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Journal of Nanobiotechnology

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https://read.qxmd.com/read/30736797/correction-to-binding-mechanism-of-anti-cancer-chemotherapeutic-drug-mitoxantrone-to-dna-characterized-by-magnetic-tweezers
#1
Dennis Kreft, Ying Wang, Michael Rattay, Katja Toensing, Dario Anselmetti
Following publication of this article [1] we found a typographical error in the results reported in the abstract. The corrected sentences should read as below.
February 8, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30728024/real-time-in-vivo-imaging-of-subpopulations-of-circulating-tumor-cells-using-antibody-conjugated-quantum-dots
#2
Chiung Wen Kuo, Di-Yen Chueh, Peilin Chen
INTRODUCTION: The detection of circulating tumor cells (CTCs) is very important for cancer diagnosis. CTCs can travel from primary tumors through the circulation to form secondary tumor colonies via bloodstream extravasation. The number of CTCs has been used as an indicator of cancer progress. However, the population of CTCs is very heterogeneous. It is very challenging to identify CTC subpopulations such as cancer stem cells (CSCs) with high metastatic potential, which are very important for cancer diagnostic management...
February 6, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30728022/long-term-live-cells-observation-of-internalized-fluorescent-fe-c-nanoparticles-in-constant-magnetic-field
#3
Anastasiia Garanina, Igor Kireev, Oxana Zhironkina, Olga Strelkova, Anton Shakhov, Irina Alieva, Valery Davydov, Sankaran Murugesan, Valery Khabashesku, Alexander Majouga, Viatcheslav Agafonov, Rustem Uzbekov
BACKGROUND: Theranostics application of superparamagnetic nanoparticles based on magnetite and maghemite is impeded by their toxicity. The use of additional protective shells significantly reduced the magnetic properties of the nanoparticles. Therefore, iron carbides and pure iron nanoparticles coated with multiple layers of onion-like carbon sheath seem to be optimal for biomedicine. Fluorescent markers associated with magnetic nanoparticles provide reliable means for their multimodal visualization...
February 6, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30728015/specific-drug-delivery-efficiently-induced-human-breast-tumor-regression-using-a-lipoplex-by-non-covalent-association-with-anti-tumor-antibodies
#4
Yu-Ling Lin, Nu-Man Tsai, Chia-Hung Chen, Yen-Ku Liu, Chung-Jen Lee, Yi-Lin Chan, Yu-Shan Wang, Yuan-Ching Chang, Chi-Hsin Lin, Tse-Hung Huang, Chao Ching Wang, Kwan-Hwa Chi, Kuang-Wen Liao
BACKGROUND: A cationic liposome-PEG-PEI complex (LPPC) was employed as a carrier for achieving targeted delivery of drug to human epidermal growth factor receptor-2 (HER2/neu)-expressing breast cancer cells. LPPC can be easily loaded with an anti-tumor drug and non-covalently associated with an anti-tumor antibody such as Herceptin that is clinically used to rapidly form immunoparticles within 1 h. RESULTS: Drug-loaded LPPC have an average size about 250 nm and a zeta potential of about 40 mV...
February 6, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30722792/two-distinct-cellular-pathways-leading-to-endothelial-cell-cytotoxicity-by-silica-nanoparticle-size
#5
Kyungmin Lee, Jangwook Lee, Minjeong Kwak, Young-Lai Cho, Byungtae Hwang, Min Ji Cho, Na Geum Lee, Jongjin Park, Sang-Hyun Lee, Jong-Gil Park, Yeon-Gu Kim, Jang-Seong Kim, Tae-Su Han, Hyun-Soo Cho, Young-Jun Park, Seon-Jin Lee, Hee Gu Lee, Won Kon Kim, In Cheul Jeung, Nam Woong Song, Kwang-Hee Bae, Jeong-Ki Min
BACKGROUND: Silica nanoparticles (SiNPs) are widely used for biosensing and diagnostics, and for the targeted delivery of therapeutic agents. Safety concerns about the biomedical and clinical applications of SiNPs have been raised, necessitating analysis of the effects of their intrinsic properties, such as sizes, shapes, and surface physicochemical characteristics, on human health to minimize risk in biomedical applications. In particular, SiNP size-associated toxicological effects, and the underlying molecular mechanisms in the vascular endothelium remain unclear...
February 5, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30711007/inhibition-of-inflammatory-response-in-human-keratinocytes-by-magnetic-nanoparticles-functionalized-with-pbp10-peptide-derived-from-the-pip2-binding-site-of-human-plasma-gelsolin
#6
Ewelina Piktel, Urszula Wnorowska, Mateusz Cieśluk, Piotr Deptula, Katarzyna Pogoda, Iwona Misztalewska-Turkowicz, Paulina Paprocka, Katarzyna Niemirowicz-Laskowska, Agnieszka Z Wilczewska, Paul A Janmey, Robert Bucki
BACKGROUND: Human plasma gelsolin (pGSN) is a multifunctional actin-binding protein involved in a variety of biological processes, including neutralization of pro-inflammatory molecules such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA) and modulation of host inflammatory response. It was found that PBP10, a synthetic rhodamine B-conjugated peptide, based on the phosphoinositide-binding site of pGSN, exerts bactericidal activity against Gram-positive and Gram-negative bacteria, interacts specifically with LPS and LTA, and limits microbial-induced inflammatory effects...
February 2, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30711005/from-one-to-all-self-assembled-theranostic-nanoparticles-for-tumor-targeted-imaging-and-programmed-photoactive-therapy
#7
Xianlei Li, Xuan Wang, Caiyan Zhao, Leihou Shao, Jianqing Lu, Yujia Tong, Long Chen, Xinyue Cui, Huiling Sun, Junxing Liu, Mingjun Li, Xiongwei Deng, Yan Wu
BACKGROUND: In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application. RESULTS: Herein, we demonstrated self-assembled nanoparticles with single structure as a "from one to all" theranostic platform for tumor-targeted dual-modal imaging and programmed photoactive therapy (PPAT)...
February 2, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30709410/indoor-nanoscale-particulate-matter-induced-coagulation-abnormality-based-on-a-human-3d-microvascular-model-on-a-microfluidic-chip
#8
Yan Li, Chuanlin Hu, Pengcheng Wang, Yan Liu, Luyang Wang, Qingmeng Pi, Zhiyong Gong, Xu Yang, Michael Mak, Yang Wu
BACKGROUND: A growing body of evidence shows that indoor concentrations of airborne particles are often higher than is typically encountered outdoors. Since exposure to indoor PM2.5 is thought to be associated with cardiovascular disease, the health impacts of indoor air pollution need to be explored. Based on animal models, ambient particulate matter has been proved to promote coagulation which is very likely involved in the pathogenic development of cardiovascular disease. However, animal models are insufficient to predict what will happen with any certainty in humans...
February 1, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30709404/high-time-resolution-and-high-signal-to-noise-monitoring-of-the-bacterial-growth-kinetics-in-the-presence-of-plasmonic-nanoparticles
#9
Marija Vukomanovic, Eduard Torrents
BACKGROUND: Emerging concepts for designing innovative drugs (i.e., novel generations of antimicrobials) frequently include nanostructures, new materials, and nanoparticles (NPs). Along with numerous advantages, NPs bring limitations, partly because they can limit the analytical techniques used for their biological and in vivo validation. From that standpoint, designing innovative drug delivery systems requires advancements in the methods used for their testing and investigations. Considering the well-known ability of resazurin-based methods for rapid detection of bacterial metabolisms with very high sensitivity, in this work we report a novel optimization for tracking bacterial growth kinetics in the presence of NPs with specific characteristics, such as specific optical properties...
February 1, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30696428/lecithin-nano-liposomal-particle-as-a-crispr-cas9-complex-delivery-system-for-treating-type-2-diabetes
#10
Eun Yi Cho, Jee-Yeon Ryu, Han A Reum Lee, Shin Hee Hong, Hye Sun Park, Kwan Soo Hong, Sang-Gyu Park, Hong Pyo Kim, Tae-Jong Yoon
BACKGROUND: Protein-based Cas9 in vivo gene editing therapeutics have practical limitations owing to their instability and low efficacy. To overcome these obstacles and improve stability, we designed a nanocarrier primarily consisting of lecithin that can efficiently target liver disease and encapsulate complexes of Cas9 with a single-stranded guide RNA (sgRNA) ribonucleoprotein (Cas9-RNP) through polymer fusion self-assembly. RESULTS: In this study, we optimized an sgRNA sequence specifically for dipeptidyl peptidase-4 gene (DPP-4) to modulate the function of glucagon-like peptide 1...
January 29, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30683129/tri-mannose-grafting-of-chitosan-nanocarriers-remodels-the-macrophage-response-to-bacterial-infection
#11
Juan Manuel Coya, Laura De Matteis, Alexandre Giraud-Gatineau, Anne Biton, Inés Serrano-Sevilla, Anne Danckaert, Marie-Agnès Dillies, Brigitte Gicquel, Jesus M De la Fuente, Ludovic Tailleux
BACKGROUND: Infectious diseases are still a leading cause of death and, with the emergence of drug resistance, pose a great threat to human health. New drugs and strategies are thus urgently needed to improve treatment efficacy and limit drug-associated side effects. Nanotechnology-based drug delivery systems are promising approaches, offering hope in the fight against drug resistant bacteria. However, how nanocarriers influence the response of innate immune cells to bacterial infection is mostly unknown...
January 25, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30683120/exosome-origin-determines-cell-targeting-and-the-transfer-of-therapeutic-nanoparticles-towards-target-cells
#12
María Sancho-Albero, Nuria Navascués, Gracia Mendoza, Víctor Sebastián, Manuel Arruebo, Pilar Martín-Duque, Jesús Santamaría
BACKGROUND: Exosomes are considered key elements for communication between cells, but very little is known about the mechanisms and selectivity of the transference processes involving exosomes released from different cells. RESULTS: In this study we have investigated the transfer of hollow gold nanoparticles (HGNs) between different cells when these HGNs were loaded within exosomes secreted by human placental mesenchymal stem cells (MSCs). These HGNs were successfully incorporated in the MSCs exosome biogenesis pathway and released as HGNs-loaded exosomes...
January 25, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30683113/enamel-remineralization-and-repair-results-of-biomimetic-hydroxyapatite-toothpaste-on-deciduous-teeth-an-effective-option-to-fluoride-toothpaste
#13
Maurizio Bossù, Matteo Saccucci, Alessandro Salucci, Gianni Di Giorgio, Erika Bruni, Daniela Uccelletti, Maria Sabrina Sarto, Giuseppe Familiari, Michela Relucenti, Antonella Polimeni
BACKGROUND: Dental caries is a recognized worldwide public health problem. Despite being one of the most effective strategies against dental caries, the excessive use of fluorine may result in a potential risk of developing dental fluorosis especially in children under age of six. The purpose of this work is to analyze a fluorine-free toothpaste containing Biomimetic Hydroxyapatite to assess enamel re-mineralizing and repairing properties. RESULTS: The study was performed in vitro and in vivo, comparing the hydroxyapatite toothpaste with two others toothpaste containing different fluorine concentrations...
January 25, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30683110/mitochondria-targeted-cyclosporin-a-delivery-system-to-treat-myocardial-ischemia-reperfusion-injury-of-rats
#14
Chang-Xiong Zhang, Ying Cheng, Dao-Zhou Liu, Miao Liu, Han Cui, Bang-le Zhang, Qi-Bing Mei, Si-Yuan Zhou
BACKGROUND: Cyclosporin A (CsA) is a promising therapeutic drug for myocardial ischemia reperfusion injury (MI/RI) because of its definite inhibition to the opening of mitochondrial permeability transition pore (mPTP). However, the application of cyclosporin A to treat MI/RI is limited due to its immunosuppressive effect to other normal organ and tissues. SS31 represents a novel mitochondria-targeted peptide which can guide drug to accumulate into mitochondria. In this paper, mitochondria-targeted nanoparticles (CsA@PLGA-PEG-SS31) were prepared to precisely deliver cyclosporin A into mitochondria of ischemic cardiomyocytes to treat MI/RI...
January 25, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30670042/a-milk-based-self-assemble-rotavirus-vp6-ferritin-nanoparticle-vaccine-elicited-protection-against-the-viral-infection
#15
Zhipeng Li, Kuiqing Cui, Hong Wang, Fuhang Liu, Kongwei Huang, Zhaojun Duan, Fengchao Wang, Deshun Shi, Qingyou Liu
BACKGROUND: Rotavirus is the leading cause of severe dehydrating diarrhea in young children and the inner capsid protein VP6 is a potential vaccine candidate that can induce cross-protective immune responses against different Rotavirus strains. The use of ferritin nanoparticles as the scaffold of the antigen can improve the immunogenicity of the subunit vaccines and provide broader protection. We here present a non-live and self-assemble recombinant rotavirus VP6-ferritin (rVP6-ferritin) nanoparticle vaccine...
January 22, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30670041/efficient-sirna-delivery-and-gene-silencing-using-a-lipopolypeptide-hybrid-vector-mediated-by-a-caveolae-mediated-and-temperature-dependent-endocytic-pathway
#16
Hironori Kasai, Kenji Inoue, Kentaro Imamura, Carlo Yuvienco, Jin K Montclare, Seiichi Yamano
BACKGROUND: We developed a non-viral vector, a combination of HIV-1 Tat peptide modified with histidine and cysteine (mTat) and polyethylenimine, jetPEI (PEI), displaying the high efficiency of plasmid DNA transfection with little toxicity. Since the highest efficiency of INTERFERin (INT), a cationic amphiphilic lipid-based reagent, for small interfering RNA (siRNA) transfection among six commercial reagents was shown, we hypothesized that combining mTat/PEI with INT would improve transfection efficiency of siRNA delivery...
January 22, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30670038/nep-1-40-modified-human-serum-albumin-nanoparticles-enhance-the-therapeutic-effect-of-methylprednisolone-against-spinal-cord-injury
#17
Yan Lin, Chunhong Li, Jian Li, Ruolan Deng, Juan Huang, Qinglian Zhang, Jiayao Lyu, Na Hao, Zhirong Zhong
BACKGROUND: Frequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes and administration routes. Albumin-based nanoparticles, which can encapsulate therapeutic drugs and release cargo in a controlled pattern, show high biocompatibility and low toxicity. The Nogo protein, expressed on the surface of oligodendrocytes, can inhibit axonal growth by binding with the axonal Nogo receptor (NgR)...
January 22, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30670029/t-cells-loaded-with-magnetic-nanoparticles-are-retained-in-peripheral-lymph-nodes-by-the-application-of-a-magnetic-field
#18
Laura Sanz-Ortega, José M Rojas, Ana Marcos, Yadileiny Portilla, Jens V Stein, Domingo F Barber
BACKGROUND: T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these therapies. Nanotechnology has been successfully used for localized release of drugs and biomolecules...
January 22, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30670028/endoplasmic-reticulum-stress-major-player-in-size-dependent-inhibition-of-p-glycoprotein-by-silver-nanoparticles-in-multidrug-resistant-breast-cancer-cells
#19
Mohana Krishna Gopisetty, Dávid Kovács, Nóra Igaz, Andrea Rónavári, Péter Bélteky, Zsolt Rázga, Viktória Venglovecz, Bálint Csoboz, Imre Miklós Boros, Zoltán Kónya, Mónika Kiricsi
BACKGROUND: Development of multidrug resistance (MDR) is a major burden of successful chemotherapy, therefore, novel approaches to defeat MDR are imperative. Although the remarkable anti-cancer propensity of silver nanoparticles (AgNP) has been demonstrated and their potential application in MDR cancer has been proposed, the nanoparticle size-dependent cellular events directing P-glycoprotein (Pgp) expression and activity in MDR cancer have never been addressed. Hence, in the present study we examined AgNP size-dependent cellular features in multidrug resistant breast cancer cells...
January 22, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30670021/bone-targeting-drug-delivery-system-of-biomineral-binding-liposomes-loaded-with-icariin-enhances-the-treatment-for-osteoporosis
#20
Xiaoduan Sun, Jun Wei, Jiayao Lyu, Tierong Bian, Zhongbing Liu, Juan Huang, Fengjuan Pi, Chunhong Li, Zhirong Zhong
BACKGROUND: Osteoporosis is a bone-incapacitating malady and it is characterized by obvious bone mass loss and bone microarchitecture deterioration. Current treatments for osteoporosis have many limitations, including the non-obvious therapeutic effect and long-term safety issues. Icariin is a pharmacologically active flavonoid glycoside, which shows potential application in treatment of osteoporosis. But its clinical application is limited by the inherent disadvantages such as poor water solubility, first pass effect after oral administration, and low bioavailability...
January 22, 2019: Journal of Nanobiotechnology
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