Hye Young Kim, Ki Wook Yun, Hee Jin Cheong, Eun Hwa Choi, Hoan Jong Lee
INTRODUCTION: Respiratory syncytial virus (RSV) infection is one of the most common causes of acute respiratory tract infections in young children and the elderly. Infants and young children aged <2 years and the elderly are at particular risk of severe infections requiring hospitalization. AREAS COVERED: This narrative review summarizes the epidemiology of RSV infection in Korea, with a particular focus on infants and the elderly, where possible, and highlights the need for effective vaccinations against RSV...
March 24, 2023: Expert Review of Vaccines
Shuang Li, Meng-Yue Zhang, Jie Yuan, Yi-Xuan Zhang
INTRODUCTION: Over the last four decades, human immunodeficiency virus type 1 (HIV-1) infection has been a major public health concern. It is acknowledged that an effective vaccine remains the best hope for eliminating the HIV-1 pandemic. The prophylaxis of HIV-1 infection remains a central theme because of the absence of an available HIV-1 vaccine. The incapability of conventional delivery strategies to induce potent immunity is a crucial task to overcome and ultimately lead to a major obstacle in HIV-1 vaccine research...
March 21, 2023: Expert Review of Vaccines
Thuan Tong Tan, Heng Joo Ng, Barnaby Young, Behram Ali Khan, Vikram Shetty, Nura Azmi, Steve Clissold
INTRODUCTION: Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including administration of booster doses, continues to be the most effective method for controlling COVID-19-related complications including progression to severe illness and death.However, there is mounting evidence that more needs to be done to protect individuals with compromised immune function. AREAS COVERED: Here, we review the effectiveness of COVID-19 vaccination in immunocompromised patients, including those with primary immunodeficiencies, HIV, cancer (including hematological malignancies), solid organ transplant recipients and chronic kidney disease, as reported in systematic reviews/meta-analyses published over a 12-month period in PubMed...
March 15, 2023: Expert Review of Vaccines
Nikki Petrakis, Mel Addison, Bianca Penak, Silja Schrader, John Mallard, Hazel J Clothier, Jim P Buttery, Nigel W Crawford, Daryl R Cheng
BACKGROUND: : Shoulder Injury Related to Vaccine Administration (SIRVA) is a preventable adverse event following incorrect vaccine administration, which can result in significant long-term morbidity. There has been a notable surge in reported cases of SIRVA as a rapid national population-based COVID-19 immunization program has been rolled out across Australia. METHODS: : Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC) in Victoria, identified 221 suspected cases of SIRVA following the commencement of the COVID-19 vaccination program, reported between February 2021 and February 2022...
March 9, 2023: Expert Review of Vaccines
Haruka Maeda, Nobuo Saito, Ataru Igarashi, Masayuki Ishida, Mayumi Terada, Takayasu Ito, Hideko Ikeda, Hiroshi Kamura, Iori Motohashi, Yuya Kimura, Masaru Komino, Hiromi Arai, Osamu Kuwamitsu, Nobuhiro Akuzawa, Eiichiro Sando, Toru Morikawa, Haruki Imura, Hiroki Inoue, Tomoichiro Hayakawa, Osamu Teshigahara, Yasuji Ohara, Motoi Suzuki, Konosuke Morimoto
BACKGROUND: Evaluating COVID-19 vaccine effectiveness (VE) domestically is crucial for assessing and determining national vaccination policy. This study aimed to evaluate VE of mRNA COVID-19 vaccines in Japan. METHODS: We conducted a multicenter test-negative case-control study. The study population comprised individuals aged <mml:math xmlns:mml=""><mml:mo>≥</mml:mo></mml:math>16 visiting medical facilities with COVID-19-related signs or symptoms from January 1 to June 26, 2022, when Omicron BA...
March 8, 2023: Expert Review of Vaccines
Hitt J Sharma, Sameer Parekh, Pramod Pujari, Sunil Shewale, Shivani Desai, Anand Kawade, Mandyam Ravi, Jitendra Oswal, Saji James, N Mahantashetti, Renuka Munshi, Apurba Ghosh, Venkateshwar Rao, Sundaram Balsubramaniam, P Varughese, A Somshekhar, Amy Sarah Ginsburg, Harish Rao, Manish Gautam, Sunil Gairola, Umesh Shaligram
BACKGROUND: This study assessed safety and immunogenicity of Serum Institute of India Pvt Ltd (SIIPL)'s tetanus toxoid (TT), diphtheria toxoid (DT), and acellular pertussis booster vaccine (Tdap). RESEARCH DESIGN AND METHODS: In this Phase II/III, multicenter, randomized, active-controlled, open-label study, 1500 healthy individuals, aged 4 - 65 years, were randomized to receive a single dose of SIIPL Tdap or comparator Tdap vaccine (Boostrix®; GlaxoSmithKlines, India)...
March 8, 2023: Expert Review of Vaccines
Paolo Lusso
No abstract text is available yet for this article.
February 24, 2023: Expert Review of Vaccines
Paula Mc Kenna, Lindsay A Broadfield, Annik Willems, Serge Masyn, Theresa Pattery, Ruxandra Draghia-Akli
INTRODUCTION: Large-scale vaccination campaigns can benefit from using digital health tools, particularly in low- and middle-income countries (LMICs). Tools vary in technical specifications, functionalities, and cost of implementation. Selecting the best tool to fit into a pre-existing digital landscape can be challenging. AREAS COVERED: We conducted a narrative review in PubMed and the grey literature for data available within five years to provide an overview of digital health tools used in large-scale vaccination campaigns for outbreak response in LMICs...
February 22, 2023: Expert Review of Vaccines
Peter W Marks
No abstract text is available yet for this article.
February 20, 2023: Expert Review of Vaccines
E Adrianne Hammershaimb, Milagritos D Tapia
No abstract text is available yet for this article.
February 19, 2023: Expert Review of Vaccines
Tia Aoun, Ray Borrow, Peter D Arkwright
INTRODUCTION: : Despite children aged 6-35 months developing more severe influenza infections, not all countries include influenza vaccines in their national immunization programs. AREAS COVERED: : This literature review examines the efficacy, immunogenicity, and safety of seasonal trivalent influenza vaccines (TIVs) and quadrivalent influenzae vaccines (QIVs) in children 6-35 months old to determine if greater valency promotes greater protection while maintaining a similar safety profile...
February 19, 2023: Expert Review of Vaccines
Xuanxuan Zhang, Xing Wu, Qian He, Junzhi Wang, Qunying Mao, Zhenglun Liang, Miao Xu
INTRODUCTION: : Potency is a critical quality attribute for controlling quality consistency and relevant biological properties of vaccines. Owing to the high demand for animals, lengthy operations and high variability of in vivo methods, in vitro alternatives for human vaccine potency assays are extensively developed. AREAS COVERED: : Herein, in vivo and in vitro methods for potency assays of previously licensed human vaccines were sorted, followed by a brief description of the background for substituting in vivo methods with in vitro alternatives...
February 13, 2023: Expert Review of Vaccines
Chih-Ming Tsai, J R Caldera, Irshad A Hajam, George Y Liu
No abstract text is available yet for this article.
February 10, 2023: Expert Review of Vaccines
Yuanze Du, Yi Wang, Ting Zhang, Juanjuan Li, Hewei Song, Yuanyuan Wang, Yifei Xu, Jingwen Cui, Ming Yang, Zengwu Wang, Xiuyun Wu, Chunping Wang
INTRODUCTION: Studies on economic evaluations of the 13-valent pneumococcal conjugate vaccine (PCV13) have been increasing over the last decade. No systematic reviews have synthesized the evidence of economic evaluations of the PCV13. AREAS COVERED: We systematically searched the literature which published on peer-reviewed journals from January 2010 to June 2022. The literature search was conducted in the following electronic databases: PubMed, Web of Science, Embase, the Cochrane Library, CNKI, Wanfang database, VIP database...
January 31, 2023: Expert Review of Vaccines
Huijie Yang, Ying Xie, Changgui Li
INTRODUCTION: : Multiple COVID-19 vaccines have been approved and employed in the fight against the pandemic. However, these vaccines have limited long-term effectiveness against severe cases and a decreased ability to prevent mild disease. AREAS COVERED: : This review discusses the relevant factors influencing the efficacy of the vaccines against mild and severe infection, analyzes the possible underlying mechanisms contributing to the different outcomes in terms of vaccine function and disease progression, and proposes improvements for the next generation of vaccines...
January 30, 2023: Expert Review of Vaccines
Sanjay Singhal, Ghanshyam Sethy, Mike Nenani Chisema, Lokesh Sharma, Krupal Joshi, Patrick Omar Nicks, Beverly Laher, Kondwani Chidzammbuyo Mamba, Kunal Deokar, Tedla Damte, John Phuka
OBJECTIVES: To boost COVID-19 vaccine uptake, an innovative 'vaccinate my village' (VMV) strategy using door-to-door vaccination by Health Surveillance Assistants (HSA) was adopted. In this study, we assessed the impact of the 'vaccinate my village' strategy on COVID-19 vaccine uptake. METHODS: This was a cross-sectional review of the data on COVID-19 vaccination obtained from the Ministry of Health, Malawi, from 11 March 2021 to September 2022. RESULTS: From March 2021-September 2022, 4,091,551 COVID-19 vaccine doses were administered, out of which 2,253,546 were administered over just six months as a part of VMV as compared to 1,838,005 doses were administered over thirteen months as a part of other strategies...
January 23, 2023: Expert Review of Vaccines
Siwei Deng, Zhike Liu, Junting Yang, Liang Zhang, Tiejun Shou, Jianming Zhu, Yan He, Rui Ma, Ning Li, Guozhang Xu, Siyan Zhan
BACKGROUND: Monitoring the risk of intussusception after the introduction of rotavirus vaccines is recommended by the World Health Organization (WHO). Although the validity of intussusception monitoring using electronic health records (EHRs) has been confirmed previously, no similar studies have been conducted in China. We aimed to verify the diagnosis and determine an algorithm with the best performance for identification of intussusception using Chinese EHR databases. RESEARCH DESIGN AND METHODS: Using the Regional Health Information Platform in Ningbo, patients aged 0-72 months from 2015 to 2021 with any related visits for intussusception were included...
2023: Expert Review of Vaccines
Béatrice Laupèze, T Mark Doherty
INTRODUCTION: Conventionally, vaccines are thought to induce a specific immune response directed against a target pathogen. Long recognized but poorly understood nonspecific benefits of vaccination, such as reduced susceptibility to unrelated diseases or cancer, are now being investigated and may be due in part to "trained immunity'. AREAS COVERED: We discuss 'trained immunity' and whether vaccine-induced 'trained immunity' could be leveraged to prevent morbidity due to a broader range of causes...
2023: Expert Review of Vaccines
Jaime E Ordóñez, Angélica Ordóñez
BACKGROUND: Pneumococcal diseases have a clinical and economic impact on the population. Until this year, a 10-valent pneumococcal vaccine (PCV10) used to be applied in Colombia, which does not contain serotypes 19A, 3, and 6A, the most prevalent in the country. Therefore, we aimed to assess the cost-effectiveness of the shift to the 13-valent pneumococcal vaccine (PCV13). RESEARCH DESIGN AND METHODS: A decision model was used for newborns in Colombia between 2022-2025 and adults over 65 years...
2023: Expert Review of Vaccines
Andrew Dakin, Ray Borrow, Peter D Arkwright
INTRODUCTION: Hexaxim is a hexavalent vaccine approved as primary and booster vaccination in infants 6 weeks and older, protecting against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B and Haemophilus influenzae type b. AREAS COVERED: To evaluate the immunogenicity and reactogenicity (safety) of Hexaxim (Hexyon, Hexacima) in primary and booster vaccine schedules; long-term antibody persistence; concomitant use with other childhood vaccines and use in immunocompromised infants...
2023: Expert Review of Vaccines
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