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Arthritis Research & Therapy

Helena Idborg, Arash Zandian, Ann-Sofi Sandberg, Bo Nilsson, Kerstin Elvin, Lennart Truedsson, Azita Sohrabian, Johan Rönnelid, John Mo, Giorgia Grosso, Marika Kvarnström, Iva Gunnarsson, Janne Lehtiö, Peter Nilsson, Elisabet Svenungsson, Per-Johan Jakobsson
BACKGROUND: Previous studies and own clinical observations of patients with systemic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. This heterogeneity might result in differences in response to treatment in different subgroups and obstruct clinical trials. Our aim was to understand how SLE subgroups may differ regarding underlying pathophysiology and characteristic biomarkers. METHODS: In a cross-sectional study, including 378 well-characterized SLE patients and 316 individually matched population controls, we defined subgroups based on the patients' autoantibody profile at inclusion...
February 18, 2019: Arthritis Research & Therapy
Eun Hye Park, Vibeke Strand, Yoon Jeong Oh, Yeong Wook Song, Eun Bong Lee
BACKGROUND: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and the involvement of multiple internal organs. Previous studies reported poorer health-related quality of life (HRQoL) in patients with SSc compared with the general population. However, very little is known about how HRQoL in SSc patients compares with that in patients with other systemic autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjogren's syndrome (SjS)...
February 15, 2019: Arthritis Research & Therapy
Johanna Estelius, Johan Lengqvist, Elena Ossipova, Helena Idborg, Erwan Le Maître, Magnus L A Andersson, Lou Brundin, Mohsen Khademi, Elisabet Svenungsson, Per-Johan Jakobsson, Jon Lampa
BACKGROUND: Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF blockade. We therefore investigated the effects of TNF blockade on the arthritis CSF proteome and how candidate proteins related to clinical measures of disease activity and inflammation...
February 15, 2019: Arthritis Research & Therapy
Y J Dakkak, D M Boeters, A C Boer, M Reijnierse, A H M van der Helm-van Mil
BACKGROUND: MRI-detected subclinical joint inflammation in the hand joints of patients with undifferentiated arthritis (UA) predicts progression to rheumatoid arthritis (RA). It is unknown if adding MRI of the foot increases predictive accuracy compared to the hand alone. METHODS: 1.5-T contrast-enhanced MRI of the unilateral foot (MTP-1-5) and hand (MCP-2-5 and wrist) was performed in 123 patients presenting with UA (not fulfilling the 2010 RA criteria) and scored for bone marrow edema (BME), synovitis and tenosynovitis...
February 14, 2019: Arthritis Research & Therapy
Jayne Moxey, Molla Huq, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian, Jenny Walker, Gemma Strickland, Michelle Wilson, Laura Ross, Gabor Major, Janet Roddy, Wendy Stevens, Mandana Nikpour
BACKGROUND: Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the significance of ANCA in these patients is unclear. The aim of this study is to determine the prevalence of ANCA in a well-characterised SSc cohort and to examine the association between ANCA and SSc clinical characteristics, other autoantibodies, treatments and mortality. METHODS: Clinical data were obtained from 5 centres in the Australian Scleroderma Cohort Study (ASCS)...
February 14, 2019: Arthritis Research & Therapy
Jeong Seok Lee, Eun Young Lee, You-Jung Ha, Eun Ha Kang, Yun Jong Lee, Yeong Wook Song
BACKGROUND: Biomarkers have been actively investigated to supplement functional and imaging modalities to predict the severity, therapeutic responsiveness, and progression of connective tissue disease-associated interstitial lung disease (CTD-ILD). This study aimed to evaluate Krebs von den Lungen 6 (KL-6) as a potential biomarker reflecting the severity of CTD-ILD as assessed through computed tomography (CT) and pulmonary function test (PFT) parameters. METHODS: This retrospective study included 549 Korean patients with rheumatoid arthritis, systemic sclerosis, inflammatory myositis, and other CTDs with or without concurrent ILD...
February 14, 2019: Arthritis Research & Therapy
Luyun Fan, Huimin Zhang, Jun Cai, Lirui Yang, Bin Liu, Dongmei Wei, Jiachen Yu, Jiali Fan, Lei Song, Wenjun Ma, Xianliang Zhou, Haiying Wu, Ying Lou
Following publication of the original article [1], the authors reported an error.
February 14, 2019: Arthritis Research & Therapy
Sarah Ohrndorf, Aleid C Boer, Debbie M Boeters, Robin M Ten Brinck, Gerd-R Burmester, Marion C Kortekaas, Annette H M van der Helm-van Mil
OBJECTIVE: Ultrasound (US) and magnetic resonance imaging (MRI) are recommended in the diagnostic process of rheumatoid arthritis. Research on its comparability in early disease phases is scarce. Therefore, we compared synovitis and tenosynovitis detected by US and MRI on joint/tendon level. METHODS: Eight hundred forty joints and 700 tendons of 70 consecutive patients, presenting with inflammatory arthritis or clinically suspect arthralgia, underwent US and MRI of MCP (2-5), wrist and MTP (1-5) joints at the same day...
February 14, 2019: Arthritis Research & Therapy
Giulio Cavalli, Alessandro Tomelleri, Giacomo De Luca, Corrado Campochiaro, Charles A Dinarello, Elena Baldissera, Loreno Dagna
No abstract text is available yet for this article.
February 13, 2019: Arthritis Research & Therapy
François Vercruysse, Thomas Barnetche, Estibaliz Lazaro, Emilie Shipley, François Lifermann, Alexandre Balageas, Xavier Delbrel, Bruno Fautrel, Christophe Richez, Thierry Schaeverbeke, Marie-Elise Truchetet
OBJECTIVES: Adult-onset Still's disease (AOSD) phenotype appears to be dichotomized in systemic or chronic articular forms. As biologicals and particularly interleukin (IL)-1 and IL-6 blockers play a more and more prominent role in the treatment, their place requires clarification. This study aimed to identify factors predictive of treatment response to anakinra or tocilizumab and investigate whether the choice of biotherapy and delays in the initiation of biotherapy influenced the likelihood of steroid discontinuation...
February 12, 2019: Arthritis Research & Therapy
Gracijela Bozovic, Rille Pullerits, Arne Ståhl, Kristina Ydström, Daniel Wenger, Jan Marsal, Pontus Thulin, Kristofer Andréasson
BACKGROUND: Systemic sclerosis (SSc) has been suggested to cause exocrine pancreatic dysfunction. However, a case-control-based autopsy study failed to associate systemic sclerosis with any pancreatic histopathology. The primary objective of this study was to examine the exocrine pancreatic function in consecutive SSc patients in relation to an age- and sex-matched control group. A secondary objective was to relate exocrine pancreatic function to radiological, laboratory, and clinical SSc characteristics...
February 12, 2019: Arthritis Research & Therapy
Olivier Fogel, Andreas Bugge Tinggaard, Maud Fagny, Nelly Sigrist, Elodie Roche, Laurence Leclere, Jean-François Deleuze, Frederic Batteux, Maxime Dougados, Corinne Miceli-Richard, Jörg Tost
BACKGROUND: MicroRNAs (MiRs) play an important role in the pathogenesis of chronic inflammatory diseases. This study is the first to investigate miR expression profiles in purified CD4+ T lymphocytes and CD14+ monocytes from patients with axial spondyloarthritis (axSpA) using a high-throughput qPCR approach. METHODS: A total of 81 axSpA patients fulfilling the 2009 ASAS classification criteria, and 55 controls were recruited from October 2014 to July 2017. CD14+ monocytes and CD4+ T lymphocytes were isolated from peripheral blood mononuclear cells...
February 12, 2019: Arthritis Research & Therapy
Lindsy J Forbess, Marios Rossides, Michael H Weisman, Julia F Simard
OBJECTIVE: The objective was to estimate the incidence of lung disease among patients with systemic lupus erythematosus (SLE). METHODS: Using Swedish register data, we identified patients with SLE and pulmonary diagnoses from the National Patient Register through ICD codes. We matched patients with SLE with individuals from the general population. Patients with SLE with a history of pulmonary disease were excluded. Incidence rates (IR) and 95% confidence intervals (CI) were calculated overall and by type of pulmonary disease for incident (2003-2013) and prevalent SLE separately...
February 6, 2019: Arthritis Research & Therapy
M C P Cleophas, T O Crişan, V Klück, N Hoogerbrugge, R T Netea-Maier, C A Dinarello, M G Netea, L A B Joosten
BACKGROUND: Acute gouty arthritis currently is the most common form of inflammatory arthritis in developed countries. Treatment is still suboptimal. Dosage of urate-lowering therapy is often too low to reach target urate levels, and adherence to therapy is poor. In this study, we therefore explore a new treatment option to limit inflammation in acute gout: specific histone deacetylase (HDAC) inhibition. METHODS: Peripheral blood mononuclear cells (PBMCs) were cultured with a combination of monosodium urate crystals (MSU) and palmitic acid (C16...
February 6, 2019: Arthritis Research & Therapy
Toryn M Poolman, Julie Gibbs, Amy L Walker, Suzanna Dickson, Laura Farrell, James Hensman, Alexandra C Kendall, Robert Maidstone, Stacey Warwood, Andrew Loudon, Magnus Rattray, Ian N Bruce, Anna Nicolaou, David W Ray
OBJECTIVE: We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA). METHODS: We recruited adults (age 16-80 years old) with a clinical diagnosis of RA (active disease [DAS28 > 3.2]). Sleep profiles were determined before inpatient measurements of saliva, serum, and peripheral blood mononuclear leukocytes (PBML). Transcriptome and proteome analyses were carried out by RNA-SEQ and LC-MS/MS. Serum samples were analysed by targeted lipidomics, along with serum from mouse collagen induced-arthritis (CIA)...
February 6, 2019: Arthritis Research & Therapy
Michael E Johnson, Jennifer M Franks, Guoshuai Cai, Bhaven K Mehta, Tammara A Wood, Kimberly Archambault, Patricia A Pioli, Robert W Simms, Nicole Orzechowski, Sarah Arron, Michael L Whitfield
BACKGROUND: Infectious agents have long been postulated to be disease triggers for systemic sclerosis (SSc), but a definitive link has not been found. Metagenomic analyses of high-throughput data allows for the unbiased identification of potential microbiome pathogens in skin biopsies of SSc patients and allows insight into the relationship with host gene expression. METHODS: We examined skin biopsies from a diverse cohort of 23 SSc patients (including lesional forearm and non-lesional back samples) by RNA-seq...
February 6, 2019: Arthritis Research & Therapy
Ingiäld Hafström, Sofia Ajeganova, Kristina Forslind, Björn Svensson
BACKGROUND: Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addressed if anti-cyclic citrullinated (anti-CCP) antibodies were associated with osteopenia or pain in patients with RA, at the time for diagnosis. METHODS: Baseline data from the BARFOT (Better Anti-Rheumatic PharmacOTherapy) cohort, which consists of patients with RA with a disease duration of 1 year or less, were analyzed...
February 4, 2019: Arthritis Research & Therapy
Kétia Ermoza, Simon Glatigny, Nadège Jah, Vânia Camilo, Hendrick Mambu Mambueni, Luiza M Araujo, Gilles Chiocchia, Maxime Breban
BACKGROUND: Spondyloarthritis (SpA) is a chronic inflammatory disease affecting primarily axial and peripheral joints and sometimes also extra-articular organs, such as the gut. Rats transgenic for HLA-B27 and human β2-microglobulin (B27-Tg rat) develop clinical manifestations resembling human disease. In this model, it has been shown that CD103+ conventional dendritic cells (cDCs) exhibited altered functions, likely promoting SpA development. CD4- cDC subpopulation expressing XCR1, a chemokine receptor involved in their migration, have been described to be tolerogenic in steady state...
February 4, 2019: Arthritis Research & Therapy
Mu Wang, Panpan Zhang, Wei Lin, Yunyun Fei, Hua Chen, Jing Li, Li Zhang, Wenjie Zheng, Yongze Li, Xiaofeng Zeng, Jiaxin Zhou, Yamin Lai, Xiaowei Liu, Huadan Xue, Yueying Cui, Lian Zhou, Jizhi Zhao, Wen Zhang
BACKGROUND: This study aimed to compare the differences and similarities in the clinical manifestations and treatment efficacy of IgG4-related disease (IgG4-RD) in patients with and without dacryoadenitis and sialoadenitis (DS). METHODS: A total of 121 untreated IgG4-RD patients in Peking Union Medical College Hospital were enrolled in this study. The patients were divided into three groups: DS-predominant (group A), non-DS (group B), and DS with other internal organs affected (group C)...
February 1, 2019: Arthritis Research & Therapy
Chi-Chien Niu, Song-Shu Lin, Li-Jen Yuan, Meng-Ling Lu, Steve W N Ueng, Chuen-Yung Yang, Tsung-Ting Tsai, Po-Liang Lai
BACKGROUND: The expression of both high-mobility group box 1 (HMGB1) and receptor for advanced glycation end-products (RAGE) is upregulated in degenerated discs. HMGB1 is known to function as a coupling factor between hypoxia and inflammation in arthritis, and this inflammatory response is modulated by microRNAs (miRNAs), with miR-107 expression downregulated during hypoxia. In this study, we investigated the regulation of the miR-107/HMGB1/RAGE pathway in degenerated nucleus pulposus cells (NPCs) after hyperbaric oxygen (HBO) treatment...
January 31, 2019: Arthritis Research & Therapy
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