journal
https://read.qxmd.com/read/38890654/rituximab-in-the-treatment-of-progressive-interstitial-lung-disease-associated-with-the-antisynthetase-syndrome
#1
MULTICENTER STUDY
Javier Narváez, Elena Cañadillas, Iván Castellví, Juan José Alegre, Vanesa Vincens-Zygmunt, Guadalupe Bermudo, Paola Vidal-Montal, María Molina Molina, Joan Miquel Nolla
OBJECTIVE: To assess the real-world, long-term effectiveness of rituximab (RTX) as a rescue therapy in patients with antisynthetase syndrome and progressive interstitial lung disease (ASS-ILD). METHODS: Multicentre observational retrospective longitudinal study of a cohort of patients with ASS-ILD that started treatment with RTX due to recurrent or ongoing progressive ILD despite therapy with glucocorticoids and immunosuppressants. RESULTS: Twenty-eight patients were analyzed...
June 18, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38879555/baricitinib-ameliorates-inflammatory-and-neuropathic-pain-in-collagen-antibody-induced-arthritis-mice-by-modulating-the-il-6-jak-stat3-pathway-and-csf-1-expression-in-dorsal-root-ganglion-neurons
#2
JOURNAL ARTICLE
Kenta Makabe, Hiroyuki Okada, Naohiro Tachibana, Hisatoshi Ishikura, Norihito Ito, Masaru Tanaka, Ryota Chijimatsu, Asuka Terashima, Fumiko Yano, Meiko Asaka, Dai Yanagihara, Shuji Taketomi, Takumi Matsumoto, Sakae Tanaka, Yasunori Omata, Taku Saito
BACKGROUND: Janus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies show that baricitinib is more effective at reducing pain than other similar drugs. Here, we aimed to elucidate the molecular mechanisms underlying the pain relief conferred by baricitinib, using a mouse model of arthritis. METHODS: We treated collagen antibody-induced arthritis (CAIA) model mice with baricitinib, celecoxib, or vehicle, and evaluated the severity of arthritis, histological findings of the spinal cord, and pain-related behaviours...
June 15, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38867295/phosphoproteomic-profiling-of-early-rheumatoid-arthritis-synovium-reveals-active-signalling-pathways-and-differentiates-inflammatory-pathotypes
#3
JOURNAL ARTICLE
Cankut Çubuk, Rachel Lau, Pedro Cutillas, Vinothini Rajeeve, Christopher R John, Anna E A Surace, Rebecca Hands, Liliane Fossati-Jimack, Myles J Lewis, Costantino Pitzalis
BACKGROUND: Kinases are intracellular signalling mediators and key to sustaining the inflammatory process in rheumatoid arthritis (RA). Oral inhibitors of Janus Kinase family (JAKs) are widely used in RA, while inhibitors of other kinase families e.g. phosphoinositide 3-kinase (PI3K) are under development. Most current biomarker platforms quantify mRNA/protein levels, but give no direct information on whether proteins are active/inactive. Phosphoproteome analysis has the potential to measure specific enzyme activation status at tissue level...
June 12, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38863059/the-integrin-cd11b-inhibits-msu-induced-nlrp3-inflammasome-activation-in-macrophages-and-protects-mice-against-msu-induced-joint-inflammation
#4
JOURNAL ARTICLE
Driss Ehirchiou, Ilaria Bernabei, Vishnuprabu Durairaj Pandian, Sonia Nasi, Veronique Chobaz, Mariela Castelblanco, Alexander So, Fabio Martinon, Xiaoyun Li, Hans Acha-Orbea, Thomas Hugle, Li Zhang, Nathalie Busso
OBJECTIVE: In gout, monosodium urate crystals are taken up by macrophages, triggering the activation of the NLRP3 inflammasome and the maturation of IL-1β. This study aimed to investigate the role of integrin CD11b in inflammasome activation in macrophages stimulated by MSU. METHODS: BMDM from WT and CD11b KO mice were stimulated in vitro with MSU crystals. Cellular supernatants were collected to assess the expression of the inflammatory cytokines by enzyme-linked immunosorbent assay and western blot methods...
June 11, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38851726/development-of-primary-osteoarthritis-during-aging-in-genetically-diverse-um-het3-mice
#5
JOURNAL ARTICLE
Sher Bahadur Poudel, Ryan R Ruff, Gozde Yildirim, Richard A Miller, David E Harrison, Randy Strong, Thorsten Kirsch, Shoshana Yakar
BACKGROUND: Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and as one ages, various joint tissues undergo gradual change, including degeneration of the articular cartilage, alterations in subchondral bone (SCB) morphology, and inflammation of the synovium. METHODS: We investigated the prevalence of primary OA in aged, genetically diverse UM-HET3 mice...
June 8, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38845046/a-phase-1-randomized-double-blind-placebo-controlled-single-and-multiple-dose-escalation-study-to-evaluate-the-safety-and-pharmacokinetics-pharmacodynamics-of-pf-06835375-a-c-x-c-chemokine-receptor-type-5-directed-antibody-in-patients-with-systemic-lupus-erythematosus
#6
RANDOMIZED CONTROLLED TRIAL
Stanley Cohen, Jean S Beebe, Vishala Chindalore, Shunjie Guan, Mina Hassan-Zahraee, Madhurima Saxena, Li Xi, Craig Hyde, Sarita Koride, Robert Levin, Shannon Lubaczewski, Mikhail Salganik, Abigail Sloan, Erin Stevens, Elena Peeva, Michael S Vincent, David A Martin, Myron Chu
BACKGROUND: The objective of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑06835375, a potent selective afucosyl immunoglobulin G1 antibody targeting C-X-C chemokine receptor type 5 (CXCR5) that potentially depletes B cells, follicular T helper (Tfh) cells, and circulating Tfh-like (cTfh) cells, in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). METHODS: This first-in-human, multicenter, double-blind, sponsor-open, placebo-controlled Phase 1 study recruited patients aged 18-70 years with SLE or RA...
June 6, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38840219/effectiveness-of-janus-kinase-inhibitors-in-relapsing-giant-cell-arteritis-in-real-world-clinical-practice-and-review-of-the-literature
#7
REVIEW
Javier Loricera, Toluwalase Tofade, Diana Prieto-Peña, Susana Romero-Yuste, Eugenio de Miguel, Anne Riveros-Frutos, Iván Ferraz-Amaro, Eztizen Labrador, Olga Maiz, Elena Becerra, Javier Narváez, Eva Galíndez-Agirregoikoa, Ismael González-Fernández, Ana Urruticoechea-Arana, Ángel Ramos-Calvo, Fernando López-Gutiérrez, Santos Castañeda, Sebastian Unizony, Ricardo Blanco
BACKGROUND: A substantial proportion of patients with giant cell arteritis (GCA) relapse despite standard therapy with glucocorticoids, methotrexate and tocilizumab. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway is involved in the pathogenesis of GCA and JAK inhibitors (JAKi) could be a therapeutic alternative. We evaluated the effectiveness of JAKi in relapsing GCA patients in a real-world setting and reviewed available literature. METHODS: Retrospective analysis of GCA patients treated with JAKi for relapsing disease at thirteen centers in Spain and one center in United States (01/2017-12/2022)...
June 5, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38835033/exploration-of-the-combined-role-of-immune-checkpoints-and-immune-cells-in-the-diagnosis-and-treatment-of-ankylosing-spondylitis-a-preliminary-study-immune-checkpoints-in-ankylosing-spondylitis
#8
JOURNAL ARTICLE
Feihong Huang, Zhiping Su, Yibin Huang, Yuxiang Huang, Chengyu Zhou, Sitan Feng, Xiong Qin, Xi Xie, Chong Liu, Chaojie Yu
OBJECTIVE: Immune checkpoints have emerged as promising therapeutic targets for autoimmune diseases. However, the specific roles of immune checkpoints in the pathophysiology of ankylosing spondylitis (AS) remain unclear. METHODS: Hip ligament samples were obtained from two patient groups: those with AS and femoral head deformity, and those with femoral head necrosis but without AS, undergoing hip arthroplasty. Label-Free Quantification (LFQ) Protein Park Analysis was used to identify the protein composition of the ligaments...
June 4, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38831441/single-cell-and-genome-wide-mendelian-randomization-identifies-causative-genes-for-gout
#9
JOURNAL ARTICLE
Yubiao Yang, Ping Hu, Qinnan Zhang, Boyuan Ma, Jinyu Chen, Bitao Wang, Jun Ma, Derong Liu, Jian Hao, Xianhu Zhou
BACKGROUND: Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to investigate the mechanisms of gene expression regulation in gout disease and elucidate its pathogenesis. METHODS: The study integrated gout genome-wide association study (GWAS) data, single-cell transcriptomics (scRNA-seq), expression quantitative trait loci (eQTL), and methylation quantitative trait loci (mQTL) data for analysis, and utilized two-sample Mendelian randomization study to comprehend the causal relationship between proteins and gout...
June 3, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38822382/malignancy-is-increased-in-patients-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis-in-china
#10
JOURNAL ARTICLE
Xiang-Yu Han, Zhi-Ying Li, Ming-Hui Zhao, Mark A Little, Min Chen
OBJECTIVE: It has been reported that in western countries malignancy risk was higher in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) compared with that in the general population. In the current study, we investigated the incidence, spectrum and risk factors of malignancy in Chinese AAV patients. METHODS: AAV patients diagnosed from 1995 to 2021 in Peking University First Hospital with a follow-up more than 12 months were recruited...
May 31, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38816759/predictive-models-of-radiographic-progression-and-pain-progression-in-patients-with-knee-osteoarthritis-data-from-the-fnih-oa-biomarkers-consortium-project
#11
JOURNAL ARTICLE
Xiaoyu Li, Chunpu Li, Peng Zhang
OBJECTIVES: The progression of knee osteoarthritis (OA) can be defined as either radiographic progression or pain progression. This study aimed to construct models to predict radiographic progression and pain progression in patients with knee OA. METHODS: We retrieved data from the FNIH OA Biomarkers Consortium project, a nested case-control study. A total of 600 subjects with mild to moderate OA (Kellgren-Lawrence grade of 1, 2, or 3) in one target knee were enrolled...
May 30, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38812033/mir-653-5p-drives-osteoarthritis-pathogenesis-by-modulating-chondrocyte-senescence
#12
JOURNAL ARTICLE
Yucheng Lin, Lu Zhang, Mingliang Ji, Sinuo Shen, Yuzhi Chen, Shichao Wu, Xiaotao Wu, Nancy Q Liu, Jun Lu
BACKGROUND: Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Accumulating evidence points to chondrocyte senescence as a key driver in OA development. This study aims to identify OA-specific microRNAs (miRNAs) targeting chondrocyte senescence to alleviate OA progression. METHODS: We screened and identified miRNAs differentially expressed in OA and normal cartilage, then confirmed the impact of miR-653-5p on chondrocyte functions and senescence phenotypes through in vitro experiments with overexpression/silencing...
May 29, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38807248/microstructural-changes-of-the-white-matter-in-systemic-lupus-erythematosus-patients-without-neuropsychiatric-symptoms-a-multi-shell-diffusion-imaging-study
#13
JOURNAL ARTICLE
Wenjun Hu, Ziru Qiu, Qin Huang, Yuhao Lin, Jiaying Mo, Linhui Wang, Jingyi Wang, Kan Deng, Yanqiu Feng, Xinyuan Zhang, Xiangliang Tan
BACKGROUND: Diffusion kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) provide more comprehensive and informative perspective on microstructural alterations of cerebral white matter (WM) than single-shell diffusion tensor imaging (DTI), especially in the detection of crossing fiber. However, studies on systemic lupus erythematosus patients without neuropsychiatric symptoms (non-NPSLE patients) using multi-shell diffusion imaging remain scarce. METHODS: Totally 49 non-NPSLE patients and 41 age-, sex-, and education-matched healthy controls underwent multi-shell diffusion magnetic resonance imaging...
May 28, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38802975/investigating-protease-mediated-peptides-of-inflammation-and-tissue-remodeling-as-biomarkers-associated-with-flares-in-psoriatic-arthritis
#14
JOURNAL ARTICLE
Solveig Skovlund Groen, Signe Holm Nielsen, Anne Christine Bay-Jensen, Mozhgan Rasti, Darshini Ganatra, Katerina Oikonomopoulou, Vinod Chandran
BACKGROUND: Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. PsA disease involves flares, which are associated with increased joint inflammation and tissue remodeling. There is a need for identifying biomarkers related to PsA disease activity and flares to improve the management of PsA patients and decrease flares. The tissue turnover imbalance that occurs during the inflammatory and fibro-proliferative processes during flares leads to an increased degradation and/or reorganization of the extracellular matrix (ECM), where increased proteolysis plays a key role...
May 27, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38802958/epidemiological-trends-in-psoriatic-arthritis-a-comprehensive-population-based-study
#15
JOURNAL ARTICLE
Amir Haddad, Perach Chen Elkayam, Nili Stein, Ilan Feldhamer, Arnon Dov Cohen, Walid Saliba, Devy Zisman
BACKGROUND: Psoriatic arthritis (PsA) is a chronic, potentially debilitating inflammatory arthritis often associated with psoriasis. Understanding the epidemiology of PsA across diverse populations can provide valuable insights into its global burden and the role of genetic and environmental factors. This study aimed to estimate PsA's temporal trends, prevalence, and incidence, while assessing variations in age, gender, and ethnicity in Israel from 2016 to 2022. METHODS: Data were sourced from the Clalit Health Services (CHS) database, covering over half of the Israeli population...
May 27, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38802957/the-prognosis-and-management-of-reclassified-systemic-lupus-erythematosus-associated-pulmonary-arterial-hypertension-according-to-2022-esc-ers-guidelines
#16
JOURNAL ARTICLE
Yutong Li, Junyan Qian, Xingbei Dong, Jiuliang Zhao, Qian Wang, Yanhong Wang, Xiaofeng Zeng, Zhuang Tian, Mengtao Li
BACKGROUND AND AIMS: The 2022 European Society of Cardiology/European Respiratory Society (ESC/ERS) guideline has recently revised the hemodynamic definition of pulmonary arterial hypertension. However, there is currently limited research on the prognosis and treatment of system lupus erythematosus-associated pulmonary arterial hypertension (SLE-PAH) patients that have been reclassified by the new hemodynamic definition. This study aims to analyze the prognosis of newly reclassified SLE-PAH patients and provide recommendations for the management strategy...
May 27, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38790040/time-to-improvement-of-pain-morning-stiffness-fatigue-and-disease-activity-in-patients-with-ankylosing-spondylitis-treated-with-tofacitinib-a-post-hoc-analysis
#17
RANDOMIZED CONTROLLED TRIAL
Victoria Navarro-Compán, Atul Deodhar, Rachid Bahiri, Andrew G Bushmakin, Joseph C Cappelleri, Jihane Rammaoui
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor for treatment of ankylosing spondylitis (AS). Time to improvement in core domains of AS was estimated in tofacitinib-treated patients with AS. METHODS: This post hoc analysis used phase 3 trial data from patients with AS receiving tofacitinib 5 mg twice daily or placebo to week (W)16; all patients received open-label tofacitinib W16-48. OUTCOMES: nocturnal pain; total back pain; fatigue, spinal pain, peripheral joint pain/swelling, enthesitis, and morning stiffness (Bath AS Disease Activity Index [BASDAI] questions 1-6); BASDAI total score; AS Disease Activity Score (ASDAS)...
May 24, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38790038/two-year-post-distraction-cartilage-related-structural-improvement-is-accompanied-by-increased-serum-full-length-sirt1
#18
JOURNAL ARTICLE
Miya Marco, Mylène Jansen, Goran van der Weiden, Eli Reich, Yonathan H Maatuf, Simon C Mastbergen, Mona Dvir-Ginzberg
BACKGROUND: Previously, fragments from Sirtuin 1 (SIRT1) were identified in preclinical and clinical samples to display an increase in serum levels for N-terminal (NT) SIRT1 vs. C-terminal (CT) SIRT1, indicative of early signs of OA. Here we tested NT/CT SIRT1 levels as well as a novel formulated sandwich assay to simultaneously detect both domains of SIRT1 in a manner that may inform us about the levels of full-length SIRT1 in the circulation (flSIRT1) of clinical cohorts undergoing knee joint distraction (KJD)...
May 24, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38783357/targeting-pathogenic-fibroblast-like-synoviocyte-subsets-in-rheumatoid-arthritis
#19
REVIEW
Hongyan Qian, Chaoqiong Deng, Shiju Chen, Xinwei Zhang, Yan He, Jingying Lan, Aodi Wang, Guixiu Shi, Yuan Liu
Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the inflamed synovium of patients with rheumatoid arthritis (RA). FLSs are emerging as promising new therapeutic targets in RA. However, fibroblasts perform many essential functions that are required for sustaining tissue homeostasis. Direct targeting of general fibroblast markers on FLSs is challenging because fibroblasts in other tissues might be altered and side effects such as reduced wound healing or fibrosis can occur...
May 23, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38783321/causal-relationship-between-rheumatoid-arthritis-and-bronchiectasis-a-bidirectional-mendelian-randomization-study
#20
JOURNAL ARTICLE
Zehu Chen, Xuegang Li, Honglei Shi, Yiying Huang, Jing Liu
BACKGROUND: Epidemiological observational studies have elucidated a correlation between rheumatoid arthritis (RA) and bronchiectasis. However, the causal nature of this association remains ambiguous. To clarify this potential causal linkage, we conducted a two-sample Mendelian randomization (MR) analysis to explore the bidirectional causality between RA and bronchiectasis. METHODS: Summary statistics for RA and bronchiectasis were obtained from the IEU OpenGWAS database We employed various methods, including inverse variance weighting (IVW), MR-Egger, weighted median, weighted mode, and simple mode, to explore potential causal links between RA and bronchiectasis...
May 23, 2024: Arthritis Research & Therapy
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