter, Fabian Necker, Tobias Bäuerle, Michael Scholz, Lars Bräuer, Friedrich Paulsen
No abstract text is available yet for this article.
April 16, 2024: Ocular Surface
Mohammad Javed Ali, Ali Djalilian
No abstract text is available yet for this article.
April 16, 2024: Ocular Surface
August Beisel, Garrett Jones, Joshua Glass, Tae Jin Lee, Marc Töteberg-Harms, Amy Estes, Lane Ulrich, Kathryn Bollinger, Shruti Sharma, Ashok Sharma
PURPOSE: Technological advancements allowing for the analysis of low-volume samples have led to the investigation of human tear fluid and aqueous humor (AH) as potential biomarker sources. However, acquiring AH samples poses significant challenges, making human tear fluid a more accessible alternative. This study aims to compare the protein compositions of these two biofluids to evaluate their suitability for biomarker discovery. METHODS: Paired tear and AH samples were collected from 20 patients undergoing cataract surgery...
March 30, 2024: Ocular Surface
Michael T M Wang, Jay J Meyer, Ally L Xue, Barry Power, Jennifer P Craig
PURPOSE: To evaluate the prognostic ability of non-contact esthesiometry corneal and lid margin sensitivity measurements in detecting symptoms and signs of dry eye disease, as defined by the global consensus TFOS DEWS II criteria. METHODS: A total of 87 community residents (58 females; mean ± SD age, 53 ± 16 years)) were recruited in an investigator-masked, prospective, prognostic accuracy study. Dry eye symptomology, tear film parameters, and ocular surface characteristics were evaluated in a single clinical session, and non-contact esthesiometry corneal and lid margin sensitivity measurements performed by an independent blinded assessor...
March 28, 2024: Ocular Surface
Francesca Giovannetti, Marta Sacchetti, Marco Marenco, Ludovico Alisi, Giacomo Visioli, Alice Bruscolini, Alessandro Lambiase
PURPOSE: To validate the use, repeatability, and reproducibility of a new, cost-effective, disposable, sterile device (KeraSenseⓇ, Dompè farmaceutici SpA, Milan Italy) compared to Cochet-Bonnet (CB) esthesiometer. Secondly, to identify a simple, safe, rapid, and low-cost test to diagnose neurotrophic keratitis (NK). METHODS: 16 patients with diagnosis of NK stage I, 25 patients with diabetes mellitus (DM), and 26 healthy subjects were included in the study...
March 21, 2024: Ocular Surface
Kevin Sheng-Kai Ma, Juien Lo, James Chodosh, Reza Dana
PURPOSE: To determine the risk and incidence of keratitis following treatment with epidermal growth factor receptor inhibitors (EGFRi) and subtypes of EGFRi-associated keratitis. METHODS: This multi-center cohort study included EGFRi-treated patients and non-users with lung cancer between 2010 and 2023. EGFRi included first-generation agent gefitinib and erlotinib, second-generation agent afatinib, and third-generation agent osimertinib. The primary outcome was new-onset keratitis...
March 18, 2024: Ocular Surface
Shinri Sato, Yoko Ogawa, Eisuke Shimizu, Kazuki Asai, Takahiro Okazaki, Robert Rusch, Masatoshi Hirayama, Shigeto Shimmura, Kazuno Negishi, Kazuo Tsubota
PURPOSE: Aging is a well-established risk factor for meibomian gland dysfunction (MGD). We previously reported an accelerated cellular senescence phenomenon in the lacrimal glands of a murine model of chronic graft-versus-host disease (cGVHD). Herein, we aimed to elucidate the relationship between cellular senescence and MGD in cGVHD mice, utilizing the senolytic agent ABT-263. METHODS: A cGVHD mouse model was established through allogeneic bone marrow transplantation (BMT) from B10...
March 16, 2024: Ocular Surface
Agni Malmin, Vilde M Thomseth, Per T Førland, HansC D Aass, Sjur Reppe, Markus V Olsen, Birger Lindtjørn, Xiangjun Chen, IngaB K Haugen, Tor P Utheim, Vegard A Forsaa
PURPOSE: To investigate cytokine levels in the tear fluid of patients receiving serial intravitreal injections (IVI) with anti-vascular endothelial growth factor (anti-VEGF) for neovascular age-related macular degeneration (nAMD). METHODS: Concentrations of six cytokines (IFN-γ, IL-1β, IL-6, IL-8, TNF and VEGF) in tears of patients receiving anti-VEGF in one eye were assayed using multiplex cytometric bead array. The fellow untreated eye served as control...
March 13, 2024: Ocular Surface
Jin-Miao Li, Na Lin, Yun Zhang, Xin Chen, Zhao Liu, Rong Lu, Fang Bian, Haixia Liu, Stephen C Pflugfelder, De-Quan Li
PURPOSE: To explore novel role and molecular mechanism of a natural osmoprotectant ectoine in protecting corneal epithelial cell survival and barrier from hyperosmotic stress. METHODS: Primary human corneal epithelial cells (HCECs) were established from donor limbus. The confluent cultures in isosmolar medium were switched to hyperosmotic media (400-500 mOsM), with or without ectoine or rhIL-37 for different time periods. Cell viability and proliferation were evaluated by MTT or WST assay...
March 13, 2024: Ocular Surface
James S Wolffsohn, Alberto Recchioni, Olivia A Hunt, Sònia Travé Huarte, Giuseppe Giannaccare, Marco Pellegrini, Marc Labetoulle
AIM: To assess whether smaller increment and regionalised subjective grading improves the repeatability of corneal fluorescein staining, and to determine the neurological approach adopted for subjective grading by practitioners. METHODS: Experienced eye-care practitioners (n = 28, aged 45 ± 12 years), graded 20 full corneal staining images of patients with mild to severe Sjögren's syndrome with the Oxford grading scheme (both in 0...
March 13, 2024: Ocular Surface
Jinghua Bu, Yuli Guo, Yang Wu, Rongrong Zhang, Jingbin Zhuang, Jiankai Zhao, Le Sun, Andrew J Quantock, Zuguo Liu, Wei Li
Meibomian gland dysfunction (MGD) is a chronic abnormality of the Meibomian glands (MGs) that is recognized as the leading cause of evaporative dry eye worldwide. Despite its prevalence, however, the pathophysiology of MGD remains elusive, and effective disease management continues to be a challenge. In the past 50 years, different models have been developed to illustrate the pathophysiological nature of MGD and the underlying disease mechanisms. An understanding of these models is crucial if researchers are to select an appropriate model to address specific questions related to MGD and to develop new treatments...
March 13, 2024: Ocular Surface
Srividya Gurumurthy, Bhaskar Srinivasan, Shweta Agarwal, Hiren Matai, Narayanasamy Angayarkanni, Geetha Iyer
PURPOSE: To clinically define a subset of patients with chronic ocular Stevens-Johnson syndrome non-responders (SJS-NR) and analyze their cytokine profile compared to clinical responders (SJS-CR). METHODS: A total of 32 SJS cases (n = 32, 64 eyes) managed over a period of three years were segregated into clinical responders (n = 24, 48 eyes) and non-responders (n = 8, 16 eyes). Cases were determined as non-responders based on persistent, refractory, and non-mechanical inflammation of the conjunctiva...
March 13, 2024: Ocular Surface
Young Chae Yoon, Sun Kyung Park, Yoo-Sun Sung, Ji Young Park, Woong Joo Whang, Kyung Sun Na, Eun Chul Kim, Hyun Seung Kim, Ho Sik Hwang
No abstract text is available yet for this article.
March 12, 2024: Ocular Surface
Minako Kaido, Reiko Arita, Yasue Mitsukura, Kazuo Tsubota
PURPOSE: To evaluate stress levels extracted from prefrontal electroencephalogram (EEG) signals and investigate their relationship with dry eye symptoms. METHODS: This prospective, cross-sectional, comparative study included 25 eyes of 25 patients with aqueous tear-deficient dry eye (low Schirmer group), 25 eyes of 25 patients with short tear breakup time dry eye (short breakup time group), and 24 eyes of 24 individuals without dry eye. An EEG test, the Japanese version of the Ocular Surface Disease Index (OSDI), and a stress questionnaire were administered...
March 6, 2024: Ocular Surface
Sofia De Arrigunaga, Sarah Wall, Despoina Theotoka, Asaf Friehmann, Matthew Camacho, Sander Dubovy, Anat Galor, Carol L Karp
PURPOSE: Chronic inflammation is a predisposing factor for metaplastic changes and ultimately dysplasia. We describe cases of OSSN occurring in the setting of chronic ocular surface inflammation. METHODS: Sixteen eyes from 14 individuals were included from one ocular oncology clinic between 2010 and 2023. Patients presented with ocular surface squamous neoplasia (OSSN) in the setting of chronic inflammation. The diagnosis of OSSN was made using anterior segment high-resolution optical coherence tomography (HR-OCT) and confirmed by histopathological analysis in all cases...
March 1, 2024: Ocular Surface
Lyvia J Zhang, Reza Dana, Alice C Lorch, Tobias Elze, Joan W Miller, Thomas H Dohlman, Isdin Oke
No abstract text is available yet for this article.
February 23, 2024: Ocular Surface
Michael E Stern, Argyrios N Theofilopoulos, Philipp Steven, Jerry Y Niederkorn, Robert Fox, Margarita Calonge, Christof Scheid, Stephen C Pflugfelder
The literature is filled with citations reporting an increased incidence of chronic dry eye disease, also known as keratoconjunctivitis sicca, in patients with systemic autoimmune diseases such as rheumatoid arthritis, Sjögren's Syndrome, systemic sclerosis and lupus. As the most environmentally exposed mucosal surface of the body, the conjunctiva constantly responds to environmental challenges which are typically self limited, but when persistent and unresolved may provoke pathogenic innate and adaptive immune reactions...
February 21, 2024: Ocular Surface
Jakob Bjerager, Morten Magnø, Xiangjun Chen, Mohamed Belmouhand, Hans Christian D Aass, Sjur Reppe, Steffen Heegaard, Michael Larsen, Tor Utheim
PURPOSE: Ocular surface disease is common and it is associated with elevated concentration levels of cytokines in tear fluid. Studies of the normal variation in tear fluid inflammatory markers are lacking. New knowledge may help guide research into ocular surface disease biomarkers and therapeutics. METHODS: In this prospective twin cohort study, healthy individuals were recruited from a population-based registry. Tear fluid was collected with the Schirmer test strips was submerged in phosphate buffered saline and stored at -80° before undergoing 27-cytokine multiplex immunoassay analysis...
February 20, 2024: Ocular Surface
Gary D Novack
No abstract text is available yet for this article.
February 20, 2024: Ocular Surface
Maria Naqvi, Fredrik Fineide, Tor Paaske Utheim, Colin Charnock
PURPOSE: The purpose of this study was to investigate the ocular microbiome in individuals with dry eye disease and to identify features of their ocular microbiome of possible health and diagnostic significance. METHODS: Conjunctival samples were collected from both eyes in duplicate from 91 individuals (61 dry eye, 30 healthy) and used for both culture-dependent and culture-independent analyses. Samples were either analysed using next generation sequencing (V3-V4 16S rDNA) or inoculated on a wide range of agar types and grown under a broad range of conditions to maximize recovery...
February 12, 2024: Ocular Surface
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