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Cancer Research and Treatment: Official Journal of Korean Cancer Association

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https://read.qxmd.com/read/30999719/validation-of-the-8th-ajcc-cancer-staging-system-for-pancreas-neuroendocrine-tumors-using-korean-nationwide-surgery-database
#1
Yunghun You, Jin-Young Jang, Song Cheol Kim, Yoo-Seok Yoon, Joon Seong Park, Chol Kyoon Cho, Sang-Jae Park, Jae Do Yang, Woo Jung Lee, Tae Ho Hong, Keun Soo Ahn, Chi-Young Jeong, Hyeon Kook Lee, Seung Eun Lee, Young Hoon Roh, Hee Joon Kim, Hongbeom Kim, In Woong Han
Purpose: The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic neuroendocrine tumor (PNET) included several significant changes. We aim to evaluate this staging system compared to the 7th edition AJCC staging system and European Neuroendocrine Tumors Society (ENETS) system. Materials and Methods: We used Korean nationwide surgery database (2000-2014). Of 972 patients who had undergone surgery for PNET, excluding patients diagnosed with ENETS/World Health Organization 2010 grade 3 (G3), only 472 patients with accurate stage were included...
April 19, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30999720/feasibility-study-of-physician-orders-for-life-sustaining-treatment-for-patients-with-terminal-cancer
#2
Ho Jung An, Hyun Jeong Jeon, Sang Hoon Chun, Hyun Ae Jung, Hee Kyung Ahn, Kyung Hee Lee, Min-Ho Kim, Ju Hee Kim, Jaekyung Cheon, JinShil Kim, Su-Jin Koh
Purpose: Physician Orders for Life-Sustaining Treatment (POLST) form is a legal document for terminally ill patients to make medical decisions with physicians near the end-of-life. A multicenter prospective study was conducted to evaluate the feasibility of POLST administration in actual oncological practice. Materials and Methods: Patients with terminal cancer, age ≥20, and capable of communicating were eligible. The primary endpoint was the completion rate of POLST...
April 18, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30999721/temsirolimus-in-asian-metastatic-recurrent-non-clear-cell-renal-carcinoma
#3
Jii Bum Lee, Hyung Soon Park, Sejung Park, Hyo Jin Lee, Kyung A Kwon, Young Jin Choi, Yu Jung Kim, Chung Mo Nam, Nam Hoon Cho, Beodeul Kang, Hyun Cheol Chung, Sun Young Rha
Purpose: Temsirolimus is effective in the treatment for metastatic non-clear cell renal cell carcinoma (nccRCC) with poor prognosis. We aim to investigate the efficacy and tolerability of temsirolimus in treatment of naïve Asian patients with metastatic/recurrent nccRCC. Materials and Methods: From January 2008 to July 2017, data of treatment-naïve, metastatic/recurrent nccRCC patients, who were treated with temsirolimus according to the standard protocol, were collected...
April 16, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30999723/prognostic-value-of-post-diagnosis-health-related-quality-of-life-for-overall-survival-in-breast-cancer-findings-from-a-10-year-prospective-cohort-in-korea
#4
Tran Thi Xuan Mai, Jin Hyuk Choi, Myung Kyung Lee, Yoon Jung Chang, So-Youn Jung, Hyunsoon Cho, Eun Sook Lee
Purpose: We aimed to evaluate health-related quality of life (HRQOL) at 1-year post-diagnosis in breast cancer (BC) patients and its association with overall survival using data from the National Cancer Center Hospital. Materials and Methods: Data of a BC cohort were first obtained between 2004 and 2006 and followed up until July 2018. HRQOL was assessed using EORTC QLQ-C30 and BC specific module QLQ-BR23 few days after diagnosis and 1 year after that. We examined and compared the difference in the two HRQOL scores measured for each patient by the patient's current survival status...
April 12, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30999722/validity-and-reliability-of-korean-version-of-simplified-nutritional-appetite-questionnaire-in-patients-with-advanced-cancer-a-multicenter-longitudinal-study
#5
So Yeon Oh, Su-Jin Koh, Ji Yeon Baek, Kyung A Kwon, Hei-Cheul Jeung, Kyung Hee Lee, Young-Woong Won, Hyun Jung Lee
Purpose: Malnutrition and a loss of muscle mass are frequent in cancer patients and have a negative effect on clinical outcome. Nutrition risk screening aims to increase awareness and allow early recognition and treatment of cancer cachexia. Therefore, screenings should be brief, inexpensive, highly sensitive, and have good specificity. Simplified Nutritional Appetite Questionnaire (SNAQ) is a simple screening tool including 4 questions, and validated to predict weight loss within 6 months in community-dwelling adults and nursing home residents...
April 12, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30971065/treatment-outcome-after-fractionated-conformal-radiotherapy-for-hepatocellular-carcinoma-in-patients-with-child-pugh-classification-b-in-korea-krog-16-05
#6
Sun Hyun Bae, Hee Chul Park, Won Sup Yoon, Sang Min Yoon, In-Hye Jung, Ik Jae Lee, Jun Won Kim, Jinsil Seong, Tae Hyun Kim, Taek-Keun Nam, Youngmin Choi, Sun Young Lee, Hong Seok Jang, Dong Soo Lee, Jin Hee Kim
Purpose: There is limited data on radiotherapy (RT) for hepatocellular carcinoma (HCC) in patients with Child-Pugh classification B (CP-B). This study aimed to evaluate the treatment outcomes of fractionated conformal RT in HCC patients with CP-B. Materials and Methods: We retrospectively reviewed the data of HCC patients with CP-B treated with RT between 2009 and 2014 at 13 institutions in Korea. HCC was diagnosed by the Korea guideline of 2009, and modern RT techniques were applied...
April 10, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30971067/characteristics-prognostic-factors-and-survival-of-patients-with-nk-t-cell-lymphoma-of-non-upper-aerodigestive-tract-a-17-year-single-center-experience
#7
Ze-Long Liu, Xi-Wen Bi, Xue-Wen Zhang, De-Xin Lei, Pan-Pan Liu, Hang Yang, Yan Gao, Yuan-Xue Jiang, Wen-Qi Jiang, Yi Xia
Purpose: The extranodal natural killer (NK)/T-cell lymphoma (NKTCL) of non-upper aerodigestive tract (NUAT) was found to have clinical heterogeneity compared with NKTCL of the upper aerodigestive tract (UAT) in small scale studies. We conducted this study in a much larger cohort to analyze the clinical characteristics, prognostic factors, treatment modality, and clinical outcomes of patients with NUAT-NKTCL. Materials and Methods: From January 2001 to December 2017, a total of 757 NKTCL patients were identified and included in this study, including 92 NUAT-NKTCL patients (12...
April 1, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30971066/inter-observer-reproducibility-in-the-pathologic-diagnosis-of-gastric-intraepithelial-neoplasia-and-early-carcinoma-in-endoscopic-submucosal-dissection-specimens-a-multi-center-study
#8
Joon Mee Kim, Jin Hee Sohn, Mee-Yon Cho, Woo Ho Kim, Hee Kyung Chang, Eun Sun Jung, Myeong-Cherl Kook, So-Young Jin, Yang Seok Chae, Young Soo Park, Mi Seon Kang, Hyunki Kim, Jae Hyuk Lee, Do Youn Park, Kyoung Mee Kim, Hoguen Kim, Young Ju Suh, Sang Yong Seol, Hwoon-Yong Jung, Deuck-Hwa Kim, Na Rae Lee, Seung-Hee Park, Ji Hye You
Purpose: The diagnostic criteria of gastric intraepithelial neoplasia (IEN) are controversial across the world. We investigated how many discrepancies occur in the pathologic diagnosis of IEN and early gastric carcinoma in endoscopic submucosal dissection (ESD) specimens, and evaluated the reasons of the discordance. Materials and Methods: We retrospectively reviewed 1,202 ESD specimens that were originally diagnosed as gastric IEN and early carcinoma at 12 institutions...
April 1, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913859/bevacizumab-plus-erlotinib-combination-therapy-for-advanced-hereditary-leiomyomatosis-and-renal-cell-carcinoma-associated-renal-cell-carcinoma-a-multicenter-retrospective-analysis-in-korean-patients
#9
Yeonjoo Choi, Bhumsuk Keam, Miso Kim, Shinkyo Yoon, Dalyong Kim, Jong Gwon Choi, Ja Young Seo, Inkeun Park, Jae Lyun Lee
Purpose: Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a rare genetic syndrome resulting from germline mutations in fumarate hydratase. The combination of bevacizumab plus erlotinib showed promising interim results for HLRCC-associated RCC. Based on these results, we analyzed the outcome of bevacizumab plus erlotinib in Korean patients with HLRCC-associated RCC. Materials and Methods: We retrospectively reviewed the efficacy and safety of bevacizumab plus erlotinib in patients with HLRCC-associated RCC who were confirmed to have germline mutations in fumarate hydratase...
March 25, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913858/clinical-significance-of-pleural-attachment-and-indentation-of-subsolid-nodule-lung-cancer
#10
Hyung-Jun Kim, Jun Yeun Cho, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jin-Haeng Chung, Sukki Cho, Kwhanmien Kim, Kyung Won Lee, Jae Ho Lee, Choon-Taek Lee
Purpose: Lung cancers presenting as subsolid nodule commonly have peripheral location, making the cancer-pleura relationship noteworthy. We aimed to evaluate the effect of pleural attachment and/or indentation on visceral pleural invasion (VPI) and recurrence-free survival. Materials and Methods: Patients who underwent curative resection of lung cancer as subsolid nodules from April 2007 to January 2016 were retrospectively evaluated. They were divided into four groups according to their relationship with the pleura...
March 25, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913860/diffuse-large-b-cell-lymphoma-arising-within-ileal-neobladder-an-expanding-spectrum-of-diffuse-large-b-cell-lymphoma-associated-with-chronic-inflammation
#11
Hyekyung Lee, Hyunbin Shin, Nae Yu Kim, Hyun Sik Park, Jinsung Park
Diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI), specifically arising in ileal neobladder, is a rare neoplasm. We present an unusual case of Epstein-Barr virus (EBV)-positive DLBCL-CI arising within neobladder with detailed clinical, histological, and immunophenotypical features in an immunocompetent patient. An 88-year-old male was admitted for gross hematuria. He had undergone radical cystectomy and ileal neobladder 17 years ago for invasive bladder cancer. Computed tomography showed enhancing lesions on dome and posterior wall of neobladder with mucosal thickening and multiple enlarged retroperitoneal lymphadenopathies...
March 22, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913861/television-viewing-time-and-breast-cancer-incidence-for-japanese-premenopausal-and-postmenopausal-women-the-jacc-study
#12
Jinhong Cao, Ehab Salah Eshak, Keyang Liu, Isao Muraki, Renzhe Cui, Hiroyasu Iso, Akiko Tamakoshi
Purpose: The evidence on effects of TV viewing time among premenopausal and postmenopausal women for breast cancer risk remains controversial and limited. Materials and Methods: A prospective study encompassing 33,276 (17,568 premenopausal, and 15,708 postmenopausal) women aged 40-79 years in whom TV viewing time, menstrual and reproductive histories were determined by a self-administered questionnaire. The follow-up was from 1988 to 2009 and hazard ratios (HRs) with 95% confidence intervals (CIs) of breast cancer incidence were calculated for longer TV viewing time in reference to shorter TV viewing time by Cox proportional hazard models...
March 21, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913862/loss-of-lkb1-protein-expression-correlates-with-increased-risk-of-recurrence-and-death-in-patients-with-resected-stage-ii-or-iii-colon-cancer
#13
Maria Sfakianaki, Chara Papadaki, Maria Tzardi, Maria Trypaki, Sardar Alam, Eleni D Lagoudaki, Ippokratis Messaritakis, Odysseas Zoras, Dimitris Mavroudis, Vassilis Georgoulias, John Souglakos
Purpose: The purpose of this study was to investigate the prognostic significance of liver kinase b1 (LKB1) loss in patients with operable colon cancer (CC). Materials and Methods: Two hundred sixty-two specimens from consecutive patients with stage III or high-risk stage II CC, who underwent surgical resection with curative intent and received adjuvant chemotherapy with fluoropyrimidine and oxaliplatin, were analyzed for LKB1 protein expression loss, by immunohistochemistry as well as for KRAS exon 2 and BRAFV600E mutations by Sanger sequencing and TS, ERCC1, MYC, and NEDD9 mRNA expression by real-time quantitative reverse transcription PCR...
March 20, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913865/cancer-statistics-in-korea-incidence-mortality-survival-and-prevalence-in-2016
#14
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee
Purpose: This study presents the 2016 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality. Materials and Methods: Cancer incidence data from 1999 to 2016 were obtained from the Korea National Cancer Incidence Database and followed until December 31, 2017. Mortality data from 1983 to 2016 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2017 among all cancer patients diagnosed since 1999...
March 18, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913864/prediction-of-cancer-incidence-and-mortality-in-korea-2019
#15
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee
Purpose: This study aimed to report on cancer incidence and mortality for the year 2019 to estimate Korea's current cancer burden. Materials and Methods: Cancer incidence data from 1999 to 2016 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2017 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years, then multiplying the projected age-specific rates by the age-specific population...
March 18, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913863/in-memoriam-waun-ki-hong-m-d-august-13-1942-january-2-2019
#16
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913867/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-re-biopsy-in-previously-treated-lung-cancer
#17
Joohae Kim, Hyo Jae Kang, Sung Ho Moon, Jong Mog Lee, Hyae Young Kim, Geon-Kook Lee, Jin Soo Lee, Bin Hwangbo
Purpose: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used for the diagnosis and staging of lung cancer. However, evidence of its usefulness for re-biopsy in treated lung cancer, especially according to the previous treatment, is limited. We evaluated the role of EBUS-TBNA for re-biopsy and its diagnostic values in patients with different treatment histories. Materials and Methods: We reviewed the medical records of patients who underwent EBUS-TBNA for re-biopsy of suspicious recurrent or progressive lesions between January 2006 and December 2016 at the National Cancer Center in South Korea...
March 15, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913866/impact-of-regional-nodal-irradiation-for-breast-cancer-patients-with-supraclavicular-and-or-internal-mammary-lymph-node-involvement-a-multicenter-retrospective-study-krog-16-14
#18
Kyubo Kim, Yuri Jeong, Kyung Hwan Shin, Jin Ho Kim, Seung Do Ahn, Su Ssan Kim, Chang-Ok Suh, Yong Bae Kim, Doo Ho Choi, Won Park, Jihye Cha, Mison Chun, Dong Soo Lee, Sun Young Lee, Jin Hee Kim, Hae Jin Park, Wonguen Jung
Purpose: The purpose of this study was to evaluate the treatment outcomes of radiotherapy (RT) for breast cancer with ipsilateral supraclavicular (SCL) and/or internal mammary (IMN) lymph node involvement. Materials and Methods: A total of 353 patients from 11 institutions were included. One hundred and thirty-six patients had SCL involvement, 148 had IMN involvement, and 69 had both. All patients received neoadjuvant systemic therapy followed by breast conserving surgery or mastectomy, and postoperative RT to whole breast/chest wall...
March 15, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913868/prognostic-value-of-baseline-and-interim-total-metabolic-tumour-volume-and-total-lesion-glycolysis-measured-on-18f-fdg-pet-ct-in-patients-with-follicular-lymphoma
#19
Jin-Hua Liang, Yun-Ping Zhang, Jun Xia, Chong-Yang Ding, Wei Wu, Li Wang, Lei Cao, Hua-Yuan Zhu, Lei Fan, Tian-Nv Li, Jian-Yong Li, Wei Xu
Purpose: The purpose of this study was to investigate the prognostic significance of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) in patients with follicular lymphoma (FL) at baseline and mid-treatment with 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scans. Methods: The study analyzed data from 48 patients with FL who were treated in Jiangsu Province Hospital and reviewed their baseline PET-CT scans. TMTV and TLG were computed by using the absolute value of 2...
March 12, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30913869/novel-prognostic-nomograms-based-on-inflammation-related-markers-for-patients-with-hepatocellular-carcinoma-underwent-hepatectomy
#20
Yifei Wang, Kaiyu Sun, Jingxian Shen, Bin Li, Ming Kuang, Qinghua Cao, Sui Peng
Purpose: Hepatocellular carcinoma (HCC) is an aggressive disease with high recurrence rate. However, current staging systems were lack of predictive capacity for HCC recurrence. We aimed to develop prognostic nomograms based on inflammation-related markers for HCC patients underwent hepatectomy. Materials and Methods: We recruited 889 surgically treated patients from two medical centres. Independent prognostic factors were identified by cox regression analyses. Nomograms for recurrence-free survival (RFS) and overall survival (OS) were established, and validated internally and externally...
March 11, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
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