journal
https://read.qxmd.com/read/38852782/emerging-role-of-immunotherapy-for-cancer-as-a-major-cause-of-drug-induced-liver-injury
#1
EDITORIAL
Nelia Hernandez, Fernando Bessone, Raul Andrade
No abstract text is available yet for this article.
June 7, 2024: Annals of Hepatology
https://read.qxmd.com/read/38852781/hepatitis-c-virus-ns5a-and-core-protein-induce-fibrosis-related-genes-regulation-on-huh7-cells-through-activation-of-lx2-cells
#2
JOURNAL ARTICLE
Tania G Heredia-Torres, Veronica Alvarado-Martínez, Ana R Rincon-Sanchez, Sonia A Lozano-Sepulveda, Kame Galan-Huerta, Daniel Arellanos-Soto, Ana M Rivas-Estilla
INTRODUCTION AND OBJECTIVES: Liver fibrosis remains a complication derived from a chronic Hepatitis C Virus (HCV) infection even when it is resolved, and no liver antifibrotic drug has been approved. Molecular mechanisms on hepatocytes and activation of hepatic stellate cells (HSCs) play a central role in liver fibrogenesis. To elucidate molecular mechanisms, it is important to analyze pathway regulation during HSC activation and HCV infection. MATERIALS AND METHODS: We evaluate the fibrosis-associated molecular mechanisms during a co-culture of human HSCs (LX2), with human hepatocytes (Huh7) that express HCV NS5A or Core protein...
June 7, 2024: Annals of Hepatology
https://read.qxmd.com/read/38851396/palliative-care-and-end-stage-liver-disease-a-cohort-analysis-of-palliative-care-use-and-factors-associated-with-referral
#3
JOURNAL ARTICLE
Hugo Miguel Oliveira, Helena Pessegueiro Miranda, Francisca Rego, Rui Nunes
INTRODUCTION AND OBJECTIVES: Prevalence and mortality of chronic liver disease have risen significantly. In end stage liver disease, the survival of patients is approximately two years. Despite the poor prognosis and high symptom burden of these patients, integration of palliative care is limited. We aim to assess associated factors and trends in palliative care use in recent years. MATERIALS AND METHODS: A Multicenter retrospective cohort of patients with end stage liver disease who suffered in-hospital mortality between 2017-2019...
June 6, 2024: Annals of Hepatology
https://read.qxmd.com/read/38851395/the-steatosis-associated-fibrosis-estimator-safe-outperformed-the-fib-4-score-in-screening-the-population-for-liver-disease
#4
JOURNAL ARTICLE
Mingkai Li, Ying Lin, Hongsheng Yu, Weichun Lin, Jianning Chen, Yidong Yang, Bin Wu
INTRODUCTION AND OBJECTIVES: Assessing fibrosis risk noninvasively is essential. The steatosis-associated fibrosis estimator (SAFE) score shows promise but needs validation. PATIENTS AND METHODS: This was a three-part study. In part 1, we compared the SAFE score with the Fibrosis-4 (FIB-4) and NAFLD fibrosis score (NFS) in the National Health and Nutrition Examination Survey (NHANES) cohort (2017-2020), using transient elastography (TE) as screening reference. In part 2, we examined patients who underwent liver biopsies at an Asian center between 2018 and 2020 to assess these models in various liver diseases...
June 6, 2024: Annals of Hepatology
https://read.qxmd.com/read/38851394/frailty-and-sarcopenia-in-patients-with-acute-on-chronic-liver-failure-assessment-and-risk-in-the-liver-transplant-setting
#5
REVIEW
Isabel Campos-Varela, Lluis Castells, Sergi Quiroga, Victor Vargas, Macarena Simon-Talero
Frailty and sarcopenia are well-recognized factors related to worse outcomes in patients with cirrhosis, including liver transplant (LT) candidates. Implications of pre-LT functional and muscle deterioration also affect post-LT outcomes. Patients with cirrhosis and acute-on-chronic liver failure (ACLF) have a lower survival rate, both before and after LT. There is a need to better identify those patients with ACLF who would benefit from LT. This review aims to present the available data about frailty and sarcopenia in patients with ACLF in the LT setting...
June 6, 2024: Annals of Hepatology
https://read.qxmd.com/read/38723748/prognostic-significance-of-low-hepatic-fat-content-in-advanced-chronic-liver-disease-mri-pdff-insights
#6
JOURNAL ARTICLE
Atsushi Nakamura, Tsubasa Yoshimura, Takeshi Ichikawa, Keiji Okuyama
INTRODUCTION AND OBJECTIVES: The mechanisms of hepatic fat loss in late-stage metabolic dysfunction-associated fatty liver disease (MASLD) are enigmatic and the prognostic significance of low hepatic fat content (LHF) in chronic liver disease (CLD) is unknown. Proton density fat fraction (PDFF), measured by magnetic resonance imaging (MRI), is considered the most accurate noninvasive method for quantifying hepatic fat content. This study aimed to address these issues by evaluating PDFF...
May 7, 2024: Annals of Hepatology
https://read.qxmd.com/read/38719079/utilizing-a-novel-mri-technique-to-identify-adverse-muscle-composition-in-end-stage-liver-disease-a-pilot-study
#7
JOURNAL ARTICLE
Avesh J Thuluvath, Mikael F Forsgren, Daniela P Ladner, Amit D Tevar, Andres Duarte-Rojo
INTRODUCTION AND OBJECTIVES: Sarcopenia is a common complication of end-stage liver disease (ESLD), but its exact relationship to myosteatosis and frailty remains unclear. In this pilot study, we tested the feasibility of a specialized MRI protocol and automated image analysis in patients with ESLD. MATERIALS AND METHODS: In a single-center prospective study, adult liver transplant candidates with ESLD underwent assessment of muscle composition between 3/2022 and 6/2022 using the AMRA® MAsS Scan...
May 6, 2024: Annals of Hepatology
https://read.qxmd.com/read/38714224/outcomes-and-risk-factors-for-mortality-in-clostridioides-difficile-infection-in-patients-with-nafld-and-nash
#8
JOURNAL ARTICLE
Ankoor H Patel, Gaurav N Pathak, Alexander Chen, Patricia Greenberg, Natale Mazzaferro, Anish Patel, Naveen Mallangada, Carlos D Minacapelli, Kaitlyn Catalano, Hansel Suthar, Vinod K Rustgi
INTRODUCTION AND OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH) and, ultimately, cirrhosis. Clostridioides difficile is the most common nosocomial cause of diarrhea and is associated with worse clinical outcomes in other liver diseases, including cirrhosis, but has not been extensively evaluated in concomitant NAFLD/NASH. METHODS: We conducted a retrospective cohort study using the National Inpatient Sample database from 2015 to 2017...
May 5, 2024: Annals of Hepatology
https://read.qxmd.com/read/38710474/coronary-artery-disease-as-a-risk-factor-for-metabolic-dysfunction-associated-steatotic-liver-disease-and-liver-fibrosis
#9
JOURNAL ARTICLE
Luis Vega, Daniela Simian, Abraham I Gajardo, Marcelo Salinas, Andrea Urra, Máximo Cattaneo, Rosario Pino, Juan P Roblero, Álvaro Urzúa, Katherine Rojas, Jaime Poniachik
INTRODUCTION AND OBJECTIVES: Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) are at an increased cardiovascular risk. On the contrary, non-alcoholic fatty liver disease (NAFLD) is highly prevalent in patients with coronary heart disease (CHD). However, it is not known whether patients with significant CHD show a higher frequency of liver fibrosis. This study aimed to determine the frequency of MASLD and liver fibrosis in patients with CHD and to assess whether coronary stenosis is significantly associated with MASLD and fibrosis...
May 4, 2024: Annals of Hepatology
https://read.qxmd.com/read/38710473/mafld-criteria-are-better-than-masld-criteria-at-predicting-the-risk-of-chronic-kidney-disease
#10
JOURNAL ARTICLE
Ziyan Pan, Moutaz Derbala, Khalid AlNaamani, Hasmik Ghazinian, Jian-Gao Fan, Mohammed Eslam
INTRODUCTION AND OBJECTIVES: Fatty liver disease is a multisystem disease. Metabolic dysfunction-associated fatty liver disease (MAFLD) is a more accurate indicator of chronic kidney disease (CKD) than nonalcoholic fatty liver disease (NAFLD). However, the relationship between recently defined metabolic dysfunction-associated steatotic liver disease (MASLD) and CKD is currently unclear. The objective of this cross-sectional study was to investigate the prevalence of CKD and albuminuria among individuals diagnosed with either MAFLD or MASLD...
May 4, 2024: Annals of Hepatology
https://read.qxmd.com/read/38710472/spending-on-nucleos-t-ide-analogues-for-hepatitis-b-in-medicaid-beneficiaries-2012-2021
#11
Stephen E Congly, Mayur Brahmania, Carla S Coffin
INTRODUCTION AND OBJECTIVES: Treatment of chronic hepatitis B (CHB) with nucelos(t)ide analogues (NA) can improve outcomes, but NA treatment is expensive for insurance plans. MATERIALS AND METHODS: The Centers for Medicare & Medicaid Services database was assessed from 2012 to 2021 to assess the use of NA for CHB in patients on Medicaid. Data extracted included the number of claims, units, and costs of each agent stratified by originator and generic. RESULTS: Over the study period, 1...
May 4, 2024: Annals of Hepatology
https://read.qxmd.com/read/38710471/genome-wide-dna-methylation-and-transcriptomic-analysis-of-liver-tissues-subjected-to-early-ischemia-reperfusion-injury-upon-human-liver-transplantation
#12
JOURNAL ARTICLE
Pablo J Giraudi, Allen A Laraño, Simeone Dal Monego, Riccardo Pravisani, Deborah Bonazza, Gabriel Gondolesi, Claudio Tiribelli, Francisco Baralle, Umberto Baccarani, Danilo Licastro
INTRODUCTION AND OBJECTIVES: Epigenetic changes represent a mechanism connecting external stresses with long-term modifications of gene expression programs. In solid organ transplantation, ischemia-reperfusion injury (IRI) appears to induce epigenomic changes in the graft, although the currently available data are extremely limited. The present study aimed to characterize variations in DNA methylation and their effects on the transcriptome in liver transplantation from brain-dead donors...
May 4, 2024: Annals of Hepatology
https://read.qxmd.com/read/38631419/the-janus-of-a-disease-diabetes-and-metabolic-dysfunction-associated-fatty-liver-disease
#13
JOURNAL ARTICLE
Francisco Barrera, Javier Uribe, Nixa Olvares, Paula Huerta, Daniel Cabrera, Manuel Romero-Gómez
Metabolic Dysfunction-Associated Fatty Liver Disease and Diabetes Mellitus are two prevalent metabolic disorders that often coexist and synergistically contribute to the progression of each other. Several pathophysiological pathways are involved in the association, including insulin resistance, inflammation, and lipotoxicity, providing a foundation for understanding the complex interrelationships between these conditions. The presence of MASLD has a significant impact on diabetes risk and the development of microvascular and macrovascular complications, and diabetes significantly contributes to an increased risk of liver fibrosis progression in MASLD and the development of hepatocellular carcinoma...
April 15, 2024: Annals of Hepatology
https://read.qxmd.com/read/38582247/alcohol-related-liver-disease-a-global-perspective
#14
JOURNAL ARTICLE
Graciela Elia Castro Narro, Luis Antonio Díaz, Eric Kauffman Ortega, María Fernanda Bautista Garín, Eira Cerda Reyes, Pindaro Sebastian Martinez Delfin, Juan Pablo Arab, Ramón Bataller
Alcohol-associated liver disease (ALD) represents one of the deadliest yet preventable consequences of excessive alcohol use. It represents 5.1% of the global burden of disease, mainly involving the productive-age population (15-44 years) and leading to an increased mortality risk from traffic road injuries, suicide, violence, cardiovascular disease, neoplasms, and liver disease, among others, accounting for 5.3% of global deaths. Daily alcohol consumption, binge drinking (BD), and heavy episodic drinking (HED) are the patterns associated with a higher risk of developing ALD...
April 4, 2024: Annals of Hepatology
https://read.qxmd.com/read/38582246/liver-rupture-in-patients-with-amyloidosis-clinical-features-and-treatment
#15
JOURNAL ARTICLE
Xiangyu Du, Liangzhi Wen, Bin Wang, Dongfeng Chen, Wei Wang
No abstract text is available yet for this article.
April 4, 2024: Annals of Hepatology
https://read.qxmd.com/read/38479458/pathophysiology-of-ascites-the-importance-of-the-intestine-a-surgical-contribution-to-the-understanding-of-a-medical-problem
#16
REVIEW
Gabriel E Gondolesi, Carolina Rumbo, Leonardo Montes, Lucia Novellis, Diego Ramisch, Ariel Riquelme Henríquez, Mariana Ortega, Federico Viano, Thomas Schiano, Valeria Descalzi, Claudio Tiribelli, Mihai Oltean, Pablo Barros-Schelotto, Héctor Solar
The understanding of the mechanisms for the development of ascites has evolved over the years, involving the liver, peritoneum, heart, and kidneys as key responsible for its formation. In this article, we review the pathophysiology of ascites formation, introducing the role of the intestine as a major responsible for ascites production through the "a game changer" case.
March 11, 2024: Annals of Hepatology
https://read.qxmd.com/read/38460715/clinical-biochemical-and-histological-features-related-to-treatment-response-and-prognosis-in-autoimmune-hepatitis
#17
JOURNAL ARTICLE
Ludmila Resende Guedes, Guilherme Grossi Lopes Cançado, Bruno Campos Santos, Luma Dos Santos Jacomassi, Mateus Jorge Nardelli, Fernanda Maria Farage Osório, Luciana Costa Faria, Cláudia Alves Couto
INTRODUCTION AND OBJECTIVES: Autoimmune hepatitis (AIH) is a rare disease with a complex and not fully understood pathogenesis. Prognostic factors that might influence treatment response, relapse rates, and transplant-free survival are not well established. This study investigates clinical and biochemical markers associated with response to immunosuppression in patients with AIH. MATERIALS AND METHODS: This retrospective cohort study included 101 patients with AIH treated with immunosuppressants and followed at the Federal University of Minas Gerais, Brazil, from 1990 to 2018...
March 7, 2024: Annals of Hepatology
https://read.qxmd.com/read/38460714/neurofilament-light-chain-but-not-glial-fibrillary-acidic-protein-is-a-potential-biomarker-of-overt-hepatic-encephalopathy-in-patients-with-cirrhosis
#18
JOURNAL ARTICLE
Koos de Wit, Diederick J van Doorn, Bregje Mol, Lonneke A van Vught, Frederik Nevens, Ulrich Beuers, Cyriel Y Ponsioen, Charlotte E Teunissen, R Bart Takkenberg
INTRODUCTION AND OBJECTIVES: Hepatic encephalopathy (HE) is a frequent complication of cirrhosis and may cause cerebral damage. Neurodegenerative diseases can induce the release of neuroproteins like neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in body fluids, including blood plasma. We investigated whether NfL and GFAP could serve as potential diagnostic plasma biomarkers for overt HE (oHE). MATERIALS AND METHODS: We included 85 patients from three prospective cohorts with different stages of liver disease and HE severity...
March 7, 2024: Annals of Hepatology
https://read.qxmd.com/read/38460713/efficacy-and-safety-of-terlipressin-and-albumin-vs-noradrenaline-and-albumin-in-adult-patients-with-hepatorenal-syndrome-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Adnan Malik, Muhammad Imran Malik, Shahbaz Qureshi, Abdul Nadir
INTRODUCTION AND OBJECTIVES: Hepatorenal syndrome (HRS) is a serious complication of cirrhosis treated with several medications. We want to evaluate terlipressin and albumin's effectiveness and safety compared to albumin and noradrenaline in adult hepatorenal disease patients. MATERIALS AND METHODS: Clinical trials from four databases were included. Cochrane's approach for calculating bias risk was utilized. We rated the quality evaluation by Grading of Recommendations Assessment, Development, and Evaluation (GRADE)...
March 7, 2024: Annals of Hepatology
https://read.qxmd.com/read/38417629/outcomes-of-liver-transplantation-for-hepatocellular-carcinoma-in-donation-after-circulatory-death-compared-with-donation-after-brain-death-a-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Abdulahad Abdulrab Mohammed Al-Ameri, Shusen Zheng
INTRODUCTION AND OBJECTIVES: Due to organ shortages, liver transplantation (LT) using donation-after-circulatory-death (DCD) grafts has become more common. There is limited and conflicting evidence on LT outcomes using DCD grafts compared to those using donation-after-brain death (DBD) grafts for patients with hepatocellular carcinoma (HCC). We aimed to summarize the current evidence on the outcomes of DCD-LT and DBD-LT in patients with HCC. MATERIALS AND METHODS: Online databases were searched for studies comparing DCD-LT and DBD-LT outcomes in patients with HCC and a meta-analysis was conducted using fixed- or random-effects models...
February 27, 2024: Annals of Hepatology
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