journal
https://read.qxmd.com/read/34729053/downregulation-of-src-family-tyrosine-kinases-by-srcasm-and-c-cbl-a-comparative-analysis
#1
JOURNAL ARTICLE
Vivian Lee, Thomas D Griffin, Yoko Suzuki-Horiuchi, Lily Wushanley, Yerin Kweon, Christine Marshall, Weijie Li, Elias Ayli, Adele Haimovic, Aliya Hines, John T Seykora
AIM: Elevated Src-Family tyrosine kinase (SFK) activity drives carcinogenesis in vivo and elevated SFK activity is found ubiquitously in human cancers. Although human squamous cell carcinomas (SCCs) demonstrate increased SFK activity, in silico analysis of SCCs demonstrates that only 0.4% of lesions contain mutations that could potentially increase SFK activity; similarly, a low frequency of activating SFK mutations is found in other major cancers. These findings indicate that SFK activation in cancers likely is not due to activating mutations but alternative mechanisms...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729052/molecular-classification-and-stratification-of-adult-diffuse-gliomas-a-tertiary-care-center-study
#2
JOURNAL ARTICLE
Nidhi Anand, Nuzhat Husain, Renu Varshney, Kiran Preet Malhotra, Mohammad Kaif
BACKGROUND: Diffuse gliomas in the adult population are the most common primary central nervous system (CNS) tumors. The World Health Organization incorporated isocitrate dehydrogenase (IDH) mutations and 1p/19q co-deletion with histopathological features into an "integrated diagnosis" in the revised classification of tumors of CNS. These molecular subgroups of diffuse gliomas are found to stratify patients into prognostically distinct groups better than the histological classification...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729051/outcome-of-routine-histopathological-examination-of-gallbladder-specimen-following-elective-laparoscopic-cholecystectomy
#3
JOURNAL ARTICLE
Ashesh Kumar Jha, Ashraf Ali, Manoj Kumar, Manoj Kumar, Punam Prasad Bhadani, Niroop B S Murthy, Kumar Chandrakant
BACKGROUND: Gallstone disease is one of the commonest surgical ailments encountered in our setup. Its prevalence in India varies from 2% to 29%. Although cholelithiasis accounts for more than 95% of gall bladder related disease, routine histopathological examination (HPE) is vital. It reveals a myriad of benign as well as the malignant surgical pathology of the gallbladder (GB). This part of the world is considered as an endemic region for GB carcinoma as well as gallstone disease. This study intends to evaluate the outcome of the routine HPE of laparoscopic cholecystectomy specimens...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729050/cancer-spectrum-in-tp53-deficient-golden-syrian-hamsters-a-new-model-for-li-fraumeni-syndrome
#4
JOURNAL ARTICLE
Jinxin Miao, Rong Li, Arnaud J Van Wettere, Haoran Guo, Alexandru-Flaviu Tabaran, M Gerald O'Sullivan, Timothy Carlson, Patricia M Scott, Kuisheng Chen, Dongling Gao, Huixiang Li, Yaohe Wang, Zhongde Wang, Robert T Cormier
Background: The TP53 tumor suppressor gene is the most commonly mutated gene in human cancers. Humans who inherit mutant TP53 alleles develop a wide range of early onset cancers, a disorder called Li-Fraumeni Syndrome (LFS). Trp53 -deficient mice recapitulate most but not all of the cancer phenotypes observed in TP53 -deficient human cancers, indicating that new animal models may complement current mouse models and better inform on human disease development. Materials and Methods: The recent application of CRISPR/Cas9 genetic engineering technology has permitted the emergence of golden Syrian hamsters as genetic models for wide range of diseases, including cancer...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729049/molecular-characterization-of-lung-carcinomas-a-study-on-diagnostic-predictive-and-prognostic-markers-using-immunohistochemical-analysis-at-a-tertiary-care-center-in-uttarakhand-india
#5
JOURNAL ARTICLE
Shalinee Rao, Michael Leonard Anthony, Nilotpal Chowdhury, Rajesh Kathrotia, Mayank Mishra, Manisha Naithani, Girish Sindhwani, Neha Singh
INTRODUCTION: Focused studies in different geographic regions would delineate the underlying biological differences and molecular alterations in non-small cell lung cancer (NSCLC) worldwide. Previous studies in literature have documented limited characterization by studying a minimal number of biological markers. This study was done to evaluate expression of multiple immunomarkers including diagnostic, prognostic, and predictive markers in NSCLC for its characterization. MATERIALS AND METHODS: This was an observational study conducted on 60 consecutive cases of NSCLC...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729048/assessment-of-correlation-between-clinical-staging-functional-staging-and-histopathological-grading-of-oral-submucous-fibrosis
#6
JOURNAL ARTICLE
Anagha A Motgi, Mrinal V Shete, Mahesh S Chavan, Nikkhiel N Diwaan, Rashmi Sapkal, Pallavi Channe
BACKGROUND: Oral submucous fibrosis (OSMF) is a premalignant condition with a greater prevalence in countries such as India. Various classifications have been put forth by multiple authors to determine the clinical, functional, and histopathological grade of the disease. The classification systems have greatly helped to determine the treatment modality for the patients. Understanding the correlation between the various classifications will help us determine the course of the disease, management, and prognosis of OSMF...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729047/serum-ceruloplasmin-as-cancer-marker-in-oral-pre-cancers-and-cancers
#7
JOURNAL ARTICLE
Manisha B Patil, T Lavanya, C Meena Kumari, Shishir Ram Shetty, Khalid Gufran, Vipin Viswanath, C Swarnalatha, J Suresh Babu, Abhishek Singh Nayyar
BACKGROUND AND AIM: Oxidative stress leads to a compensatory increase in levels of serum ceruloplasmin in patients with such imbalances. Greater than normal serum ceruloplasmin levels are noticed in numerous cancers including the leukemias and Hodgkin's lymphoma. The purpose of the present study was to estimate and evaluate the efficacy of serum ceruloplasmin levels as a potential biomarker in the early detection of oral potentially malignant epithelial lesions (PMELs) including leukoplakia, oral submucous fibrosis (OSMF), and oral squamous cell carcinoma (OSCC) patients...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729046/study-of-dosimetry-and-clinical-factors-for-assessment-of-xerostomia-in-head-and-neck-squamous-cell-carcinoma-treated-by-intensity-modulated-radiotherapy-a-prospective-study
#8
JOURNAL ARTICLE
Vrinda Singla, Vipul Nautiyal, Meenu Gupta, Viney Kumar, Shivani Mehra, Mushtaq Ahmad
AIM: Clinical and dosimetric factors related to toxicity in terms of xerostomia in patients with head and neck squamous cell cancer (HNSCC) treated with intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS: Patients older than 18 years, with the WHO Performance Status Score <2 with primary diagnosis of HNSCC Stage II, III, and IV who had undergone primary or postoperative radiotherapy (RT) treated by IMRT at the center, from November 2015 to November 2016 were included in the study...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729045/evaluation-and-comparison-of-performance-of-low-dose-128-slice-ct-scanner-with-different-mas-values-a-phantom-study
#9
JOURNAL ARTICLE
Shilpa Singh, Rajesh Sukkala
OBJECTIVE: Radiation dose in computed tomography (CT) has been the concern of physicists ever since the introduction of CT scan. The objective of this study was to evaluate the performance of low-dose 128-slice CT scanner with different mAs values. MATERIALS AND METHODS: Quantitative study was carried out at different values of mAs. Philips brilliance CT phantom with Philips ingenuity 128-slice low-dose CT scanner was chosen for this study. CT number linearity, CT number accuracy, slice thickness accuracy, high-contrast resolution, and low-contrast resolution were calculated and estimated computed tomography dose index volume (CTDIvol ) for all the mAs values were recorded...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729044/role-of-cancer-stem-cells-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review
#10
REVIEW
Preeti Singh, Dominic Augustine, Roopa S Rao, Shankargouda Patil, Kamran Habib Awan, Samudrala Venkatesiah Sowmya, Vanishri C Haragannavar, Kavitha Prasad
Targeting cancer stem cell (CSC) subpopulation within the tumor remains an obstacle for specific therapy in head-and-neck squamous cell carcinoma (HNSCC). Few studies in the literature describe a panel of stem cell makers, however a distinct panel has not been put forth. This systematic review aims to enhance the knowledge of additional markers to accurately relate their expression to tumorigenesis, metastasis, and therapy resistance. Databases, including PubMed, Google Scholar, Ebsco, and Science Direct, were searched from 2010 to 2017 using various combinations of the following keywords: "Stem cell markers in HNSCC" and "chemoresistance and radioresistence in HNSCC...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34729043/expression-and-clinicopathological-correlation-of-ki-67-in-gallbladder-carcinoma
#11
JOURNAL ARTICLE
Amit Gupta, Sweety Gupta, Deepak Rajput, Prashant Durgapal, Jaine John Chennatt, Sanjeev Kishore, Shalinee Rao, Puneet Dhar, Manoj Gupta, Ravi Kant
INTRODUCTION: Gallbladder cancer is an aggressive cancer with short median survival from the time of diagnosis. Improved understanding of the pathological molecular mechanisms of gallbladder carcinogenesis is important to refine the diagnosis, prognosis, and also to develop novel targeted therapies for patients with advanced Gallbladder cancer (GBC) malignancy. Ki-67 is a marker of cell proliferation and its detection by immunohistochemistry is considered to be an effective method for the detection of prognosis in several tumors...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34526856/insights-into-the-role-of-estrogens-and-androgens-in-glial-tumorigenesis
#12
REVIEW
Bhavna Daswani, Yasmin Khan
Gliomas are more common in males than in females. Emerging evidence from several studies in vitro and in vivo have shown the role of estrogens and androgens in glial tumorigenesis. In recent times, studies have also shed light on the actions of estrogen receptors, alpha and beta, and androgen receptor. Here, we provide a comprehensive overview of the research hitherto on estrogens and androgens along with an emphasis on their receptors in glioma pathophysiology. Studies with conflicting results are discussed and future possibilities are put forward...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34526855/understanding-the-molecular-mechanism-associated-with-reversal-of-oral-submucous-fibrosis-targeting-hydroxylysine-aldehyde-derived-collagen-cross-links
#13
REVIEW
Smitha Sammith Shetty, Mohit Sharma, Shama Prasada Kabekkodu, Nv Anil Kumar, Kapaettu Satyamoorthy, Raghu Radhakrishnan
Fibrosis is a pathological state characterized by excessive deposition of the extracellular matrix components leading to impaired tissue function in the affected organ. It results in scarring of the affected tissue akin to an over-healing wound as a consequence of chronic inflammation and repair in response to injury. Persistent trauma of susceptible oral mucosa due to habitual chewing of betel quid resulting in zealous healing of the mucosal tissue is one plausible explanation for the onset of oral submucous fibrosis (OSF)...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34447288/angiopoietin-like-protein-4-is-a-chromatin-bound-protein-that-enhances-mammosphere-formation-in-vitro-and-experimental-triple-negative-breast-cancer-brain-and-liver-metastases-in-vivo
#14
JOURNAL ARTICLE
Jodi Simeon, Jessica Thrush, Tameka A Bailey
INTRODUCTION: Metastatic progression in triple-negative breast cancer (TNBC) patients occurs primarily because of nuclear reprogramming that includes chromatin remodeling and epigenetic modifications. The existing and most successful chemotherapies available for metastatic TNBC target nuclear proteins or damage DNA. The objectives here are to investigate an undescribed role for the molecular biology of nuclear angiopoietin-like protein 4 (ANGPTL4) and to characterize the effect of ectopic overexpression of ANGPTL4 in the metastatic biology of TNBC...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34429714/melatonin-effect-on-hypoxia-inducible-factor-1%C3%AE-and-clinical-response-in-patients-with-oral-squamous-cell-carcinoma-receiving-neoadjuvant-chemotherapy-a-randomized-controlled-trial
#15
JOURNAL ARTICLE
Diani Kartini, Akmal Taher, Sonar Soni Panigoro, Rianto Setiabudy, Sri Widia Jusman, Sofia Mubarika Haryana, Abdullah Murdani, Primariadewi Rustamadji, Adlina Karisyah, Sani Hadiyan Rasyid
CONTEXT: Chemoresistance is a major issue in patients with locally advanced oral squamous cell carcinoma (OSCC). In this study, we evaluated the effectiveness of melatonin in conjunction with neoadjuvant chemotherapy (NC) on hypoxia-inducible factor-1α (HIF-1α) expression and clinical response in locally advanced OSCC patients. AIMS: To study the effects of melatonin on HIF-1α expression and its effect on the clinical response of patients with locally advanced OSCC...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34321957/expression-of-human-epidermal-growth-factor-receptor-2-survivin-enhancer-of-zeste-homolog-2-cyclooxygenase-2-p53-and-p16-molecular-markers-in-gall-bladder-carcinoma
#16
JOURNAL ARTICLE
Amit Gupta, Sweety Gupta, Rishit Mani, Prashant Durgapal, Bela Goyal, Deepak Rajput, Shalinee Rao, Puneet Dhar, Manoj Gupta, Sanjeev Kishore, Ravi Kant
INTRODUCTION: Gallbladder cancer exhibits striking variability in the global rates, reaching epidemic levels for some regions and ethnicities. The basis of its variability resides in differences in environmental exposure and intrinsic genetic predisposition to carcinogenesis. There is little information present regarding genetic and molecular alterations in gall bladder cancer (GBC). We, therefore, have evaluated the molecular marker expression in GBC and studied their correlation with clinicopathological staging...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34321956/demographic-and-clinicopathological-profile-of-gall-bladder-cancer-patients-study-from-a-tertiary-care-center-of-the-sub-himalayan-region-in-indo-gangetic-belt
#17
JOURNAL ARTICLE
Amit Gupta, Sweety Gupta, Rohik Anjum T Siddeek, Jaine John Chennatt, Tanuj Singla, Deepak Rajput, Navin Kumar, Amit Sehrawat, Sanjeev Kishore, Manoj Gupta
INTRODUCTION: Gall bladder cancer (GBC) accounts for 80%-95% of biliary tract malignancies in the world. There is however striking variability in the global incidence of gallbladder cancer, reaching epidemic levels for some regions and ethnicities. The aim of this study was to evaluate the demographic and clinicopathological profile of the gallbladder cancer patients. MATERIALS AND METHODS: All patients of carcinoma gall bladder presenting to department of surgery in hepatopancreaticobiliary unit from July 2017 to November 2020 were included in this study...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34321955/lipid-metabolism-in-cancer-a-systematic-review
#18
REVIEW
Wafa Khan, Dominic Augustine, Roopa S Rao, Shankargouda Patil, Kamran Habib Awan, Samudrala Venkatesiah Sowmya, Vanishri C Haragannavar, Kavitha Prasad
Preclinical studies and clinical trials have emphasized the decisive role of lipid metabolism in tumor proliferation and metastasis. This systematic review aimed to explore the existing literature to evaluate the role and significance of the genes and pathways most commonly involved in the regulation of lipid metabolism in cancer. The literature search was performed as per Preferred Reporting Items for Systematic Reviews and Meta-analyses. Approximately 2396 research articles were initially selected, of which 215 were identified as potentially relevant for abstract review...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34211339/clinical-diagnostic-criteria-versus-advanced-imaging-in-prediction-of-cervical-lymph-node-metastasis-in-oral-squamous-cell-carcinomas-a-magnetic-resonance-imaging-based-study
#19
JOURNAL ARTICLE
F Lalfamkima, G L Georgeno, N Koteswara Rao, Rajkumar Selvakumar, Vimal Joseph Devadoss, Niroshini Rajaram, Shomaila Farid, T Lalchhuanawma, Abhishek Singh Nayyar
CONTEXT AND AIM: The inaccuracies in clinical examination have been well documented, while advanced imaging modalities, including computed tomography and magnetic resonance imaging (MRI), have been shown to have superior diagnostic accuracy in detecting occult and nodal metastasis. The aim of the present study was to identify as well as evaluate the inaccuracies in clinical examination and of clinical diagnostic criteria in known cases of oral squamous cell carcinomas (OSCCs) with the help of MRI...
2021: Journal of Carcinogenesis
https://read.qxmd.com/read/34211338/wrong-place-wrong-time-runt-related-transcription-factor-2-satb2-pathway-in-bone-development-and-carcinogenesis
#20
REVIEW
Yusha Zhu, Angelica Ortiz, Max Costa
Upregulation or aberrant expression of genes such as special AT-rich sequence-binding protein 2 (SATB2) is necessary for normal cell differentiation and tissue development and is often associated with carcinogenesis and metastatic progression. SATB2 is a critical transcription factor for biological development of various specialized cell lineages, such as osteoblasts and neurons. The dysregulation of SATB2 expression has recently been associated with various types of cancer, while the mechanisms and pathways by which it mediates tumorigenesis are not well elucidated...
2021: Journal of Carcinogenesis
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