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Journals Birth Defects Research. Part B...

Birth Defects Research. Part B, Developmental and Reproductive Toxicology

https://read.qxmd.com/read/26663788/advanced-paternal-age-and-risk-of-musculoskeletal-congenital-anomalies-in-offspring
#21
JOURNAL ARTICLE
Stine Kjaer Urhoj, Laust Hvas Mortensen, Anne-Marie Nybo Andersen
OBJECTIVE: Previous research suggests that advanced paternal age increases the risk of musculoskeletal congenital anomalies (CAs) in offspring, but findings are inconsistent. This study aims to investigate the risk of musculoskeletal CAs according to paternal age at birth in an unselected population covering cohort of children. STUDY DESIGN: A register-based prospective study of 1,605,885 children born in Denmark, 1978-2004, using information from record-linked health and administrative registers...
December 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26663754/visualizing-compound-distribution-during-zebrafish-embryo-development-the-effects-of-lipophilicity-and-dmso
#22
JOURNAL ARTICLE
Coco de Koning, Manon Beekhuijzen, Marysia Tobor-Kapłon, Selinda de Vries-Buitenweg, Dick Schoutsen, Nico Leeijen, Beppy van de Waart, Harry Emmen
The predictability of the zebrafish embryo model is highly influenced by internal exposure of the embryo/larva. As compound uptake is likely to be influenced by factors such as lipophilicity, solvent use, and chorion presence, this article focuses on investigating their effects on compound distribution within the zebrafish embryo. To visualize compound uptake and distribution, zebrafish embryos were exposed for 96 hr, starting at 4 hr postfertilization, to water-soluble dyes: Schiff's reagent (logP -4.63), Giemsa stain (logP -0...
December 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26626128/early-vaginal-opening-in-juvenile-female-rats-given-braf-inhibitor-dabrafenib-is-not-associated-with-early-physiologic-sexual-maturation
#23
JOURNAL ARTICLE
Lorraine M Posobiec, Justin D Vidal, Angela Hughes-Earle, Susan B Laffan, Timothy Hart
Dabrafenib (DAB), an inhibitor of BRAF kinase activity, is approved for metastatic melanoma with a BRAF V600E mutation. In support of pediatric cancer development, a nonclinical juvenile rat toxicity study was conducted in which females had early vaginal opening (VO). It was hypothesized that the early VO was not indicative of sexual maturation, but a result of a local effect on the vagina. An investigative study was conducted that mimicked the definitive study design, with rats given DAB or vehicle orally from Postnatal Day (PND) 7 to 35 and with necropsy subsets just before VO, at the first and second estrus, along with age-matched controls...
December 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26551443/exposure-duration-dependent-ovarian-recovery-in-methoxychlor-treated-mice
#24
JOURNAL ARTICLE
Lawrence V Tannenbaum, Jodi A Flaws
The pesticide methoxychlor (MXC) is known to target ovarian antral follicles in the mouse. In previous in vivo studies, MXC administration for 20 days increased atresia, but did not affect female fertility immediately after dosing. Thus, we hypothesized that perhaps not enough time had elapsed between the onset of MXC-induced atresia and actual follicle loss to result in reduced fertility. The current study was undertaken to determine whether MXC treatment for 20 days results in reduced antral follicle numbers and fertility at 30 and 60 days after dosing...
December 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26431353/effects-of-maternal-exposure-to-piperonyl-butoxide-pbo-on-behavioral-development-in-f1-generation-mice
#25
JOURNAL ARTICLE
Toyohito Tanaka, Akiko Inomata
Female mice were exposed maternally to piperonyl butoxide (PBO) through diet to provide dietary levels of 0% (control), 0.01%, 0.03%, and 0.09% during gestation and lactation periods, and selected reproductive and neurobehavioral parameters were measured in the F1 generation. There was no adverse effect of PBO on litter size, litter weight, or sex ratio at birth. The average body weights of male offspring decreased significantly in dose-related manners on postnatal days (PNDs) 0, 4, 7, and 14 (p = 0.0019, 0...
December 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26439775/effect-of-age-duration-of-exposure-and-dose-of-atrazine-on-sexual-maturation-and-the-luteinizing-hormone-surge-in-the-female-sprague-dawley-rat
#26
JOURNAL ARTICLE
Charles B Breckenridge, Pragati Sawhney Coder, Merrill O Tisdel, James W Simpkins, Kun Don Yi, Chad D Foradori, Robert J Handa
Atrazine (ATZ) was administered daily by gavage to pregnant female Sprague Dawley rats at doses of 0, 6.25, 25 or 50 mg/kg/day, either during gestation, lactation and post-weaning (G/L/PW cohort) to F1 generation female offspring or only from postnatal day (PND 21) until five days after sexual maturation (vaginal opening) when the estrogen-primed, luteinizing hormone (LH) surge was evaluated (PW cohort). Additional subgroups of F1 females received the vehicle or ATZ from PND 21-133 or from PND 120-133. Slight reductions in fertility and the percentage of F1 generation pups surviving to PND 21 in the gestationally exposed 50 mg/kg dose group were accompanied by decreased food intake and body weight of dams and F1 generation offspring...
October 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26401846/the-effect-of-dofetilide-on-the-heart-rate-of-gd11-and-gd13-rat-embryos-in-vivo-using-ultrasound
#27
JOURNAL ARTICLE
Helen Ritchie, Diana Oakes, Tzong-tyng Hung, Elizabeth Hegedus, Shreya Sood, William Webster
BACKGROUND: There are a wide range of drugs including antidepressants, anticonvulsants and antipsychotics that cause embryonic bradycardia in vitro but it is unknown if they have a similar effect in vivo. One way to verify whether these in vitro findings are replicated in vivo is by the use of ultrasound examination of dosed pregnant rats. We tested this by examining the effect of dofetilide on embryonic heart rate (HR) in vivo using ultrasound. METHODS: Rats were dosed with dofetilide (4 or 2...
October 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26375421/impact-of-early-postnatal-nsaid-treatment-on-nephrogenesis-in-wistar-rats
#28
JOURNAL ARTICLE
Ruud R G Bueters, Annelies Klaasen, Nuria Maicas, Sandrine Florquin, Lambertus P van den Heuvel, Michiel F Schreuder
BACKGROUND: Prematurely born children with patent ductus arteriosus are treated with ibuprofen or indomethacin, which may inhibit kidney development. We determined whether clinical doses affected kidney development and function, with or without extrauterine growth retardation. METHODS: Wistar rats were cross-fostered in normal food (NF) or food restricted (FR) litters at postnatal day (PND) 2. On PND 3 to 4, three doses of 0.9% NaCl, 0.1 mg/kg indomethacin, or 10 mg/kg ibuprofen were administered via intraperitoneal injection with 12-hr intervals...
October 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26339763/effect-of-himatanthus-sucuuba-in-maternal-reproductive-outcome-and-fetal-anomaly-frequency-in-rats
#29
JOURNAL ARTICLE
Thaigra de Sousa Soares, Débora Cristina Damasceno, Wilma De Grava Kempinas, Flávia Mayara Campos Resende, Maria Aparecida Correa dos Santos, Clélia Akiko Hiruma-Lima, Gustavo Tadeu Volpato
The aim of this study was to evaluate the effect of Himatanthus sucuuba on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant rats were randomly divided into three experimental groups as follows: Control = treated with water (vehicle), treated 250 = treated with H. sucuuba at dose 250 mg/kg, and treated 500 = treated with H. sucuuba at dose 500 mg/kg. The rats were orally treated, by gavage, with H. sucuuba or vehicle (water) during preimplantation and organogenic period (from gestational day 0-14)...
October 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26331294/the-effect-of-exposure-to-atrazine-on-dopaminergic-development-in-pubertal-male-sd-rats
#30
JOURNAL ARTICLE
Yan-Shu Li, Xi He, Kun Ma, Yan-Ping Wu, Bai-Xiang Li
Atrazine (ATR, 2-chloro-4-ethylamino-6-isopropylamino-s-triazine) is used worldwide as a herbicide, and its presence in the environment has resulted in documented human exposure. A lack of strong evidence for genetic heritability of idiopathic Parkinson's disease has focused attention on environmental toxicants in the disease etiology, particularly agrichemicals. Parkinson's disease is associated with advanced age and is characterized by the degeneration of dopaminergic neurons, but it is unclear whether specific neuronal damage could result from insults during development...
October 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26305274/valproic-acid-induces-the-hyperacetylation-of-p53-expression-of-p53-target-genes-and-markers-of-the-intrinsic-apoptotic-pathway-in-midorganogenesis-murine-limbs
#31
JOURNAL ARTICLE
France-Hélène Paradis, Barbara F Hales
In utero exposure to valproic acid (VPA), an anticonvulsant and histone deacetylase inhibitor (HDACi), increases the risk of congenital malformations. Although the mechanisms leading to the teratogenicity of VPA remain unsolved, several HDAC inhibitors increase cell death in cancer cell lines and embryonic tissues. Moreover, P53, the master regulator of apoptosis, is an established HDAC target. The purpose of this study was to investigate the effects of VPA on P53 signaling and markers of apoptosis during midorganogenesis in vitro limb development...
October 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26303163/reproductive-and-developmental-toxicity-of-orally-administered-botanical-composition-up446-part-i-effects-on-embryo-fetal-development-in-new-zealand-white-rabbits-and-sprague-dawley-rats
#32
JOURNAL ARTICLE
Mesfin Yimam, Young-Chul Lee, Eu-Jin Hyun, Qi Jia
The pharmacotoxicology impacts of dietary supplements taken at the time of pregnancy have remained alarming since women are the frequent herbal medicine users in many countries as a complement to the conventional pregnancy management. The use of herbal medicines and diet supplements in expectant mothers linked closely to the health of the childbearing mothers and the fetuses where the lack of developmental safety data imposes a challenge to make the right choices. Here, we describe the potential adverse effects of UP446, a standardized bioflavonoid composition from the roots of Scutellaria baicalensis and the heartwoods of Acacia catechu, on embryo-fetal development following maternal exposure during the critical period of major organogenesis in rabbits and rats...
August 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26173630/reproductive-and-developmental-toxicity-of-orally-administered-botanical-composition-up446-part-iii-effects-on-fertility-and-early-embryonic-development-to-implantation-in-sprague-dawley-rats
#33
JOURNAL ARTICLE
Mesfin Yimam, Young-Chul Lee, Eu-Jin Hyun, Qi Jia
In recent years, high prevalence of adverse effects associated to the use of traditional medicines during pregnancy is becoming alarming due to the self-medication of oral supplements by expecting mothers without supervision. Many expectant mothers use alternative and complementary medicines as a supplement to conventional pregnancy management with an inherent belief of considering herbal remedies as harmless. To the contrary, herbal remedies could incur a potential teratogenic risk both to the child bearing mother and the developing fetuses when consumed before or at the time of gestation...
August 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26033919/reproductive-and-developmental-toxicity-of-orally-administered-botanical-composition-up446-part-ii-effects-on-prenatal-and-postnatal-development-including-maternal-function-in-sprague-dawley-rats
#34
JOURNAL ARTICLE
Mesfin Yimam, Young-Chul Lee, Eu-Jin Hyun, Qi Jia
Almost all herbal remedies could be therapeutic at one dose and toxic at another. These facts become more troubling and a double threat when uncharacterized medicinal herbs are blended together and used by expectant mothers as a supplement to conventional pregnancy management with an inherent belief of considering herbal remedies as harmless. Here we describe the potential adverse effects of UP446, a standardized bioflavonoid composition from the roots of Scutellaria baicalensis and the heartwoods of Acacia catechu, on the maternal and their first filial generation (F1) developmental and functional toxicity following exposure at doses of 250, 500, and 1000 mg/kg/day...
August 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26216019/corrigendum
#35
(no author information available yet)
No abstract text is available yet for this article.
June 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26195315/developmental-toxicity-and-fertility-assessment-in-rabbits-with-tabalumab-a-human-igg4-monoclonal-antibody
#36
JOURNAL ARTICLE
William J Breslin, Kim G Hilbish, Jennifer A Martin, Carolyn A Halstead, Tammy L Edwards
Tabalumab is a human immunoglobulin G subclass 4 monoclonal antibody that has been under development for autoimmune disorders. Tabalumab has full neutralizing activity against both soluble and membrane B-cell activating factor, a B-cell survival factor. The objectives of these studies were to assess the effects of tabalumab on embryo-fetal development and on male (M) and female (F) fertility in rabbits, a pharmacologically relevant species. Doses were administered at 0 (vehicle control), 0.3 (embryo-fetal study only), 1...
June 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26195230/an-enhanced-pre-and-postnatal-development-study-in-cynomolgus-monkeys-with-tabalumab-a-human-igg4-monoclonal-antibody
#37
JOURNAL ARTICLE
William J Breslin, Kim G Hilbish, Jennifer A Martin, Carolyn A Halstead, Deanna L Newcomb, Gary J Chellman
Tabalumab, a human IgG4 monoclonal antibody (mAb) with neutralizing activity against both soluble and membrane B-cell activating factor (BAFF), has been under development for the treatment of autoimmune diseases. The purpose of this study was to determine the potential adverse effects of maternal tabalumab exposure on pregnancy, parturition, and lactation of the mothers and on the growth, viability, and development of the offspring through postnatal day (PND) 204. Tabalumab was administered by subcutaneous injection to presumed pregnant cynomolgus monkeys (16-19 per group) every 2 weeks from gestation day (GD) 20 to 22 until parturition at doses of 0, 0...
June 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26195119/agent-orange-exposure-and-2-3-7-8-tetrachlorodibenzo-p-dioxin-tcdd-in-human-milk
#38
JOURNAL ARTICLE
Anthony R Scialli, Deborah K Watkins, Michael E Ginevan
Agent Orange was sprayed in parts of southern Vietnam during the U.S.-Vietnam war and was a mixture of two chlorophenoxy herbicides. The mixture was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD and other dioxins and furans are measurable in the milk of Vietnamese women. We explored whether the TCDD in milk from these women was from Agent Orange and whether lactational exposure can be a mode of transgenerational effects of TCDD from Agent Orange. A review of the world's literature on milk concentrations of polychlorinated compounds showed the presence of TCDD and other dioxins and furans in all countries that have been assessed...
June 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26194980/time-course-for-onset-and-recovery-from-effects-of-a-novel-male-reproductive-toxicant-implications-for-apical-preclinical-study-designs
#39
JOURNAL ARTICLE
Nicola Powles-Glover, Terri Mitchard, Jane Stewart
In the pharmaceutic ICH S5(R2) guidelines for reproductive toxicity testing, a premating dose duration of 14 days is considered sufficient for assessment of male fertility for compounds that are not testicular toxicants. A novel α7 subtype of nicotinic acetylcholine receptor (α7nAChR) agonist, originally intended for treatment of Alzheimer's disease, did not cause changes in sperm counts, motility, or testicular histopathology in rat toxicity studies of up to 6 months duration. However, profound decrements in male fertility (reduced pregnancy rates and litter sizes) occurred after 11 weeks of dosing in male rats...
June 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://read.qxmd.com/read/26097067/obituary-edward-w-carney-1959-2015
#40
JOURNAL ARTICLE
George P Daston, John M Rogers
No abstract text is available yet for this article.
April 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
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